Detailed information for compound 1269804

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.58 | Formula: C28H32N4O
  • H donors: 0 H acceptors: 2 LogP: 4.87 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)cccc2N1CCN([C@H](C1)C)CCc1c(C)ccc2c1ccc(=O)n2C
  • InChi: 1S/C28H32N4O/c1-19-8-12-26-23(11-13-28(33)30(26)4)22(19)14-15-31-16-17-32(18-21(31)3)27-7-5-6-25-24(27)10-9-20(2)29-25/h5-13,21H,14-18H2,1-4H3/t21-/m0/s1
  • InChiKey: UUWQIBYZFVEIMA-NRFANRHFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi AT19640p 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 390 aa 335 aa 21.8 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0067 0.0112 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0131 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Brugia malayi Cathepsin L-like precursor 0.0054 0.0071 0.0078
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Leishmania major aldo-keto reductase-like protein 0.0036 0.0011 0.0045
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0253 0.0707 0.0719
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0983 0.305 0.3326
Echinococcus granulosus intermediate filament protein 0.0229 0.0632 0.0699
Schistosoma mansoni tar DNA-binding protein 0.0449 0.1336 0.1477
Echinococcus granulosus expressed protein 0.0054 0.0069 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0053 0.0059
Echinococcus multilocularis TGF beta signal transducer SmadC 0.011 0.0251 0.0277
Loa Loa (eye worm) thioredoxin reductase 0.0729 0.2235 0.247
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.0071 0.0078
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0031 0.013
Loa Loa (eye worm) hypothetical protein 0.0106 0.0238 0.0264
Echinococcus multilocularis mothers against decapentaplegic 2 0.0049 0.0055 0.0061
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0222 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0061 0.0268
Loa Loa (eye worm) oxidoreductase 0.0036 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0081 0.0158 0.0174
Echinococcus multilocularis thioredoxin glutathione reductase 0.073 0.2238 0.2474
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0112 0.0674
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0112 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Loa Loa (eye worm) hypothetical protein 0.0493 0.1478 0.1634
Mycobacterium tuberculosis Probable oxidoreductase 0.1848 0.5825 0.582
Echinococcus multilocularis musashi 0.0229 0.0632 0.0699
Brugia malayi carbohydrate phosphorylase 0.0067 0.0111 0.0122
Leishmania major cathepsin L-like protease 0.0206 0.0558 0.2493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0071 0.0215
Echinococcus granulosus hypothetical protein 0.0036 0.0011 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.0791 0.2435 0.2691
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0112 0.0674
Echinococcus granulosus cathepsin l1 0.0036 0.0013 0.0015
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0253 0.0707 0.0782
Loa Loa (eye worm) Smad1 0.011 0.0251 0.0277
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.01 0.0099
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0253 0.0707 0.3161
Entamoeba histolytica glycogen phosphorylase, putative 0.0067 0.0111 0.0359
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1662 0.523 0.5225
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0034 0.0154
Echinococcus granulosus lamin dm0 0.0229 0.0632 0.0699
Echinococcus granulosus lamin 0.0229 0.0632 0.0699
Trypanosoma cruzi aldo/keto reductase, putative 0.0036 0.0011 0.0045
Brugia malayi mothers against decapentaplegic homolog 3 0.0049 0.0055 0.0061
Echinococcus granulosus mothers against decapentaplegic 6 0.0049 0.0055 0.0061
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0253 0.0707 0.077
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0034 0.0154
Echinococcus granulosus chromobox protein 1 0.0071 0.0124 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.0251 0.0277
Mycobacterium tuberculosis Probable esterase LipL 0.0493 0.1478 0.1469
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0112 0.0497
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0037 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.09 0.2783 0.3075
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0186 0.0492 0.0544
Trypanosoma cruzi major cysteine proteinase, putative 0.0162 0.0417 0.186
Brugia malayi TAR-binding protein 0.0449 0.1336 0.1477
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0178 0.0196
Loa Loa (eye worm) oxidoreductase 0.0036 0.0011 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0493 0.1478 0.9789
Loa Loa (eye worm) hypothetical protein 0.0156 0.0396 0.0438
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0131 0.0145
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0067 0.0112 0.1452
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0036 0.0011 0.0012
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0067 0.0112 0.0057
Loa Loa (eye worm) hypothetical protein 0.0156 0.0396 0.0438
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0112 0.0674
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0049 0.0055 0.0294
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0124 0.0756
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0025 0.009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0366 0.107 0.1183
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.1314 0.1452
Trypanosoma brucei NADH dehydrogenase 0.0067 0.0112 0.0497
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1848 0.5825 0.582
Echinococcus multilocularis cysteine protease 0.0054 0.0071 0.0078
Brugia malayi Bromodomain containing protein 0.0159 0.0407 0.045
Trichomonas vaginalis glycogen phosphorylase, putative 0.0067 0.0111 0.0665
Brugia malayi glutamate synthase 0.0067 0.0112 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Echinococcus granulosus mothers against decapentaplegic 5 0.011 0.0251 0.0277
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0253 0.0707 0.3161
Echinococcus granulosus TGF beta signal transducer SmadC 0.011 0.0251 0.0277
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0112 0.0674
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Brugia malayi Probable ClpP-like protease 0.2853 0.9048 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.107 0.1183
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0067 0.0112 0.0057
Mycobacterium tuberculosis Probable lipase LipE 0.0493 0.1478 0.1469
Mycobacterium ulcerans glutamate synthase subunit beta 0.0067 0.0112 0.0112
Brugia malayi Cathepsin L-like precursor 0.0054 0.0071 0.0078
Onchocerca volvulus 0.0054 0.0071 0.0397
Brugia malayi Ets-domain containing protein 0.0087 0.0178 0.0196
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0031 0.013
Schistosoma mansoni Smad4 0.0049 0.0055 0.0061
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0151
Echinococcus multilocularis aldo keto reductase 0.0036 0.0011 0.0012
Echinococcus granulosus chromobox protein 1 0.0071 0.0124 0.0137
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0036 0.0011 0.0012
Plasmodium vivax SET domain protein, putative 0.0063 0.01 0.0044
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0983 0.305 0.332
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0112 0.0674
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.01 0.0111
Leishmania major hypothetical protein, conserved 0.0051 0.0061 0.0268
Leishmania major trypanothione reductase 0.0729 0.2235 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0013 0.0014
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0253 0.0707 0.0782
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0054 0.0069 0.0058
Onchocerca volvulus 0.0054 0.0071 0.0397
Brugia malayi Intermediate filament tail domain containing protein 0.0229 0.0632 0.0699
Schistosoma mansoni glutaminase 0.0291 0.0832 0.0919
Schistosoma mansoni hypothetical protein 0.0067 0.0112 0.0124
Echinococcus granulosus serotonin transporter 0.0073 0.0131 0.0145
Echinococcus multilocularis serotonin receptor 0.0156 0.0396 0.0438
Schistosoma mansoni chromobox protein 0.0071 0.0124 0.0137
Onchocerca volvulus 0.0493 0.1478 0.9789
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0366 0.107 0.1183
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0036 0.0011 0.0045
Loa Loa (eye worm) cysteine protease 0.0054 0.0071 0.0078
Trichomonas vaginalis glutamate synthase, putative 0.0067 0.0112 0.0674
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.004 0.0044
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0067 0.0112 0.0124
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0123 0.0291 0.0322
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0067 0.0112 0.0112
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Leishmania major hypothetical protein, conserved 0.0067 0.0112 0.0497
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0729 0.2235 0.2226
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0067 0.0112 0.0112
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0071 0.0078
Leishmania major cathepsin L-like protease 0.0054 0.0071 0.0311
Onchocerca volvulus 0.0054 0.0071 0.0397
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0186 0.0492 0.0544
Schistosoma mansoni hypothetical protein 0.0133 0.0324 0.0358
Entamoeba histolytica hypothetical protein 0.09 0.2783 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0543 0.06
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0067 0.0112 0.0101
Loa Loa (eye worm) hypothetical protein 0.0493 0.1478 0.1634
Trypanosoma cruzi hypothetical protein, conserved 0.0493 0.1478 0.6613
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0013 0.0014
Entamoeba histolytica hypothetical protein 0.09 0.2783 1
Echinococcus multilocularis Smad4 0.011 0.0251 0.0277
Schistosoma mansoni Smad4 0.011 0.0251 0.0277
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0131 0.0069
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0093 0.0103
Schistosoma mansoni ferritin 0.0054 0.0069 0.0076
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0253 0.0707 0.0667
Treponema pallidum NADH oxidase 0.0253 0.0707 0.0711
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0067 0.0112 0.0497
Echinococcus granulosus aldo keto reductase 0.0036 0.0011 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0493 0.1478 0.6613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0067 0.0112 0.0112
Brugia malayi glutaminase DH11.1 0.0291 0.0832 0.0919
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0253 0.0707 0.0697
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0131 0.0145
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0112 0.0497
Schistosoma mansoni smad1 5 8 and 0.011 0.0251 0.0277
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0067 0.0112 0.0124
Giardia lamblia Glycogen phosphorylase 0.0067 0.0111 0.1431
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0493 0.1478 0.1634
Loa Loa (eye worm) hypothetical protein 0.0493 0.1478 0.1634
Echinococcus granulosus biogenic amine 5HT receptor 0.0156 0.0396 0.0438
Echinococcus granulosus tumor protein p63 0.1375 0.4307 0.4761
Loa Loa (eye worm) MH2 domain-containing protein 0.1617 0.5086 0.5621
Schistosoma mansoni tar DNA-binding protein 0.0449 0.1336 0.1477
Loa Loa (eye worm) RNA binding protein 0.0449 0.1336 0.1477
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0061 0.0268
Echinococcus multilocularis aldo keto reductase 0.0036 0.0011 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0449 0.1336 0.1477
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0067 0.0112 0.0674
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1662 0.523 0.5225
Onchocerca volvulus 0.0075 0.0138 0.0844
Loa Loa (eye worm) hypothetical protein 0.0106 0.0238 0.0264
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0253 0.0707 0.3161
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0253 0.0707 0.0782
Trypanosoma cruzi trypanothione reductase, putative 0.0253 0.0707 0.3161
Echinococcus multilocularis tar DNA binding protein 0.0449 0.1336 0.1477
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0253 0.0707 0.3161
Trypanosoma brucei trypanothione reductase 0.0729 0.2235 1
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0067 0.0112 0.0101
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0067 0.0112 0.0124
Loa Loa (eye worm) glycogen phosphorylase 0.0067 0.0111 0.0122
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1662 0.523 0.5225
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.005 0.0056
Schistosoma mansoni lamin 0.0229 0.0632 0.0699
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0067 0.0112 0.0112
Schistosoma mansoni cellular tumor antigen P53 0.0201 0.0543 0.06
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0067 0.0112 0.0497
Schistosoma mansoni lamin 0.0229 0.0632 0.0699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Loa Loa (eye worm) glutaminase 0.0291 0.0832 0.0919
Onchocerca volvulus 0.0073 0.0131 0.0802
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0067 0.0112 0.0112
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0053 0.0059
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0131 0.0145
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0099 0.0216 0.0239
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0067 0.0112 0.0365
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0112 0.0124
Schistosoma mansoni zinc finger protein 0.0041 0.003 0.0033
Brugia malayi Heterochromatin protein 1 0.0071 0.0124 0.0137
Onchocerca volvulus 0.0493 0.1478 0.9789
Mycobacterium tuberculosis Conserved protein 0.0493 0.1478 0.1469
Trichomonas vaginalis mercuric reductase, putative 0.0253 0.0707 0.4644
Schistosoma mansoni TGF-beta signal transducer Smad2 0.011 0.0251 0.0277
Schistosoma mansoni pol-related 0.0036 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.187 0.5895 0.5891
Loa Loa (eye worm) intermediate filament protein 0.0229 0.0632 0.0699
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.005 0.0056
Plasmodium falciparum ferrodoxin reductase-like protein 0.0067 0.0112 0.0057
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0102
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0112 0.0124
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0067 0.0112 0.0497
Brugia malayi Cathepsin L-like precursor 0.0054 0.0071 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0449 0.1336 0.1477
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.0071 0.0011
Mycobacterium ulcerans bacterioferritin BfrB 0.0054 0.0069 0.0064
Echinococcus granulosus histone lysine methyltransferase setb 0.0099 0.0216 0.0239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0112 0.0112
Onchocerca volvulus 0.0054 0.0071 0.0397
Loa Loa (eye worm) programmed cell death 8 0.0067 0.0112 0.0124
Schistosoma mansoni tar DNA-binding protein 0.0449 0.1336 0.1477
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0493 0.1478 0.1469
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Schistosoma mansoni zinc finger protein 0.0032 0.0001 0.0001
Echinococcus granulosus peptidase Clp S14 family 0.187 0.5895 0.6516
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0067 0.0112 0.0101
Trichomonas vaginalis ferritin, putative 0.0054 0.0069 0.0387
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0111 0.0252 0.0278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0067 0.0112 0.0112
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0054 0.0069 0.0064
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0131 0.0145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0253 0.0707 0.3161
Schistosoma mansoni ferritin 0.0054 0.0069 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0138 0.0152
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0067 0.0112 0.0112
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0111 0.0252 0.0278
Leishmania major hypothetical protein, conserved 0.0067 0.0112 0.0497
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0178 0.0196
Brugia malayi Thioredoxin reductase 0.0729 0.2235 0.247
Plasmodium vivax vivapain-2 0.0054 0.0071 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Echinococcus granulosus smad 0.011 0.0251 0.0277
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0067 0.0112 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0071 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0071 0.0397
Giardia lamblia NADH oxidase lateral transfer candidate 0.0253 0.0707 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0055 0.0061
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0067 0.0112 0.0365
Schistosoma mansoni Smad4 0.0049 0.0055 0.0061
Echinococcus multilocularis glutamate synthase 0.0067 0.0112 0.0124
Echinococcus granulosus microtubule associated protein 2 0.0791 0.2435 0.2691
Leishmania major cathepsin L-like protease 0.0054 0.0071 0.0311
Schistosoma mansoni glutamate synthase 0.0067 0.0112 0.0124
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0126 0.0303 0.0335
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Schistosoma mansoni glutamate synthase 0.0067 0.0112 0.0124
Plasmodium falciparum thioredoxin reductase 0.0729 0.2235 0.2419
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0067 0.0112 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.187 0.5895 0.5891
Echinococcus granulosus cathepsin l1 0.0054 0.0071 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Echinococcus granulosus thioredoxin glutathione reductase 0.073 0.2238 0.2474
Onchocerca volvulus 0.0054 0.0071 0.0397
Loa Loa (eye worm) ctsf protein 0.0054 0.0071 0.0078
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0071 0.0078
Chlamydia trachomatis thioredoxin reductase 0.0067 0.0112 0.0002
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Schistosoma mansoni aldo-keto reductase 0.0036 0.0011 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0025 0.009
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0034 0.0154
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0253 0.0707 0.0711
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.0358 0.0396
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0067 0.0112 0.0057
Schistosoma mansoni ets-related 0.0265 0.0749 0.0828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0071 0.0078
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0067 0.0112 0.0124
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0253 0.0707 0.077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0061 0.0067
Trypanosoma brucei prostaglandin f synthase 0.0036 0.0011 0.0045
Toxoplasma gondii cathepsin CPL 0.0054 0.0071 0.0066
Loa Loa (eye worm) glutaminase 2 0.0291 0.0832 0.0919
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0067 0.0112 0.0497
Brugia malayi MH1 domain containing protein 0.0061 0.0093 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Schistosoma mansoni smad1 5 8 and 0.011 0.0251 0.0277
Echinococcus multilocularis aldo keto reductase 0.0036 0.0011 0.0012
Brugia malayi Cathepsin L-like precursor 0.0036 0.0013 0.0015
Brugia malayi Cathepsin L-like precursor 0.0054 0.0071 0.0078
Trypanosoma cruzi NADH dehydrogenase, putative 0.0067 0.0112 0.0497
Plasmodium falciparum glutathione reductase 0.0253 0.0707 0.0719
Loa Loa (eye worm) transcription factor SMAD2 0.1617 0.5086 0.5621
Echinococcus multilocularis glycogen phosphorylase 0.0067 0.0111 0.0122
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0983 0.305 0.3363
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0126 0.0303 0.0335
Mycobacterium ulcerans glutaminase 0.0291 0.0832 0.0908
Leishmania major cathepsin L-like protease 0.0054 0.0071 0.0311
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0067 0.0112 0.0124
Loa Loa (eye worm) hypothetical protein 0.0111 0.0252 0.0278
Giardia lamblia Thioredoxin reductase 0.0067 0.0112 0.1452
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0071 0.0078
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0013 0.0014
Onchocerca volvulus 0.0493 0.1478 0.9789
Mycobacterium ulcerans dehydrogenase 0.0067 0.0112 0.0112
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.004 0.0044
Schistosoma mansoni ferritin 0.0054 0.0069 0.0076
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0071 0.0397
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0112 0.0674
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2853 0.9048 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0025 0.0027
Trypanosoma cruzi NADH dehydrogenase, putative 0.0067 0.0112 0.0497
Brugia malayi hypothetical protein 0.09 0.2783 0.3075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0216 0.0239
Schistosoma mansoni glycogen phosphorylase 0.0067 0.0111 0.0122
Mycobacterium tuberculosis Probable dehydrogenase 0.1662 0.523 0.5225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Loa Loa (eye worm) oxidoreductase 0.0036 0.0011 0.0012
Echinococcus multilocularis aldo keto reductase 0.0036 0.0011 0.0012
Treponema pallidum oxidoreductase 0.0067 0.0112 0.0048
Entamoeba histolytica disulphide oxidoreductase, putative 0.0067 0.0112 0.0365
Echinococcus multilocularis lamin 0.0229 0.0632 0.0699
Echinococcus multilocularis peptidase Clp (S14 family) 0.187 0.5895 0.6516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Loa Loa (eye worm) oxidoreductase 0.0036 0.0011 0.0012
Trichomonas vaginalis glutaminase, putative 0.0291 0.0832 0.5474
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0112 0.0112
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.2853 0.9048 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Onchocerca volvulus 0.0036 0.0013 0.0015
Toxoplasma gondii hypothetical protein 0.0983 0.305 0.3363
Brugia malayi PHD-finger family protein 0.0053 0.0066 0.0073
Plasmodium vivax ferrodoxin reductase, putative 0.0067 0.0112 0.0057
Plasmodium falciparum glutathione reductase 0.0729 0.2235 0.2419
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0253 0.0707 0.0719
Schistosoma mansoni bromodomain containing protein 0.0134 0.0327 0.0362
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0023
Loa Loa (eye worm) beta-lactamase 0.0493 0.1478 0.1634
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0112 0.0497
Schistosoma mansoni hypothetical protein 0.0044 0.0037 0.0041
Echinococcus multilocularis expressed protein 0.0054 0.0069 0.0076
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0036 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0015
Echinococcus multilocularis serotonin receptor 0.0156 0.0396 0.0438
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0124 0.0756
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0067 0.0112 0.0124
Echinococcus granulosus aldo keto reductase 0.0036 0.0011 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0123 0.0291 0.0322
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0493 0.1478 0.1624
Loa Loa (eye worm) oxidoreductase 0.0036 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0131 0.0145
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0067 0.0112 0.0112
Brugia malayi Smad1 0.011 0.0251 0.0277
Entamoeba histolytica cysteine protease, putative 0.0054 0.0071 0.0215
Echinococcus granulosus Smad4 0.011 0.0251 0.0277
Onchocerca volvulus 0.0054 0.0071 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0112 0.0674
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0983 0.305 0.3326
Onchocerca volvulus 0.0201 0.0543 0.3546
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0055 0.0061
Schistosoma mansoni ferritin light chain 0.0054 0.0069 0.0076
Brugia malayi chromobox protein homolog 3 0.004 0.0025 0.0027
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0071 0.0078
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0124 0.0137
Schistosoma mansoni sulfide quinone reductase 0.0067 0.0112 0.0124
Trichomonas vaginalis glutamate synthase, putative 0.0067 0.0112 0.0674
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0493 0.1478 0.1634
Loa Loa (eye worm) hypothetical protein 0.0054 0.0071 0.0078
Echinococcus multilocularis tumor protein p63 0.1375 0.4307 0.4761
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0071 0.0078
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0067 0.0112 0.0124
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0112 0.0674
Loa Loa (eye worm) hypothetical protein 0.0073 0.0131 0.0145
Schistosoma mansoni apoferritin-2 0.0054 0.0069 0.0076
Brugia malayi Cathepsin L-like precursor 0.0054 0.0071 0.0078
Onchocerca volvulus 0.0503 0.151 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0493 0.1478 0.1634
Giardia lamblia Glutamate synthase 0.0067 0.0112 0.1452
Brugia malayi Pre-SET motif family protein 0.0063 0.01 0.0111
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0067 0.0112 0.0365
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0141 0.0156
Loa Loa (eye worm) hypothetical protein 0.0493 0.1478 0.1634
Loa Loa (eye worm) fli-1 protein 0.0265 0.0749 0.0828
Loa Loa (eye worm) hypothetical protein 0.0229 0.0632 0.0699
Echinococcus multilocularis ferritin 0.0054 0.0069 0.0076
Toxoplasma gondii thioredoxin reductase 0.0729 0.2235 0.2461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Trypanosoma cruzi cysteine peptidase, putative 0.0206 0.0558 0.2493
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0061 0.0055
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0067 0.0112 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0358 0.0396
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0067 0.0112 0.0101
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0067 0.0112 0.0112
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.0071 0.0011
Onchocerca volvulus 0.0054 0.0071 0.0397
Echinococcus multilocularis Glycosyl transferase, family 35 0.0067 0.0111 0.0122
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0054 0.0069 0.0058
Loa Loa (eye worm) hypothetical protein 0.0073 0.0131 0.0145
Schistosoma mansoni smad 0.0049 0.0055 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0036 0.0011 0.0012
Mycobacterium ulcerans ferredoxin reductase 0.0067 0.0112 0.0112
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0112 0.0124
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0188 0.0501 0.2237
Onchocerca volvulus 0.0229 0.0632 0.4145
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0071 0.0078
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1848 0.5825 0.6434
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Brugia malayi RNA recognition motif domain containing protein 0.0449 0.1336 0.1477
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0067 0.0112 0.0497
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0141 0.0156
Trichomonas vaginalis set domain proteins, putative 0.0503 0.151 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0067 0.0112 0.0124
Echinococcus granulosus glutamate synthase 0.0067 0.0112 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.004 0.0044
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0112 0.0497
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0067 0.0112 0.0101
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Loa Loa (eye worm) hypothetical protein 0.0225 0.0619 0.0684
Trichomonas vaginalis esterase, putative 0.0493 0.1478 0.9789
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0071 0.0078
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Brugia malayi hypothetical protein 0.0051 0.0061 0.0067
Trypanosoma brucei aldo-keto reductase, putative 0.0036 0.0011 0.0045
Schistosoma mansoni transcription factor LCR-F1 0.09 0.2783 0.3075
Brugia malayi glutathione reductase 0.0729 0.2235 0.247
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0067 0.0112 0.0124
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0067 0.0112 0.0365
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0013 0.0014
Mycobacterium ulcerans hypothetical protein 0.0493 0.1478 0.1624
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.187 0.5895 0.6511
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0067 0.0112 0.0101
Trypanosoma cruzi cysteine peptidase, putative 0.0206 0.0558 0.2493
Echinococcus granulosus mothers against decapentaplegic 2 0.0049 0.0055 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.0206 0.0558 0.2493
Trichomonas vaginalis D-aminoacylase, putative 0.0493 0.1478 0.9789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Brugia malayi RNA binding protein 0.0449 0.1336 0.1477
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0025 0.009
Mycobacterium ulcerans lipase LipD 0.0493 0.1478 0.1624
Echinococcus granulosus glycogen phosphorylase 0.0067 0.0111 0.0122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0222 0.0246
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Mycobacterium tuberculosis Conserved protein 0.0493 0.1478 0.1469
Loa Loa (eye worm) hypothetical protein 0.0099 0.0216 0.0239
Schistosoma mansoni ferritin light chain 0.0054 0.0069 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0493 0.1478 0.1577
Leishmania major NADH dehydrogenase, putative 0.0067 0.0112 0.0497
Schistosoma mansoni ferritin 0.0054 0.0069 0.0076
Echinococcus granulosus tar DNA binding protein 0.0449 0.1336 0.1477
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0253 0.0707 0.3161
Echinococcus granulosus aldo keto reductase 0.0036 0.0011 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.0791 0.2435 0.2691
Mycobacterium ulcerans hypothetical protein 0.0067 0.0112 0.0112
Plasmodium vivax glutathione reductase, putative 0.0729 0.2235 0.2419
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0067 0.0112 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Loa Loa (eye worm) hypothetical protein 0.2853 0.9048 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0067 0.0112 0.0048
Leishmania major hypothetical protein, conserved 0.0067 0.0112 0.0497
Brugia malayi intermediate filament protein 0.0229 0.0632 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0222 0.0246
Echinococcus multilocularis lamin dm0 0.0229 0.0632 0.0699
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0178 0.0196
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0013 0.0015
Onchocerca volvulus 0.0067 0.0112 0.0674
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.004 0.0044
Leishmania major cathepsin L-like protease 0.0206 0.0558 0.2493
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0112 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0071 0.0397
Loa Loa (eye worm) glutathione reductase 0.0729 0.2235 0.247
Brugia malayi MH1 domain containing protein 0.011 0.0251 0.0277
Toxoplasma gondii ABC1 family protein 0.0493 0.1478 0.1624
Brugia malayi beta-lactamase 0.0493 0.1478 0.1634
Schistosoma mansoni tar DNA-binding protein 0.0449 0.1336 0.1477
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0067 0.0112 0.0112
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0253 0.0707 0.3161
Loa Loa (eye worm) hypothetical protein 0.009 0.0187 0.0207
Onchocerca volvulus Cathepsin F homolog 0.0054 0.0071 0.0397
Loa Loa (eye worm) hypothetical protein 0.0069 0.0119 0.0132
Leishmania major cathepsin L-like protease 0.0054 0.0071 0.0311
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.2853 0.9048 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Echinococcus granulosus ferritin 0.0054 0.0069 0.0076
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0253 0.0707 0.3161
Leishmania major cysteine peptidase A (CPA) 0.0054 0.0071 0.0311
Loa Loa (eye worm) hypothetical protein 0.0493 0.1478 0.1634
Echinococcus multilocularis zinc finger protein 0.0041 0.003 0.0033
Schistosoma mansoni glutamate synthase 0.0067 0.0112 0.0124
Schistosoma mansoni peptidase Clp (S14 family) 0.2853 0.9048 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0067 0.0112 0.0112
Schistosoma mansoni aldo-keto reductase 0.0036 0.0011 0.0012
Plasmodium falciparum thioredoxin reductase 0.0253 0.0707 0.0719
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0493 0.1478 0.1634
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0071 0.0311
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1848 0.5825 0.582
Trichomonas vaginalis glutathione reductase, putative 0.0253 0.0707 0.4644
Mycobacterium ulcerans bacterioferritin BfrA 0.0054 0.0069 0.0064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.09 0.2783 0.3075
Brugia malayi beta-lactamase family protein 0.0493 0.1478 0.1634
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Schistosoma mansoni intermediate filament proteins 0.0229 0.0632 0.0699
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0253 0.0707 0.0719
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2853 0.9048 1
Echinococcus granulosus Glycosyl transferase family 35 0.0067 0.0111 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0493 0.1478 0.9789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0013 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0112 0.0497
Toxoplasma gondii NADPH-glutathione reductase 0.0253 0.0707 0.077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0174 0.0192
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1662 0.523 0.5775
Loa Loa (eye worm) nuclear factor I 0.0061 0.0093 0.0102
Treponema pallidum thioredoxin reductase (trxB) 0.0067 0.0112 0.0048
Leishmania major hypothetical protein, conserved 0.0493 0.1478 0.6613
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0493 0.1478 0.1469
Trypanosoma cruzi aldo-keto reductase 0.0036 0.0011 0.0045
Entamoeba histolytica thioredoxin reductase, putative 0.0067 0.0112 0.0365
Loa Loa (eye worm) hypothetical protein 0.015 0.0378 0.0417
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Schistosoma mansoni gabp alpha 0.0087 0.0178 0.0196
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0324 0.0358
Loa Loa (eye worm) hypothetical protein 0.0321 0.0927 0.1025
Brugia malayi Ets-domain containing protein 0.0087 0.0178 0.0196
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0131 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Schistosoma mansoni chromobox protein 0.0071 0.0124 0.0137
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0324 0.0358
Echinococcus multilocularis mothers against decapentaplegic 6 0.0049 0.0055 0.0061
Mycobacterium ulcerans NADH dehydrogenase 0.0067 0.0112 0.0112
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0071 0.0215
Schistosoma mansoni hypothetical protein 0.0069 0.0119 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0358 0.0396
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0229 0.0632 0.0699
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Mycobacterium tuberculosis Probable lipase LipD 0.0493 0.1478 0.1469
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.0071 0.0078
Loa Loa (eye worm) fibroinase 0.0054 0.0071 0.0078
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1662 0.523 0.5225
Mycobacterium ulcerans monoxygenase 0.0067 0.0112 0.0112
Loa Loa (eye worm) MH1 domain-containing protein 0.011 0.0251 0.0277
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0253 0.0707 0.0719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Brugia malayi MH1 domain containing protein 0.011 0.0251 0.0277
Brugia malayi MH1 domain containing protein 0.0061 0.0093 0.0102
Brugia malayi MH2 domain containing protein 0.1617 0.5086 0.5621
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0253 0.0707 0.3161
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Mycobacterium tuberculosis Probable hydrolase 0.0493 0.1478 0.1469
Echinococcus granulosus glycogen phosphorylase 0.0067 0.0111 0.0122
Brugia malayi MH2 domain containing protein 0.0049 0.0055 0.0061
Mycobacterium ulcerans esterase/lipase LipP 0.0493 0.1478 0.1624
Echinococcus multilocularis glycogen phosphorylase 0.0067 0.0111 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0493 0.1478 0.6613
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0067 0.0112 0.0674
Brugia malayi Pre-SET motif family protein 0.0442 0.1314 0.1452
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0032 0.0001 0.0001
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Mycobacterium tuberculosis Probable reductase 0.1662 0.523 0.5225
Brugia malayi hypothetical protein 0.0033 0.0003 0.0003
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0112 0.0497
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.01 0.0111
Echinococcus multilocularis smad 0.011 0.0251 0.0277
Schistosoma mansoni hypothetical protein 0.09 0.2783 0.3075
Loa Loa (eye worm) hypothetical protein 0.0493 0.1478 0.1634
Leishmania major cathepsin L-like protease 0.0206 0.0558 0.2493
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0061 0.0268
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0071 0.0397
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0253 0.0707 0.077
Trichomonas vaginalis glycogen phosphorylase, putative 0.0067 0.0111 0.0665
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0036 0.0011 0.0045
Brugia malayi beta-lactamase family protein 0.0493 0.1478 0.1634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0071 0.0397
Mycobacterium leprae Probable lipase LipE 0.0493 0.1478 0.1624
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.0071 0.0011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0253 0.0707 0.0711
Trypanosoma cruzi cruzipain precursor, putative 0.0206 0.0558 0.2493
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.005 0.0056
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0067 0.0112 0.0057
Entamoeba histolytica glycogen phosphorylase, putative 0.0067 0.0111 0.0359
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Brugia malayi cathepsin L-like precursor 0.0036 0.0013 0.0015
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0036 0.0011 0.0012
Brugia malayi MH2 domain containing protein 0.011 0.0251 0.0277
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0253 0.0707 0.0782
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0216 0.0239
Entamoeba histolytica hypothetical protein 0.09 0.2783 1
Brugia malayi Fli-1 protein 0.0265 0.0749 0.0828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0013 0.0008
Leishmania major prostaglandin f synthase, putative 0.0036 0.0011 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0366 0.107 0.1183
Loa Loa (eye worm) hypothetical protein 0.0067 0.0112 0.0124
Mycobacterium tuberculosis Conserved protein 0.0493 0.1478 0.1469
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2853 0.9048 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0067 0.0112 0.0674
Leishmania major cathepsin L-like protease 0.0054 0.0071 0.0311
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0493 0.1478 0.1469
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0067 0.0112 0.0048
Toxoplasma gondii selenide, water dikinase 0.0067 0.0112 0.0112
Schistosoma mansoni smad1 5 8 and 0.011 0.0251 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Echinococcus multilocularis beta LACTamase domain containing family member 0.0493 0.1478 0.1634
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0067 0.0112 0.0048
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.0071 0.0078
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0013 0.0015
Echinococcus multilocularis cysteine protease 0.0054 0.0071 0.0078
Echinococcus multilocularis chromobox protein 1 0.0071 0.0124 0.0137
Trypanosoma cruzi trypanothione reductase, putative 0.0729 0.2235 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0222 0.0246
Brugia malayi Cathepsin L-like precursor 0.0054 0.0071 0.0078
Schistosoma mansoni glycogen phosphorylase 0.0067 0.0111 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Brugia malayi Bromodomain containing protein 0.0081 0.0157 0.0174
Plasmodium vivax vivapain-2 0.0054 0.0071 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0493 0.1478 0.9789
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Onchocerca volvulus 0.0229 0.0632 0.4145
Mycobacterium leprae conserved hypothetical protein 0.0493 0.1478 0.1624
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0253 0.0707 0.077
Entamoeba histolytica hypothetical protein 0.09 0.2783 1
Schistosoma mansoni sulfide quinone reductase 0.0067 0.0112 0.0124
Plasmodium vivax thioredoxin reductase, putative 0.0729 0.2235 0.2419
Trichomonas vaginalis D-aminoacylase, putative 0.0493 0.1478 0.9789
Schistosoma mansoni smad 0.011 0.0251 0.0277
Brugia malayi Cathepsin L-like precursor 0.0036 0.0013 0.0015
Echinococcus multilocularis mothers against decapentaplegic 5 0.011 0.0251 0.0277
Mycobacterium ulcerans beta-lactamase 0.0493 0.1478 0.1624
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0017 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0156 0.0396 0.0438
Echinococcus multilocularis serotonin transporter 0.0073 0.0131 0.0145
Echinococcus granulosus beta LACTamase domain containing family member 0.0493 0.1478 0.1634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.0558 0.2493
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0067 0.0112 0.0112
Schistosoma mansoni disulfide oxidoreductase 0.0067 0.0112 0.0124
Echinococcus multilocularis chromobox protein 1 0.0071 0.0124 0.0137
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0067 0.0112 0.0124
Echinococcus granulosus zinc finger protein 0.0041 0.003 0.0033
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0036 0.0011 0.0012
Loa Loa (eye worm) TAR-binding protein 0.0449 0.1336 0.1477
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0119 0.0132
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0067 0.0112 0.0124
Onchocerca volvulus Glycogen phosphorylase homolog 0.0067 0.0111 0.0665
Brugia malayi MH2 domain containing protein 0.011 0.0251 0.0277
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0055 0.0061
Schistosoma mansoni apoferritin-2 0.0054 0.0069 0.0076

Activities

Activity type Activity value Assay description Source Reference
Intrinsic activity (binding) = 0 Intrinsic activity at human 5-HT1A receptor expressed in HEK293 cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Intrinsic activity (binding) = 0 Intrinsic activity at human 5-HT1D receptor expressed in CHO cells assessed as effect on GTPgammaS binding by scintillation proximity assay relative to 5HT ChEMBL. 20951584
Ki (binding) = 5.8 Displacement of [3H]-dofetilide in human ERG expressed in CHO cells by proximity assay ChEMBL. 20951584
Ki (functional) > 6 Antagonist activity at human 5-HT1B receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584
Ki (functional) = 7.7 Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584
Ki (functional) = 8.4 Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay ChEMBL. 20951584
Ki (binding) = 9.3 Displacement of [3H]-citalopram in human SERT expressed in LLCPK cells by filtration assay ChEMBL. 20951584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.