Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 163 aa | 133 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | peptidylprolyl isomerase | 0.0039 | 0.9623 | 0.5 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.004 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.6919 | 0.6919 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.6919 | 0.6919 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.6919 | 0.6919 |
Echinococcus multilocularis | lamin | 0.0033 | 0.6919 | 0.6844 |
Onchocerca volvulus | 0.0033 | 0.6919 | 0.5 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.9623 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.6919 | 0.6844 |
Trichomonas vaginalis | rotamase, putative | 0.004 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.9623 | 0.5 |
Schistosoma mansoni | rotamase | 0.004 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.004 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.6919 | 0.6844 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.9623 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0922 | 0.0922 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.6919 | 0.6606 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0236 | 0.0236 |
Echinococcus granulosus | lamin | 0.0033 | 0.6919 | 0.6844 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0039 | 0.9623 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.6919 | 0.6606 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.6682 | 0.6682 |
Onchocerca volvulus | 0.0033 | 0.6919 | 0.5 | |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0039 | 0.9623 | 0.5 |
Echinococcus granulosus | expressed protein | 0.004 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.6919 | 0.6844 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.6919 | 0.6844 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0178 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.