Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome P450 reductase, putative | 0.1093 | 0.8159 | 0.8159 |
Giardia lamblia | Hypothetical protein | 0.1093 | 0.8159 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0762 | 0.3805 | 0.3805 |
Plasmodium vivax | flavodoxin domain containing protein | 0.1093 | 0.8159 | 0.8159 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1233 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1233 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1233 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1233 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1233 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0612 | 0.1841 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1233 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1233 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1233 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0762 | 0.3805 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1233 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1233 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1233 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0621 | 0.1964 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0762 | 0.3805 | 0.3805 |
Treponema pallidum | flavodoxin | 0.0472 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0472 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1233 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.1233 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0612 | 0.1841 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.1093 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1233 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1093 | 0.8159 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0762 | 0.3805 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.1233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0472 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0472 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.1233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0472 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0472 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1233 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1233 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.