Detailed information for compound 1271401

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 468.461 | Formula: C26H20N4O5
  • H donors: 3 H acceptors: 5 LogP: 1.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)C(=O)N(C2)C[C@@]1(C#Cc2ccc(cc2)c2ncccc2O)NC(=O)NC1=O
  • InChi: 1S/C26H20N4O5/c1-35-19-9-8-18-14-30(23(32)20(18)13-19)15-26(24(33)28-25(34)29-26)11-10-16-4-6-17(7-5-16)22-21(31)3-2-12-27-22/h2-9,12-13,31H,14-15H2,1H3,(H2,28,29,33,34)/t26-/m1/s1
  • InChiKey: AUWCRYUPRHMNCJ-AREMUKBSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor necrosis factor Starlite/ChEMBL No references
Homo sapiens ADAM metallopeptidase domain 17 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus Blood coagulation inhibitor Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma japonicum ko:K06059 a disintegrin and metalloproteinase domain 17, putative Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma mansoni ADAM17 peptidase (M12 family) Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Disintegrin family protein ADAM metallopeptidase domain 17 824 aa 724 aa 27.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi gonadotropin-releasing hormone receptor 2 0.033 0.3995 0.3994
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0017 0.0023 0.0000024624
Echinococcus granulosus adam 17 protease 0.0245 0.2922 0.5815
Giardia lamblia Reverse transcriptase/endonuclease 0.0016 0.0016 0.0027
Loa Loa (eye worm) intermediate filament protein 0.0028 0.017 0.0168
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.033 0.3995 0.3994
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0022 0.0016
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.02 0.0326
Toxoplasma gondii exonuclease III APE 0.0021 0.0071 0.0643
Giardia lamblia Ribonuclease H 0.0043 0.0356 0.1127
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0076 0.0074
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0083 0.0149
Echinococcus multilocularis somatostatin receptor 0.033 0.3995 0.7956
Schistosoma mansoni neuropeptide receptor 0.033 0.3995 0.4454
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0416 0.0456
Toxoplasma gondii thioredoxin reductase 0.005 0.0439 0.3953
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0092
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.0064 0.0621 0.5596
Onchocerca volvulus Putative thymidylate kinase 0.0073 0.0735 0.1015
Schistosoma mansoni thymidylate kinase 0.0073 0.0735 0.0812
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Schistosoma mansoni intermediate filament proteins 0.0028 0.017 0.0182
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Brugia malayi G-protein coupled receptor 0.033 0.3995 0.3994
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0076 0.0137
Echinococcus granulosus g-protein coupled receptor 0.033 0.3995 0.7956
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0076 0.0137
Toxoplasma gondii hypothetical protein 0.0049 0.0426 0.3842
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni hypothetical protein 0.033 0.3995 0.4454
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0439 0.0436
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0016 0.0008 0.0075
Echinococcus multilocularis ribonuclease H1 0.0043 0.0356 0.0695
Brugia malayi hypothetical protein 0.0016 0.0016 0.0014
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.1256 0.3441
Onchocerca volvulus Ribonuclease H1 homolog 0.0043 0.0356 0.0486
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Entamoeba histolytica hypothetical protein 0.0049 0.0432 0.1373
Brugia malayi RNase H family protein 0.0043 0.0356 0.0353
Brugia malayi Probable ATP-dependent helicase DHX35 0.0034 0.0238 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.0116
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0022
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0076 0.0077
Brugia malayi hypothetical protein 0.0161 0.1847 0.1845
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Loa Loa (eye worm) glutathione reductase 0.005 0.0439 0.0436
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0016 0.0008 0.0005
Onchocerca volvulus 0.033 0.3995 0.5571
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Echinococcus granulosus hypothetical protein 0.033 0.3995 0.7956
Echinococcus granulosus adam 0.0039 0.0301 0.0585
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.014 0.1585 0.3148
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0439 0.1187
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0016 0.0016 0.0027
Trypanosoma brucei thymidine kinase 0.0259 0.3096 0.345
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus lamin 0.0028 0.017 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.0116
Loa Loa (eye worm) G-protein coupled receptor 0.033 0.3995 0.3994
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0105 0.1146 0.2271
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0027 0.0025
Schistosoma mansoni amine GPCR 0.033 0.3995 0.4454
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.162 0.4444
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus granulosus tm gpcr rhodopsin 0.033 0.3995 0.7956
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.033 0.3995 0.7956
Trypanosoma cruzi thymidine kinase, putative 0.0259 0.3096 0.8511
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1109 0.123
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1245 0.8776
Schistosoma mansoni amine GPCR 0.033 0.3995 0.4454
Plasmodium vivax glutathione reductase, putative 0.005 0.0439 0.5957
Entamoeba histolytica hypothetical protein 0.0049 0.0432 0.1373
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0076 0.0077
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni opsin-like receptor 0.033 0.3995 0.4454
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Echinococcus granulosus neuropeptides capa receptor 0.033 0.3995 0.7956
Plasmodium vivax thymidylate kinase, putative 0.0073 0.0735 1
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus tm gpcr rhodopsin 0.033 0.3995 0.7956
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.3995 0.7956
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.1256 0.2491
Brugia malayi Melibiase family protein 0.0068 0.0676 0.0674
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0095 0.0148
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1256 0.1395
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0038
Echinococcus multilocularis neuropeptide Y receptor 0.033 0.3995 0.7956
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Echinococcus multilocularis orexin receptor type 2 0.033 0.3995 0.7956
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0676 0.0746
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.033 0.3995 0.7956
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0578 0.1137
Brugia malayi reverse transcriptase 0.0016 0.0016 0.0014
Schistosoma mansoni opsin-like receptor 0.033 0.3995 0.4454
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0096 0.0867
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0027 0.0265
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.033 0.3995 0.7956
Echinococcus multilocularis tachykinin peptides receptor 99D 0.033 0.3995 0.7956
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0016 0.0016 0.0012
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1256 0.4043
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.033 0.3995 0.4454
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Loa Loa (eye worm) fli-1 protein 0.0226 0.268 0.2678
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0549 0.1081
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0083 0.008
Onchocerca volvulus 0.0049 0.0432 0.0592
Toxoplasma gondii DNA polymerase family B protein 0.0016 0.0008 0.007
Onchocerca volvulus 0.033 0.3995 0.5571
Plasmodium vivax DNA polymerase alpha, putative 0.0046 0.0393 0.5334
Leishmania major thymidylate kinase-like protein 0.0073 0.0735 0.2003
Echinococcus granulosus G protein coupled receptor 139 0.033 0.3995 0.7956
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0071 0.0943
Entamoeba histolytica hypothetical protein 0.0021 0.0076 0.0222
Plasmodium falciparum glutathione reductase 0.005 0.0439 0.5927
Brugia malayi PAS domain containing protein 0.0048 0.0416 0.0414
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0027 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.3995 0.7956
Echinococcus granulosus neuropeptide receptor 0.033 0.3995 0.7956
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0071 0.0108
Brugia malayi RNase H family protein 0.0043 0.0356 0.0353
Brugia malayi ADAMTS-like protease 0.0017 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Loa Loa (eye worm) phosphofructokinase 0.0114 0.1256 0.1254
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0074
Echinococcus granulosus ribonuclease H1 0.0043 0.0356 0.0695
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.033 0.3995 0.4454
Brugia malayi Pre-SET motif family protein 0.0061 0.0578 0.0575
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0043 0.0355 0.0352
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0563 0.062
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0027 0.0033
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.033 0.3995 0.3994
Echinococcus granulosus thymidylate kinase 0.0073 0.0735 0.145
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.033 0.3995 0.7956
Echinococcus granulosus peptide allatostatin:somatostatin 0.033 0.3995 0.7956
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus granulosus neuropeptide Y receptor 0.033 0.3995 0.7956
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0022 0.0091 0.0093
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0035 0.003
Entamoeba histolytica hypothetical protein 0.0035 0.0258 0.0811
Brugia malayi thymidylate kinase 0.0073 0.0735 0.0732
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0643 0.7977 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0095 0.0148
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0347 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.0116
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0076 0.0074
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0258 0.05
Treponema pallidum thymidylate kinase (tmk) 0.0073 0.0735 0.5769
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0016
Schistosoma mansoni amine GPCR 0.033 0.3995 0.4454
Loa Loa (eye worm) hypothetical protein 0.0049 0.0432 0.0429
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0074
Echinococcus granulosus 7TM GPCR rhodopsin 0.033 0.3995 0.7956
Schistosoma mansoni ets-related 0.0226 0.268 0.2985
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.008 0.083 0.0828
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0027 0.0005
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0096 0.0442
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.3995 0.7956
Brugia malayi hypothetical protein 0.0021 0.0076 0.0074
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0105 0.1146 0.1144
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0025 0.0123 0.0318
Echinococcus granulosus single minded 2 0.0035 0.0259 0.05
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0258 0.05
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0076 0.0074
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.3637 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1109 0.123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0578 0.5208
Schistosoma mansoni growth hormone secretagogue receptor 0.033 0.3995 0.4454
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0438 0.5366 0.5365
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0071 0.0305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0016
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0076 0.0074
Schistosoma mansoni phosphoglucomutase 0.0043 0.0356 0.0389
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0064 0.0621 0.0685
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1245 0.6795
Echinococcus granulosus g protein coupled receptor 0.033 0.3995 0.7956
Giardia lamblia O-linked GlcNAc transferase 0.0043 0.035 0.1109
Brugia malayi intermediate filament protein 0.0028 0.017 0.0168
Treponema pallidum ribonuclease H (rnhA) 0.0043 0.0356 0.2699
Brugia malayi DNA polymerase alpha catalytic subunit 0.0046 0.0393 0.039
Plasmodium falciparum thymidylate kinase 0.0073 0.0735 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0236
Schistosoma mansoni hypothetical protein 0.033 0.3995 0.4454
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.038 0.0378
Entamoeba histolytica Thymidylate kinase, putative 0.0073 0.0735 0.2353
Echinococcus multilocularis G protein coupled receptor 139 0.033 0.3995 0.7956
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.017 0.0168
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.02 0.0326
Brugia malayi hypothetical protein 0.0039 0.0301 0.0299
Trichomonas vaginalis thymidylate kinase, putative 0.0073 0.0735 0.1231
Onchocerca volvulus 0.033 0.3995 0.5571
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Loa Loa (eye worm) TYRA-2 protein 0.033 0.3995 0.3994
Entamoeba histolytica hypothetical protein 0.0021 0.0076 0.0222
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0071 0.0069
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Brugia malayi Disintegrin family protein 0.0022 0.0091 0.0089
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0083 0.0149
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0027 0.0057
Schistosoma mansoni protein kinase 0.0016 0.0016 0.0009
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.02 0.1802
Loa Loa (eye worm) hypothetical protein 0.0324 0.3924 0.3922
Entamoeba histolytica hypothetical protein 0.0023 0.0096 0.0286
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0074
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1256 0.1395
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0027 0.0005
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0025 0.0123 0.0196
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0025 0.0123 0.0318
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Trichomonas vaginalis reverse transcriptases, putative 0.0016 0.0016 0.0014
Onchocerca volvulus 0.0016 0.0016 0.0012
Brugia malayi DNA polymerase family B containing protein 0.0016 0.0008 0.0005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.033 0.3995 0.7956
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0016 0.0016 0.0009
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0095 0.0092
Echinococcus granulosus g protein coupled receptor 0.033 0.3995 0.7956
Echinococcus multilocularis neuropeptide receptor 0.033 0.3995 0.7956
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0064 0.0621 0.1223
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1245 0.6795
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1256 0.1395
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Schistosoma mansoni hypothetical protein 0.0167 0.1925 0.2142
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0076 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus disintegrin and metalloproteinase 0.0022 0.0091 0.0166
Loa Loa (eye worm) neuropeptide F receptor 0.033 0.3995 0.3994
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni hypothetical protein 0.0052 0.0465 0.0511
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.083 0.0828
Trypanosoma brucei thymidylate kinase, putative 0.0073 0.0735 0.0812
Brugia malayi G-protein coupled receptor 0.033 0.3995 0.3994
Brugia malayi Cytochrome P450 family protein 0.0016 0.0018 0.0015
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1256 0.4043
Brugia malayi reverse transcriptase 0.0016 0.0016 0.0014
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0025 0.0123 0.0129
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0071 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0027 0.0053
Brugia malayi G protein-coupled receptor 0.033 0.3995 0.3994
Schistosoma mansoni neuropeptide F-like receptor 0.033 0.3995 0.4454
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0016 0.0016 0.0017
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0096 0.0243
Schistosoma mansoni phosphoglucomutase 0.0043 0.0356 0.0389
Trypanosoma brucei ribonuclease H1 0.0043 0.0356 0.0389
Onchocerca volvulus 0.0579 0.7165 1
Echinococcus granulosus orexin receptor type 2 0.033 0.3995 0.7956
Echinococcus multilocularis neuropeptides capa receptor 0.033 0.3995 0.7956
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0022 0.0091 0.0093
Echinococcus granulosus neuropeptide receptor A26 0.033 0.3995 0.7956
Loa Loa (eye worm) thymidylate kinase 0.0073 0.0735 0.0732
Brugia malayi sulfakinin receptor protein 0.033 0.3995 0.3994
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.014 0.1585 0.3148
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.02 0.2486
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0078 0.0799 0.1105
Echinococcus granulosus dro:myosuppressin receptor 0.033 0.3995 0.7956
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0071 0.0392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.0116
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0027 0.005
Brugia malayi hypoxia-induced factor 1 0.0148 0.1689 0.1687
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0071 0.0206
Echinococcus granulosus lamin dm0 0.0028 0.017 0.0325
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.02 0.2643
Leishmania major thymidine kinase, putative 0.0259 0.3096 0.8511
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0022 0.0091 0.0166
Trichomonas vaginalis DNA polymerase II, putative 0.0025 0.0123 0.0196
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.02 0.0326
Trichomonas vaginalis thymidine kinase, putative 0.0259 0.3096 0.5233
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0076 0.0137
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Onchocerca volvulus 0.033 0.3995 0.5571
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0029 0.0172 0.0453
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.02 0.2643
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0076 0.0137
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.3995 0.7956
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.083 0.0919
Echinococcus multilocularis g protein coupled receptor 0.033 0.3995 0.7956
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.033 0.3995 0.4454
Trypanosoma brucei unspecified product 0.0059 0.0563 0.062
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.083 0.1641
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.02 0.1802
Schistosoma mansoni hypothetical protein 0.033 0.3995 0.4454
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0076 0.0077
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0016 0.0016 0.0017
Schistosoma mansoni biogenic amine (5HT) receptor 0.033 0.3995 0.4454
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.1216
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0105 0.1146 0.2271
Brugia malayi Dopamine receptor protein 1 0.033 0.3995 0.3994
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Loa Loa (eye worm) replication-associated protein 0.0049 0.0432 0.0429
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Plasmodium vivax SET domain protein, putative 0.0061 0.0578 0.7857
Loa Loa (eye worm) hypothetical protein 0.0078 0.0799 0.0796
Echinococcus granulosus bloom syndrome protein 0.0023 0.0095 0.0174
Onchocerca volvulus 0.0028 0.017 0.0227
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0018 0.0028
Chlamydia trachomatis thymidylate kinase 0.0073 0.0735 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1256 0.2116
Schistosoma mansoni biogenic amine receptor 0.033 0.3995 0.4454
Echinococcus multilocularis fmrfamide receptor 0.033 0.3995 0.7956
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0076 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0018 0.0015
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0016 0.0016 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.038 0.0416
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0347 0.0379
Loa Loa (eye worm) DEAH box polypeptide 35 0.0034 0.0238 0.0236
Brugia malayi putative neuropeptide receptor NPR1 0.033 0.3995 0.3994
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0578 0.1137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0578 0.0637
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0076 0.0074
Entamoeba histolytica thymidine kinase, putative 0.0259 0.3096 1
Brugia malayi Melatonin receptor type 1A 0.033 0.3995 0.3994
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0016 0.0008 0.0075
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0076 0.0137
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.033 0.3995 0.7956
Onchocerca volvulus 0.033 0.3995 0.5571
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Echinococcus granulosus tachykinin peptides receptor 99D 0.033 0.3995 0.7956
Brugia malayi Ets-domain containing protein 0.0074 0.0755 0.0752
Schistosoma mansoni neuropeptide f receptor 76f 0.033 0.3995 0.4454
Echinococcus multilocularis g-protein coupled receptor 0.033 0.3995 0.7956
Brugia malayi neuropeptide F receptor 0.033 0.3995 0.3994
Brugia malayi G protein-coupled receptor F59B2.13 0.033 0.3995 0.3994
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Brugia malayi hypothetical protein 0.0124 0.1388 0.1386
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.033 0.3995 0.7956
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0578 0.1137
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.033 0.3995 0.7956
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0016 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1256 0.3441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0076 0.0074
Toxoplasma gondii melibiase subfamily protein 0.0102 0.1109 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.02 0.0326
Loa Loa (eye worm) hypothetical protein 0.0468 0.5758 0.5757
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1256 0.1254
Onchocerca volvulus 0.0016 0.0016 0.0012
Giardia lamblia DNA polymerase alpha subunit A 0.0048 0.0418 0.133
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0347 0.0935
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.3637 1
Loa Loa (eye worm) G-protein coupled receptor 0.033 0.3995 0.3994
Brugia malayi Dopamine receptor 0.033 0.3995 0.3994
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1256 0.2116
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus granulosus RNA directed DNA polymerase 0.0016 0.0016 0.0017
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1245 0.6795
Trypanosoma brucei thymidylate kinase, putative 0.0073 0.0735 0.0812
Schistosoma mansoni biogenic amine (dopamine) receptor 0.033 0.3995 0.4454
Echinococcus multilocularis O glycosyltransferase 0.0043 0.0356 0.0696
Brugia malayi ORL1-like opioid receptor 0.033 0.3995 0.3994
Schistosoma mansoni ap endonuclease 0.0021 0.0071 0.0071
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.1256 0.2491
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.3995 0.7956
Onchocerca volvulus 0.0049 0.0432 0.0592
Brugia malayi hypothetical protein 0.0021 0.0076 0.0074
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0027 0.0033
Loa Loa (eye worm) RecQ helicase 0.0023 0.0095 0.0092
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.162 0.4444
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.033 0.3995 0.4454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.038 0.0416
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0439 0.0859
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0022 0.0091 0.0166
Loa Loa (eye worm) hypothetical protein 0.0028 0.017 0.0168
Echinococcus granulosus geminin 0.0167 0.1925 0.3826
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0076 0.0116
Echinococcus multilocularis expressed protein 0.041 0.502 1
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0578 0.0637
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Brugia malayi Tachykinin-like peptides receptor 99D 0.033 0.3995 0.3994
Echinococcus granulosus neuropeptide FF receptor 2 0.033 0.3995 0.7956
Echinococcus granulosus KRAB A domain containing protein 0.0016 0.0016 0.0017
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0139 0.0136
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0073 0.0735 0.4876
Onchocerca volvulus 0.0049 0.0432 0.0592
Plasmodium falciparum thioredoxin reductase 0.0017 0.0027 0.0265
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0022
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.033 0.3995 0.3994
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1405 0.7681
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0076 0.0077
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.02 0.1434
Echinococcus multilocularis allatostatin A receptor 0.033 0.3995 0.7956
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0043 0.035 0.3158
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0064 0.0621 0.1689
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0016 0.0016 0.0009
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0016 0.0016 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0076 0.0077
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1245 0.6795
Toxoplasma gondii DNA polymerase 0.0016 0.0008 0.007
Schistosoma mansoni histamine h1 receptor 0.033 0.3995 0.4454
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0057 0.0529 0.104
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0046 0.0393 0.3542
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0016 0.0013 0.0068
Echinococcus granulosus biogenic amine 5HT receptor 0.033 0.3995 0.7956
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0071 0.0175
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0076 0.0137
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1825 1
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0064 0.0621 0.1689
Brugia malayi neuropeptide F receptor 0.033 0.3995 0.3994
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.02 0.0622
Brugia malayi 6-phosphofructokinase 0.0114 0.1256 0.1254
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1256 0.1254
Brugia malayi Serotonin/octopamine receptor family protein 7 0.033 0.3995 0.3994
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0027 0.0053
Brugia malayi Cytochrome P450 family protein 0.0026 0.0139 0.0136
Treponema pallidum NADH oxidase 0.0017 0.0027 0.0033
Echinococcus multilocularis geminin 0.0167 0.1925 0.3826
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.1256 0.8861
Mycobacterium ulcerans hypothetical protein 0.0017 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Loa Loa (eye worm) hypothetical protein 0.0161 0.1847 0.1845
Onchocerca volvulus 0.033 0.3995 0.5571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Echinococcus multilocularis fmrfamide receptor 0.033 0.3995 0.7956
Brugia malayi ADAM-TS Spacer 1 family protein 0.0017 0.0019 0.0016
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.02 0.2486
Loa Loa (eye worm) neuropeptide F receptor 0.033 0.3995 0.3994
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0076 0.0074
Echinococcus granulosus sex peptide receptor 0.033 0.3995 0.7956
Schistosoma mansoni single-minded 0.0048 0.0416 0.0456
Echinococcus multilocularis neuropeptide s receptor 0.033 0.3995 0.7956
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Brugia malayi AKH receptor 0.033 0.3995 0.3994
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.038 0.0743
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.038 0.0743
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Schistosoma mansoni hypothetical protein 0.0073 0.0735 0.0812
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.033 0.3995 0.7956
Echinococcus granulosus g protein coupled receptor 0.033 0.3995 0.7956
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.033 0.3995 0.3994
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0071 0.0069
Toxoplasma gondii thymidylate kinase 0.0073 0.0735 0.6622
Brugia malayi Serotonin receptor 0.033 0.3995 0.3994
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0073 0.0735 0.3972
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0096 0.0099
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Brugia malayi Thioredoxin reductase 0.005 0.0439 0.0436
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.033 0.3995 0.4454
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.3637 0.4053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.033 0.3995 0.4454
Schistosoma mansoni amine GPCR 0.033 0.3995 0.4454
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0076 0.0137
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Brugia malayi larval opioid receptor 0.033 0.3995 0.3994
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0578 0.0637
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.02 0.0326
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0096 0.0867
Schistosoma mansoni biogenic amine receptor 0.033 0.3995 0.4454
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.0064 0.0617 0.0615
Brugia malayi 6-phosphofructokinase 0.0114 0.1256 0.1254
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0043 0.0356 0.0389
Schistosoma mansoni hypothetical protein 0.0721 0.896 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.033 0.3995 0.7956
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0356 0.0959
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0018 0.0011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.033 0.3995 0.7956
Toxoplasma gondii ribonuclease HI protein 0.0043 0.0356 0.3208
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0676 0.1132
Echinococcus multilocularis adam 17 protease 0.0223 0.264 0.5252
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.033 0.3995 0.7956
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0259 0.0256
Loa Loa (eye worm) melatonin receptor type 1A 0.033 0.3995 0.3994
Echinococcus granulosus expressed protein 0.041 0.502 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0027 0.0338
Echinococcus granulosus neuropeptide receptor 0.033 0.3995 0.7956
Brugia malayi Serotonin receptor 0.033 0.3995 0.3994
Trichomonas vaginalis set domain proteins, putative 0.048 0.5909 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0016 0.0016 0.0017
Brugia malayi Zinc knuckle family protein 0.0016 0.0016 0.0014
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.038 0.0743
Schistosoma mansoni adenoreceptor 0.033 0.3995 0.4454
Echinococcus granulosus allatostatin A receptor 0.033 0.3995 0.7956
Leishmania major ribonuclease H1, putative 0.0043 0.0356 0.0959
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0422 0.5169 0.5168
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0439 0.2335
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0018 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0071 0.0127
Brugia malayi angiogenesis inhibito 0.0017 0.0019 0.0016
Echinococcus granulosus neuropeptide Y receptor 0.033 0.3995 0.7956
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0076 0.0137
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.3995 0.7956
Plasmodium falciparum thioredoxin reductase 0.005 0.0439 0.5927
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Brugia malayi reverse transcriptase 0.0016 0.0016 0.0014
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0071 0.0061
Schistosoma mansoni alpha-1 adrenergic receptor 0.033 0.3995 0.4454
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0027 0.0244
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0059 0.0563 0.062
Trypanosoma cruzi thymidine kinase, putative 0.0259 0.3096 0.8511
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0043 0.0355 0.0352
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.1256 0.6856
Schistosoma mansoni neuropeptide receptor 0.033 0.3995 0.4454
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.033 0.3995 0.7956
Trypanosoma cruzi thymidylate kinase, putative 0.0073 0.0735 0.2003
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.02 0.2698
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0076 0.0137
Schistosoma mansoni biogenic amine (5HT) receptor 0.033 0.3995 0.4454
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus multilocularis neuropeptide receptor 0.033 0.3995 0.7956
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0083 0.0084
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0043 0.0356 0.0419
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.0064 0.0621 0.8446
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0027 0.005
Onchocerca volvulus 0.033 0.3995 0.5571
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0356 0.0959
Mycobacterium ulcerans hypothetical protein 0.0159 0.1825 1
Schistosoma mansoni neuropeptide receptor 0.033 0.3995 0.4454
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.0064 0.0621 0.4006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0578 0.0575
Loa Loa (eye worm) reprolysin 0.0022 0.0091 0.0089
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.033 0.3995 0.7956
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1256 0.4043
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0016 0.0016 0.0009
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.033 0.3995 0.5571
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0076 0.0077
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0027 0.005
Schistosoma mansoni peptide (allatostatin)-like receptor 0.033 0.3995 0.4454
Trypanosoma cruzi thymidylate kinase, putative 0.0073 0.0735 0.2003
Echinococcus granulosus biogenic amine 5HT receptor 0.033 0.3995 0.7956
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0016 0.0016 0.0017
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.033 0.3995 0.4454
Schistosoma mansoni neuropeptide receptor 0.033 0.3995 0.4454
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0439 0.0859
Giardia lamblia O-linked GlcNAc transferase 0.0025 0.0126 0.0382
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus multilocularis adam 0.0039 0.0301 0.0585
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0016 0.0016 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0083 0.0084
Schistosoma mansoni dihydroceramide desaturase 0.0022 0.0091 0.0093
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1256 0.2116
Schistosoma mansoni gabp alpha 0.0074 0.0755 0.0834
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.1256 1
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0064 0.0621 0.0618
Loa Loa (eye worm) hypothetical protein 0.0028 0.0164 0.0161
Echinococcus multilocularis neuropeptide FF receptor 2 0.033 0.3995 0.7956
Onchocerca volvulus 0.033 0.3995 0.5571
Onchocerca volvulus 0.0049 0.0432 0.0592
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus granulosus fmrfamide receptor 0.033 0.3995 0.7956
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0016 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.0116
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0105 0.1146 0.1271
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0016 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0074
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.033 0.3995 0.7956
Onchocerca volvulus 0.033 0.3995 0.5571
Trichomonas vaginalis reverse transcriptases, putative 0.0016 0.0016 0.0014
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0433
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0073 0.0735 0.0895
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Entamoeba histolytica hypothetical protein 0.0035 0.0258 0.0811
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.02 0.1802
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.033 0.3995 0.3994
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1245 0.6795
Schistosoma mansoni ap endonuclease 0.0021 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.033 0.3995 0.4454
Echinococcus multilocularis lamin dm0 0.0028 0.017 0.0325
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0076 0.0137
Echinococcus granulosus alpha 1A adrenergic receptor 0.033 0.3995 0.7956
Brugia malayi Fli-1 protein 0.0226 0.268 0.2678
Echinococcus granulosus neuropeptide s receptor 0.033 0.3995 0.7956
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0076 0.0137
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0076 0.0077
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.3637 1
Onchocerca volvulus 0.048 0.5909 0.8246
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0057 0.0529 0.104
Echinococcus multilocularis neuropeptide receptor A26 0.033 0.3995 0.7956
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0016 0.0008 0.0075
Brugia malayi orotate phosphoribosyltransferase family protein 0.0064 0.0621 0.0618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Trypanosoma brucei trypanothione reductase 0.005 0.0439 0.0481
Trichomonas vaginalis thymidine kinase, putative 0.0259 0.3096 0.5233
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.038 0.0743
Mycobacterium ulcerans thymidylate kinase 0.0073 0.0735 0.3965
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0076 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0074
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.033 0.3995 0.7956
Loa Loa (eye worm) replication-associated protein 0.0049 0.0432 0.0429
Schistosoma mansoni biogenic amine (dopamine) receptor 0.033 0.3995 0.4454
Schistosoma mansoni myosin xvIII 0.033 0.3995 0.4454
Brugia malayi phosphofructokinase 0.0114 0.1256 0.1254
Brugia malayi hypothetical protein 0.0016 0.0016 0.0014
Trichomonas vaginalis ribonuclease H1, putative 0.0043 0.0356 0.059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.038 0.0416
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0083 0.008
Leishmania major cytochrome p450-like protein 0.0016 0.0018 0.0028
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.033 0.3995 0.7956
Echinococcus granulosus rhodopsin orphan GPCR 0.033 0.3995 0.7956
Brugia malayi Dopamine receptor protein 2 0.033 0.3995 0.3994
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.1281
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1405 0.7681
Echinococcus granulosus serotonin receptor 0.033 0.3995 0.7956
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0755 0.149
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1109 0.123
Echinococcus granulosus O glycosyltransferase 0.0043 0.0356 0.0696
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0029 0.0172 0.0453
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0035
Brugia malayi DNA polymerase delta catalytic subunit 0.0016 0.0008 0.0005
Giardia lamblia CDC8 0.0073 0.0735 0.2353
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1256 0.2116
Onchocerca volvulus 0.0049 0.0432 0.0592
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.083 0.1641
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0076 0.0137
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.162 0.1801
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0258 0.028
Echinococcus multilocularis sex peptide receptor 0.033 0.3995 0.7956
Schistosoma mansoni amine GPCR 0.033 0.3995 0.4454
Mycobacterium tuberculosis Probable reductase 0.0113 0.1245 0.6795
Schistosoma mansoni phosphoglucomutase 0.0043 0.0356 0.0389
Entamoeba histolytica hypothetical protein 0.0049 0.0432 0.1373
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Brugia malayi putative neuropeptide receptor 0.033 0.3995 0.3994
Schistosoma mansoni thymidylate kinase 0.0073 0.0735 0.0812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.02 0.0326
Schistosoma mansoni lamin 0.0028 0.017 0.0182
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0009
Brugia malayi PXA domain containing protein 0.0021 0.0076 0.0074
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0039 0.0301 0.0328
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0027 0.0022
Echinococcus multilocularis biogenic amine (5HT) receptor 0.033 0.3995 0.7956
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0027 0.0338
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0071 0.0296
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0439 0.5957
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus granulosus neuropeptides capa receptor 0.033 0.3995 0.7956
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.02 0.0326
Brugia malayi Pre-SET motif family protein 0.0422 0.5169 0.5168
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0057 0.0529 0.0582
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.1109 0.2198
Schistosoma mansoni biogenic amine receptor 0.033 0.3995 0.4454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0578 0.0637
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0096 0.1028
Brugia malayi RNase H family protein 0.0043 0.0356 0.0353
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.0079 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Echinococcus multilocularis serotonin receptor 0.033 0.3995 0.7956
Loa Loa (eye worm) hypothetical protein 0.0022 0.0091 0.0089
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus granulosus tm gpcr rhodopsin 0.033 0.3995 0.7956
Onchocerca volvulus 0.0028 0.017 0.0227
Echinococcus granulosus uridine 5' monophosphate synthase 0.0064 0.0621 0.1223
Schistosoma mansoni opsin-like receptor 0.033 0.3995 0.4454
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0027 0.0053
Echinococcus multilocularis g protein coupled receptor 0.033 0.3995 0.7956
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1405 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0016
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0076 0.0077
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.1109 0.2198
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0027 0.0053
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0064 0.0621 0.1689
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.033 0.3995 0.4454
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0076 0.0137
Brugia malayi RE15519p 0.033 0.3995 0.3994
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0071 0.0108
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0076 0.0077
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.033 0.3995 0.3994
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.1256 0.6853
Entamoeba histolytica hypothetical protein 0.0035 0.0258 0.0811
Echinococcus multilocularis lamin 0.0028 0.017 0.0325
Onchocerca volvulus 0.008 0.083 0.1149
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0076 0.0074
Onchocerca volvulus Neuropeptide F receptor homolog 0.033 0.3995 0.5571
Brugia malayi GnHR receptor homolog 0.033 0.3995 0.3994
Leishmania major hypothetical protein, conserved 0.0029 0.0172 0.0453
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0071 0.0175
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Plasmodium falciparum glutathione reductase 0.0017 0.0027 0.0265
Trypanosoma brucei ingi protein (ORF1) 0.0059 0.0563 0.062
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0076 0.0137
Trichomonas vaginalis thymidine kinase, putative 0.0259 0.3096 0.5233
Onchocerca volvulus 0.033 0.3995 0.5571
Echinococcus multilocularis musashi 0.0028 0.017 0.0325
Schistosoma mansoni neuropeptide F-like receptor 0.033 0.3995 0.4454
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Echinococcus multilocularis disintegrin and metalloproteinase 0.0022 0.0091 0.0166
Brugia malayi hypothetical protein 0.033 0.3995 0.3994
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0593
Echinococcus granulosus somatostatin receptor 0.033 0.3995 0.7956
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0076 0.0137
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.033 0.3995 0.7956
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0347 0.0935
Echinococcus multilocularis neuropeptides capa receptor 0.033 0.3995 0.7956
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0223 0.264 0.294
Leishmania major trypanothione reductase 0.005 0.0439 0.1187
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Brugia malayi hypothetical protein 0.0035 0.0258 0.0256
Brugia malayi Zinc knuckle family protein 0.0016 0.0016 0.0014
Brugia malayi hypothetical protein 0.0016 0.0016 0.0014
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.0064 0.0621 0.3336
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.02 0.0622
Brugia malayi Protein kinase domain containing protein 0.0438 0.5366 0.5365
Echinococcus multilocularis serotonin receptor 0.033 0.3995 0.7956
Brugia malayi Ets-domain containing protein 0.0074 0.0755 0.0752
Echinococcus granulosus intermediate filament protein 0.0028 0.017 0.0325
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0016 0.0016 0.0027
Echinococcus multilocularis thymidylate kinase 0.0073 0.0735 0.145
Brugia malayi Pao retrotransposon peptidase family protein 0.0016 0.0016 0.0014
Schistosoma mansoni hypothetical protein 0.0167 0.1925 0.2142
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0071 0.0071
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0465 0.1259
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0027 0.0244
Giardia lamblia Thymidine kinase 0.0259 0.3096 1
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Brugia malayi PXA domain containing protein 0.0021 0.0076 0.0074
Brugia malayi glutathione reductase 0.005 0.0439 0.0436
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.033 0.3995 0.3994
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.006 0.0721
Schistosoma mansoni hypothetical protein 0.0035 0.0258 0.028
Entamoeba histolytica hypothetical protein 0.0021 0.0076 0.0222
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.0064 0.0621 0.8434
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0064 0.0621 0.1689
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Echinococcus multilocularis RNA directed DNA polymerase 0.0016 0.0016 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1405 0.7681
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0016 0.0016 0.0014
Brugia malayi hypothetical protein 0.0016 0.0016 0.0014
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0096 0.0433
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.02 0.2698
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0027 0.0022
Schistosoma mansoni lamin 0.0028 0.017 0.0182
Loa Loa (eye worm) hypothetical protein 0.0068 0.0676 0.0674
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0027 0.006
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0259 0.1331
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0027 0.0265
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.1109 0.2198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.033 0.3995 0.4454
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.1689 0.1687
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0064 0.0621 0.0685
Entamoeba histolytica hypothetical protein 0.0035 0.0258 0.0811
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0071 0.0206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.033 0.3995 0.4454
Loa Loa (eye worm) hypothetical protein 0.033 0.3995 0.3994
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0071 0.0175
Echinococcus multilocularis dro:myosuppressin receptor 0.033 0.3995 0.7956
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0016 0.0016 0.0027
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0016 0.0008 0.0005
Trypanosoma brucei RNA helicase, putative 0.0721 0.896 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.033 0.3995 0.7956
Echinococcus multilocularis g protein coupled receptor 0.033 0.3995 0.7956
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.038 0.0378
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0676 0.0746
Onchocerca volvulus 0.0035 0.0259 0.035
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0095 0.0174
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0755 0.149
Loa Loa (eye worm) replication-associated protein 0.0049 0.0432 0.0429
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0259 0.05
Onchocerca volvulus 0.0061 0.0578 0.0796
Trypanosoma brucei ingi protein (ORF1) 0.0059 0.0563 0.062
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0027 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.033 0.3995 0.7956
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0755 0.0752
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1109 0.123
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0076 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.033 0.3995 0.7956
Brugia malayi Cytochrome P450 family protein 0.0016 0.0018 0.0015
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0016 0.0016 0.0017
Echinococcus granulosus 7tm_1 domain containing protein 0.033 0.3995 0.7956
Trichomonas vaginalis thymidylate kinase, putative 0.0073 0.0735 0.1231
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.033 0.3995 0.4454
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.017 0.0168
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0071 0.0875

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 117 nM Antiinflammatory activity in human whole blood assessed as inhibition of LPS-induced TNFalpha production after 3.5 hrs by ELISA ChEMBL. 21106451
IC50 (binding) = 117 nM BindingDB_Patents: Inhibition Assay. Inhibition assay using TNF-alpha. ChEMBL. No reference
IC50 (binding) = 117 nM BindingDB_Patents: Inhibition Assay. Inhibition assay using TNF-alpha. ChEMBL. No reference
Ki (binding) = 0.07 nM Inhibition of TACE ChEMBL. 21106451
Ki (binding) = 0.074 nM BindingDB_Patents: Inhibition Assay. Inhibition assay using TNF-alpha. ChEMBL. No reference
Ki (binding) = 0.074 nM BindingDB_Patents: Inhibition Assay. Inhibition assay using TNF-alpha. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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