Detailed information for compound 1271518

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 605.625 | Formula: C33H31F4N5O2
  • H donors: 3 H acceptors: 4 LogP: 5.53 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#C[C@H](Cc1ccc(cc1F)C#N)NC(=O)[C@H](C(C)C)N[C@H](C(F)(F)F)c1ccc(cc1)c1ccc(cc1)C1(CC1)C(=O)N
  • InChi: 1S/C33H31F4N5O2/c1-19(2)28(30(43)41-26(18-39)16-24-4-3-20(17-38)15-27(24)34)42-29(33(35,36)37)23-7-5-21(6-8-23)22-9-11-25(12-10-22)32(13-14-32)31(40)44/h3-12,15,19,26,28-29,42H,13-14,16H2,1-2H3,(H2,40,44)(H,41,43)/t26-,28-,29-/m0/s1
  • InChiKey: CDFSITIHQOZSIN-ZXRKZBAXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin F Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin V Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin V 334 aa 357 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.016 0.2292 0.6531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.016 0.2292 0.7594
Leishmania major cathepsin L-like protease 0.016 0.2292 0.6531
Brugia malayi Cathepsin L-like precursor 0.016 0.2292 0.7594
Onchocerca volvulus 0.016 0.2292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.1212 0.3404
Plasmodium vivax vivapain-1 0.0085 0.0708 0.3088
Leishmania major cathepsin L-like protease 0.016 0.2292 0.6531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.016 0.2292 1
Schistosoma mansoni cathepsin F (C01 family) 0.016 0.2292 0.7594
Loa Loa (eye worm) hypothetical protein 0.0109 0.1212 0.4015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.1212 0.3404
Onchocerca volvulus Cathepsin L homolog 0.016 0.2292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.016 0.2292 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0654 0.2168
Plasmodium vivax glutathione reductase, putative 0.0053 0.0037 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0654 0.2168
Onchocerca volvulus 0.016 0.2292 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0654 0.2168
Plasmodium falciparum cysteine proteinase falcipain 1 0.0085 0.0708 0.2974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1753 0.1722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Leishmania major cathepsin L-like protease 0.0217 0.3489 1
Plasmodium vivax vivapain-3 0.0085 0.0708 0.3088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0654 0.207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0708 0.0326
Brugia malayi Cathepsin L-like cysteine proteinase 0.0109 0.1212 0.4015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0037 0.0163
Plasmodium falciparum cysteine proteinase falcipain 2a 0.016 0.2292 1
Mycobacterium tuberculosis Conserved protein 0.0082 0.0654 0.0619
Brugia malayi Cathepsin L-like precursor 0.016 0.2292 0.7594
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0654 0.1875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0708 0.1942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1753 0.1722
Entamoeba histolytica cysteine proteinase, putative 0.016 0.2292 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.3018 1
Onchocerca volvulus 0.016 0.2292 1
Echinococcus granulosus cathepsin L cysteine protease 0.0085 0.0708 0.2249
Leishmania major hypothetical protein, conserved 0.0082 0.0654 0.1787
Brugia malayi cathepsin L-like precursor 0.0109 0.1212 0.4015
Brugia malayi glutathione reductase 0.0053 0.0037 0.0124
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0654 0.2168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0676 0.2241
Onchocerca volvulus 0.016 0.2292 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Echinococcus granulosus cathepsin L 0.0085 0.0708 0.2249
Mycobacterium tuberculosis Conserved protein 0.0082 0.0654 0.0619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Leishmania major cathepsin L-like protease 0.016 0.2292 0.6531
Loa Loa (eye worm) papain family cysteine protease containing protein 0.016 0.2292 0.7594
Onchocerca volvulus 0.0109 0.1212 0.3404
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.1469 0.7412
Giardia lamblia Cathepsin B precursor 0.0083 0.0676 0.5
Entamoeba histolytica cysteine proteinase, putative 0.016 0.2292 1
Onchocerca volvulus Cathepsin L homolog 0.016 0.2292 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.1212 0.3182
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0654 0.207
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0708 0.2345
Entamoeba histolytica cysteine protease, putative 0.016 0.2292 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.1469 0.1437
Giardia lamblia Cathepsin B precursor 0.0083 0.0676 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0194 0.3018 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.3018 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Mycobacterium tuberculosis Conserved protein 0.0082 0.0654 0.0619
Trypanosoma cruzi cysteine peptidase, putative 0.016 0.2292 0.6568
Echinococcus granulosus cysteine protease 0.0085 0.0708 0.2249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Echinococcus multilocularis cathepsin b 0.0194 0.3018 1
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.0708 0.2028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.1469 0.1437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Loa Loa (eye worm) ctsf protein 0.016 0.2292 0.7594
Echinococcus granulosus cathepsin b 0.0194 0.3018 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.1469 0.1437
Trypanosoma cruzi cysteine proteinase, putative 0.0085 0.0708 0.2028
Loa Loa (eye worm) hypothetical protein 0.0082 0.0654 0.2168
Onchocerca volvulus 0.016 0.2292 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0166 0.2409 0.6905
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0085 0.0708 0.2345
Echinococcus multilocularis cathepsin l cysteine peptidase 0.016 0.2292 0.7564
Trypanosoma cruzi major cysteine proteinase, putative 0.009 0.0825 0.2365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0037 0.0107
Echinococcus granulosus cathepsin l cysteine peptidase 0.016 0.2292 0.7564
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.016 0.2292 1
Brugia malayi Thioredoxin reductase 0.0053 0.0037 0.0124
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.3018 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.016 0.2292 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0654 0.0619
Trypanosoma cruzi cysteine peptidase, putative 0.0217 0.3489 1
Mycobacterium ulcerans lipase LipD 0.0082 0.0654 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0654 0.2168
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0083 0.0676 0.1938
Echinococcus multilocularis cathepsin L 0.0085 0.0708 0.2249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Echinococcus multilocularis cysteine protease 0.016 0.2292 0.7564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Plasmodium vivax unspecified product 0.0085 0.0708 0.3088
Echinococcus multilocularis cysteine protease 0.016 0.2292 0.7564
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0654 0.0619
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0654 0.0619
Toxoplasma gondii cathepsin CPL 0.016 0.2292 1
Echinococcus granulosus cathepsin l1 0.016 0.2292 0.7564
Brugia malayi beta-lactamase family protein 0.0082 0.0654 0.2168
Loa Loa (eye worm) hypothetical protein 0.0082 0.0654 0.2168
Loa Loa (eye worm) glutathione reductase 0.0053 0.0037 0.0124
Brugia malayi Cathepsin L-like precursor 0.016 0.2292 0.7594
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0654 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0654 0.5
Brugia malayi beta-lactamase 0.0082 0.0654 0.2168
Leishmania major cysteine peptidase A (CPA) 0.016 0.2292 0.6531
Loa Loa (eye worm) hypothetical protein 0.0082 0.0654 0.2168
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0085 0.0708 0.2345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.3018 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0654 0.2168
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0654 0.0619
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Onchocerca volvulus 0.016 0.2292 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0654 0.2168
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0194 0.3018 0.8649
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0654 0.0619
Loa Loa (eye worm) hypothetical protein 0.016 0.2292 0.7594
Schistosoma mansoni cathepsin F (C01 family) 0.0109 0.1212 0.4015
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0083 0.0676 0.1851
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0037 0.0124
Loa Loa (eye worm) hypothetical protein 0.0109 0.1212 0.4015
Brugia malayi Papain family cysteine protease containing protein 0.016 0.2292 0.7594
Echinococcus granulosus cathepsin b 0.0194 0.3018 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1753 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.016 0.2292 0.7564
Trypanosoma cruzi cysteine peptidase, putative 0.0217 0.3489 1
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0654 0.0619
Plasmodium vivax vivapain-2 0.016 0.2292 1
Brugia malayi Cathepsin L-like precursor 0.016 0.2292 0.7594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Giardia lamblia Cathepsin B precursor 0.0083 0.0676 0.5
Leishmania major cathepsin L-like protease 0.0217 0.3489 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0654 0.2855
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Trypanosoma cruzi cysteine proteinase, putative 0.0085 0.0708 0.2028
Brugia malayi beta-lactamase family protein 0.0082 0.0654 0.2168
Echinococcus multilocularis cathepsin b 0.0194 0.3018 1
Brugia malayi Cathepsin L-like precursor 0.0109 0.1212 0.4015
Trypanosoma cruzi cruzipain precursor, putative 0.0217 0.3489 1
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0654 0.0619
Loa Loa (eye worm) hypothetical protein 0.0109 0.1212 0.4015
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0654 0.1875
Echinococcus granulosus cathepsin l1 0.0109 0.1212 0.394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0708 0.0326
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0085 0.0708 0.2028
Leishmania major cathepsin L-like protease 0.016 0.2292 0.6531
Echinococcus multilocularis cathepsin l cysteine peptidase 0.016 0.2292 0.7564
Loa Loa (eye worm) cathepsin B 0.0083 0.0676 0.2241
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0194 0.3018 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Echinococcus multilocularis cathepsin L cysteine protease 0.016 0.2292 0.7564
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0085 0.0708 0.2345
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0676 0.0133
Loa Loa (eye worm) fibroinase 0.016 0.2292 0.7594
Mycobacterium ulcerans hypothetical protein 0.0082 0.0654 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Trypanosoma cruzi cysteine protease, putative 0.0085 0.0708 0.2028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Trypanosoma cruzi cysteine peptidase, putative 0.0217 0.3489 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1753 0.1722
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0217 0.3489 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.016 0.2292 1
Mycobacterium tuberculosis Probable reductase 0.0121 0.1469 0.1437
Schistosoma mansoni cathepsin F (C01 family) 0.016 0.2292 0.7594
Mycobacterium ulcerans beta-lactamase 0.0082 0.0654 0.5
Onchocerca volvulus 0.016 0.2292 1
Toxoplasma gondii ABC1 family protein 0.0082 0.0654 0.2737
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0708 0.2345
Toxoplasma gondii cathepsin B 0.0083 0.0676 0.2834
Brugia malayi Cathepsin L-like precursor 0.0109 0.1212 0.4015
Trypanosoma brucei cysteine peptidase C (CPC) 0.0083 0.0676 0.1851
Leishmania major cathepsin L-like protease 0.0217 0.3489 1
Loa Loa (eye worm) cysteine protease 0.016 0.2292 0.7594
Loa Loa (eye worm) beta-lactamase 0.0082 0.0654 0.2168
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.1469 0.1437
Echinococcus multilocularis cathepsin L cysteine protease 0.016 0.2292 0.7564
Brugia malayi Cathepsin L-like precursor 0.016 0.2292 0.7594
Onchocerca volvulus Cathepsin F homolog 0.016 0.2292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2292 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0708 0.1942
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0654 0.1787
Plasmodium vivax vivapain-2 0.016 0.2292 1
Brugia malayi Cathepsin L-like precursor 0.016 0.2292 0.7594
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.1469 0.1437

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.2 nM Inhibition of Trypanosoma cruzi Cruzipain ChEMBL. 21041084
IC50 (binding) = 3 nM Inhibition of human Cat K expressed in Ramos cells ChEMBL. 21041084
IC50 (binding) = 16 nM Inhibition of human Cat F expressed in rabbit HIG82 cells ChEMBL. 21041084
IC50 (binding) = 41 nM Inhibition of human Cat B in HepG2 cells ChEMBL. 21041084
IC50 (binding) = 79 nM Inhibition of human Cat V ChEMBL. 21041084
IC50 (binding) = 98 nM Inhibition of human Cat L ChEMBL. 21041084
IC50 (binding) = 408 nM Inhibition of human Cat S expressed in Ramos cells ChEMBL. 21041084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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