Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0425 | 0.276 | 0.276 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0425 | 0.276 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0425 | 0.276 | 1 |
Onchocerca volvulus | 0.0076 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.276 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0425 | 0.276 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.2155 | 0.781 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0425 | 0.276 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0425 | 0.276 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.