Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0651 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.8268 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.8268 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0127 | 0.0127 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0542 | 0.0635 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.8268 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.8268 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.8268 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.4729 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.8268 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.4403 | 0.5 | |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.8268 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.8268 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4688 | 0.5299 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.8268 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.8268 | 0.8268 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.8268 | 0.5 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8869 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.8268 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.8268 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4688 | 0.5299 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4403 | 0.4403 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.8268 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.4715 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.04 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.