Detailed information for compound 1271887

Basic information

Technical information
  • TDR Targets ID: 1271887
  • Name: 5-methyl-1-phenyl-6H-pyrido[4,3-b]carbazole
  • MW: 308.376 | Formula: C22H16N2
  • H donors: 1 H acceptors: 1 LogP: 5.59 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c2ccnc(c2cc2c1[nH]c1c2cccc1)c1ccccc1
  • InChi: 1S/C22H16N2/c1-14-16-11-12-23-22(15-7-3-2-4-8-15)18(16)13-19-17-9-5-6-10-20(17)24-21(14)19/h2-13,24H,1H3
  • InChiKey: ORUPXFHZHTYMFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5531-75-9
  • NCIOpen2_009547
  • NSC86715
  • NCI60_041921

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens NAD(P)H dehydrogenase, quinone 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Giardia lamblia NADPH oxidoreductase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Giardia lamblia NADPH oxidoreductase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis NAD(P)H dehydrogenase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis NAD(P)H dehydrogenase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Giardia lamblia NADPH oxidoreductase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis NAD(P)H dehydrogenase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis NAD(P)H dehydrogenase, putative NAD(P)H dehydrogenase, quinone 2 231 aa 213 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0079 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0079 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0079 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Schistosoma mansoni opsin-like receptor 0.0079 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0079 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0079 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0079 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0 0.5
Echinococcus granulosus fmrfamide receptor 0.0079 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0079 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0079 0 0.5
Brugia malayi G-protein coupled receptor 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Brugia malayi G-protein coupled receptor 0.0079 0 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0079 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0 0.5
Brugia malayi larval opioid receptor 0.0079 0 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Onchocerca volvulus 0.0079 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Echinococcus multilocularis somatostatin receptor 0.0079 0 0.5
Giardia lamblia NADPH oxidoreductase, putative 0.0096 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0079 0 0.5
Brugia malayi putative neuropeptide receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0079 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0079 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0079 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0 0.5
Brugia malayi RE15519p 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0079 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Brugia malayi AKH receptor 0.0079 0 0.5
Brugia malayi neuropeptide F receptor 0.0079 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0079 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0079 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Echinococcus granulosus g-protein coupled receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Brugia malayi Dopamine receptor 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0079 0 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0079 0 0.5
Brugia malayi neuropeptide F receptor 0.0079 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0079 0 0.5
Brugia malayi GnHR receptor homolog 0.0079 0 0.5
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 1 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Schistosoma mansoni hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Schistosoma mansoni hypothetical protein 0.0079 0 0.5
Schistosoma mansoni amine GPCR 0.0079 0 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0079 0 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0079 0 0.5
Echinococcus multilocularis orexin receptor type 2 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Echinococcus granulosus g protein coupled receptor 0.0079 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0 0.5
Schistosoma mansoni hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0079 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0079 0 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0079 0 0.5
Echinococcus multilocularis serotonin receptor 0.0079 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0 0.5
Schistosoma mansoni amine GPCR 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0079 0 0.5
Giardia lamblia NADPH oxidoreductase, putative 0.0096 1 0.5
Brugia malayi sulfakinin receptor protein 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0079 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Onchocerca volvulus 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0 0.5
Schistosoma mansoni myosin xvIII 0.0079 0 0.5
Schistosoma mansoni opsin-like receptor 0.0079 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0079 0 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0079 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0079 0 0.5
Echinococcus granulosus sex peptide receptor 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Echinococcus granulosus neuropeptide s receptor 0.0079 0 0.5
Schistosoma mansoni hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0079 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0079 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0079 0 0.5
Echinococcus granulosus hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0079 0 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0079 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0 0.5
Schistosoma mansoni adenoreceptor 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0079 0 0.5
Schistosoma mansoni histamine h1 receptor 0.0079 0 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0079 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0079 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0079 0 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0079 0 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0079 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0079 0 0.5
Brugia malayi Serotonin receptor 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0079 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0079 0 0.5
Echinococcus granulosus allatostatin A receptor 0.0079 0 0.5
Schistosoma mansoni opsin-like receptor 0.0079 0 0.5
Brugia malayi Serotonin receptor 0.0079 0 0.5
Echinococcus granulosus serotonin receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis allatostatin A receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Brugia malayi G protein-coupled receptor 0.0079 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0 0.5
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0079 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0079 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0 0.5
Echinococcus multilocularis sex peptide receptor 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0 0.5
Schistosoma mansoni amine GPCR 0.0079 0 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0079 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Echinococcus multilocularis serotonin receptor 0.0079 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0079 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0079 0 0.5
Schistosoma mansoni amine GPCR 0.0079 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0079 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0079 0 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Echinococcus granulosus orexin receptor type 2 0.0079 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0079 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0 0.5
Schistosoma mansoni amine GPCR 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Echinococcus granulosus somatostatin receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Schistosoma mansoni biogenic amine receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0079 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0096 1 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5
Onchocerca volvulus 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0079 0 0.5

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.212 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.995 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.902 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.876 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.679 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.611 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.538 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.525 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.472 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 2.1 uM Inhibition of human recombinant NQO2 ChEMBL. 21074425
Inhibition (binding) Inhibition of human recombinant NQO2 at 100 uM ChEMBL. 21074425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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