Detailed information for compound 1272070

Basic information

Technical information
  • TDR Targets ID: 1272070
  • Name: 3,4-dimethoxy-N-[(Z)-3-(4-methylpiperazin-1-y l)-3-oxo-1-thiophen-2-ylprop-1-en-2-yl]benzam ide
  • MW: 415.506 | Formula: C21H25N3O4S
  • H donors: 1 H acceptors: 2 LogP: 2.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C(=O)N/C(=C\c1cccs1)/C(=O)N1CCN(CC1)C
  • InChi: 1S/C21H25N3O4S/c1-23-8-10-24(11-9-23)21(26)17(14-16-5-4-12-29-16)22-20(25)15-6-7-18(27-2)19(13-15)28-3/h4-7,12-14H,8-11H2,1-3H3,(H,22,25)/b17-14-
  • InChiKey: GVTBPEKEVYXBAL-VKAVYKQESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dimethoxy-N-[3-(4-methylpiperazin-1-yl)-3-oxo-1-thiophen-2-ylprop-1-en-2-yl]benzamide
  • 3,4-dimethoxy-N-[(Z)-1-(4-methylpiperazine-1-carbonyl)-2-(2-thienyl)vinyl]benzamide
  • 3,4-dimethoxy-N-[1-(4-methylpiperazine-1-carbonyl)-2-(2-thienyl)vinyl]benzamide
  • 3,4-dimethoxy-N-[(Z)-1-[(4-methyl-1-piperazinyl)-oxomethyl]-2-(2-thienyl)vinyl]benzamide
  • 3,4-dimethoxy-N-[1-[(4-methyl-1-piperazinyl)-oxomethyl]-2-(2-thienyl)vinyl]benzamide
  • 3,4-dimethoxy-N-[(Z)-3-(4-methylpiperazin-1-yl)-3-oxo-1-thiophen-2-yl-prop-1-en-2-yl]benzamide
  • 3,4-dimethoxy-N-[3-(4-methylpiperazin-1-yl)-3-oxo-1-thiophen-2-yl-prop-1-en-2-yl]benzamide
  • BAS 03273553

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.2075 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3712 1
Echinococcus granulosus muscleblind protein 0.0164 0.822 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1895 0.1895
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 1 1
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0138 0.0168
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0282 0.0344
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.2075 0.2525
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0138 0.0665
Mycobacterium ulcerans hypothetical protein 0.0004 0 0.5
Onchocerca volvulus 0.0007 0.0138 0.0138
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.2075 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0138 0.0168
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1562 0.1562
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0004 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3712 1
Schistosoma mansoni regulator of G protein signaling 0.001 0.0282 0.0761
Echinococcus granulosus tar DNA binding protein 0.0076 0.3712 0.4516
Echinococcus granulosus son of sevenless 1 0.0007 0.0138 0.0168
Schistosoma mansoni hypothetical protein 0.0019 0.0759 0.2044
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0282 0.0344
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0138 0.0665
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2875 0.2875
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2875 0.2875
Brugia malayi RasGEF domain containing protein 0.0007 0.0138 0.0138
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.2075 0.2525
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.2075 0.559
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0222 0.027
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0282 0.0344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3562 0.9594
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0331 0.0403
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0183 0.0884
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0138 0.0372
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3712 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0183 0.0884
Echinococcus multilocularis GPCR, family 2 0.0019 0.0759 0.0923
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.2075 0.559
Echinococcus granulosus cpg binding protein 0.0037 0.1664 0.2025
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0759 0.0923
Brugia malayi RNA binding protein 0.0076 0.3712 0.3712
Mycobacterium leprae Conserved hypothetical protein 0.0004 0 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.2075 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0759 0.0923
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0282 0.0761
Schistosoma mansoni hypothetical protein 0.0019 0.0759 0.2044
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0324 0.0324
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.2075 1
Onchocerca volvulus 0.0035 0.1562 0.1562
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0282 0.0282
Onchocerca volvulus 0.001 0.0282 0.0282
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3712 0.3712
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.2075 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.822 0.822
Brugia malayi N-terminal motif family protein 0.0007 0.0138 0.0138
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0138 0.0138
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0183 0.0884
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.2364 0.6368
Loa Loa (eye worm) hypothetical protein 0.001 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0164 0.822 0.822
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.2075 0.2525
Mycobacterium tuberculosis Conserved hypothetical protein 0.0004 0 0.5
Brugia malayi RasGEF domain containing protein 0.0007 0.0138 0.0138
Mycobacterium ulcerans transcriptional regulatory protein 0.0004 0 0.5
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0282 0.0282
Treponema pallidum catabolite gene activator 0.0004 0 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0183 0.0884
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0759 0.0923
Brugia malayi hypothetical protein 0.001 0.0282 0.0282
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.012 0.0324
Brugia malayi N-terminal motif family protein 0.0007 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0007 0.0138 0.0138
Schistosoma mansoni dishevelled 0.001 0.0282 0.0761
Loa Loa (eye worm) hypothetical protein 0.001 0.0282 0.0282
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0138 0.0665
Schistosoma mansoni cpg binding protein 0.0035 0.1562 0.4209
Schistosoma mansoni hypothetical protein 0.0019 0.0759 0.2044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0183 0.0884
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.0138 0.0138
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.2075 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.2364 0.2876
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0282 0.0344
Brugia malayi hypothetical protein 0.001 0.0282 0.0282
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0282 0.0344
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0138 0.0168
Schistosoma mansoni hypothetical protein 0.0041 0.1895 0.5105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0035 0.0095
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.2075 0.2525
Treponema pallidum catabolite gene activator (Crp) 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.2875 0.2875
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.3158 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0138 0.0372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.2364 0.2364
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3712 0.3712
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0282 0.0344
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0138 0.0372
Loa Loa (eye worm) hypothetical protein 0.0019 0.0759 0.0759
Mycobacterium ulcerans regulatory protein 0.0004 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0004 0 0.5
Echinococcus multilocularis son of sevenless 1 0.0007 0.0138 0.0168
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3712 0.4516
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.2075 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.2075 0.2525
Echinococcus multilocularis muscleblind protein 0.0164 0.822 1
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0282 0.0282
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0759 0.0923
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0004 0 0.5
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0138 0.0168
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0282 0.0344
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0282 0.0344
Toxoplasma gondii hypothetical protein 0.001 0.0282 0.0894
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0138 0.0168
Mycobacterium ulcerans hypothetical protein 0.0004 0 0.5
Brugia malayi RasGEF domain containing protein 0.0007 0.0138 0.0138
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0138 0.0138
Mycobacterium ulcerans hypothetical protein 0.0004 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.2364 0.6368
Schistosoma mansoni dishevelled 0.001 0.0282 0.0761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.2364 0.2876
Brugia malayi Muscleblind-like protein 0.0164 0.822 0.822
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3712 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0004 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.2075 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.2364 0.2364
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3712 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0759 0.0759
Echinococcus multilocularis cpg binding protein 0.0037 0.1664 0.2025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0331 0.0403
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0331 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Schistosoma mansoni cpg binding protein 0.0037 0.1664 0.4483
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0138 0.0168
Trichomonas vaginalis helicase, putative 0.0008 0.0183 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.2364 0.2876
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.2075 1
Mycobacterium ulcerans transmembrane transport protein 0.0004 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0076 0.3712 0.3712
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0138 0.0665
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0004 0 0.5
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0138 0.0168
Treponema pallidum cyclic nucleotide binding protein 0.0004 0 0.5
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0282 0.0344
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0282 0.0282
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1895 0.1895
Echinococcus granulosus GPCR family 2 0.0019 0.0759 0.0923
Echinococcus multilocularis muscleblind protein 1 0.0164 0.822 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0138 0.0372
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0183 0.0884
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0004 0 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0759 0.2044
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0138 0.0372
Echinococcus granulosus Protein son of sevenless 0.0007 0.0138 0.0168
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.001 0.0282 0.0282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2875 0.2875
Treponema pallidum cyclic nucleotide binding protein 0.0004 0 0.5
Schistosoma mansoni dep domain containing protein 0.001 0.0282 0.0761
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0004 0 0.5
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0282 0.0761
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.2364 0.2876
Mycobacterium tuberculosis Conserved protein 0.0004 0 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0282 0.0344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0222 0.0599
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0138 0.0665
Trypanosoma cruzi hypothetical protein 0.0007 0.0138 0.0665
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0004 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Schistosoma mansoni cpg binding protein 0.0037 0.1664 0.4483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0759 0.0759
Brugia malayi CXXC zinc finger family protein 0.0035 0.1562 0.1562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.2364 0.6368
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0183 0.0884
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0138 0.0138
Mycobacterium tuberculosis Conserved hypothetical protein 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.2075 0.2075
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0222 0.027
Brugia malayi DIX domain containing protein 0.001 0.0282 0.0282
Plasmodium falciparum cGMP-dependent protein kinase 0.0004 0 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3712 0.3712
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0222 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0183 0.0884
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.2075 0.2075
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0282 0.0282
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0004 0 0.5
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0282 0.0282
Trypanosoma cruzi hypothetical protein 0.0007 0.0138 0.0665
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0222 0.027
Loa Loa (eye worm) hypothetical protein 0.0199 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0183 0.0884
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.2075 0.2525
Brugia malayi TAR-binding protein 0.0076 0.3712 0.3712

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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