Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.1563 | 1 | 1 |
Onchocerca volvulus | 0.0264 | 0.0656 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.0656 | 0.0656 |
Onchocerca volvulus | 0.0264 | 0.0656 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0264 | 0.0656 | 0.5 |
Plasmodium falciparum | choline kinase | 0.0173 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0264 | 0.0656 | 0.0656 |
Brugia malayi | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Onchocerca volvulus | 0.0264 | 0.0656 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Echinococcus multilocularis | neuroligin | 0.0264 | 0.0656 | 0.0656 |
Plasmodium vivax | choline kinase, putative | 0.0173 | 0 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0264 | 0.0656 | 0.0656 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0264 | 0.0656 | 0.0656 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0264 | 0.0656 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.0656 | 0.0656 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0264 | 0.0656 | 0.0656 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0264 | 0.0656 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0264 | 0.0656 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1563 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0264 | 0.0656 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1563 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1563 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1563 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0264 | 0.0656 | 0.0656 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1563 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1563 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0264 | 0.0656 | 0.0656 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0264 | 0.0656 | 0.0656 |
Onchocerca volvulus | 0.0264 | 0.0656 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1563 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.0656 | 0.0656 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0264 | 0.0656 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0656 | 0.0656 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0173 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1563 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0264 | 0.0656 | 0.0656 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.0656 | 0.0656 |
Onchocerca volvulus | 0.0264 | 0.0656 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0264 | 0.0656 | 0.0656 |
Brugia malayi | Carboxylesterase family protein | 0.1563 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4654 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.