Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0033 | 0.387 | 0.5 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0871 | 0.1977 |
Onchocerca volvulus | 0.0033 | 0.387 | 0.5 | |
Echinococcus granulosus | lamin | 0.0033 | 0.387 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0871 | 0.0871 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3738 | 0.3738 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0871 | 0.1977 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.387 | 0.6116 |
Schistosoma mansoni | lamin | 0.0033 | 0.387 | 0.6116 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.387 | 0.387 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0871 | 0.0375 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0871 | 0.1977 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5775 | 0.5775 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.387 | 0.387 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5775 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0516 | 0.0516 |
Schistosoma mansoni | lamin | 0.0033 | 0.387 | 0.6116 |
Echinococcus multilocularis | lamin | 0.0033 | 0.387 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.387 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.387 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.387 | 0.387 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.387 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0871 | 0.1977 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5775 | 0.5545 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.387 | 0.3537 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0871 | 0.0375 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0871 | 0.1977 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.387 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0871 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0871 | 0.0871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.9953 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.