Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0031 | 0.0062 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0029 | 0.14 | 1 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0031 | 0.0062 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2332 | 0.2332 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0861 | 0.0861 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0.14 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0774 | 0.543 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0029 | 0.14 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0687 | 0.1384 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2332 | 0.4699 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0029 | 0.14 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 0.0031 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0861 | 0.0861 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0031 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0861 | 0.0861 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.375 | 0.375 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0029 | 0.14 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0029 | 0.14 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0029 | 0.14 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.375 | 0.375 |
Brugia malayi | AMP-binding enzyme family protein | 0.0029 | 0.14 | 0.14 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0031 | 0.0062 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0687 | 0.0687 |
Brugia malayi | AMP-binding enzyme family protein | 0.0029 | 0.14 | 0.14 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0031 | 0.0062 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0029 | 0.14 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2332 | 0.2332 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.14 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0029 | 0.14 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0774 | 0.543 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4963 | 0.4963 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0861 | 0.6065 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0.0031 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0031 | 0.0062 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0774 | 0.543 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.14 | 0.14 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0861 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0029 | 0.14 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0031 | 0.0062 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0687 | 0.1384 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.14 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0.0031 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0861 | 0.0861 |
Echinococcus granulosus | ferritin | 0.001 | 0.0031 | 0.0062 |
Brugia malayi | AMP-binding enzyme family protein | 0.0029 | 0.14 | 0.14 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0687 | 0.1384 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0861 | 0.0861 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.14 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0021 | 0.0861 | 0.6065 |
Schistosoma mansoni | ferritin | 0.001 | 0.0031 | 0.0062 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.14 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0861 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0687 | 0.1384 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.14 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0687 | 0.1384 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0687 | 0.1384 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.14 | 0.14 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0029 | 0.14 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.375 | 0.375 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0029 | 0.14 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0687 | 0.1384 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0687 | 0.1384 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0861 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0687 | 0.0687 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0687 | 0.1384 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.375 | 0.375 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0774 | 0.543 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0.0031 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.14 | 0.5 | |
Schistosoma mansoni | ferritin | 0.001 | 0.0031 | 0.0062 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.14 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0687 | 0.0687 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0687 | 0.1384 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.14 | 0.14 |
Schistosoma mansoni | ferritin | 0.001 | 0.0031 | 0.0062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.