Detailed information for compound 1272734

Basic information

Technical information
  • TDR Targets ID: 1272734
  • Name: 1-[4-(2-phenylpyrimidin-4-yl)phenyl]benzimida zole
  • MW: 348.4 | Formula: C23H16N4
  • H donors: 0 H acceptors: 3 LogP: 4.7 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)c1nccc(n1)c1ccc(cc1)n1cnc2c1cccc2
  • InChi: 1S/C23H16N4/c1-2-6-18(7-3-1)23-24-15-14-20(26-23)17-10-12-19(13-11-17)27-16-25-21-8-4-5-9-22(21)27/h1-16H
  • InChiKey: YVYVJGXSDFOSEC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[4-(2-phenyl-4-pyrimidinyl)phenyl]benzimidazole
  • 1-[4-(2-phenyl-4-pyrimidinyl)phenyl]-1H-1,3-benzimidazole
  • MLS000541324
  • 4T-0282
  • ZINC01390279
  • SMR000126182

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens protein tyrosine kinase 2 beta Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Envelope polyprotein GP160 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.002 0.0082 0.0915
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0387 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0082 0.0915
Loa Loa (eye worm) carboxylesterase 0.01 0.1055 0.1495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Schistosoma mansoni tyrosine kinase 0.0305 0.3558 0.3558
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0327 0.0463
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.9043
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0403 0.0572
Echinococcus multilocularis acetylcholinesterase 0.0592 0.7056 0.7032
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0775 0.9947
Loa Loa (eye worm) hypothetical protein 0.0077 0.0779 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Loa Loa (eye worm) acetylcholinesterase 1 0.0592 0.7056 1
Schistosoma mansoni BC026374 protein (S09 family) 0.01 0.1055 0.1055
Echinococcus multilocularis carboxylesterase 5A 0.0592 0.7056 0.7032
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0082 0.2021
Echinococcus multilocularis para nitrobenzyl esterase 0.01 0.1055 0.0982
Schistosoma mansoni acetylcholinesterase 0.01 0.1055 0.1055
Loa Loa (eye worm) cysteine protease 0.002 0.0082 0.0116
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0775 0.9947
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0082 0.0116
Onchocerca volvulus 0.01 0.1055 1
Echinococcus granulosus neuroligin 0.01 0.1055 0.1055
Schistosoma mansoni DNA polymerase eta 0.0077 0.0779 0.0779
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0573 0.7326
Onchocerca volvulus 0.002 0.0082 0.0773
Echinococcus multilocularis neuroligin 0.01 0.1055 0.0982
Schistosoma mansoni neuroligin 3 (S09 family) 0.01 0.1055 0.1055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0779 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0509 0.0509
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.9043
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0082 0.0116
Brugia malayi Carboxylesterase family protein 0.01 0.1055 0.1495
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0775 0.9947
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Echinococcus granulosus family S9 non peptidase ue S09 family 0.01 0.1055 0.1055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0403 0.511
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0227 0.281
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0779 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.01 0.1055 0.1055
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0315 0.3961
Trypanosoma brucei unspecified product 0.0047 0.0403 0.511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0509 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0403 0.511
Leishmania major DNA polymerase eta, putative 0.0045 0.0387 0.489
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0509 0.0509
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0082 0.2021
Onchocerca volvulus Cathepsin L homolog 0.002 0.0082 0.0773
Leishmania major DNA polymerase kappa, putative 0.0047 0.0403 0.511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Echinococcus multilocularis dna polymerase eta 0.0077 0.0779 0.0703
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6647 0.6619
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0082 0.0082
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0315 0.8101
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0082 0.0211
Echinococcus granulosus dna polymerase kappa 0.0047 0.0403 0.0403
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0082 1
Echinococcus multilocularis acetylcholinesterase 0.0592 0.7056 0.7032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0509 0.0509
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0387 0.489
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0082 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Leishmania major cathepsin L-like protease 0.002 0.0082 0.0915
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1495
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0365 0.0365
Trichomonas vaginalis spcc417.12 protein, putative 0.01 0.1055 0.2732
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0315 0.3961
Brugia malayi hypothetical protein 0.0043 0.0365 0.0517
Leishmania major cathepsin L-like protease 0.0077 0.0775 0.9947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.01 0.1055 0.1055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.01 0.1055 1
Loa Loa (eye worm) carboxylesterase 0.0592 0.7056 1
Brugia malayi glutaminase DH11.1 0.033 0.3862 0.5473
Echinococcus granulosus BC026374 protein S09 family 0.01 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.0592 0.7056 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Onchocerca volvulus 0.002 0.0082 0.0773
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0082 0.0082
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.01 0.1055 1
Onchocerca volvulus 0.01 0.1055 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0327 0.0847
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0403 0.0403
Brugia malayi Carboxylesterase family protein 0.0592 0.7056 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0509 0.0431
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0403 0.1045
Echinococcus granulosus dna polymerase eta 0.0077 0.0779 0.0779
Mycobacterium ulcerans glutaminase 0.033 0.3862 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.01 0.1055 0.2732
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0403 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1495
Brugia malayi Cathepsin L-like precursor 0.002 0.0082 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.9043
Schistosoma mansoni glutaminase 0.033 0.3862 0.3862
Brugia malayi Cathepsin L-like precursor 0.002 0.0082 0.0116
Brugia malayi Protein kinase domain containing protein 0.0309 0.3602 0.5104
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0315 0.7816
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0779 0.1104
Echinococcus multilocularis BC026374 protein (S09 family) 0.01 0.1055 0.0982
Onchocerca volvulus 0.01 0.1055 1
Echinococcus granulosus cathepsin l1 0.002 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0365 0.0286
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0403 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0227 0.281
Loa Loa (eye worm) hypothetical protein 0.002 0.0082 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0403 0.0572
Onchocerca volvulus 0.002 0.0082 0.0773
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1495
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0403 0.1045
Loa Loa (eye worm) TK/FAK protein kinase 0.0309 0.3602 0.5104
Onchocerca volvulus 0.002 0.0082 0.0773
Onchocerca volvulus 0.002 0.0082 0.0773
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0509 0.0509
Leishmania major cathepsin L-like protease 0.0077 0.0775 0.9947
Brugia malayi Cathepsin L-like precursor 0.002 0.0082 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Brugia malayi polk-prov protein 0.0014 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1495
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6647 0.6619
Toxoplasma gondii cathepsin CPL 0.002 0.0082 0.187
Giardia lamblia DINP protein human, muc B family 0.0047 0.0403 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Plasmodium vivax vivapain-2 0.002 0.0082 1
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0403 0.511
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0403 0.511
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0403 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Leishmania major cathepsin L-like protease 0.002 0.0082 0.0915
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0082 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0509 0.0431
Schistosoma mansoni gliotactin 0.01 0.1055 0.1055
Entamoeba histolytica cysteine protease, putative 0.002 0.0082 0.2021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Loa Loa (eye worm) ctsf protein 0.002 0.0082 0.0116
Loa Loa (eye worm) glutaminase 2 0.033 0.3862 0.5473
Brugia malayi hypothetical protein 0.01 0.1055 0.1495
Onchocerca volvulus Cathepsin F homolog 0.002 0.0082 0.0773
Loa Loa (eye worm) carboxylesterase 0.01 0.1055 0.1495
Schistosoma mansoni rotamase 0.004 0.0327 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0403 0.0403
Brugia malayi Cathepsin L-like precursor 0.002 0.0082 0.0116
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0403 0.1018
Brugia malayi Carboxylesterase family protein 0.01 0.1055 0.1495
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0082 1
Onchocerca volvulus 0.002 0.0082 0.0773
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0315 0.3961
Schistosoma mansoni hypothetical protein 0.0043 0.0365 0.0365
Trichomonas vaginalis rotamase, putative 0.0039 0.0315 0.0817
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Leishmania major DNA polymerase eta, putative 0.0077 0.0779 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0693 0.8884
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0403 0.511
Onchocerca volvulus 0.002 0.0082 0.0773
Brugia malayi Cathepsin L-like precursor 0.002 0.0082 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0775 0.9947
Loa Loa (eye worm) hypothetical protein 0.0592 0.7056 1
Leishmania major cathepsin L-like protease 0.002 0.0082 0.0915
Echinococcus granulosus acetylcholinesterase 0.0592 0.7056 0.7056
Entamoeba histolytica hypothetical protein 0.0043 0.0365 0.9043
Echinococcus granulosus acetylcholinesterase 0.0592 0.7056 0.7056
Echinococcus granulosus protein tyrosine kinase 0.0305 0.3558 0.3558
Loa Loa (eye worm) fibroinase 0.002 0.0082 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0509 0.0721
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0327 0.0463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0082 0.0211
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0082 0.0082
Loa Loa (eye worm) glutaminase 0.033 0.3862 0.5473
Trichomonas vaginalis glutaminase, putative 0.033 0.3862 1
Trichomonas vaginalis rotamase, putative 0.004 0.0327 0.0847
Brugia malayi Cathepsin L-like precursor 0.002 0.0082 0.0116
Brugia malayi Carboxylesterase family protein 0.0592 0.7056 1
Trypanosoma brucei unspecified product 0.0032 0.0227 0.281
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.01 0.1055 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0016
Trypanosoma brucei unspecified product 0.0032 0.0227 0.281
Echinococcus granulosus expressed protein 0.004 0.0327 0.0327
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0082 1
Onchocerca volvulus 0.01 0.1055 1
Mycobacterium ulcerans carboxylesterase, LipT 0.01 0.1055 0.2711
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0509 0.0721
Leishmania major cathepsin L-like protease 0.0077 0.0775 0.9947
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0227 0.281
Leishmania major cathepsin L-like protease 0.002 0.0082 0.0915
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6647 0.6647
Onchocerca volvulus Cathepsin L homolog 0.002 0.0082 0.0773
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0315 0.3961
Echinococcus granulosus para nitrobenzyl esterase 0.01 0.1055 0.1055
Leishmania major cysteine peptidase A (CPA) 0.002 0.0082 0.0915
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0403 0.0403
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0365 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0403 0.511
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0403 0.511
Echinococcus multilocularis protein tyrosine kinase 0.0305 0.3558 0.3505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.01 0.1055 0.0982
Onchocerca volvulus 0.01 0.1055 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0403 0.511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0775 0.9947
Plasmodium vivax vivapain-2 0.002 0.0082 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0403 0.1018
Brugia malayi Carboxylesterase family protein 0.01 0.1055 0.1495
Echinococcus granulosus carboxylesterase 5A 0.0592 0.7056 0.7056
Echinococcus multilocularis expressed protein 0.004 0.0327 0.0247
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.01 0.1055 0.1055
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0403 0.511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0082 0.0211
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0592 0.7056 0.7056
Brugia malayi Carboxylesterase family protein 0.01 0.1055 0.1495
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6647 0.6647

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.637 um PUBCHEM_BIOASSAY: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2). (Class of assay: confirmatory) [Related pubchem assays: 794, 727, 810 ] ChEMBL. No reference
IC50 (functional) 14.722 uM PubChem BioAssay. Counterscreen for discovery of small molecules that bind to the HIV-1-gp120 binding antibody, PG9: TR-FRET-based biochemical high throughput dose response assay to identify small molecules that bind to the control antibody, PG126, which binds to a distinct site on the HIV envelope different from the PG9 binding site. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 21.953 uM PubChem BioAssay. TRFRET-based biochemical high throughput dose response assay for small molecules that bind to the HIV-1-gp120 binding antibody, PG9. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 54.498 uM PubChem BioAssay. Counterscreen for discovery of small molecules that bind to the HIV-1-gp120 binding antibody, PG9: TR-FRET-based biochemical high throughput dose response assay to identify small molecules that bind to the control antibody, PGV04, which binds to a distinct site on the HIV envelope different from the PG9 binding site. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.5283 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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