Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0012 | 0.0492 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0012 | 0.0492 | 0.0245 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0012 | 0.0492 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5363 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.1606 | 0.1681 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.0776 | 0.1446 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0012 | 0.0492 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0492 | 0.0245 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.336 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0012 | 0.0492 | 0.0917 |
Echinococcus multilocularis | 0.0012 | 0.0492 | 0.0917 | |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.5363 | 0.5363 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.7027 | 0.8801 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.7027 | 0.8798 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7943 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.5363 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0012 | 0.0492 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0492 | 0.0218 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4318 | 0.8051 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.336 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0012 | 0.0492 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0326 | 0.0607 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0012 | 0.0492 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0492 | 0.0245 |
Schistosoma mansoni | cytochrome P450 | 0.0012 | 0.0492 | 0.0492 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0012 | 0.0492 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.336 | 0.3984 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4013 | 0.4856 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0012 | 0.0492 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.879 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4318 | 0.4318 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1606 | 0.2995 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.1606 | 0.2995 |
Brugia malayi | hypothetical protein | 0.003 | 0.336 | 0.4001 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0012 | 0.0492 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.501 | 0.615 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4318 | 0.4318 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0012 | 0.0492 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0326 | 0.0607 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.501 | 0.616 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.0492 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.5363 | 0.5363 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0012 | 0.0492 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.336 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7943 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0012 | 0.0492 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1606 | 0.1681 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1606 | 0.2995 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0012 | 0.0492 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.336 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0012 | 0.0492 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5363 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5363 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0012 | 0.0492 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.4013 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5363 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.1699 | 0.1826 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.0776 | 0.1446 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7943 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0012 | 0.0492 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0776 | 0.0776 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0012 | 0.0492 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.1606 | 0.2995 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0012 | 0.0492 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0012 | 0.0492 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7943 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1606 | 0.1606 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0492 | 0.0218 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1606 | 0.2995 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.1606 | 0.1704 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4318 | 0.8051 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0012 | 0.0492 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.1606 | 0.1704 |
Mycobacterium leprae | putative cytochrome p450 | 0.0012 | 0.0492 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1606 | 0.2995 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.336 | 0.3457 |
Brugia malayi | hypothetical protein | 0.0043 | 0.5363 | 0.6623 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.336 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.5363 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0012 | 0.0492 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0492 | 0.0245 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0012 | 0.0492 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4013 | 0.4842 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1606 | 0.1606 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.336 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0012 | 0.0492 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.501 | 0.501 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0012 | 0.0492 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.336 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1606 | 0.1606 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0012 | 0.0492 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1606 | 0.1606 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0012 | 0.0492 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4013 | 0.4013 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0012 | 0.0492 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0492 | 0.0218 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0012 | 0.0492 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 35.43 um | PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)] | ChEMBL. | No reference |
EC50 (functional) | > 35.43 um | PUBCHEM_BIOASSAY: Fluorescence-based cell-based high-throughput dose response assay for agonists of NPY-Y2. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)] | ChEMBL. | No reference |
EC50 (functional) | > 35.43 um | PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay to identify inhibitors of cyclic nucleotide gated ion channel (CNGC) activity. In this assay, the parental HEK293 cell line transfected with a cyclic-nucleotide gated ion channel (CNGC)-based cAMP sensor is used to measure inhibition of isoproterenol-induced CNGC activity by test compound. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.