Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2706 | 0.3537 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0287 | 0.0375 |
Onchocerca volvulus | 0.0033 | 0.2706 | 0.5 | |
Echinococcus granulosus | lamin | 0.0033 | 0.2706 | 0.2491 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2706 | 0.2491 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4242 | 0.5545 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0287 | 0.0375 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2706 | 0.2491 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0287 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2706 | 0.3537 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2706 | 0.2491 |
Schistosoma mansoni | lamin | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2706 | 0.3537 |
Onchocerca volvulus | 0.0033 | 0.2706 | 0.5 | |
Schistosoma mansoni | lamin | 0.0033 | 0.2706 | 0.2491 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2599 | 0.3397 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7651 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4242 | 0.5545 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2706 | 0.3537 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4242 | 0.4073 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7651 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2706 | 0.3537 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0287 | 0.0375 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.