Detailed information for compound 1273334

Basic information

Technical information
  • TDR Targets ID: 1273334
  • Name: 6-bromo-8-methoxy-3-(4-pyridin-2-ylpiperazine -1-carbonyl)chromen-2-one
  • MW: 444.279 | Formula: C20H18BrN3O4
  • H donors: 0 H acceptors: 3 LogP: 3.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(Br)cc2c1oc(=O)c(c2)C(=O)N1CCN(CC1)c1ccccn1
  • InChi: 1S/C20H18BrN3O4/c1-27-16-12-14(21)10-13-11-15(20(26)28-18(13)16)19(25)24-8-6-23(7-9-24)17-4-2-3-5-22-17/h2-5,10-12H,6-9H2,1H3
  • InChiKey: NMOWLZPXJNKWON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-bromo-8-methoxy-3-[4-(2-pyridyl)piperazine-1-carbonyl]chromen-2-one
  • 6-bromo-8-methoxy-3-[oxo-[4-(2-pyridyl)-1-piperazinyl]methyl]-2-chromenone
  • 6-bromo-8-methoxy-3-[4-(2-pyridyl)piperazine-1-carbonyl]coumarin
  • 6-bromo-8-methoxy-3-(4-pyridin-2-ylpiperazin-1-yl)carbonyl-chromen-2-one
  • 6-bromo-8-methoxy-3-{[4-(2-pyridinyl)-1-piperazinyl]carbonyl}-2H-chromen-2-one
  • MLS000537401
  • SMR000143839

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0085 0.2581 0.5245
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0964 0.0149
Brugia malayi Bromodomain containing protein 0.0046 0.1071 0.1417
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0337 0.151
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0248 0.035
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0964 0.957
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0082 0.0366
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.1008 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0082 0.0366
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0095 0.2951 0.9703
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0964 0.0149
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4847 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0095 0.2951 0.9703
Loa Loa (eye worm) hypothetical protein 0.0043 0.0964 0.1852
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0964 0.1852
Schistosoma mansoni inositol monophosphatase 0.0045 0.1008 0.4509
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0097 0.3039 0.6205
Mycobacterium tuberculosis Conserved protein 0.0043 0.0964 0.0149
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0337 0.0865
Brugia malayi beta-lactamase family protein 0.0043 0.0964 0.1174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1418 0.6345
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0964 0.2985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1418 0.6345
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0095 0.2951 0.9703
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1418 0.4518
Brugia malayi Protein kinase domain containing protein 0.0097 0.3039 0.5889
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0964 0.957
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1418 0.4518
Onchocerca volvulus 0.0043 0.0964 0.5
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0964 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0199 0.0397
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0964 0.0149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1008 1
Brugia malayi MH2 domain containing protein 0.0144 0.4847 1
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0095 0.2951 0.9703
Brugia malayi beta-lactamase 0.0043 0.0964 0.1174
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0964 0.957
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0964 0.5
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1008 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0961 0.2973
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1418 0.6345
Brugia malayi Bromodomain containing protein 0.0091 0.278 0.5302
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0095 0.2951 0.9703
Loa Loa (eye worm) hypothetical protein 0.0043 0.0964 0.1852
Loa Loa (eye worm) beta-lactamase 0.0043 0.0964 0.1852
Loa Loa (eye worm) hypothetical protein 0.0043 0.0964 0.1852
Mycobacterium tuberculosis Conserved protein 0.0043 0.0964 0.0149
Onchocerca volvulus 0.0043 0.0964 0.5
Brugia malayi Inositol-1 0.0045 0.1008 0.1273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1418 0.4518
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1008 1
Echinococcus multilocularis kinase protein 0.0095 0.2951 0.9703
Loa Loa (eye worm) hypothetical protein 0.0046 0.1074 0.2083
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0097 0.3039 1
Schistosoma mansoni bromodomain containing protein 0.0076 0.2235 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.1008 0.3131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1418 0.4518
Loa Loa (eye worm) hypothetical protein 0.0043 0.0964 0.1852
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1418 0.2803
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0964 0.1174
Loa Loa (eye worm) hypothetical protein 0.0043 0.0964 0.1852
Loa Loa (eye worm) hypothetical protein 0.0043 0.0964 0.1852
Loa Loa (eye worm) hypothetical protein 0.0052 0.1274 0.2501
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0095 0.2951 0.9703
Schistosoma mansoni hypothetical protein 0.0025 0.0248 0.1112
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.1008 0.3131
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0337 0.0865
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1008 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.1008 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0097 0.3039 1
Echinococcus multilocularis kinase protein 0.0095 0.2951 0.9703
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0964 0.0149
Leishmania major hypothetical protein, conserved 0.0043 0.0964 0.957
Brugia malayi beta-lactamase family protein 0.0043 0.0964 0.1174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1008 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0964 0.0149
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0964 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0082 0.0366
Mycobacterium leprae Probable lipase LipE 0.0043 0.0964 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1418 0.2205
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.1008 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0082 0.0366
Echinococcus granulosus zinc finger protein 0.0024 0.0199 0.0397
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0964 0.2985
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4847 1
Loa Loa (eye worm) inositol-1 0.0045 0.1008 0.1943
Onchocerca volvulus 0.0043 0.0964 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.2068 0.6717
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0961 0.2973
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0964 0.0149
Schistosoma mansoni inositol monophosphatase 0.0045 0.1008 0.4509
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1008 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.1008 0.5
Schistosoma mansoni zinc finger protein 0.0024 0.0199 0.0891
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0964 0.4315
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0964 0.0149
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.1008 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1185 0.2314
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.011 0.006
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.2068 0.6717
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0964 0.4315

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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