Detailed information for compound 1273435

Basic information

Technical information
  • TDR Targets ID: 1273435
  • Name: N-[[2-(thiophen-2-ylmethoxy)phenyl]methyl]cyc lohexanamine hydrochloride
  • MW: 337.907 | Formula: C18H24ClNOS
  • H donors: 1 H acceptors: 0 LogP: 5.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)NCc1ccccc1OCc1cccs1.Cl
  • InChi: 1S/C18H23NOS.ClH/c1-2-8-16(9-3-1)19-13-15-7-4-5-11-18(15)20-14-17-10-6-12-21-17;/h4-7,10-12,16,19H,1-3,8-9,13-14H2;1H
  • InChiKey: GNVAYTRLVUXJJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[2-(2-thienylmethoxy)phenyl]methyl]cyclohexanamine hydrochloride
  • cyclohexyl-[2-(2-thenyloxy)benzyl]amine hydrochloride
  • N-[2-(2-thienylmethoxy)benzyl]cyclohexanamine hydrochloride
  • SMR000198656
  • MLS000579373

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0603 0.0588
Loa Loa (eye worm) hypothetical protein 0.0499 0.2718 0.3604
Echinococcus granulosus lamin 0.0056 0.0159 0.0354
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0365 0.1945 0.2575
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0407 0.2188 0.2191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0217 0.1093 0.1442
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Plasmodium falciparum endoplasmin, putative 0.0035 0.004 0.0148
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0424 0.0551
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0038 0.0041
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0046 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0217 0.1093 0.2789
Echinococcus multilocularis para nitrobenzyl esterase 0.008 0.0299 0.0279
Echinococcus granulosus Nuclear hormone receptor HR96 0.0103 0.043 0.1062
Schistosoma mansoni immunophilin 0.0049 0.0121 0.0256
Treponema pallidum heat shock protein 90 0.0045 0.01 0.2955
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0038 0.0038
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0099 0.0119
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.017 0.0385
Brugia malayi Bromodomain containing protein 0.0157 0.0745 0.0979
Echinococcus multilocularis nuclear receptor nhr 48 0.0103 0.043 0.0412
Schistosoma mansoni hypothetical protein 0.0075 0.0273 0.0652
Schistosoma mansoni thyroid hormone receptor 0.035 0.1859 0.4782
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0115 0.0501 0.1247
Brugia malayi hypoxia-induced factor 1 0.0317 0.1669 0.2208
Schistosoma mansoni nuclear receptor nhr-48 0.0103 0.043 0.1062
Onchocerca volvulus 0.008 0.0299 0.0915
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0573 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0035 0.0047
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0076 0.0072
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0103 0.043 0.1062
Echinococcus multilocularis protein patched 0.0045 0.0095 0.0073
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.003 0.0008
Brugia malayi Dehydrogenases, short chain protein 2 0.0032 0.0023 0.0017
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0117 0.0155
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0148 0.0167
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0217 0.1093 0.2789
Schistosoma mansoni hypothetical protein 0.0043 0.0086 0.0164
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Entamoeba histolytica hypothetical protein 0.0149 0.0696 0.0897
Brugia malayi steroid hormone receptor 0.0217 0.1093 0.1442
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0045 0.0099 0.0132
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0071 0.0049
Loa Loa (eye worm) hypothetical protein 0.0144 0.0671 0.088
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0499 0.2718 1
Trichomonas vaginalis conserved hypothetical protein 0.0499 0.2718 0.3612
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0678 0.1706
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.017 0.0385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0259 0.0615
Trichomonas vaginalis fk506-binding protein, putative 0.0057 0.0166 0.0221
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.003 0.0033
Echinococcus granulosus FTZ F1 alpha 0.0217 0.1093 0.2789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0217 0.1093 0.1442
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0156 0.1008
Echinococcus granulosus endothelin converting enzyme 1 0.0289 0.1503 0.3857
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0146 0.0678 0.1708
Plasmodium vivax hexose transporter 0.011 0.0473 0.1725
Schistosoma mansoni hypothetical protein 0.0043 0.0086 0.0164
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0324 0.0785
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0118 0.0519 0.1292
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0095 0.0189
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.0299 0.0719
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0146 0.0678 0.1708
Echinococcus granulosus glutamate receptor 2 0.0058 0.0173 0.0391
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Mycobacterium tuberculosis Probable reductase 0.0091 0.0363 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0473 0.0629
Echinococcus granulosus Dipeptidyl peptidase 9 0.0114 0.0497 0.1237
Entamoeba histolytica hypothetical protein 0.0149 0.0696 0.0897
Schistosoma mansoni jun-related protein 0.0072 0.0253 0.06
Brugia malayi PHD-finger family protein 0.0052 0.0139 0.0173
Toxoplasma gondii oxidoreductase, putative 0.0032 0.0023 0.0023
Trypanosoma cruzi lanosterol synthase, putative 0.0331 0.1747 0.2299
Onchocerca volvulus 0.0365 0.1945 0.6371
Schistosoma mansoni lamin 0.0056 0.0159 0.0354
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0057 0.0166 0.0208
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0045 0.0099 0.0346
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.1332 0.7524 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0148 0.0167
Schistosoma mansoni integrin alpha-ps 0.0075 0.0269 0.0643
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0023 0.0001
Brugia malayi hypothetical protein 0.0052 0.0137 0.017
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0125 0.056 0.0544
Brugia malayi hypothetical protein 0.0149 0.0696 0.0913
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0032 0.0023 0.0114
Loa Loa (eye worm) hypothetical protein 0.0089 0.035 0.0453
Plasmodium vivax steroid dehydrogenase, putative 0.0032 0.0023 0.0063
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0023
Brugia malayi orphan nuclear receptor NR2E1 0.0103 0.043 0.0559
Echinococcus granulosus synaptic glycoprotein sc2 0.0499 0.2718 0.702
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0104 0.0441 0.1387
Loa Loa (eye worm) hypothetical protein 0.0085 0.0331 0.0427
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0148 0.0167
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0324 0.0424
Trypanosoma cruzi lanosterol synthase, putative 0.0331 0.1747 0.2299
Echinococcus multilocularis jun protein 0.0088 0.0349 0.033
Plasmodium falciparum geranylgeranyltransferase, putative 0.0045 0.0099 0.0365
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0045 0.0099 0.0119
Echinococcus granulosus para nitrobenzyl esterase 0.008 0.0299 0.0719
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0324 0.1191
Leishmania major phospholipase A1, putative 0.0365 0.1945 0.2562
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0573 0.0551
Loa Loa (eye worm) hypothetical protein 0.0213 0.1069 0.1409
Schistosoma mansoni aryl hydrocarbon receptor 0.0102 0.043 0.106
Trypanosoma cruzi phospholipase A1, putative 0.0365 0.1945 0.2562
Trichomonas vaginalis conserved hypothetical protein 0.0499 0.2718 0.3612
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.007 0.0244 0.0576
Echinococcus multilocularis carboxylesterase 5A 0.0472 0.2564 0.2572
Trypanosoma cruzi protein farnesyltransferase, putative 0.0045 0.0099 0.0102
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0057 0.0166 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0678 0.1706
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.008 0.0299 0.0397
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0103 0.043 0.1062
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0068 0.0046
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0032 0.0023 0.0083
Plasmodium vivax heat shock protein, putative 0.0183 0.0894 0.3275
Echinococcus multilocularis acetylcholinesterase 0.0472 0.2564 0.2572
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0045 0.0099 0.0119
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0038 0.0016
Loa Loa (eye worm) hypothetical protein 0.0218 0.1098 0.1448
Schistosoma mansoni neprilysin 0.0075 0.0273 0.0652
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.003 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0259 0.0237
Trypanosoma brucei glucose transporter 1E 0.0034 0.0035 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0217 0.1093 0.1442
Loa Loa (eye worm) sugar transporter 0.011 0.0473 0.0617
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Brugia malayi TAR-binding protein 0.0194 0.0956 0.1259
Echinococcus multilocularis thyroid hormone receptor alpha 0.035 0.1859 0.1858
Entamoeba histolytica steroid 5-alpha reductase, putative 0.1332 0.7524 1
Loa Loa (eye worm) hypothetical protein 0.0472 0.2564 0.3399
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0472 0.2564 0.662
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0088 0.0104
Echinococcus multilocularis heat shock protein 0.0048 0.0117 0.0095
Toxoplasma gondii oxidoreductase, putative 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0384
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0045 0.0099 0.0365
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0035 0.0017
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0035 0.0017
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0058 0.0173 0.0152
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.0473 0.1174
Brugia malayi Glutamate receptor 1 precursor 0.0049 0.0119 0.0146
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.003 0.0112
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0045 0.0099 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Toxoplasma gondii carbonyl reductase 1, putative 0.0032 0.0023 0.0023
Trichomonas vaginalis heat shock protein, putative 0.0045 0.01 0.0132
Loa Loa (eye worm) carboxylesterase 0.008 0.0299 0.0384
Loa Loa (eye worm) glutamate receptor 1 0.0049 0.0119 0.0146
Loa Loa (eye worm) hypothetical protein 0.0073 0.0259 0.0331
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0038 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0217 0.1093 0.1442
Echinococcus multilocularis NMDA receptor 0.0078 0.0288 0.0269
Entamoeba histolytica hypothetical protein 0.0149 0.0696 0.0897
Trypanosoma brucei Heat shock protein 83, putative 0.0048 0.0117 0.0125
Brugia malayi beta-lactamase 0.0073 0.0259 0.0331
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0499 0.2718 0.702
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Loa Loa (eye worm) hypothetical protein 0.0213 0.1069 0.1409
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0156 0.0349
Loa Loa (eye worm) carboxylesterase 0.0472 0.2564 0.3399
Mycobacterium ulcerans lipase LipD 0.0073 0.0259 0.0237
Brugia malayi Retinol dehydrogenase 12 0.0032 0.0023 0.0017
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0259 0.0237
Echinococcus granulosus glutamate receptor 2 0.004 0.0068 0.012
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0023
Loa Loa (eye worm) acetylcholinesterase 1 0.0472 0.2564 0.3399
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0071 0.0127
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0023 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0217 0.1093 0.2789
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0045 0.0099 0.0132
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0259 0.0344
Trichomonas vaginalis heat shock protein, putative 0.0035 0.004 0.0053
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0148 0.0167
Brugia malayi follicle stimulating hormone receptor 0.0242 0.1232 0.1627
Schistosoma mansoni hypothetical protein 0.0354 0.1882 0.4843
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0044 0.0057
Schistosoma mansoni hypothetical protein 0.0043 0.0086 0.0164
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0032 0.0023 0.0114
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0045 0.0099 0.02
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0148 0.0167
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.007 0.0244 0.0576
Onchocerca volvulus 0.0076 0.0276 0.084
Mycobacterium ulcerans carboxylesterase, LipT 0.008 0.0299 0.0277
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Schistosoma mansoni hypothetical protein 0.0075 0.0273 0.0652
Trypanosoma cruzi ISWI complex protein 0.0032 0.0023 0.0001
Echinococcus multilocularis neuroligin 0.008 0.0299 0.0279
Loa Loa (eye worm) pax transcription factor protein 2 0.0254 0.1306 0.1725
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0148 0.0326
Brugia malayi nuclear hormone receptor family member odr-7 0.0103 0.043 0.0559
Schistosoma mansoni zinc finger protein 0.0103 0.043 0.1062
Loa Loa (eye worm) hypothetical protein 0.0089 0.035 0.0453
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0045 0.0099 0.02
Schistosoma mansoni hypothetical protein 0.011 0.0473 0.1174
Loa Loa (eye worm) hypothetical protein 0.0045 0.0095 0.0113
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Brugia malayi mbt repeat family protein 0.0058 0.017 0.0214
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0217 0.1093 0.2789
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0068 0.0231
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0173 0.0152
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.0473 0.1174
Loa Loa (eye worm) hypothetical protein 0.0058 0.017 0.0214
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0119 0.0098
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0114 0.0497 0.0633
Echinococcus granulosus integrin alpha 3 0.0245 0.1255 0.321
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0259 0.0237
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0045 0.0099 0.0102
Schistosoma mansoni hypothetical protein 0.0043 0.0088 0.017
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.0675 0.1698
Echinococcus multilocularis ecdysone induced protein 78C 0.0217 0.1093 0.1083
Schistosoma mansoni integrin alpha-ps 0.0144 0.0667 0.1678
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0217 0.1093 0.1442
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0363 0.0341
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0499 0.2718 0.3593
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0035 0.0047
Schistosoma mansoni hypothetical protein 0.0043 0.0086 0.0164
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0259 0.0344
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0384
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.0473 0.0456
Echinococcus granulosus endoplasmin 0.0045 0.01 0.0201
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0045 0.0099 0.0102
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0363 0.0341
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0499 0.2718 0.3612
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0049 0.0122 0.0155
Schistosoma mansoni neuroligin 3 (S09 family) 0.008 0.0299 0.0719
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0052 0.0056
Echinococcus granulosus thyroid hormone receptor alpha 0.0103 0.043 0.1062
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0045 0.01 0.2555
Brugia malayi PAS domain containing protein 0.0102 0.043 0.0559
Mycobacterium leprae Probable lipase LipE 0.0073 0.0259 0.1691
Schistosoma mansoni immunophilin 0.0057 0.0166 0.0374
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0103 0.043 0.0412
Loa Loa (eye worm) hypothetical protein 0.0242 0.1236 0.1632
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0114 0.0497 0.0633
Onchocerca volvulus 0.0069 0.0239 0.0717
Plasmodium falciparum heat shock protein 90, putative 0.0183 0.0894 0.3289
Echinococcus multilocularis geminin 0.0697 0.3862 0.3885
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0035 0.0047
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0259 0.0237
Onchocerca volvulus Protein ultraspiracle homolog 0.0217 0.1093 0.3549
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0148 0.0127
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Schistosoma mansoni glucose transport protein 0.011 0.0473 0.1174
Schistosoma mansoni gliotactin 0.008 0.0299 0.0719
Echinococcus granulosus X box binding protein 1 0.0303 0.159 0.4082
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.0473 0.0456
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.034 0.1799 0.4627
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.007 0.0244 0.0576
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0045 0.0099 0.02
Brugia malayi bHLH-PAS transcription factor 0.0076 0.0276 0.0354
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0045 0.0099 0.0132
Plasmodium falciparum plasmepsin I 0.0049 0.0122 0.0448
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0217 0.1093 0.1083
Brugia malayi photoreceptor-specific nuclear receptor 0.0217 0.1093 0.1442
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0118 0.0519 0.1292
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0117 0.0125
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.034 0.1799 0.4627
Toxoplasma gondii ABC1 family protein 0.0073 0.0259 0.0337
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0217 0.1093 0.2789
Echinococcus multilocularis fk506 binding protein 0.0057 0.0166 0.0145
Onchocerca volvulus Phospholipase A2 homolog 0.0555 0.304 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Echinococcus multilocularis lamin 0.0056 0.0159 0.0138
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Echinococcus multilocularis lamin dm0 0.0056 0.0159 0.0138
Loa Loa (eye worm) TAR-binding protein 0.0194 0.0956 0.1259
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0259 0.0934
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0115 0.0501 0.1247
Onchocerca volvulus 0.0073 0.0259 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0035 0.0047
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0095 0.0073
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0224 0.0524
Schistosoma mansoni smad1 5 8 and 0.0035 0.0038 0.0041
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0114 0.0497 0.0633
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0217 0.1093 0.2789
Echinococcus granulosus intermediate filament protein 0.0056 0.0159 0.0354
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0166 0.0221
Brugia malayi peptidase family M13 containing protein 0.007 0.0244 0.0311
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0324 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0224 0.0285
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0068 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0148 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0217 0.1093 0.1083
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0324 0.1174
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0045 0.0099 0.0125
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0032 0.0023 0.0017
Schistosoma mansoni acetylcholinesterase 0.008 0.0299 0.0719
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0259 0.0615
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0023
Giardia lamblia Grp94/Hsp90 0.0045 0.01 0.0286
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0035 0.0047
Schistosoma mansoni survival motor neuron protein 0.0101 0.0424 0.1045
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0289 0.1503 0.3857
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.0421 0.04
Schistosoma mansoni hypothetical protein 0.0075 0.0273 0.0652
Onchocerca volvulus 0.0365 0.1945 0.6371
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Echinococcus granulosus integrin alpha ps 0.0144 0.0667 0.1678
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0041 0.0076 0.014
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0217 0.0505
Schistosoma mansoni immunophilin 0.0057 0.0166 0.0374
Onchocerca volvulus 0.0499 0.2718 0.8934
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0049 0.0122 0.0162
Brugia malayi MH1 domain containing protein 0.0035 0.0038 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0224 0.0524
Brugia malayi dehydrogenases, short chain protein 9 0.0032 0.0023 0.0017
Brugia malayi hypothetical protein 0.0115 0.0501 0.0654
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0159 0.0198
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0114 0.0497 0.1237
Plasmodium vivax geranylgeranyltransferase, putative 0.0045 0.0099 0.0346
Onchocerca volvulus 0.0101 0.0424 0.1329
Trypanosoma cruzi heat shock protein 90, putative 0.0048 0.0117 0.0125
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0324 0.2126
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.2525 0.2508
Echinococcus multilocularis GPCR, family 2 0.0067 0.0224 0.0203
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0111 0.023
Brugia malayi Probable ClpP-like protease 0.0084 0.0324 0.0418
Plasmodium falciparum thioredoxin reductase 0.004 0.0068 0.025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0224 0.0203
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0217 0.1093 0.2789
Loa Loa (eye worm) dehydrogenase 0.0032 0.0023 0.0017
Echinococcus multilocularis musashi 0.0056 0.0159 0.0138
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0437 0.0568
Brugia malayi hypothetical protein 0.0087 0.0342 0.0442
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0045 0.0099 0.0132
Brugia malayi conserved hypotetical protein 0.0103 0.043 0.0559
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0032 0.0023 0.0023
Echinococcus granulosus carboxylesterase 5A 0.0472 0.2564 0.662
Brugia malayi oxidoreductase 0.0032 0.0023 0.0017
Echinococcus granulosus heat shock protein 0.0048 0.0117 0.0245
Leishmania major lanosterol synthase, putative 0.0285 0.1486 0.195
Loa Loa (eye worm) hypothetical protein 0.0049 0.0122 0.0149
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0286 0.0266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.003 0.0008
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0167 0.0804 0.1042
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0045 0.0099 0.0119
Schistosoma mansoni hypothetical protein 0.0075 0.0273 0.0652
Brugia malayi beta-lactamase family protein 0.0073 0.0259 0.0331
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0044 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0115 0.0501 0.0654
Plasmodium vivax heat shock protein 86, putative 0.0048 0.0117 0.041
Schistosoma mansoni nuclear receptor 0.0103 0.043 0.1062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0217 0.1093 0.1442
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.0421 0.04
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0032 0.0023 0.0002
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0057 0.0166 0.0374
Schistosoma mansoni retinoic acid receptor RXR 0.0321 0.1693 0.435
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0956 0.2431
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0363 0.0341
Brugia malayi hypothetical protein 0.008 0.0299 0.0384
Loa Loa (eye worm) hypothetical protein 0.0148 0.0694 0.091
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.0473 0.0622
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0032 0.0023 0.0001
Trichomonas vaginalis steroid dehydrogenase, putative 0.0032 0.0023 0.003
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.008 0.0299 0.0277
Toxoplasma gondii heat shock protein 75, putative 0.0032 0.0023 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0125 0.056 0.1401
Brugia malayi isocitrate dehydrogenase 0.0033 0.003 0.0028
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0384
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0117 0.0125
Loa Loa (eye worm) steroid hormone receptor 0.0217 0.1093 0.1442
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0095 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0956 0.2431
Loa Loa (eye worm) MH2 domain-containing protein 0.0509 0.2774 0.3679
Echinococcus multilocularis integrin alpha ps 0.0069 0.0235 0.0215
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0242 0.1236 0.1632
Brugia malayi hypothetical protein 0.0344 0.1823 0.2412
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0499 0.2718 0.702
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0217 0.1093 0.1083
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0045 0.0099 0.02
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.034 0.1799 0.5888
Schistosoma mansoni hypothetical protein 0.0133 0.0603 0.1513
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.0363 0.2385
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0115 0.0501 0.1247
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0273 0.0253
Loa Loa (eye worm) hypothetical protein 0.0218 0.1098 0.1448
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0045 0.01 0.0077
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0032 0.0023 0.0083
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0111 0.0089
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0183 0.0895 0.0874
Trypanosoma brucei glucose transporter 2A 0.0034 0.0035 0.0017
Schistosoma mansoni patched 1 0.0045 0.0095 0.0189
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0078 0.0288 0.0269
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0166 0.0191
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0437 0.0552
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0324 1
Loa Loa (eye worm) heat shock protein 75 0.0032 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.0129 0.0583 0.0763
Schistosoma mansoni hypothetical protein 0.0075 0.0273 0.0652
Echinococcus granulosus heat shock protein 90 0.0048 0.0117 0.0245
Brugia malayi prolyl oligopeptidase family protein 0.034 0.1799 0.2381
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1332 0.7524 1
Echinococcus multilocularis expressed conserved protein 0.0097 0.04 0.0382
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0499 0.2718 0.3608
Brugia malayi hypothetical protein 0.0115 0.0501 0.0654
Onchocerca volvulus 0.008 0.0299 0.0915
Schistosoma mansoni lamin 0.0056 0.0159 0.0354
Brugia malayi Carboxylesterase family protein 0.008 0.0299 0.0384
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Brugia malayi Thioredoxin reductase 0.004 0.0068 0.0078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0217 0.1093 0.1083
Plasmodium falciparum plasmepsin IV 0.0049 0.0122 0.0448
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Entamoeba histolytica hypothetical protein 0.0149 0.0696 0.0897
Loa Loa (eye worm) hypothetical protein 0.0289 0.1503 0.1988
Brugia malayi Nuclear hormone receptor E75 0.0103 0.043 0.0559
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1744 0.9906 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0499 0.2718 0.3612
Giardia lamblia Synaptic glycoprotein SC2 0.0499 0.2718 1
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0045 0.0099 0.0125
Leishmania major geranylgeranyltransferase, putative 0.0045 0.0099 0.0102
Onchocerca volvulus 0.0058 0.017 0.049
Plasmodium vivax plasmepsin IV, putative 0.0049 0.0122 0.0429
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0363 0.0341
Schistosoma mansoni BC026374 protein (S09 family) 0.008 0.0299 0.0719
Loa Loa (eye worm) hypothetical protein 0.0213 0.1069 0.1409
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0573 0.1433
Loa Loa (eye worm) carboxylesterase 0.008 0.0299 0.0384
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0217 0.1093 0.2789
Loa Loa (eye worm) Smad1 0.0035 0.0038 0.0038
Schistosoma mansoni glutamate receptor kainate 0.0109 0.0465 0.1153
Brugia malayi Carboxylesterase family protein 0.008 0.0299 0.0384
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0499 0.2718 0.3608
Leishmania major trypanothione reductase 0.004 0.0068 0.0061
Echinococcus multilocularis General substrate transporter 0.0095 0.0384 0.0366
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0032 0.0023 0.0001
Echinococcus granulosus GPCR family 2 0.0067 0.0224 0.0524
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0167 0.0804 0.1042
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.0473 0.1174
Brugia malayi beta-lactamase family protein 0.0073 0.0259 0.0331
Echinococcus multilocularis zinc finger protein 0.0041 0.0075 0.0053
Loa Loa (eye worm) hypothetical protein 0.0218 0.1098 0.1448
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Plasmodium vivax aspartyl proteinase, putative 0.0049 0.0122 0.0429
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0045 0.0099 0.0102
Schistosoma mansoni nuclear hormone receptor 0.0103 0.043 0.1062
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0058 0.0173 0.0391
Mycobacterium tuberculosis Carboxylesterase LipT 0.008 0.0299 0.0277
Schistosoma mansoni glutamate receptor kainate 0.0109 0.0465 0.1153
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0149 0.0696 0.0681
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0224 0.0285
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0259 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0217 0.1093 0.1442
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0166 0.0191
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0437 0.1078
Brugia malayi Isocitrate dehydrogenase 0.0033 0.003 0.0028
Schistosoma mansoni hypothetical protein 0.0067 0.0224 0.0524
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0032 0.0023 0.0114
Loa Loa (eye worm) hypothetical protein 0.0115 0.0501 0.0654
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0156 0.0134
Brugia malayi MAP kinase sur-1 0.0054 0.0148 0.0184
Echinococcus multilocularis integrin alpha ps 0.0144 0.0667 0.0652
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Loa Loa (eye worm) nuclear hormone receptor 0.0292 0.1525 0.2016
Brugia malayi Synaptic glycoprotein SC2 0.0499 0.2718 0.3604
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0259 0.0237
Brugia malayi nuclear receptor NHR-88 0.0217 0.1093 0.1442
Schistosoma mansoni hypothetical protein 0.0075 0.0273 0.0652
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.017 0.015
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0259 0.0237
Onchocerca volvulus 0.0254 0.1306 0.4253
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0103 0.043 0.1351
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.043 0.0412
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.0299 0.0719
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0259 0.0331
Brugia malayi hypothetical protein 0.0069 0.0239 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0099 0.0102
Echinococcus granulosus glutamate NMDA receptor subunit 0.0049 0.0119 0.0252
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1332 0.7524 1
Onchocerca volvulus 0.0103 0.043 0.1351
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0078 0.0288 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0217 0.1093 0.1442
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.0302 0.0372
Plasmodium vivax polyprenol reductase, putative 0.0499 0.2718 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0044 0.0022
Leishmania major glucose transporter, lmgt1 0.0034 0.0035 0.0017
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Schistosoma mansoni hypothetical protein 0.0697 0.3862 1
Toxoplasma gondii heat shock protein HSP90 0.0048 0.0117 0.0148
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0217 0.1093 0.1442
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0045 0.0099 0.0132
Leishmania major fk506-binding protein 1-like protein 0.0057 0.0166 0.0191
Echinococcus multilocularis synaptic glycoprotein sc2 0.0499 0.2718 0.2727
Echinococcus granulosus zinc finger protein 0.0041 0.0075 0.0136
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0032 0.0023 0.0023
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.0497 0.0649
Schistosoma mansoni hypothetical protein 0.0144 0.0671 0.1689
Schistosoma mansoni endoplasmin 0.0048 0.0117 0.0245
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0005 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0217 0.1093 0.2789
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0045 0.0099 0.0119
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0095 0.0189
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0078 0.0288 0.0692
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0032 0.0023 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0217 0.1093 0.1442
Loa Loa (eye worm) glutamate receptor 2 0.0049 0.0119 0.0146
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.017 0.0385
Loa Loa (eye worm) hypothetical protein 0.0251 0.1289 0.1703
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0146 0.0678 0.1708
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0211 0.1057 0.1393
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.0573 0.0733
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0678 0.0663
Brugia malayi hypothetical protein 0.0089 0.035 0.0453
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.017 0.0385
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.0276 0.0256
Echinococcus granulosus survival motor neuron protein 1 0.0497 0.2709 0.6996
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.003 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0573 0.0551
Loa Loa (eye worm) hypothetical protein 0.0115 0.0501 0.0654
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Trichomonas vaginalis spcc417.12 protein, putative 0.008 0.0299 0.0397
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0115 0.0501 0.0654
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0045 0.0099 0.0119
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0678 0.0889
Loa Loa (eye worm) hypothetical protein 0.0177 0.0858 0.1128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0224 0.0203
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0035 0.0017
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1332 0.7524 1
Trichomonas vaginalis immunophilin, putative 0.0057 0.0166 0.0221
Echinococcus granulosus heat shock protein 90 0.0041 0.0076 0.014
Echinococcus granulosus lamin dm0 0.0056 0.0159 0.0354
Plasmodium falciparum plasmepsin II 0.0049 0.0122 0.0448
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0044 0.0022
Schistosoma mansoni heat shock protein 0.0032 0.0023 0.0002
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0049 0.0122 0.01
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Echinococcus granulosus acetylcholinesterase 0.0472 0.2564 0.662
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0437 0.0419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.003 0.0008
Brugia malayi Carboxylesterase family protein 0.008 0.0299 0.0384
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0302 0.0372
Echinococcus granulosus neuroligin 0.008 0.0299 0.0719
Loa Loa (eye worm) hypothetical protein 0.0289 0.1503 0.1988
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0324 1
Schistosoma mansoni smad1 5 8 and 0.0035 0.0038 0.0041
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0057 0.0166 0.0532
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0045 0.0099 0.0078
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0118 0.0519 0.0502
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.003 0.0011
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0045 0.0099 0.0132
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0023 0.0002
Schistosoma mansoni hypothetical protein 0.0067 0.0224 0.0524
Leishmania major hypothetical protein, conserved 0.0032 0.0023 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.0573 0.0557
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0103 0.043 0.0559
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0069 0.0235 0.0554
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0032 0.0023 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0956 0.2431
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0148 0.0197
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.003 0.0008
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0166 0.0374
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0146 0.0678 0.1708
Loa Loa (eye worm) hypothetical protein 0.0218 0.1098 0.1448
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0259 0.0315
Toxoplasma gondii thioredoxin reductase 0.004 0.0068 0.0083
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.003 0.0033
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Mycobacterium ulcerans short chain dehydrogenase 0.1761 1 1
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0045 0.0099 0.02
Schistosoma mansoni heat shock protein 0.0048 0.0117 0.0245
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0045 0.0099 0.0125
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0324 0.0785
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Onchocerca volvulus 0.0056 0.0159 0.0451
Mycobacterium tuberculosis Conserved protein 0.0073 0.0259 0.0237
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0114 0.0497 0.0633
Echinococcus granulosus BC026374 protein S09 family 0.008 0.0299 0.0719
Loa Loa (eye worm) hypothetical protein 0.0087 0.0342 0.0442
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0321 0.1693 0.435
Echinococcus multilocularis FTZ F1 alpha 0.0217 0.1093 0.1083
Plasmodium falciparum glutathione reductase 0.004 0.0068 0.025
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0023
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0045 0.0099 0.02
Brugia malayi Dehydrogenases, short chain protein 30 0.0032 0.0023 0.0017
Loa Loa (eye worm) heat shock protein 90 0.0048 0.0117 0.0142
Echinococcus multilocularis Smad4 0.0035 0.0038 0.0016
Loa Loa (eye worm) prolyl oligopeptidase 0.034 0.1799 0.2381
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0045 0.0099 0.0078
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0032 0.0023 0.003
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0057 0.0166 0.0144
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0217 0.0505
Brugia malayi Pax transcription factor protein 2 0.0254 0.1306 0.1725
Schistosoma mansoni smad 0.0035 0.0038 0.0041
Brugia malayi hypothetical protein 0.0129 0.0583 0.0763
Brugia malayi hypothetical protein 0.008 0.0302 0.0388
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0038 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0217 0.1093 0.1083
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0118 0.0519 0.1292
Trypanosoma brucei phospholipase A1, putative 0.0365 0.1945 0.2562
Leishmania major farnesyltransferase beta subunit 0.0045 0.0099 0.0102
Brugia malayi Phospholipase A2 family protein 0.0555 0.304 0.4032
Loa Loa (eye worm) hypothetical protein 0.0305 0.1596 0.2111
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0324 0.0424
Brugia malayi dehydrogenases, short chain protein 2 0.0032 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Echinococcus multilocularis heat shock protein 90 0.0048 0.0117 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0678 0.0663
Schistosoma mansoni transcription factor LCR-F1 0.0149 0.0696 0.1753
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0045 0.01 0.0628
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0103 0.043 0.0412
Brugia malayi hypothetical protein 0.0103 0.043 0.0559
Echinococcus granulosus integrin alpha ps 0.0069 0.0235 0.0554
Schistosoma mansoni glutamate receptor AMPA 0.0049 0.0119 0.0252
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0032 0.0023 0.0114
Loa Loa (eye worm) hypothetical protein 0.0086 0.0335 0.0432
Loa Loa (eye worm) hypothetical protein 0.0289 0.1503 0.1988
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0076 0.0072
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Brugia malayi RNA binding protein 0.0194 0.0956 0.1259
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0148 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Mycobacterium ulcerans zinc metalloprotease 0.0289 0.1503 0.1484
Schistosoma mansoni bromodomain containing protein 0.0133 0.0604 0.1514
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0057 0.0166 0.0374
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0156 0.0136
Loa Loa (eye worm) peptidase family M13 containing protein 0.0213 0.1069 0.1409
Plasmodium vivax heat shock protein 90, putative 0.0032 0.0023 0.0065
Echinococcus multilocularis endothelin converting enzyme 1 0.0289 0.1503 0.1498
Schistosoma mansoni hypothetical protein 0.0072 0.0253 0.06
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0148 0.0127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0217 0.1093 0.2789
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0103 0.043 0.0559
Brugia malayi Smad1 0.0035 0.0038 0.0038
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0499 0.2718 0.2727
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0231 0.1171 0.2992
Schistosoma mansoni Smad4 0.0035 0.0038 0.0041
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0032 0.0023 0.0017
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.0473 0.0456
Onchocerca volvulus Huntingtin homolog 0.0129 0.0583 0.1857
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0035 0.0017
Plasmodium falciparum polyprenol reductase, putative 0.0499 0.2718 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.003 0.0011
Schistosoma mansoni coup transcription factor 0.0217 0.1093 0.2789
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0035 0.0017
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0384
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0302 0.111
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0121 0.01
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0217 0.1093 0.1442
Giardia lamblia Heat shock protein HSP 90-alpha 0.0048 0.0117 0.0349
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0671 0.088
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.0693 0.1747
Schistosoma mansoni endoplasmin 0.0048 0.0117 0.0245
Onchocerca volvulus 0.0073 0.0259 0.0783
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0068 0.0061
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0286 0.0686
Loa Loa (eye worm) hypothetical protein 0.0499 0.2718 0.3604
Loa Loa (eye worm) hypothetical protein 0.008 0.0302 0.0388
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0045 0.01 0.0103
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Toxoplasma gondii Hsp90 domain-containing protein 0.0183 0.0894 0.1182
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0117 0.0125
Schistosoma mansoni endothelin-converting enzyme-related 0.007 0.0244 0.0576
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0384
Brugia malayi ecdysone receptor 0.0103 0.043 0.0559
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0384
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0032 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0101 0.0421 0.0547
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Loa Loa (eye worm) FKBP5 protein 0.0057 0.0166 0.0208
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0044 0.0057
Loa Loa (eye worm) hypoxia-induced factor 1 0.0317 0.1669 0.2208
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.1232 0.1627
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0078 0.0288 0.0269
Schistosoma mansoni RAR-like nuclear receptor 0.0217 0.1093 0.2789
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0217 0.1093 0.1442
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Schistosoma mansoni integrin alpha 0.032 0.1686 0.4333
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0259 0.0344
Echinococcus granulosus family S9 non peptidase ue S09 family 0.008 0.0299 0.0719
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0217 0.0196
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0032 0.0023 0.0023
Loa Loa (eye worm) glutathione reductase 0.004 0.0068 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0217 0.1093 0.1442
Mycobacterium ulcerans hypothetical protein 0.1332 0.7524 0.7518
Plasmodium falciparum steroid dehydrogenase, putative 0.0032 0.0023 0.0083
Brugia malayi HSF-type DNA-binding domain containing protein 0.0104 0.0441 0.0574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.043 0.1062
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.0573 0.0551
Schistosoma mansoni nuclear hormone receptor 0.0103 0.043 0.1062
Brugia malayi nuclear receptor NHR-88 0.0103 0.043 0.0559
Plasmodium falciparum hexose transporter 0.011 0.0473 0.1742
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0603 0.1513
Mycobacterium tuberculosis Conserved protein 0.0073 0.0259 0.0237
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0217 0.0505
Schistosoma mansoni ATP-binding cassette transporter 0.0049 0.0119 0.0252
Schistosoma mansoni hypothetical protein 0.0036 0.0046 0.0061
Brugia malayi glutathione reductase 0.004 0.0068 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0259 0.0344
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0114 0.0497 0.0654
Loa Loa (eye worm) hypothetical protein 0.0075 0.0269 0.0346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0678 0.1706
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0166 0.0221
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0148 0.0184
Loa Loa (eye worm) hypothetical protein 0.0218 0.1098 0.1448
Mycobacterium tuberculosis Conserved protein 0.0073 0.0259 0.0237
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0045 0.0099 0.0365
Loa Loa (eye worm) hypothetical protein 0.0073 0.0259 0.0331
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0139 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0956 0.2431
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.0421 0.04
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Loa Loa (eye worm) hypothetical protein 0.0143 0.0663 0.087
Loa Loa (eye worm) hypothetical protein 0.0497 0.2709 0.3592
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0035 0.0017
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.034 0.1799 0.1798
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0049 0.0122 0.0258
Brugia malayi MH1 domain containing protein 0.0035 0.0038 0.0038
Brugia malayi Bromodomain containing protein 0.008 0.0301 0.0388
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0045 0.0099 0.0346
Loa Loa (eye worm) zinc metallopeptidase 4 0.007 0.0244 0.0311
Trypanosoma brucei ISWI complex protein 0.0032 0.0023 0.0001
Loa Loa (eye worm) beta-lactamase 0.0073 0.0259 0.0331
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0038 0.0038
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0363 0.0341
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0114 0.0497 0.0633
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0023 0.0063
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Brugia malayi Carboxylesterase family protein 0.008 0.0299 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0148 0.0326
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0057 0.0166 0.0208
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.0299 0.0719
Brugia malayi MH2 domain containing protein 0.0035 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0101 0.0424 0.1045
Schistosoma mansoni glutamate receptor NMDA 0.0058 0.0173 0.0391
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0166 0.0191
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0057 0.0166 0.0191
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0119 0.0252
Loa Loa (eye worm) dehydrogenase 0.0032 0.0023 0.0017
Schistosoma mansoni zinc finger protein 0.0041 0.0075 0.0136
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.003 0.0021
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0032 0.0023 0.0017
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0148 0.0465
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0166 0.0191
Echinococcus multilocularis survival motor neuron protein 1 0.0497 0.2709 0.2718
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Loa Loa (eye worm) hypothetical protein 0.0045 0.0099 0.0119
Schistosoma mansoni glucose transport protein 0.011 0.0473 0.1174
Brugia malayi nuclear hormone receptor 0.0217 0.1093 0.1442
Mycobacterium leprae probable zinc metalloprotease 0.0289 0.1503 1
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0117 0.0125
Trypanosoma cruzi Heat shock protein 83, putative 0.0048 0.0117 0.0125
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.0473 0.0456
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0095 0.0126
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0057 0.0166 0.5044
Echinococcus granulosus expressed conserved protein 0.0097 0.04 0.0984
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0075 0.0273 0.0652
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.0573 0.1433
Brugia malayi Hsp90 protein 0.0032 0.0023 0.0018
Loa Loa (eye worm) DR-78 0.0103 0.043 0.0559
Schistosoma mansoni smad1 5 8 and 0.0035 0.0038 0.0041
Mycobacterium leprae Probable oxidoreductase 0.0032 0.0023 0.0114
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0103 0.043 0.1062
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1332 0.7524 1
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0045 0.0099 0.0102
Trichomonas vaginalis esterase, putative 0.0073 0.0259 0.0344
Loa Loa (eye worm) peptidase family M13 containing protein 0.0213 0.1069 0.1409
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0324 0.0302
Leishmania major glucose transporter, lmgt2 0.0034 0.0035 0.0017
Loa Loa (eye worm) hypothetical protein 0.0084 0.0324 0.0418
Echinococcus granulosus Nuclear hormone receptor HR96 0.0103 0.043 0.1062
Brugia malayi hypothetical protein 0.0032 0.0023 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0573 0.1433
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0118 0.0519 0.0502
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0259 0.0315
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0057 0.0166 0.0592
Brugia malayi nuclear hormone receptor 0.0103 0.043 0.0559
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.0349 0.033
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.019
Mycobacterium ulcerans hypothetical protein 0.0073 0.0259 0.0237
Mycobacterium ulcerans heat shock protein 90 0.0045 0.01 0.0077
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0103 0.043 0.1351
Plasmodium falciparum plasmepsin VI 0.0049 0.0122 0.0448
Leishmania major peptidylprolyl isomerase-like protein 0.0057 0.0166 0.0191
Toxoplasma gondii peptidase family M13 protein 0.0289 0.1503 0.1992
Brugia malayi intermediate filament protein 0.0056 0.0159 0.0198
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0035 0.0047
Echinococcus multilocularis acetylcholinesterase 0.0472 0.2564 0.2572
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0289 0.1503 0.1988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0044 0.0057
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.003 0.0028
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0045 0.0099 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0956 0.2431
Brugia malayi MH2 domain containing protein 0.0509 0.2774 0.3679
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0148 0.0197
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.0441 0.0558
Brugia malayi hypothetical protein 0.0103 0.043 0.0559
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1332 0.7524 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0166 0.0191
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.003 0.0008
Trichomonas vaginalis heat shock protein, putative 0.0045 0.01 0.0132
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.1332 0.7524 1
Brugia malayi ecdysteroid receptor 0.0217 0.1093 0.1442
Echinococcus granulosus acetylcholinesterase 0.0472 0.2564 0.662
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0149 0.0696 0.1753
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0499 0.2718 0.3593
Trypanosoma brucei lanosterol synthase 0.0331 0.1747 0.2299
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0159 0.0198
Echinococcus multilocularis tumor protein p63 0.0356 0.1892 0.1892
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0159 0.0198
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.017 0.049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0217 0.1093 0.1442
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0148 0.0189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0217 0.1093 0.1442
Schistosoma mansoni hypothetical protein 0.0032 0.0023 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0121 0.0148
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0499 0.2718 0.3612
Trypanosoma cruzi phospholipase A1, putative 0.0365 0.1945 0.2562
Onchocerca volvulus 0.008 0.0299 0.0915
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.003 0.0021
Echinococcus multilocularis X box binding protein 1 0.0303 0.159 0.1586
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0217 0.1093 0.1442
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0049 0.0122 0.0149
Loa Loa (eye worm) hypothetical protein 0.0089 0.0354 0.0458
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.017 0.0385
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0117 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0217 0.1093 0.1442
Echinococcus granulosus tar DNA binding protein 0.0194 0.0956 0.2431
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0118 0.0519 0.0502
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0045 0.0099 0.0132
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0259 0.0237
Schistosoma mansoni neprilysin-2 (M13 family) 0.0146 0.0678 0.1708
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0057 0.0166 0.0611
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Loa Loa (eye worm) hypothetical protein 0.008 0.0299 0.0384
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0499 0.2718 0.702
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0217 0.1093 0.1442
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0302 0.111
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0224 0.0285
Loa Loa (eye worm) hypothetical protein 0.0218 0.1098 0.1448
Leishmania major hypothetical protein, conserved 0.008 0.0302 0.0372
Loa Loa (eye worm) hypothetical protein 0.0056 0.0159 0.0198
Loa Loa (eye worm) hypothetical protein 0.0344 0.1823 0.2412
Trichomonas vaginalis endoplasmin, putative 0.0035 0.004 0.0053
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.003 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0678 0.0889
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0259 0.0239
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0076 0.0102
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0407 0.2188 0.5639
Leishmania major glucose transporter, lmgt3 0.0034 0.0035 0.0017
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0166 0.0191
Loa Loa (eye worm) integrin alpha pat-2 0.0494 0.2687 0.3563
Loa Loa (eye worm) nuclear receptor NHR-67 0.0103 0.043 0.0559
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Onchocerca volvulus 0.0056 0.0159 0.0451
Trypanosoma cruzi hexose transporter 0.0034 0.0035 0.0017
Loa Loa (eye worm) hypothetical protein 0.0211 0.1057 0.1393
Loa Loa (eye worm) hypothetical protein 0.0069 0.0235 0.03
Schistosoma mansoni heat shock protein 0.0048 0.0117 0.0245
Brugia malayi Endoplasmin precursor 0.0048 0.0117 0.0142
Brugia malayi Carboxylesterase family protein 0.0472 0.2564 0.3399
Echinococcus multilocularis integrin alpha ps 0.0144 0.0667 0.0652
Loa Loa (eye worm) hypothetical protein 0.0104 0.0441 0.0574
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0259 0.0237
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0217 0.0196
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0259 0.0237
Loa Loa (eye worm) hypothetical protein 0.0129 0.0583 0.0763
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0289 0.1503 0.1484
Brugia malayi nuclear receptor RXR 0.0115 0.0501 0.0654
Echinococcus granulosus nuclear receptor nhr 48 0.0103 0.043 0.1062
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0121 0.0256
Echinococcus granulosus General substrate transporter 0.0095 0.0384 0.0942
Echinococcus granulosus jun protein 0.0088 0.0349 0.0849
Echinococcus multilocularis endoplasmin 0.0045 0.01 0.0078
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.017 0.015
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.0693 0.0679
Trypanosoma cruzi ISWI complex protein 0.0032 0.0023 0.0001
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.008 0.0299 0.0277
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.017 0.0214
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0217 0.1093 0.1442
Toxoplasma gondii heat shock protein 90, putative 0.0048 0.0117 0.0148
Onchocerca volvulus Huntingtin homolog 0.0129 0.0583 0.1857
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0259 0.1691
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0217 0.1093 0.1442
Echinococcus multilocularis BC026374 protein (S09 family) 0.008 0.0299 0.0279
Schistosoma mansoni glutamate receptor AMPA 0.0049 0.0119 0.0252
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0115 0.0501 0.0484
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1332 0.7524 1
Brugia malayi Integrin alpha pat-2 precursor 0.032 0.1686 0.2231
Echinococcus multilocularis heat shock protein 90 0.0041 0.0076 0.0054
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0045 0.0099 0.0102
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0217 0.0275
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0103 0.043 0.0412
Entamoeba histolytica hypothetical protein 0.0499 0.2718 0.3593
Loa Loa (eye worm) hypothetical protein 0.008 0.0302 0.0389
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0678 0.1706
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0446 0.1103
Echinococcus multilocularis tar DNA binding protein 0.0194 0.0956 0.0945
Loa Loa (eye worm) hypothetical protein 0.0066 0.0217 0.0275
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0259 0.0615
Schistosoma mansoni nuclear hormone receptor 0.0217 0.1093 0.2789
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0148 0.0167
Loa Loa (eye worm) hypothetical protein 0.0472 0.2564 0.3399
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0217 0.1093 0.2789
Echinococcus granulosus geminin 0.0697 0.3862 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.007 0.0244 0.0576
Brugia malayi nuclear receptor RXR 0.0103 0.043 0.0559
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Plasmodium falciparum heat shock protein 90 0.0048 0.0117 0.0429
Leishmania major heat shock protein, putative 0.0032 0.0023 0.0001
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0057 0.0166 0.0191
Brugia malayi Nuclear hormone receptor-like 1 0.0115 0.0501 0.0654
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.0573 0.0755
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0035 0.0017
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.1332 0.7524 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0038 0.0016
Giardia lamblia Rab geranylgeranyltransferase 0.0045 0.0099 0.0285
Brugia malayi hypothetical protein 0.0032 0.0023 0.0017
Trypanosoma cruzi protein farnesyltransferase, putative 0.0045 0.0099 0.0102
Echinococcus granulosus tumor protein p63 0.0356 0.1892 0.487
Loa Loa (eye worm) oxidoreductase 0.0032 0.0023 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0259 0.0344
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0206 0.103 0.1019
Brugia malayi Peptidase family M13 containing protein 0.0289 0.1503 0.1988
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0231 0.1171 0.1162
Loa Loa (eye worm) MBCTL1 0.0066 0.0217 0.0275
Onchocerca volvulus Phospholipase A2 homolog 0.0101 0.0421 0.1321
Schistosoma mansoni intermediate filament proteins 0.0056 0.0159 0.0354
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0365 0.1945 0.2575
Echinococcus multilocularis glutamate receptor 2 0.004 0.0068 0.0046
Loa Loa (eye worm) endoplasmin 0.0048 0.0117 0.0142
Onchocerca volvulus 0.0143 0.0663 0.2123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.0956 0.1259
Echinococcus granulosus Smad4 0.0035 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.0104 0.0437 0.0568
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Echinococcus multilocularis protein dispatched 1 0.0051 0.0131 0.011
Brugia malayi CHE-14 protein 0.0045 0.0095 0.0113
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Schistosoma mansoni hypothetical protein 0.0149 0.0696 0.1753
Loa Loa (eye worm) hypothetical protein 0.1332 0.7524 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0148 0.0197
Trypanosoma brucei heat shock protein, putative 0.0048 0.0117 0.0125
Brugia malayi Steroid receptor seven-up type 2 0.0407 0.2188 0.2899
Schistosoma mansoni cathepsin D (A01 family) 0.0145 0.0675 0.1698
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0499 0.2718 0.3612
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0217 0.1093 0.2789
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0045 0.0099 0.0102
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0049 0.0122 0.0258
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0057 0.0166 0.0532
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.008 0.0299 0.0279
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.0441 0.0558
Brugia malayi nuclear hormone receptor family member nhr-6 0.0103 0.043 0.0559
Loa Loa (eye worm) hypothetical protein 0.0555 0.304 0.4032
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.0956 0.1259
Loa Loa (eye worm) hypothetical protein 0.0217 0.1093 0.1442
Brugia malayi Carboxylesterase family protein 0.0472 0.2564 0.3399
Trypanosoma brucei protein kinase, putative 0.0054 0.0148 0.0167
Plasmodium vivax endoplasmin, putative 0.0048 0.0117 0.041
Onchocerca volvulus 0.0073 0.0259 0.0783
Schistosoma mansoni thyroid hormone receptor 0.035 0.1859 0.4782
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0017
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0044 0.0057
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0023 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0302 0.0372
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0259 0.0331
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.0441 0.0558
Mycobacterium ulcerans putative regulatory protein 0.0076 0.0276 0.0254
Brugia malayi heat shock protein 90 0.0048 0.0117 0.0142
Giardia lamblia Heat shock protein HSP 90-alpha 0.0041 0.0076 0.02
Schistosoma mansoni hypothetical protein 0.0697 0.3862 1
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.0302 0.1092
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0156 0.0134
Brugia malayi Sugar transporter family protein 0.011 0.0473 0.0617
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.007 0.0244 0.0576
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.0473 0.1174
Schistosoma mansoni single-minded 0.0102 0.043 0.106
Echinococcus multilocularis integrin alpha 3 0.0245 0.1255 0.1247
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.0302 0.0394
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0117 0.0125
Loa Loa (eye worm) hypothetical protein 0.0052 0.0139 0.0172
Loa Loa (eye worm) transcription factor SMAD2 0.0509 0.2774 0.3679
Loa Loa (eye worm) hypothetical protein 0.0073 0.0259 0.0331
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Giardia lamblia Prenyltransferase 0.0045 0.0099 0.0285
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0499 0.2718 0.3593
Schistosoma mansoni nuclear receptor 0.0103 0.043 0.1062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.0421 0.2776
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Schistosoma mansoni hypothetical protein 0.0067 0.0224 0.0524
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Schistosoma mansoni hypothetical protein 0.0303 0.159 0.4082
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0117 0.0125
Echinococcus granulosus ecdysone induced protein 78C 0.0217 0.1093 0.2789
Onchocerca volvulus 0.0365 0.1945 0.6371
Brugia malayi mbt repeat family protein 0.0058 0.017 0.0214
Loa Loa (eye worm) hypothetical protein 0.0103 0.043 0.0559
Brugia malayi Glutamate receptor 2 precursor 0.0049 0.0119 0.0146
Brugia malayi MH2 domain containing protein 0.0035 0.0038 0.0038
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0166 0.0145
Onchocerca volvulus 0.008 0.0299 0.0915
Brugia malayi Calcitonin receptor-like protein seb-1 0.0211 0.1057 0.1393
Trypanosoma brucei trypanothione reductase 0.004 0.0068 0.0061
Onchocerca volvulus 0.0217 0.1093 0.3549
Schistosoma mansoni hypothetical protein 0.0067 0.0224 0.0524
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0032 0.0023 0.003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0273 0.0652
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0049 0.0119 0.0098
Loa Loa (eye worm) hypothetical protein 0.0115 0.0501 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0099 0.0102
Brugia malayi hypothetical protein 0.0497 0.2709 0.3592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0211 0.1057 0.1393
Schistosoma mansoni glucose transport protein 0.011 0.0473 0.1174
Schistosoma mansoni zinc finger protein 0.0032 0.0023 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0217 0.1093 0.1442
Onchocerca volvulus Bile acid receptor homolog 0.0217 0.1093 0.3549
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.003 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0035 0.0047
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0045 0.0099 0.0132
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0324 0.0302
Onchocerca volvulus 0.0052 0.0139 0.0385
Loa Loa (eye worm) hypothetical protein 0.0073 0.0259 0.0331
Onchocerca volvulus 0.008 0.0299 0.0915
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0111 0.023
Leishmania major hypothetical protein, conserved 0.0073 0.0259 0.0315
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0217 0.1093 0.3549
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0046 0.0061
Schistosoma mansoni eyes absent homolog 0.0089 0.035 0.0852
Brugia malayi bZIP transcription factor family protein 0.0088 0.0349 0.0451
Loa Loa (eye worm) hypothetical protein 0.0073 0.0259 0.0331
Loa Loa (eye worm) hypothetical protein 0.0073 0.0259 0.0331
Loa Loa (eye worm) hypothetical protein 0.0213 0.1069 0.1409
Echinococcus granulosus smad 0.0035 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.0115 0.0501 0.0654
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0499 0.2718 0.3593
Mycobacterium ulcerans beta-lactamase 0.0073 0.0259 0.0237
Schistosoma mansoni glutamate receptor kainate 0.0049 0.0119 0.0252
Brugia malayi tailless protein 0.0103 0.043 0.0559
Toxoplasma gondii aspartyl protease ASP1 0.0049 0.0122 0.0155
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.003 0.0092
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 0.0023 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0678 0.1706
Loa Loa (eye worm) RNA binding protein 0.0194 0.0956 0.1259
Brugia malayi nuclear receptor NHR-67 0.0103 0.043 0.0559
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.0349 0.0849
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0114 0.0497 0.048
Plasmodium vivax glutathione reductase, putative 0.004 0.0068 0.0231
Leishmania major heat shock protein 83-1 0.0048 0.0117 0.0125
Echinococcus granulosus single minded 2 0.0076 0.0276 0.066
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0044 0.0057
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0324 0.0305
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0148 0.0326
Brugia malayi Nuclear hormone receptor E75 0.0103 0.043 0.0559
Echinococcus multilocularis smad 0.0035 0.0038 0.0016
Onchocerca volvulus 0.0103 0.043 0.1351
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0499 0.2718 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0035 0.0017
Loa Loa (eye worm) hypothetical protein 0.0067 0.0224 0.0285

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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