Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.7595 | 0.7595 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4665 | 0.6142 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 0.7595 | 1 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0051 | 0 | 0.5 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 0.7595 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0301 | 0.7595 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.038 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0301 | 0.7595 | 0.7595 |
Brugia malayi | Carboxylesterase family protein | 0.0301 | 0.7595 | 0.7595 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0301 | 0.7595 | 0.7595 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0051 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.7595 | 0.7595 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Echinococcus granulosus | geminin | 0.0205 | 0.4665 | 0.6142 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0051 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0301 | 0.7595 | 1 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 0.7595 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4665 | 0.6142 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0051 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0301 | 0.7595 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 0.7595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.4356 | 0.4356 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4665 | 0.6142 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.038 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0301 | 0.7595 | 0.7595 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.038 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.