Detailed information for compound 1273679

Basic information

Technical information
  • TDR Targets ID: 1273679
  • Name: N-(3-methylsulfanylphenyl)-3-phenylpyrrolidin e-1-carbothioamide
  • MW: 328.495 | Formula: C18H20N2S2
  • H donors: 1 H acceptors: 0 LogP: 4.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1cccc(c1)NC(=S)N1CCC(C1)c1ccccc1
  • InChi: 1S/C18H20N2S2/c1-22-17-9-5-8-16(12-17)19-18(21)20-11-10-15(13-20)14-6-3-2-4-7-14/h2-9,12,15H,10-11,13H2,1H3,(H,19,21)
  • InChiKey: ADBVHZZHQWFIHF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(3-methylsulfanylphenyl)-3-phenyl-pyrrolidine-1-carbothioamide
  • N-[3-(methylthio)phenyl]-3-phenyl-1-pyrrolidinecarbothioamide
  • N-[3-(methylthio)phenyl]-3-phenyl-pyrrolidine-1-carbothioamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0787 0.0787
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0073 0.1394 0.5093
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0148 0.0316
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0034
Mycobacterium ulcerans polyketide synthase 0.0073 0.1394 0.3215
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0148 0.0316
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0336 0.1094
Brugia malayi hypothetical protein 0.0043 0.0787 0.1848
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.021 0.4188 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0141 0.0173
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0016 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0148 0.0148
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0115 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0008 0.007 0.013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0484 0.1121
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0141 0.0301
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.021 0.4188 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0148 0.0316
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0148 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0148 0.0132
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0148 0.0148
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0148 0.0132
Echinococcus multilocularis cpg binding protein 0.0037 0.0648 0.0633
Mycobacterium ulcerans polyketide synthase Pks9 0.0073 0.1394 0.3215
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0137 0.2692 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0484 0.1004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1028 0.1028
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0484 0.1121
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) 0.0137 0.2692 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0148 0.0316
Entamoeba histolytica hypothetical protein 0.0043 0.0787 1
Onchocerca volvulus Fatty acid synthase homolog 0.0073 0.1394 0.8891
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0484 0.1121
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0141 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0484 0.1004
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0141 0.0173
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0074 0.1418 0.3273
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0073 0.1394 0.5049
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.007 0.009
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0148 0.0316
Echinococcus granulosus cpg binding protein 0.0037 0.0648 0.0633
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0484 0.1121
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0148 0.0316
Mycobacterium ulcerans hypothetical protein 0.0029 0.0484 0.1004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0148 0.0316
Mycobacterium leprae Probable polyketide synthase Pks1 0.0073 0.1394 0.5049
Entamoeba histolytica hypothetical protein 0.0043 0.0787 1
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.021 0.4188 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0148 0.0316
Loa Loa (eye worm) hypothetical protein 0.0012 0.0141 0.0301
Loa Loa (eye worm) hypothetical protein 0.0021 0.0336 0.0766
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0059
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0141 0.0126
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Toxoplasma gondii type I fatty acid synthase, putative 0.0074 0.1418 0.3273
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) 0.0137 0.2692 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0073 0.1394 0.5093
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0148 0.0132
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0141 1
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0016 0.0016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0073 0.1394 0.3215
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.007 0.009
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0148 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0148 0.0316
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0148 0.0316
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.003 0.003
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0073 0.1394 0.5049
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0148 0.0316
Brugia malayi CXXC zinc finger family protein 0.0035 0.0608 0.1418
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0141 0.0173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0336 0.0766
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.007 0.013
Onchocerca volvulus 0.0012 0.0141 0.0809
Schistosoma mansoni coup transcription factor 0.0012 0.0148 0.0148
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0148 0.0132
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0484 0.1004
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.021 0.4188 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.003 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0484 0.1004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0484 0.5772
Onchocerca volvulus 0.0029 0.0484 0.3018
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0073 0.1394 0.5049
Brugia malayi AMP-binding enzyme family protein 0.0008 0.007 0.013
Loa Loa (eye worm) hypothetical protein 0.0073 0.1394 0.3303
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0141 0.0301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0312 0.1004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0148 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0148 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0141 0.0173
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0073 0.1394 0.5093
Entamoeba histolytica hypothetical protein 0.0012 0.0141 0.0994
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0118 0.0102
Onchocerca volvulus 0.0012 0.0148 0.0851
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.021 0.4188 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.021 0.4188 0.4179
Mycobacterium ulcerans fatty acid synthase Fas 0.0073 0.1394 0.3215
Mycobacterium ulcerans polyketide synthase 0.0073 0.1394 0.3215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0148 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1028 0.1028
Treponema pallidum DNA ligase (lig) 0.0012 0.0141 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0787 0.0772
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0016 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0608 0.1418
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0141 0.0173
Onchocerca volvulus 0.0008 0.007 0.035
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.021 0.4188 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1028 0.1014
Brugia malayi nuclear hormone receptor 0.0012 0.0148 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0148 0.0316
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Loa Loa (eye worm) hypothetical protein 0.0021 0.0336 0.0766
Schistosoma mansoni DNA ligase IV 0.0012 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1028 0.1014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0148 0.0132
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0074 0.0059
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0484 0.1004
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0141 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0141 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.007 0.009
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.021 0.4188 1
Mycobacterium ulcerans polyketide synthase MbtC 0.0073 0.1394 0.3215
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0137 0.2692 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0073 0.1394 0.3303
Onchocerca volvulus 0.0008 0.007 0.035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0336 0.0766
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0016 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0148 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0008 0.007 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0141 0.0173
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0141 0.0126
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0141 0.0994
Toxoplasma gondii type I fatty acid synthase, putative 0.0073 0.1394 0.3215
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.007 0.009
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0073 0.1394 0.5093
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0073 0.1394 0.5049
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0118 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0148 0.0316
Loa Loa (eye worm) hypothetical protein 0.0012 0.0141 0.0301
Brugia malayi steroid hormone receptor 0.0012 0.0148 0.0316
Loa Loa (eye worm) hypothetical protein 0.0029 0.0484 0.1121
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.007 0.009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0074 0.0074
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0336 0.048
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0141 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0141 0.0173
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0073 0.1394 0.5093
Mycobacterium ulcerans polyketide synthase Pks13 0.0073 0.1394 0.3215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0148 0.0316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1028 0.1014
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.007 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0141 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0484 0.1653
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.1394 0.3215
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0484 0.5772
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0073 0.1394 0.3215
Brugia malayi nuclear receptor RXR 0.0006 0.003 0.0034
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0484 0.1004
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.007 0.0054
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0484 0.5772
Schistosoma mansoni hypothetical protein 0.0043 0.0787 0.0787
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0312 0.1004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1242 0.2846
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0034
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.007 0.013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0148 0.0132
Brugia malayi nuclear receptor NHR-88 0.0012 0.0148 0.0316
Brugia malayi topoisomerase 0.0012 0.0141 0.0301
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0148 0.0148
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0484 0.1004
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0073 0.1394 0.5093
Onchocerca volvulus 0.0082 0.1566 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0073 0.1394 0.5093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0141 0.0301
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0141 0.0141
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0141 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1028 0.1028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0148 0.0316
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.1394 0.3215
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0073 0.1394 0.5093
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.007 0.0054
Schistosoma mansoni topbp1 0.0012 0.0141 0.0141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.003 0.003
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0073 0.1394 0.5093
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.021 0.4188 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0073 0.1394 0.5093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0148 0.0851
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0073 0.1394 0.5049
Brugia malayi hypothetical protein 0.0006 0.003 0.0034
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.021 0.4188 1
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.021 0.4188 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0141 0.0272
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.007 0.136
Loa Loa (eye worm) hypothetical protein 0.0012 0.0141 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0148 0.0316
Echinococcus multilocularis nibrin 0.0012 0.0141 0.0126
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0336 0.0645
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1028 0.1014
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0073 0.1394 0.5093
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0073 0.1394 0.3215
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.007 0.009
Schistosoma mansoni cpg binding protein 0.0037 0.0648 0.0648
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.021 0.4188 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0141 0.0173
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0074 0.0059
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0141 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0148 0.0132
Schistosoma mansoni hypothetical protein 0.0494 1 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.021 0.4188 0.4188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0148 0.0132
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0336 0.0645
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.021 0.4188 1
Echinococcus granulosus nibrin 0.0012 0.0141 0.0126
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0484 0.1004
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.007 0.136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0148 0.0132
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.1394 0.3215
Brugia malayi ecdysteroid receptor 0.0012 0.0148 0.0316
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0073 0.1394 0.5093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.007 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0148 0.0316
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0073 0.1394 0.3303
Schistosoma mansoni cpg binding protein 0.0035 0.0608 0.0608
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0336 0.0645
Brugia malayi hypothetical protein 0.0012 0.0141 0.0301
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0148 0.0132
Entamoeba histolytica hypothetical protein 0.0043 0.0787 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0141 0.0173
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0073 0.1394 0.5049
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0148 0.0851
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0484 0.1653
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0148 0.0148
Brugia malayi hypothetical protein 0.0006 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0141 0.0301
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0787 0.0772
Loa Loa (eye worm) hypothetical protein 0.0008 0.007 0.013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0148 0.0132
Loa Loa (eye worm) oxidoreductase 0.0008 0.007 0.013
Brugia malayi DKFZp564C0469 protein 0.0012 0.0141 0.0301
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0336 0.0766
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0073 0.1394 0.5049
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0148 0.0132
Onchocerca volvulus 0.0035 0.0608 0.3817
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0148 0.0148
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0148 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1403 0.1403
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1028 0.2426
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0484 0.1577
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0148 0.0148
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.007 0.007
Schistosoma mansoni topbp1 0.0012 0.0141 0.0141
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0148 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0148 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0148 0.0316
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0073 0.1394 0.3215
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0141 1
Schistosoma mansoni nuclear receptor 0.0006 0.0016 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0118 0.0102
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.003 0.0014
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.007 0.013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0148 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0148 0.0148
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0148 0.0132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0059
Mycobacterium leprae Polyketide synthase Pks13 0.0073 0.1394 0.5049
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.007 0.013
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0073 0.1394 0.3215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0484 0.1121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0148 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0484 0.1577
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0073 0.1394 0.3215
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0484 0.1004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0141 0.0301
Brugia malayi hypothetical protein 0.0012 0.0141 0.0301
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.007 0.009
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.003 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.003 0.0034
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.007 0.009
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0148 0.0316
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0073 0.1394 0.3215
Onchocerca volvulus 0.0008 0.007 0.035
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0073 0.1394 0.5093
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0148 0.0851
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.007 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0148 0.0316
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0034
Schistosoma mansoni cpg binding protein 0.0037 0.0648 0.0648
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.021 0.4188 0.4179
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.007 0.013
Entamoeba histolytica hypothetical protein 0.0043 0.0787 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0148 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0008 0.007 0.013
Loa Loa (eye worm) hypothetical protein 0.0074 0.1418 0.336
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0312 0.1004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1028 0.2426
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0073 0.1394 0.5093
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0484 0.1004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0073 0.1394 0.5093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0312 0.1004
Schistosoma mansoni zinc finger protein 0.0006 0.0016 0.0016
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.021 0.4188 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0148 0.0148
Schistosoma mansoni nuclear receptor 0.0006 0.0016 0.0016

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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