Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Onchocerca volvulus | 4'-phosphopantetheinyl transferase ffp | 224 aa | 186 aa | 26.3 % | |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Entamoeba histolytica | hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 198 aa | 28.3 % |
Trichomonas vaginalis | conserved hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 197 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0068 | 0.2538 | 0.2538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2538 | 0.4878 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2538 | 0.4878 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2538 | 0.4878 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.2538 | 0.2538 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1368 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5204 | 0.5204 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.01 | 0.5204 | 0.3573 |
Onchocerca volvulus | 0.01 | 0.5204 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.2538 | 0.2538 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.01 | 0.5204 | 0.3573 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2538 | 0.4878 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.2538 | 0.2538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.2538 | 0.4878 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.2538 | 0.2538 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.2538 | 0.2538 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1368 | 0.1368 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1368 | 0.1368 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.01 | 0.5204 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 1 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.01 | 0.5204 | 0.5204 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1368 | 0.1368 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | PUBCHEM_BIOASSAY: Factor XIIa 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID800] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.