Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.6063 | 0.6063 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3886 | 0.3886 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0145 | 0.3886 | 0.3886 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0211 | 0.7234 | 0.7234 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.7234 | 0.7234 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0267 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.071 | 0.071 |
Entamoeba histolytica | hypothetical protein | 0.0153 | 0.4295 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0153 | 0.4295 | 0.4295 |
Entamoeba histolytica | hypothetical protein | 0.0153 | 0.4295 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.4295 | 0.4295 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0267 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0153 | 0.4295 | 0.4295 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0154 | 0.0154 |
Echinococcus granulosus | tar DNA binding protein | 0.0267 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.6063 | 0.6063 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0081 | 0.071 | 0.071 |
Brugia malayi | TAR-binding protein | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0267 | 1 | 1 |
Brugia malayi | RhoGAP domain containing protein | 0.007 | 0.0154 | 0.0154 |
Entamoeba histolytica | hypothetical protein | 0.0153 | 0.4295 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0211 | 0.7234 | 0.7234 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0211 | 0.7234 | 0.7234 |
Brugia malayi | RhoGAP domain containing protein | 0.0081 | 0.071 | 0.071 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0153 | 0.4295 | 0.4295 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0188 | 0.6063 | 0.6063 |
Schistosoma mansoni | rac gtpase activating protein | 0.0081 | 0.071 | 0.071 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0081 | 0.071 | 0.071 |
Loa Loa (eye worm) | RNA binding protein | 0.0267 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3886 | 0.3886 |
Giardia lamblia | Rho GAP, putative | 0.007 | 0.0154 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0153 | 0.4295 | 0.4295 |
Entamoeba histolytica | hypothetical protein | 0.0153 | 0.4295 | 0.5 |
Echinococcus granulosus | geminin | 0.0188 | 0.6063 | 0.6063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.