Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0132 | 0.3389 | 0.5549 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0306 | 1 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0147 | 0.3944 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0132 | 0.3389 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0306 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0114 | 0.2696 | 0.7119 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.3788 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0132 | 0.3389 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0132 | 0.3389 | 0.8947 |
Echinococcus multilocularis | fk506 binding protein | 0.0132 | 0.3389 | 0.5549 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0132 | 0.3389 | 0.3148 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0132 | 0.3389 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0132 | 0.3389 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0132 | 0.3389 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0132 | 0.3389 | 0.5549 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0145 | 0.3867 | 0.0723 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0132 | 0.3389 | 0.8947 |
Mycobacterium ulcerans | hypothetical protein | 0.0161 | 0.449 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0132 | 0.3389 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0235 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0132 | 0.3389 | 1 |
Schistosoma mansoni | immunophilin | 0.0132 | 0.3389 | 0.5549 |
Trichomonas vaginalis | immunophilin, putative | 0.0132 | 0.3389 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0132 | 0.3389 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0147 | 0.3944 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0132 | 0.3389 | 0.3148 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0161 | 0.449 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0145 | 0.3867 | 0.0723 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0147 | 0.3944 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0132 | 0.3389 | 0.5549 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0306 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0132 | 0.3389 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0147 | 0.3944 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0132 | 0.3389 | 0.5549 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0132 | 0.3389 | 0.3148 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0145 | 0.3867 | 0.3643 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0132 | 0.3389 | 0.3148 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0132 | 0.3389 | 0.5549 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0132 | 0.3389 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 100 uM | PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 67.4555 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.