Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2607 | 0.3643 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2607 | 0.3425 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2607 | 0.3425 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2607 | 0.3643 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0093 | 0.761 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0081 | 0.4126 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2607 | 0.2607 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2607 | 0.3425 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2607 | 0.3643 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2607 | 0.3425 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0081 | 0.4126 | 0.2055 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2607 | 0.3425 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2607 | 0.2607 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.01 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.