TDR Targets

Basic information

Technical information

TDR Targets ID: 1274999
Name: 1H-quinoline-2-thione
MW: 161.224 | Formula: C9H7NS
H donors: 0 H acceptors: 1 LogP: 2.67 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Sc1ccc2c(n1)cccc2
InChi: 1S/C9H7NS/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)
InChiKey: KXZSVYHFYHTNBI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2637-37-8
4481-48-5
MLS001006012
SMR000384164
116270_ALDRICH
AIDS167471
AI3-18648
NSC408468
Carbostyril, thio- (VAN) (8CI)
EINECS 220-132-4
2(1H)-Quinolinethione
2-Mercaptoquinoline
2-Quinolinethiol
2-Quinolinylthiol
Carbostyril, thio-
NSC43642
Thiocarbostyril
NSC 43642
Quinoline-2-thiol
NSC 408468
AIDS-167471

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0107	0.1063
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0078	0.0037
Toxoplasma gondii	NADPH-glutathione reductase	0.0023	0.0054	0.0215
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0034	0.0134	0.0192
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0023	0.0054	0.0057
Schistosoma mansoni	SET domain protein	0.0034	0.0134	0.0556
Onchocerca volvulus	Huntingtin homolog	0.0141	0.087	0.434
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.0521	0.1128
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.009	0.0521	0.1128
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0181	0.1151	0.5635
Brugia malayi	RNA binding protein	0.0076	0.0425	0.2122
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0037	0.0153	0.0651
Plasmodium falciparum	thioredoxin reductase	0.0023	0.0054	0.0426
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0521	0.2049
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0292	0.1431
Onchocerca volvulus	Huntingtin homolog	0.0141	0.087	0.434
Entamoeba histolytica	hypothetical protein	0.0043	0.0197	0.0773
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Onchocerca volvulus		0.0105	0.0622	0.3105
Brugia malayi	Pre-SET motif family protein	0.0037	0.0153	0.0765
Echinococcus multilocularis	neutral alpha glucosidase AB	0.004	0.0175	0.0261
Brugia malayi	glutaminase DH11.1	0.0304	0.2002	0.999
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Entamoeba histolytica	hypothetical protein	0.0383	0.2544	1
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0107	0.2108
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0097	0.0375
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0023	0.0054	0.0118
Giardia lamblia	NADPH oxidoreductase, putative	0.1461	1	1
Trichomonas vaginalis	glutathione reductase, putative	0.0023	0.0054	0.0054
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0553	0.0907
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0059	0.0128
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0078	0.0381
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0044	0.0096
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0023	0.0054	0.0057
Brugia malayi	hypothetical protein	0.0141	0.087	0.434
Loa Loa (eye worm)	hypothetical protein	0.009	0.0516	0.2523
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0096	0.0561	0.1213
Schistosoma mansoni	hypothetical protein	0.0171	0.1078	0.5226
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Schistosoma mansoni	alpha-glucosidase	0.0156	0.0977	0.4724
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0181	0.1151	0.1928
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0056
Plasmodium vivax	glutathione reductase, putative	0.0066	0.0353	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0197	0.0866
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0683	0.4623	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0162
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0044	0.0217
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0048	0.0226	0.0889
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0323	0.2133	0.4614
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0553	0.0907
Toxoplasma gondii	hypothetical protein	0.011	0.0659	1
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0041	0.0041
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0115	0.0688	0.3369
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0107	0.0231
Brugia malayi	TAR-binding protein	0.0076	0.0425	0.2122
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0175	0.0687
Mycobacterium ulcerans	hypothetical protein	0.036	0.2386	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0175	0.0175
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0022	0.0108
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0022	0.0106
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0425	0.2082
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Trichomonas vaginalis	mercuric reductase, putative	0.0023	0.0054	0.0054
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.0553	0.2706
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0066	0.0353	0.1328
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0023	0.0054	0.0057
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0044	0.0096
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0553	0.2628
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0425	0.1997
Echinococcus granulosus	thioredoxin glutathione reductase	0.0066	0.0353	0.1637
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0078	0.118
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0292	0.1431
Echinococcus granulosus	histone lysine methyltransferase setb	0.0037	0.0153	0.0651
Brugia malayi	Importin beta-1 subunit	0.0029	0.0097	0.0486
Loa Loa (eye worm)	glutaminase 2	0.0304	0.2002	0.9799
Plasmodium falciparum	glutathione reductase	0.0066	0.0353	1
Schistosoma mansoni	alpha glucosidase	0.004	0.0175	0.0758
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0688	0.0688
Schistosoma mansoni	tsg101-related	0.0058	0.03	0.1378
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0107	0.0231
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0078	0.0169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0553	0.2628
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0054	0.0118
Echinococcus multilocularis	dual specificity	0.009	0.0521	0.0853
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0023	0.0054	0.0426
Trypanosoma brucei	polo-like protein kinase	0.0115	0.0688	0.1489
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0044	0.0096
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0425	0.2082
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0096	0.0561	0.1213
Brugia malayi	RNA, U transporter 1	0.0083	0.0468	0.2336
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.0553	0.2759
Schistosoma mansoni	tsg101-related	0.0058	0.03	0.1378
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0078	0.0595
Brugia malayi	Flap endonuclease-1	0.0026	0.0078	0.0389
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1461	1	1
Giardia lamblia	Kinase, PLK	0.0115	0.0688	0.065
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0118
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0136	0.0568
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0175	0.0687
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0425	0.1997
Leishmania major	hypothetical protein, conserved	0.003	0.0107	0.0231
Plasmodium falciparum	glutathione reductase	0.0023	0.0054	0.0426
Schistosoma mansoni	flap endonuclease-1	0.0024	0.006	0.0192
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0175	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0034	0.0134	0.0556
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0054	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0425	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0141	0.087	0.4257
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0252	0.1642	0.8038
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0078	0.0306
Brugia malayi	hypothetical protein	0.0305	0.2004	1
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0023	0.0054	0.0426
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0383	0.2544	0.2544
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0107	0.2108
Loa Loa (eye worm)	glutathione reductase	0.0066	0.0353	0.1726
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0023	0.0054	0.0426
Schistosoma mansoni	importin beta-1	0.0029	0.0097	0.0375
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0023	0.0054	0.0057
Trichomonas vaginalis	set domain proteins, putative	0.0287	0.1882	0.1882
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0521	0.2472
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0023	0.0054	0.0118
Brugia malayi	hypothetical protein	0.007	0.0381	0.1903
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0292	0.1459
Leishmania major	trypanothione reductase	0.0066	0.0353	0.0763
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0041	0.0089
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0115	0.0688	0.1138
Onchocerca volvulus		0.0305	0.2004	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.004	0.0175	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0553	0.2628
Plasmodium falciparum	thioredoxin reductase	0.0066	0.0353	1
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0097	0.0129
Schistosoma mansoni	ap endonuclease	0.0021	0.0041	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0041	0.0205
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0425	0.1997
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0688	0.0688
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Schistosoma mansoni	hypothetical protein	0.0039	0.0167	0.072
Loa Loa (eye worm)	hypothetical protein	0.009	0.0516	0.2523
Schistosoma mansoni	hypothetical protein	0.031	0.2043	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0175	0.0175
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0097	0.1805
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0117	0.0706	0.1528
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0097	0.0211
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0097	0.0911
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Loa Loa (eye worm)	hypothetical protein	0.007	0.0381	0.1866
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0041	0.0097
Brugia malayi	glutathione reductase	0.0066	0.0353	0.176
Brugia malayi	Glycosyl hydrolases family 31 protein	0.004	0.0175	0.0872
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0041	0.0089
Entamoeba histolytica	hypothetical protein	0.0043	0.0197	0.0773
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0118
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0023	0.0054	0.0272
Loa Loa (eye worm)	thioredoxin reductase	0.0066	0.0353	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0521	0.2601
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.009	0.0521	0.2551
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0688	0.0688
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0023	0.0054	0.0013
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0115	0.0688	0.3299
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0893	0.4373
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0115	0.0688	0.1489
Entamoeba histolytica	hypothetical protein	0.0043	0.0197	0.0773
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1461	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0688	0.0688
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.029	0.029
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.004	0.0175	0.0855
Entamoeba histolytica	Ran family GTPase	0.0021	0.0044	0.0174
Trypanosoma brucei	trypanothione reductase	0.0066	0.0353	0.0763
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0041	0.0041
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0023	0.0054	0.5
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0023	0.0054	0.0118
Schistosoma mansoni	kinase	0.0058	0.03	0.1379
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0175	0.0175
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0893	0.4373
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0175	0.0378
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0115	0.0688	0.2706
Schistosoma mansoni	ran	0.0021	0.0044	0.0112
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0175	0.0175
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0017	0.0012	0.0062
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0323	0.2133	0.4614
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0153	0.0651
Entamoeba histolytica	protein kinase, putative	0.009	0.0521	0.2049
Trichomonas vaginalis	sucrase-isomaltase, putative	0.004	0.0175	0.0175
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0054	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0097	0.0211
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.1078	0.7352	0.7352
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0553	0.2628
Mycobacterium tuberculosis	Probable oxidoreductase	0.0023	0.0054	0.0057
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0023	0.0054	0.0426
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0078	0.0169
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0683	0.4623	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.2004	0.9809
Brugia malayi	MH2 domain containing protein	0.0144	0.0893	0.4458
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0688	0.0688
Treponema pallidum	NADH oxidase	0.0023	0.0054	1
Leishmania major	alpha glucosidase II subunit, putative	0.004	0.0175	0.0378
Echinococcus granulosus	neutral alpha glucosidase AB	0.004	0.0175	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0425	0.2122
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0292	0.1459
Plasmodium vivax	thioredoxin reductase, putative	0.0066	0.0353	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0153	0.0651
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0022	0.0051	0.0111
Trypanosoma cruzi	trypanothione reductase, putative	0.0023	0.0054	0.0118
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0044	0.0003
Onchocerca volvulus		0.0037	0.0153	0.0765
Echinococcus multilocularis	snurportin 1	0.031	0.2043	0.3451
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0041	0.0201
Brugia malayi	Thioredoxin reductase	0.0066	0.0353	0.176
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0167	0.0818
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.007	0.0381	0.0614
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0044	0.0051
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0197	0.0299
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0181	0.1151	0.1928
Leishmania major	mitochondrial DNA polymerase beta	0.0683	0.4623	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0059	0.0233
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0175	0.0175
Plasmodium vivax	SET domain protein, putative	0.0037	0.0153	0.3599
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0044	0.0221
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0037	0.0153	0.0225
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0096	0.0561	0.1213
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.0688	0.1489
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0044	0.0112
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0096	0.0561	0.1213
Toxoplasma gondii	thioredoxin reductase	0.0066	0.0353	0.5045
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0733	0.4965	0.4965
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0078	0.0169
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Echinococcus granulosus	snurportin 1	0.031	0.2043	1
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0059	0.0059
Echinococcus granulosus	geminin	0.0171	0.1078	0.5226
Entamoeba histolytica	protein kinase, putative	0.009	0.0521	0.2049
Schistosoma mansoni	glutaminase	0.0304	0.2002	0.9797
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0037	0.0153	0.1816
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trypanosoma brucei	glucosidase, putative	0.004	0.0175	0.0378
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0078	0.0096
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Giardia lamblia	NADPH oxidoreductase, putative	0.1461	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0425	0.1997
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0059	0.0128
Trypanosoma cruzi	trypanothione reductase, putative	0.0066	0.0353	0.0763
Brugia malayi	Pre-SET motif family protein	0.0252	0.1642	0.8194
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0167	0.0834
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0683	0.4623	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.087	0.4257
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0078	0.118
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0041	0.0162
Mycobacterium tuberculosis	Conserved hypothetical protein	0.036	0.2386	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0041	0.0033
Leishmania major	GTP-binding protein, putative	0.0021	0.0044	0.0096
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0865	0.588	1
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0688	0.3299
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0197	0.0866
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0066	0.0353	0.0565
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0153	0.075
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0197	0.0866
Plasmodium falciparum	importin beta, putative	0.0029	0.0097	0.1805
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0037	0.0153	0.0225
Entamoeba histolytica	hypothetical protein	0.0043	0.0197	0.0773
Entamoeba histolytica	hypothetical protein	0.009	0.0521	0.2049
Brugia malayi	hypothetical protein	0.0043	0.0197	0.0982
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Brugia malayi	serine/threonine-protein kinase plk-2	0.0115	0.0688	0.3435
Loa Loa (eye worm)	glutaminase	0.0304	0.2002	0.9799
Brugia malayi	hypothetical protein	0.002	0.0032	0.0161
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.004	0.0175	0.2164
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0022	0.0051	0.0111
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0425	0.0689
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0323	0.2133	0.4614
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0078	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0097	0.0477
Schistosoma mansoni	ran	0.0021	0.0044	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.2544	0.2544
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.0688	0.1489
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0041	0.0089
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0023	0.0054	0.5
Schistosoma mansoni	tsg101-related	0.0048	0.0226	0.1012
Echinococcus granulosus	lysosomal alpha glucosidase	0.0181	0.1151	0.5588
Brugia malayi	hypothetical protein	0.003	0.0107	0.0533
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0017	0.0012	0.0062
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0078	0.0078
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0688	0.0688
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.007	0.0381	0.1779
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.009	0.0521	0.1128
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0059	0.0059
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0044	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Schistosoma mansoni	ap endonuclease	0.0021	0.0041	0.0097
Schistosoma mansoni	alpha-glucosidase	0.0156	0.0977	0.4724
Echinococcus multilocularis	geminin	0.0171	0.1078	0.1803
Trichomonas vaginalis	glutaminase, putative	0.0304	0.2002	0.2002
Mycobacterium ulcerans	glutaminase	0.0304	0.2002	0.8363
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1461	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0107	0.2108
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.031	0.2043	1
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0022	0.0108
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0023	0.0054	0.0215
Echinococcus granulosus	dual specificity	0.009	0.0521	0.2472
Schistosoma mansoni	hypothetical protein	0.0171	0.1078	0.5226
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0023	0.0054	0.0118
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0553	0.2628
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.029	0.029
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0115	0.0688	0.3435
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0425	0.2082
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0688	0.0688
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0107	0.0231
Leishmania major	hypothetical protein, conserved	0.0022	0.0051	0.0111
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0044	0.0101
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0383	0.2544	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0023	0.0054	0.0057
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0023	0.0054	0.0057
Trichomonas vaginalis	ran, putative	0.0021	0.0044	0.0044
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0044	0.0101
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0054	0.0118
Trichomonas vaginalis	hypothetical protein	0.0034	0.0133	0.0133
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0425	0.1997
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0181	0.1151	0.5745
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0733	0.4965	0.4965
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0153	0.0651
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0054	0.0118
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Onchocerca volvulus		0.0287	0.1882	0.9393
Trichomonas vaginalis	modulator of drug activity B, putative	0.0383	0.2544	0.2544
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0106
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0175	0.0378
Loa Loa (eye worm)	hypothetical protein	0.003	0.0107	0.0523
Trichomonas vaginalis	conserved hypothetical protein	0.1461	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0175	0.0175
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.0521	0.1128
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0041	0.0089
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0383	0.2544	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	4.4668 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	10.6213 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1387650

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1274999