Detailed information for compound 1275060

Basic information

Technical information
  • TDR Targets ID: 1275060
  • Name: SMR000200398
  • MW: 389.879 | Formula: C17H12ClN3O2S2
  • H donors: 1 H acceptors: 4 LogP: 5.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccccc1Nc1sc(c(n1)S(=O)(=O)c1ccc(cc1)C)Cl
  • InChi: 1S/C17H12ClN3O2S2/c1-11-6-8-13(9-7-11)25(22,23)16-15(18)24-17(21-16)20-14-5-3-2-4-12(14)10-19/h2-9H,1H3,(H,20,21)
  • InChiKey: KWJHJPQOVPXFBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01125053
  • 2-({5-chloro-4-[(4-methylphenyl)sulfonyl]-1,3-thiazol-2-yl}amino)benzonitrile
  • MLS000581157

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0092 0.0092
Brugia malayi ecdysteroid receptor 0.0031 0.0058 0.0058
Echinococcus multilocularis hexokinase type 2 0.1477 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0058 0.0058
Echinococcus granulosus hexokinase 0.1477 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Brugia malayi hexokinase type II 0.047 0.3073 0.3073
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0058 0.0058
Loa Loa (eye worm) hexokinase 0.0457 0.2986 0.2986
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0058 0.0058
Brugia malayi Hexokinase family protein 0.1477 1 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1084 0.1084
Trypanosoma cruzi hexokinase, putative 0.1477 1 1
Trypanosoma brucei hexokinase, putative 0.1477 1 1
Brugia malayi Muscleblind-like protein 0.018 0.1084 0.1084
Brugia malayi Pre-SET motif family protein 0.0036 0.0092 0.0092
Entamoeba histolytica hexokinase 2 0.1477 1 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0092 0.0092
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0685 0.4554 0.4522
Loa Loa (eye worm) hypothetical protein 0.018 0.1084 0.1084
Echinococcus granulosus hexokinase 0.1477 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0058 0.0058
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0058 0.0058
Trypanosoma cruzi hexokinase, putative 0.1477 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0058 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.047 0.3073 0.3073
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0058 0.0058
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0 0.5
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1811 1
Leishmania major hexokinase, putative 0.1477 1 1
Trypanosoma brucei hexokinase 0.1477 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0058 0.0058
Brugia malayi Hexokinase family protein 0.0457 0.2986 0.2986
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0058 0.0058
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1007 0.6771 0.6771
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0058 0.0058
Entamoeba histolytica hexokinase 1 0.1477 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0058 0.0058
Toxoplasma gondii hexokinase 0.1477 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3683 0.3683
Echinococcus multilocularis hexokinase 0.1477 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3683 0.3683
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0058 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3683 0.3683
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0224 0.0224
Brugia malayi nuclear hormone receptor 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0092 0.0092
Echinococcus granulosus muscleblind protein 0.018 0.1084 0.1084
Brugia malayi Pre-SET motif family protein 0.0251 0.1572 0.1572
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0 0.5
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5574 0.5574
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0058 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0092 0.0092
Brugia malayi nuclear hormone receptor 0.0669 0.4441 0.4441
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0058 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0224 0.0224
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0058 0.0058
Onchocerca volvulus 0.0036 0.0092 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0058 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0058 0.0058
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0058 0.0058
Onchocerca volvulus 0.0927 0.6215 0.6193
Brugia malayi steroid hormone receptor 0.0031 0.0058 0.0058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0058 0.0058
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0058 0.0058
Onchocerca volvulus 0.0286 0.1811 0.1763
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1572 0.1572
Loa Loa (eye worm) hexokinase 0.1477 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Echinococcus granulosus hexokinase type 2 0.1477 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0 0.5
Echinococcus multilocularis hexokinase 0.1477 1 1
Treponema pallidum hexokinase (hxk) 0.1477 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0058 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0092 0.0092
Trypanosoma brucei hexokinase 0.1477 1 1
Leishmania major hexokinase, putative 0.1477 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0224 0.0224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0058 0.0058
Loa Loa (eye worm) hexokinase type II 0.1477 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0224 0.0224
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0058 0.0058
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0058 0.0058
Echinococcus multilocularis muscleblind protein 1 0.018 0.1084 0.1084
Echinococcus granulosus hexokinase 0.1477 1 1
Loa Loa (eye worm) hypothetical protein 0.0654 0.434 0.434
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0058 0.0058
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0058 0.0058
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0058 0.0058
Schistosoma mansoni coup transcription factor 0.0031 0.0058 0.0058
Echinococcus multilocularis hexokinase 0.1477 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0092 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0224 0.0224
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0083 0.0083
Echinococcus multilocularis muscleblind protein 0.018 0.1084 0.1084
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0058 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058
Plasmodium falciparum hexokinase 0.1477 1 1
Loa Loa (eye worm) hexokinase 0.1477 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5574 0.5574
Loa Loa (eye worm) hexokinase 0.0927 0.6215 0.6215
Plasmodium vivax hexokinase, putative 0.1477 1 1
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3683 0.3683
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0058 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0224 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0058 0.0058
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0058 0.0058
Brugia malayi Hexokinase family protein 0.0927 0.6215 0.6215
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0058 0.0058
Onchocerca volvulus 0.1477 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0058 0.0058
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0058 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5574 0.5574
Onchocerca volvulus 0.1477 1 1
Schistosoma mansoni hexokinase 0.1477 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0058 0.0058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0058 0.0058
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0058 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.047 0.3073 0.3073
Onchocerca volvulus 0.1477 1 1
Brugia malayi nuclear receptor NHR-88 0.0031 0.0058 0.0058
Onchocerca volvulus Hexokinase homolog 0.0927 0.6215 0.6193
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0669 0.4441 0.4441
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0058

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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