Detailed information for compound 1275336

Basic information

Technical information
  • TDR Targets ID: 1275336
  • Name: [7-(difluoromethyl)-5-phenylpyrazolo[1,5-a]py rimidin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)m ethanone
  • MW: 404.412 | Formula: C23H18F2N4O
  • H donors: 0 H acceptors: 3 LogP: 4.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1cc(nc2n1ncc2C(=O)N1CCCc2c1cccc2)c1ccccc1)F
  • InChi: 1S/C23H18F2N4O/c24-21(25)20-13-18(15-7-2-1-3-8-15)27-22-17(14-26-29(20)22)23(30)28-12-6-10-16-9-4-5-11-19(16)28/h1-5,7-9,11,13-14,21H,6,10,12H2
  • InChiKey: BXGNSBPSPQYBRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [7-(difluoromethyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)methanone
  • [7-(difluoromethyl)-5-phenyl-3-pyrazolo[1,5-a]pyrimidinyl]-(3,4-dihydro-2H-quinolin-1-yl)methanone
  • ZINC01071487
  • 1-{[7-(difluoromethyl)-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl]carbonyl}-1,2,3,4-tetrahydroquinoline
  • MLS000538002
  • SMR000144239

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0027 0.0031 0.0096
Schistosoma mansoni rotamase 0.0038 0.0116 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0017
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0094 0.0555 0.124
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0163 0.0163
Giardia lamblia Flap structure-specific endonuclease 0.0116 0.0728 0.2422
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0163 0.0163
Schistosoma mansoni heat shock protein 0.0156 0.1042 0.1042
Onchocerca volvulus 0.0043 0.016 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0552 0.1835
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.003 0.0092
Brugia malayi Ets-domain containing protein 0.0036 0.0098 0.0138
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.042 0.042
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0121 0.0266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0017
Trichomonas vaginalis heat shock protein, putative 0.0146 0.0967 0.3222
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0394 0.1847
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0393 0.0393
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0027 0.0031 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0163 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0163 0.021
Schistosoma mansoni chromobox protein 0.0025 0.0013 0.0013
Toxoplasma gondii isocitrate dehydrogenase 0.0104 0.0631 0.1411
Trypanosoma cruzi prolyl endopeptidase 0.0027 0.003 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0116 0.0377
Trypanosoma brucei polo-like protein kinase 0.0404 0.2996 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0923 0.119
Plasmodium falciparum ataxin-2 like protein, putative 0.0141 0.0923 0.2066
Echinococcus granulosus dna polymerase eta 0.0209 0.1463 0.1463
Loa Loa (eye worm) hypothetical protein 0.0155 0.1038 0.1338
Brugia malayi serine/threonine-protein kinase plk-2 0.0404 0.2996 0.4254
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0177 0.1211 0.4038
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0305 0.2216 0.2216
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0103 0.0631 0.2071
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0393 0.0393
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0072 0.0385 0.0859
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0027 0.0031 0.0096
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0394 0.0394
Brugia malayi Flap endonuclease-1 0.0116 0.0728 0.1033
Echinococcus granulosus smad 0.0063 0.031 0.031
Schistosoma mansoni 6-phosphogluconolactonase 0.0027 0.0031 0.0031
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0305 0.2216 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0039 0.0081
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.016 0.016
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0303 0.0673
Mycobacterium tuberculosis Conserved hypothetical protein 0.0124 0.0796 0.3883
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0393 0.0393
Schistosoma mansoni egf-like domain protein 0.003 0.0055 0.0055
Trypanosoma brucei DNA damage repair protein, putative 0.0039 0.0121 0.0396
Trichomonas vaginalis heat shock protein, putative 0.0133 0.0865 0.2882
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0036 0.0098 0.0126
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Echinococcus multilocularis 6 phosphogluconolactonase 0.0027 0.0031 0.0031
Onchocerca volvulus 0.0044 0.0163 0.0502
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.4207 0.4207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0564 0.0564
Brugia malayi nuclear hormone receptor 0.0044 0.0163 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0121 0.0396
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0205
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.4207 0.4207
Echinococcus granulosus ETS domain containing protein Elk 1 0.0036 0.0098 0.0098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0394 0.1665
Trypanosoma cruzi metacaspase, putative 0.0028 0.0039 0.012
Brugia malayi Smad1 0.0063 0.031 0.044
Echinococcus granulosus Chromobox protein 3 0.0025 0.0013 0.0013
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0104 0.0631 0.3051
Loa Loa (eye worm) hypothetical protein 0.0095 0.0562 0.0724
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0046 0.0181 0.0401
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0545 0.4099 0.5821
Loa Loa (eye worm) hypothetical protein 0.0069 0.0363 0.0467
Loa Loa (eye worm) AStacin protease 0.0065 0.033 0.0425
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.007 0.0365 0.1211
Brugia malayi Bromodomain containing protein 0.0062 0.0303 0.043
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0163 0.0231
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0044 0.0164 0.0211
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.016 0.0656
Schistosoma mansoni cpg binding protein 0.0035 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Echinococcus granulosus mothers against decapentaplegic 6 0.0028 0.0038 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0172 0.1172 0.1172
Loa Loa (eye worm) beta-lactamase 0.0043 0.016 0.0205
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0163 0.0163
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Schistosoma mansoni Smad4 0.0028 0.0038 0.0038
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0132 0.0515
Leishmania major heat shock protein, putative 0.0103 0.0631 0.21
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0332 0.243 0.5447
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.016 0.0656
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0104 0.0631 0.0631
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0303 0.039
Loa Loa (eye worm) MH2 domain-containing protein 0.0919 0.7041 0.9077
Toxoplasma gondii ABC1 family protein 0.0043 0.016 0.0352
Loa Loa (eye worm) hypothetical protein 0.0082 0.0461 0.0593
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0305 0.2216 0.7395
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0121 0.0396
Trichomonas vaginalis chromobox protein, putative 0.0152 0.1013 0.3376
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0163 0.0163
Echinococcus multilocularis smad 0.0063 0.031 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.007 0.0365 0.1211
Mycobacterium leprae Probable lipase LipE 0.0043 0.016 0.1381
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0863 0.2875
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.016 0.0592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0564 0.0564
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0404 0.2996 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.007 0.0365 0.0365
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.016 0.0656
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0146 0.0967 0.3222
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0071
Trichomonas vaginalis ran, putative 0.007 0.0365 0.1211
Plasmodium falciparum heat shock protein 90 0.0156 0.1042 0.2333
Echinococcus multilocularis mothers against decapentaplegic 6 0.0028 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Onchocerca volvulus Matrix metalloproteinase homolog 0.0041 0.0142 0.0432
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.033 0.1095
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0109 0.0353
Trypanosoma brucei DNA polymerase IV, putative 0.0147 0.0977 0.3256
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0106 0.065 0.3143
Loa Loa (eye worm) nuclear hormone receptor 0.0211 0.1473 0.1898
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0404 0.2996 0.2996
Loa Loa (eye worm) hypothetical protein 0.01 0.0603 0.0778
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0163 0.0231
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0332 0.243 0.8108
Echinococcus multilocularis isocitrate dehydrogenase 0.0104 0.0631 0.0631
Leishmania major DNA polymerase eta, putative 0.0209 0.1463 0.488
Entamoeba histolytica hypothetical protein 0.0025 0.0013 0.0036
Trypanosoma cruzi polo-like protein kinase, putative 0.0404 0.2996 1
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0047 0.0147
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0027 0.0031 0.0096
Toxoplasma gondii heat shock protein HSP90 0.0156 0.1042 0.2333
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Toxoplasma gondii heat shock protein 90, putative 0.0156 0.1042 0.2333
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0144 0.0954 0.0954
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.007 0.0365 0.0518
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.012
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.003 0.0039
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0305 0.2216 0.7395
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0063 0.0314 0.0314
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0169 0.1149 0.383
Schistosoma mansoni endoplasmin 0.0156 0.1042 0.1042
Trypanosoma brucei chrX additional, unordered contigs 0.0039 0.0121 0.0396
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0124 0.0796 0.0795
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.016 0.0524
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.016 0.016
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0044 0.0164 0.0363
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0163 0.0163
Echinococcus granulosus heat shock protein 90 0.0133 0.0865 0.0865
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0013 0.0024
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0039 0.0081
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0104 0.0631 0.2101
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0205
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0013 0.0013
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0228 0.1608 0.5347
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0116 0.0728 0.1627
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Loa Loa (eye worm) hypothetical protein 0.0044 0.0164 0.0211
Echinococcus granulosus caspase 2 0.0028 0.0039 0.0039
Trypanosoma brucei heat shock protein 84, putative 0.0103 0.0631 0.21
Echinococcus granulosus dna polymerase kappa 0.0155 0.1037 0.1037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0564 0.0564
Loa Loa (eye worm) flap endonuclease-1 0.0116 0.0728 0.0938
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0042 0.0132
Brugia malayi Inositol-1 0.0045 0.0168 0.0239
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0163 0.0163
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0163 0.0163
Brugia malayi prolyl oligopeptidase family protein 0.0169 0.1149 0.1632
Loa Loa (eye worm) helicase 0.0025 0.0013 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0163 0.0163
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.016 0.0592
Trichomonas vaginalis esterase, putative 0.0043 0.016 0.0524
Echinococcus multilocularis flap endonuclease 1 0.0116 0.0728 0.0728
Plasmodium falciparum metacaspase 1 0.0028 0.0039 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Echinococcus granulosus laminin 0.0034 0.0082 0.0082
Schistosoma mansoni kinase 0.0205 0.1433 0.1433
Trypanosoma brucei 6-phosphogluconolactonase 0.0027 0.0031 0.0096
Brugia malayi latrophilin 2 splice variant baaae 0.0372 0.2745 0.3897
Loa Loa (eye worm) XPG I-region family protein 0.0024 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0013 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0013 0.0036
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0109 0.0353
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0039 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.016 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0163 0.0231
Schistosoma mansoni hypothetical protein 0.0172 0.1172 0.1172
Giardia lamblia Heat shock protein HSP 90-alpha 0.0156 0.1042 0.3473
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0146 0.0967 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0141 0.0923 0.3075
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0169 0.1149 0.383
Loa Loa (eye worm) hypothetical protein 0.0545 0.4099 0.5284
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0063 0.031 0.031
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0095 0.0568 0.0568
Schistosoma mansoni caspase-3 (C14 family) 0.0028 0.0039 0.0038
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0163 0.0163
Echinococcus granulosus bloom syndrome protein 0.0107 0.0657 0.0657
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2996 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0044 0.0164 0.0164
Loa Loa (eye worm) fli-1 protein 0.0745 0.5675 0.7316
Loa Loa (eye worm) RNA binding protein 0.0073 0.0393 0.0507
Leishmania major DNA polymerase eta, putative 0.0124 0.0789 0.2627
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.0141 0.0923 0.2066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Echinococcus granulosus chromobox protein 1 0.0152 0.1013 0.1013
Plasmodium vivax heat shock protein 90, putative 0.0103 0.0631 0.1411
Loa Loa (eye worm) prolyl oligopeptidase 0.0228 0.1608 0.2073
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0013 0.0013
Schistosoma mansoni SET domain protein 0.0025 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0172 0.1172 0.1172
Echinococcus multilocularis ewsr:fli fusion protein type 0.0036 0.0098 0.0098
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0109 0.0237
Echinococcus granulosus ewsr:fli fusion protein type 0.0036 0.0098 0.0098
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0063 0.031 0.031
Echinococcus multilocularis GPCR, family 2 0.0172 0.1172 0.1172
Loa Loa (eye worm) hypothetical protein 0.0106 0.0649 0.0837
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0234 0.1655 0.1655
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0104 0.0637 0.0637
Trypanosoma cruzi heat shock protein, putative 0.0103 0.0631 0.21
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0163 0.0163
Echinococcus multilocularis chromobox protein 1 0.0152 0.1013 0.1013
Trichomonas vaginalis endoplasmin, putative 0.0113 0.0706 0.2351
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.009 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0163 0.0231
Echinococcus granulosus ETS transcription factor Elf 2 0.0036 0.0098 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0564 0.0564
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0332 0.243 0.8108
Entamoeba histolytica hypothetical protein 0.0077 0.0421 0.1397
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0039
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0034 0.0082 0.0105
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.007 0.0368 0.0368
Trichomonas vaginalis DNA helicase recq, putative 0.0057 0.0266 0.088
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.016 0.0524
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0027 0.0031 0.0096
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.042 0.042
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0332 0.243 0.5447
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.101 0.7757 1
Echinococcus multilocularis ETS transcription factor Elf 5 0.0036 0.0098 0.0098
Loa Loa (eye worm) glutaminase 0.0289 0.2092 0.2697
Plasmodium vivax endoplasmin, putative 0.0156 0.1042 0.2333
Brugia malayi Endoplasmin precursor 0.0156 0.1042 0.148
Plasmodium falciparum heat shock protein 90, putative 0.059 0.4458 1
Onchocerca volvulus 0.0043 0.016 0.049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0075 0.0242
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0393 0.0507
Loa Loa (eye worm) nuclear factor I 0.0035 0.009 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.003 0.0092
Brugia malayi Fli-1 protein 0.0745 0.5675 0.806
Onchocerca volvulus 0.0043 0.016 0.049
Echinococcus granulosus Dipeptidyl peptidase 9 0.0169 0.1149 0.1149
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2001 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0363 0.1203
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0169 0.1149 0.1149
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0169 0.1149 0.1149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0414 0.0414
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.003 0.0092
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0228 0.1608 0.1608
Brugia malayi Cell death protein 3 precursor 0.0028 0.0039 0.0055
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0305 0.2216 0.2216
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.016 0.0159
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0163 0.0163
Trypanosoma brucei DNA polymerase IV, putative 0.0155 0.1037 0.3456
Schistosoma mansoni blooms syndrome DNA helicase 0.0084 0.0481 0.048
Brugia malayi MH1 domain containing protein 0.0063 0.031 0.044
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Brugia malayi MH1 domain containing protein 0.0063 0.031 0.044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0003
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0132 0.0855 0.2849
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.003 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.2996 0.2996
Schistosoma mansoni ran 0.007 0.0365 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0168 0.0168
Echinococcus multilocularis GTP binding nuclear protein Ran 0.007 0.0365 0.0365
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0353 0.0785
Echinococcus granulosus dnaJ subfamily B 0.0494 0.37 0.37
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0564 0.0727
Loa Loa (eye worm) glutaminase 2 0.0289 0.2092 0.2697
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0177 0.1211 0.4038
Brugia malayi hypothetical protein 0.0025 0.0013 0.0019
Echinococcus granulosus Chromo domain 0.0025 0.0013 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0393 0.0393
Brugia malayi isocitrate dehydrogenase 0.0104 0.0631 0.0896
Trypanosoma brucei metacaspase MCA2 0.0028 0.0039 0.012
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.003 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.012
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0124 0.0789 0.1765
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0199 0.1384 0.6194
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Schistosoma mansoni DNA polymerase eta 0.0209 0.1463 0.1463
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0013 0.0036
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0115 0.0719 0.1607
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0027 0.0031 0.0096
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0109 0.0353
Schistosoma mansoni chromobox protein 0.0152 0.1013 0.1013
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0163 0.0163
Brugia malayi hypothetical protein 0.0088 0.0506 0.0719
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0168 0.0168
Onchocerca volvulus 0.0155 0.1038 0.3435
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Schistosoma mansoni hypothetical protein 0.1295 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0124 0.0789 0.2627
Mycobacterium ulcerans lipase LipD 0.0043 0.016 0.0592
Brugia malayi Latrophilin receptor protein 2 0.0172 0.1172 0.1665
Mycobacterium ulcerans hypothetical protein 0.0043 0.016 0.0592
Plasmodium vivax flap endonuclease 1, putative 0.0116 0.0728 0.1627
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0132 0.0855 0.4187
Schistosoma mansoni hypothetical protein 0.0372 0.2745 0.2744
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0017
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Leishmania major hypothetical protein, conserved 0.0141 0.0923 0.3075
Brugia malayi Hemopexin family protein 0.0026 0.0025 0.0035
Plasmodium vivax ataxin-2 like protein, putative 0.0141 0.0923 0.2066
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Toxoplasma gondii Hsp90 domain-containing protein 0.059 0.4458 1
Leishmania major GTP-binding protein, putative 0.007 0.0365 0.1211
Plasmodium falciparum importin beta, putative 0.0095 0.0562 0.1254
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.007 0.0365 0.1211
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1391 0.4638
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0039
Brugia malayi beta-lactamase family protein 0.0043 0.016 0.0226
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.016 0.0226
Brugia malayi Isocitrate dehydrogenase 0.0104 0.0631 0.0896
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0057 0.0266 0.088
Trypanosoma cruzi heat shock protein 90, putative 0.0156 0.1042 0.3473
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0168 0.0554
Entamoeba histolytica heat shock protein 90, putative 0.0156 0.1042 0.3473
Loa Loa (eye worm) hypothetical protein 0.0095 0.0568 0.0732
Toxoplasma gondii calcium binding egf domain-containing protein 0.0034 0.0082 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0163 0.0231
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Brugia malayi mothers against decapentaplegic homolog 3 0.0028 0.0038 0.0053
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis DNA polymerase eta, putative 0.0155 0.1037 0.3456
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0116 0.0728 0.2422
Echinococcus granulosus GA binding protein alpha chain 0.0245 0.1747 0.1747
Schistosoma mansoni ets 0.0036 0.0098 0.0097
Loa Loa (eye worm) endoplasmin 0.0156 0.1042 0.1343
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.0488 0.1591
Brugia malayi MH1 domain containing protein 0.0035 0.009 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2996 1
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0305 0.2216 1
Mycobacterium ulcerans heat shock protein 90 0.0146 0.0967 0.4286
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0027 0.003 0.0092
Treponema pallidum heat shock protein 90 0.0146 0.0967 0.4283
Trypanosoma cruzi metacaspase, putative 0.0028 0.0039 0.012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0273 0.1961 0.1961
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0116 0.0164
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0163 0.0163
Echinococcus granulosus endoplasmin 0.0146 0.0967 0.0967
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0303 0.0673
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0013 0.0019
Plasmodium falciparum endoplasmin, putative 0.0113 0.0706 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Schistosoma mansoni heat shock protein 0.0103 0.0631 0.0631
Trichomonas vaginalis DNA helicase recq1, putative 0.0107 0.0657 0.2186
Brugia malayi XPG I-region family protein 0.0024 0.0003 0.0004
Echinococcus granulosus mothers against decapentaplegic 5 0.0063 0.031 0.031
Brugia malayi Bloom's syndrome protein homolog 0.0107 0.0657 0.0933
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0133 0.0865 0.0865
Schistosoma mansoni transcription factor LCR-F1 0.0273 0.1961 0.1961
Schistosoma mansoni importin beta-1 0.0095 0.0562 0.0561
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0163 0.0163
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0172 0.1172 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.012
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0044 0.0166 0.0546
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.003 0.003
Trichomonas vaginalis heat shock protein, putative 0.0091 0.053 0.176
Loa Loa (eye worm) heterochromatin protein 1 0.0152 0.1013 0.1306
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Leishmania major metacaspase, putative 0.0028 0.0039 0.012
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Onchocerca volvulus Matrilysin homolog 0.0118 0.0746 0.2457
Trypanosoma cruzi DNA damage repair protein, putative 0.0039 0.0121 0.0396
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0104 0.0637 0.0821
Echinococcus multilocularis laminin 0.0034 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0038 0.0037
Trichomonas vaginalis heat shock protein, putative 0.0146 0.0967 0.3222
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0163 0.0231
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.016 0.0524
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0172 0.1172 0.1172
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0393 0.0393
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0195
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0013 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0039 0.0081
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0393 0.0558
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.4207 0.4207
Echinococcus granulosus flap endonuclease GEN 1 0.0024 0.0003 0.0003
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0169 0.1149 0.383
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0024 0.0003 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0209 0.1463 0.488
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0028 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0077 0.042 0.0597
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0063 0.0314 0.0314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0075 0.0242
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0163 0.0163
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0013 0.0013
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0132 0.1083
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2996 1
Plasmodium falciparum heat shock protein 90, putative 0.0091 0.053 0.1182
Schistosoma mansoni 6-phosphogluconolactonase 0.0027 0.0031 0.0031
Entamoeba histolytica deoxycytidyl transferase, putative 0.0124 0.0796 0.2649
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0303 0.0302
Trichomonas vaginalis glutaminase, putative 0.0289 0.2092 0.6981
Echinococcus multilocularis exonuclease 1 0.0024 0.0003 0.0003
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0104 0.0631 0.2101
Schistosoma mansoni inositol monophosphatase 0.0045 0.0168 0.0168
Echinococcus granulosus 6 phosphogluconolactonase 0.0027 0.0031 0.0031
Echinococcus granulosus heat shock protein 0.0156 0.1042 0.1042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0163 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0163 0.0163
Plasmodium vivax DNA repair protein REV1, putative 0.0039 0.0121 0.0266
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.007 0.0365 0.047
Echinococcus granulosus ETS transcription factor Elf 5 0.0036 0.0098 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2996 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Schistosoma mansoni smad 0.0063 0.031 0.031
Brugia malayi transcription factor E74 isoform 0.0036 0.0098 0.0138
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0027 0.0031 0.0096
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0104 0.0631 0.1411
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0199 0.1384 0.31
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0028 0.0039 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0163 0.0231
Schistosoma mansoni hypothetical protein 0.1295 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.042 0.042
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.016 0.0656
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0044 0.0164 0.0164
Onchocerca volvulus Alhambra homolog 0.0062 0.0303 0.097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0273 0.1961 0.1961
Loa Loa (eye worm) heat shock protein 75 0.0103 0.0631 0.0813
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0027 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0163 0.0231
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.003 0.0055 0.0071
Plasmodium falciparum flap endonuclease 1 0.0116 0.0728 0.1627
Brugia malayi hypothetical protein 0.0091 0.0531 0.0754
Trypanosoma cruzi DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0013 0.0024
Schistosoma mansoni hypothetical protein 0.0062 0.0303 0.0302
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.016 0.0656
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0104 0.0631 0.0631
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0168 0.0632
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0109 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0488 0.1621
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0124 0.0796 0.0796
Schistosoma mansoni glutaminase 0.0289 0.2092 0.2092
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0027 0.0031 0.0005
Trypanosoma brucei heat shock protein 90, putative 0.0156 0.1042 0.3473
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0303 0.039
Onchocerca volvulus Prolyl endopeptidase homolog 0.0027 0.003 0.0056
Brugia malayi beta-lactamase family protein 0.0043 0.016 0.0226
Giardia lamblia NADPH oxidoreductase, putative 0.0177 0.1211 0.4038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0168 0.0554
Loa Loa (eye worm) transcription factor SMAD2 0.0919 0.7041 0.9077
Schistosoma mansoni hypothetical protein 0.0036 0.0098 0.0097
Trypanosoma brucei unspecified product 0.0086 0.0492 0.1635
Plasmodium falciparum peptidase, putative 0.0027 0.003 0.0062
Echinococcus granulosus cpg binding protein 0.0037 0.0106 0.0106
Echinococcus multilocularis ETS transcription factor Elf 2 0.0036 0.0098 0.0098
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.003 0.0055 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0163 0.0231
Giardia lamblia Heat shock protein HSP 90-alpha 0.0133 0.0865 0.2882
Brugia malayi heat shock protein 90 0.0156 0.1042 0.148
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.0819 0.1056
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0163 0.0163
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0163 0.021
Brugia malayi Ets-domain containing protein 0.0245 0.1747 0.2481
Leishmania major DNA damage repair protein, putative 0.0039 0.0121 0.0396
Trypanosoma cruzi heat shock protein 90, putative 0.0133 0.0865 0.2882
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0077 0.0421 0.1397
Echinococcus multilocularis mothers against decapentaplegic 2 0.0028 0.0038 0.0038
Trypanosoma cruzi oligopeptidase b 0.0027 0.003 0.0092
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Trypanosoma brucei DNA polymerase IV, putative 0.0155 0.1037 0.3456
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0163 0.0163
Trichomonas vaginalis heat shock protein, putative 0.0156 0.1042 0.3473
Loa Loa (eye worm) hypothetical protein 0.021 0.1467 0.1891
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0163 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0855 0.2849
Echinococcus multilocularis mothers against decapentaplegic 5 0.0063 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0273 0.1961 0.1961
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0393 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0075 0.0242
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0172 0.1172 0.1665
Echinococcus granulosus caspase 8 0.0028 0.0039 0.0039
Echinococcus granulosus flap endonuclease 1 0.0116 0.0728 0.0728
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.37 0.37
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Leishmania major oligopeptidase b 0.0027 0.003 0.0092
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0028 0.0038 0.0082
Echinococcus multilocularis caspase 8 0.0028 0.0039 0.0039
Loa Loa (eye worm) ets-domain-containing protein 0.0036 0.0098 0.0126
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0172 0.1172 0.1511
Echinococcus multilocularis heat shock protein 90 0.0133 0.0865 0.0865
Schistosoma mansoni cpg binding protein 0.0037 0.0106 0.0106
Trichomonas vaginalis heat shock protein, putative 0.0113 0.0706 0.2351
Brugia malayi Steroid receptor seven-up type 2 0.0234 0.1655 0.2351
Echinococcus multilocularis dna polymerase eta 0.0209 0.1463 0.1463
Giardia lamblia NADPH oxidoreductase, putative 0.0177 0.1211 0.4038
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0124 0.0796 0.0796
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0024 0.0003 0.0003
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0104 0.0631 0.0631
Entamoeba histolytica hypothetical protein 0.0273 0.1961 0.6543
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0104 0.0631 0.2101
Entamoeba histolytica serine/threonine protein kinase, putative 0.0404 0.2996 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.016 0.0656
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.016 0.0159
Toxoplasma gondii prolyl endopeptidase 0.0027 0.003 0.0062
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.003 0.0092
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Trypanosoma brucei heat shock protein 90, putative 0.0156 0.1042 0.3473
Trypanosoma cruzi heat shock protein 85, putative 0.0156 0.1042 0.3473
Schistosoma mansoni cpg binding protein 0.0037 0.0106 0.0106
Trypanosoma cruzi Heat shock protein 83, putative 0.0156 0.1042 0.3473
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0013 0.0036
Entamoeba histolytica hypothetical protein 0.0025 0.0013 0.0036
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0116 0.0149
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0013 0.0024
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0163 0.0502
Brugia malayi ImpB/MucB/SamB family protein 0.0124 0.0796 0.113
Loa Loa (eye worm) Smad1 0.0063 0.031 0.0399
Entamoeba histolytica recQ family helicase, putative 0.0057 0.0266 0.088
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Echinococcus granulosus tar DNA binding protein 0.0073 0.0393 0.0393
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0036 0.0098 0.0098
Trypanosoma brucei unspecified product 0.0147 0.0977 0.3256
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0027 0.0031 0.004
Loa Loa (eye worm) heat shock protein 90 0.0156 0.1042 0.1343
Plasmodium falciparum DNA repair protein REV1, putative 0.0039 0.0121 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.012
Plasmodium vivax heat shock protein 86, putative 0.0156 0.1042 0.2333
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.007 0.0368 0.0368
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0163 0.0163
Brugia malayi chromobox protein homolog 3 0.0085 0.0488 0.0693
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0393 0.0507
Schistosoma mansoni inositol monophosphatase 0.0045 0.0168 0.0168
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0013 0.0036
Schistosoma mansoni Smad4 0.0063 0.031 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0013 0.0019
Mycobacterium leprae conserved hypothetical protein 0.0043 0.016 0.1381
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0098 0.0589 0.196
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0109 0.0353
Echinococcus multilocularis chromobox protein 1 0.0152 0.1013 0.1013
Brugia malayi nuclear receptor NHR-88 0.0044 0.0163 0.0231
Trypanosoma brucei metacaspase 5, putative 0.0028 0.0039 0.012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0071 0.0379 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Brugia malayi ImpB/MucB/SamB family protein 0.0209 0.1463 0.2078
Brugia malayi CHD4 protein 0.0027 0.0029 0.0041
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.003 0.0092
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.0039 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0163 0.0231
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0332 0.243 0.8108
Loa Loa (eye worm) MH2 domain-containing protein 0.0063 0.031 0.0399
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0168 0.0554
Echinococcus multilocularis importin subunit beta 1 0.0095 0.0562 0.0562
Trypanosoma brucei oligopeptidase b 0.0027 0.003 0.0092
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.003 0.0062
Echinococcus multilocularis Chromo domain 0.0025 0.0013 0.0013
Echinococcus granulosus expressed protein 0.0038 0.0116 0.0116
Entamoeba histolytica hypothetical protein 0.0044 0.0166 0.0546
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0075 0.0242
Trypanosoma brucei importin beta-1 subunit, putative 0.0095 0.0562 0.1867
Echinococcus multilocularis dna polymerase kappa 0.0155 0.1037 0.1037
Loa Loa (eye worm) MH1 domain-containing protein 0.0028 0.0038 0.0048
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0104 0.0631 0.1411
Schistosoma mansoni coup transcription factor 0.0044 0.0163 0.0163
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0013 0.0036
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.003 0.0092
Brugia malayi hypothetical protein 0.0141 0.0923 0.1311
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0303 0.0303
Trypanosoma brucei Heat shock protein 83, putative 0.0156 0.1042 0.3473
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0049
Schistosoma mansoni hypothetical protein 0.0063 0.0314 0.0313
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0092 0.0539 0.1761
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.016 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0292 0.0967
Toxoplasma gondii HEAT repeat-containing protein 0.0095 0.0562 0.1254
Schistosoma mansoni hypothetical protein 0.101 0.7757 0.7757
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0205
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0013 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Giardia lamblia PHD finger protein 15 0.0062 0.0303 0.1002
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Schistosoma mansoni hypothetical protein 0.0026 0.0025 0.0025
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0044 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0372 0.2745 0.3538
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0121 0.0396
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0394 0.1665
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0163 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0564 0.0564
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0163 0.0163
Echinococcus granulosus TGF beta signal transducer SmadC 0.0063 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0172 0.1172 0.1172
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.042 0.0542
Trypanosoma cruzi metacaspase, putative 0.0028 0.0039 0.012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0163 0.0163
Echinococcus granulosus Smad4 0.0063 0.031 0.031
Echinococcus granulosus peregrin 0.0082 0.0461 0.0461
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0027 0.0031 0.0096
Schistosoma mansoni hypothetical protein 0.0172 0.1172 0.1172
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2996 1
Trichomonas vaginalis chromobox protein, putative 0.0152 0.1013 0.3376
Echinococcus multilocularis caspase 2 0.0028 0.0039 0.0039
Echinococcus multilocularis heat shock protein 90 0.0156 0.1042 0.1042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0168 0.0554
Mycobacterium tuberculosis Conserved protein 0.0043 0.016 0.0656
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0163 0.021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0172 0.1172 0.1172
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0104 0.0631 0.0631
Loa Loa (eye worm) inositol-1 0.0045 0.0168 0.0217
Loa Loa (eye worm) hypothetical protein 0.0537 0.4043 0.5211
Schistosoma mansoni endoplasmin 0.0156 0.1042 0.1042
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0405 0.0405
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0039 0.0038
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0078 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0075 0.0242
Loa Loa (eye worm) D-ets-2 protein 0.0036 0.0098 0.0126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0017
Toxoplasma gondii isocitrate dehydrogenase 0.0104 0.0631 0.1411
Brugia malayi CXXC zinc finger family protein 0.0035 0.009 0.0128
Brugia malayi MH2 domain containing protein 0.0063 0.031 0.044
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0163 0.0163
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.016 0.0205
Echinococcus multilocularis endoplasmin 0.0146 0.0967 0.0967
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0039 0.012
Echinococcus granulosus importin subunit beta 1 0.0095 0.0562 0.0562
Echinococcus multilocularis heat shock protein 0.0156 0.1042 0.1042
Echinococcus multilocularis flap endonuclease GEN 1 0.0024 0.0003 0.0003
Brugia malayi Matrixin family protein 0.0122 0.0775 0.1101
Brugia malayi ecdysteroid receptor 0.0044 0.0163 0.0231
Echinococcus granulosus snurportin 1 0.101 0.7757 0.7757
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2996 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0332 0.243 0.8108
Brugia malayi Hsp90 protein 0.0103 0.0631 0.0896
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0013 0.0036
Trypanosoma cruzi heat shock protein 85, putative 0.0133 0.0865 0.2882
Giardia lamblia Sgs1 DNA helicase, putative 0.0044 0.0164 0.054
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0168 0.0554
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.016 0.0524
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0044 0.0164 0.0233
Schistosoma mansoni Smad4 0.0028 0.0038 0.0038
Giardia lamblia DINP protein human, muc B family 0.0132 0.0855 0.2849
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0155 0.1037 0.3456
Plasmodium vivax metacaspase 1, putative 0.0028 0.0039 0.0081
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0027 0.0031 0.0096
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0013 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0017
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0177 0.1211 0.4038
Brugia malayi TAR-binding protein 0.0073 0.0393 0.0558
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0013 0.0019
Trypanosoma brucei metacaspase MCA3 0.0028 0.0039 0.012
Echinococcus granulosus ETS transcription factor Elf 2 0.0036 0.0098 0.0098
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0163 0.0163
Trypanosoma brucei PAB1-binding protein , putative 0.0141 0.0923 0.3075
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0121 0.0396
Schistosoma mansoni exonuclease 0.0024 0.0003 0.0002
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0036 0.0098 0.0097
Schistosoma mansoni ets-related 0.0036 0.0098 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Loa Loa (eye worm) hypothetical protein 0.0085 0.0488 0.0629
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0163 0.0163
Trypanosoma cruzi DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Echinococcus multilocularis fibrillin 1 0.0034 0.0082 0.0082
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0044 0.0164 0.0363
Loa Loa (eye worm) MH2 domain-containing protein 0.0028 0.0038 0.0048
Trypanosoma brucei metacaspase 0.0028 0.0039 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0305 0.2216 0.7395
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0029 0.0029
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0103 0.0631 0.0631
Schistosoma mansoni SET domain protein 0.007 0.0368 0.0368
Loa Loa (eye worm) matrixin family protein 0.0122 0.0775 0.0999
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0039 0.0081
Echinococcus multilocularis expressed protein 0.0038 0.0116 0.0116
Mycobacterium ulcerans DNA polymerase IV 0.0155 0.1037 0.4607
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0071
Echinococcus granulosus prolyl endopeptidase 0.0027 0.003 0.003
Trypanosoma cruzi heat shock protein 85, putative 0.0156 0.1042 0.3473
Brugia malayi MH2 domain containing protein 0.0063 0.031 0.044
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Toxoplasma gondii hypothetical protein 0.0027 0.003 0.0062
Trypanosoma brucei unspecified product 0.0086 0.0492 0.1635
Trypanosoma cruzi metacaspase, putative 0.0028 0.0039 0.012
Echinococcus multilocularis protein C ets 2 0.0036 0.0098 0.0098
Schistosoma mansoni flap endonuclease-1 0.0105 0.064 0.064
Brugia malayi hypothetical protein 0.0155 0.1038 0.1474
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0104 0.0631 0.2101
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0163 0.0163
Trichomonas vaginalis rotamase, putative 0.0038 0.0116 0.0377
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0124 0.0796 0.1025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.016 0.0656
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.007 0.0365 0.0813
Schistosoma mansoni hypothetical protein 0.0025 0.0013 0.0013
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0013 0.0036
Echinococcus multilocularis peregrin 0.0082 0.0461 0.0461
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0024 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Trypanosoma cruzi DNA polymerase eta, putative 0.0209 0.1463 0.488
Brugia malayi polk-prov protein 0.0069 0.0363 0.0515
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0044 0.0166 0.0546
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0044 0.0164 0.0233
Entamoeba histolytica hypothetical protein 0.0025 0.0013 0.0036
Trypanosoma brucei Metacaspase-4 0.0028 0.0039 0.012
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0404 0.2996 0.3862
Toxoplasma gondii LsmAD domain-containing protein 0.0141 0.0923 0.2066
Brugia malayi MH2 domain containing protein 0.0028 0.0038 0.0053
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0013 0.0013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Echinococcus multilocularis caspase 0.0028 0.0039 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0075 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2996 1
Brugia malayi hypothetical protein 0.0273 0.1961 0.2785
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.003 0.0092
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0116 0.0728 0.2422
Leishmania major importin beta-1 subunit, putative 0.0077 0.0421 0.1397
Entamoeba histolytica Flap nuclease, putative 0.0116 0.0728 0.2422
Schistosoma mansoni ran 0.007 0.0365 0.0365
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0169 0.1149 0.383
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0163 0.021
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0168 0.0554
Brugia malayi MH2 domain containing protein 0.0919 0.7041 1
Echinococcus granulosus caspase 0.0028 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.012
Trichomonas vaginalis importin beta-1, putative 0.0077 0.0421 0.1397
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0013 0.0024
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0213 0.1492 0.1924
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Plasmodium vivax hypothetical protein, conserved 0.0027 0.003 0.0062
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.003 0.0092
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0027 0.0031 0.0096
Plasmodium falciparum phd finger protein, putative 0.0062 0.0303 0.0673
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0013 0.0036
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0013 0.0036
Echinococcus granulosus ETS transcription factor Elf 1 0.0036 0.0098 0.0098
Trichomonas vaginalis rotamase, putative 0.0037 0.0109 0.0353
Leishmania major hypothetical protein, conserved 0.0043 0.016 0.0524
Schistosoma mansoni smad1 5 8 and 0.0063 0.031 0.031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0545 0.4099 0.5284
Trypanosoma brucei DNA damage repair protein, putative 0.0039 0.0121 0.0396
Echinococcus granulosus exonuclease 1 0.0024 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0163 0.021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0205
Schistosoma mansoni hypothetical protein 0.0036 0.0098 0.0097
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Echinococcus multilocularis cpg binding protein 0.0037 0.0106 0.0106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0062 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0141 0.0923 0.3075
Entamoeba histolytica hypothetical protein 0.0273 0.1961 0.6543
Brugia malayi 6-phosphogluconolactonase family protein 0.0027 0.0031 0.0044
Entamoeba histolytica hypothetical protein 0.0273 0.1961 0.6543
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0029 0.0029
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.0039 0.0055
Echinococcus granulosus mothers against decapentaplegic 2 0.0028 0.0038 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0168 0.0554
Echinococcus multilocularis bloom syndrome protein 0.0107 0.0657 0.0657
Echinococcus multilocularis geminin 0.1295 1 1
Onchocerca volvulus 0.0067 0.0343 0.1105
Echinococcus granulosus protein C ets 2 0.0036 0.0098 0.0098
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0027 0.0031 0.0096
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0234 0.1655 0.1655
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Trichomonas vaginalis chromobox protein, putative 0.0092 0.0539 0.1791
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0013 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0552 0.1835
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0057 0.0266 0.088
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0017
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Schistosoma mansoni DNA polymerase IV / kappa 0.0039 0.0121 0.0121
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0202 0.1406 0.1406
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0146 0.0967 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0095 0.0562 0.1867
Onchocerca volvulus 0.0028 0.0038 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0144 0.0954 0.0954
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.0612 0.2037
Schistosoma mansoni DNA helicase recq1 0.0044 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0209 0.1463 0.1886
Mycobacterium ulcerans DNA polymerase IV 0.0155 0.1037 0.4607
Brugia malayi Fibulin-1 precursor 0.0034 0.0082 0.0116
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0044 0.0166 0.0546
Trypanosoma cruzi polo-like protein kinase, putative 0.0404 0.2996 1
Entamoeba histolytica Ran family GTPase 0.007 0.0365 0.1211
Brugia malayi RNA binding protein 0.0073 0.0393 0.0558
Onchocerca volvulus 0.0035 0.009 0.0258
Schistosoma mansoni elf1 0.0036 0.0098 0.0097
Loa Loa (eye worm) RecQ helicase 0.0107 0.0657 0.0847
Trichomonas vaginalis CAMK family protein kinase 0.02 0.1391 0.4638
Echinococcus granulosus chromobox protein 1 0.0152 0.1013 0.1013
Leishmania major DNA polymerase kappa, putative 0.0132 0.0855 0.2849
Giardia lamblia DNA damage repair protein 0.0039 0.0121 0.0396
Trypanosoma cruzi heat shock protein 85, putative 0.0156 0.1042 0.3473
Schistosoma mansoni jumonji domain containing protein 0.0161 0.108 0.1079
Loa Loa (eye worm) latrophilin receptor protein 2 0.0172 0.1172 0.1511
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0394 0.1308
Echinococcus multilocularis snurportin 1 0.101 0.7757 0.7757
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0126
Echinococcus multilocularis GA binding protein alpha chain 0.0245 0.1747 0.1747
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.0493 0.0493
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.003 0.0092
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0394 0.0394
Entamoeba histolytica heat shock protein 90, putative 0.0156 0.1042 0.3473
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0029 0.0037
Plasmodium falciparum metacaspase-like protein 0.0028 0.0039 0.0081
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0228 0.1608 0.1608
Loa Loa (eye worm) hypothetical protein 0.0067 0.0343 0.0442
Echinococcus granulosus heat shock protein 90 0.0156 0.1042 0.1042
Giardia lamblia Grp94/Hsp90 0.0146 0.0967 0.3222
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0404 0.2996 0.2996
Echinococcus multilocularis ets variant gene 4 0.0036 0.0098 0.0098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0044 0.0164 0.0363
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.003 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0082 0.0116
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.0044 0.0163 0.021
Schistosoma mansoni hypothetical protein 0.0494 0.37 0.37
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.003 0.0092
Mycobacterium ulcerans glutaminase 0.0289 0.2092 0.9433
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0169 0.1149 0.383
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0029 0.0029
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0104 0.0631 0.2101
Entamoeba histolytica hypothetical protein 0.0273 0.1961 0.6543
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.003 0.0043
Trypanosoma cruzi importin beta-1 subunit, putative 0.0077 0.0421 0.1397
Brugia malayi Importin beta-1 subunit 0.0095 0.0562 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0039 0.012
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0228 0.1608 0.1608
Brugia malayi beta-lactamase 0.0043 0.016 0.0226
Brugia malayi MH1 domain containing protein 0.0035 0.009 0.0127
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0088 0.0506 0.0652
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1211 0.4038
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0305 0.2216 0.2216
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0048
Schistosoma mansoni chromobox protein 0.0025 0.0013 0.0013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0168 0.0554
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Brugia malayi RNA, U transporter 1 0.0269 0.1933 0.2745
Loa Loa (eye worm) MH1 domain-containing protein 0.0063 0.031 0.0399
Mycobacterium ulcerans hypothetical protein 0.0039 0.0121 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0155 0.1037 0.3456
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0488 0.1621
Brugia malayi prolyl oligopeptidase family protein 0.0228 0.1608 0.2283
Schistosoma mansoni terminal deoxycytidyl transferase 0.0124 0.0796 0.0795
Schistosoma mansoni smad1 5 8 and 0.0063 0.031 0.031
Brugia malayi Ets-domain containing protein 0.0245 0.1747 0.2481
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0043 0.016 0.0352
Leishmania major DNA polymerase kappa, putative 0.0039 0.0121 0.0396
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0163 0.0502
Trichomonas vaginalis DNA helicase recq, putative 0.0107 0.0657 0.2186
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0036
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0303 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0163 0.0231
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0104 0.0631 0.0631
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.003 0.0092
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0146 0.0967 0.4753
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Echinococcus multilocularis prolyl endopeptidase 0.0027 0.003 0.003
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0013 0.0013
Echinococcus granulosus Tolloid protein 1 0.0104 0.0637 0.0637
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0168 0.0372
Schistosoma mansoni ets-related 0.0745 0.5675 0.5675
Brugia malayi glutaminase DH11.1 0.0289 0.2092 0.2971
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.003 0.0092
Schistosoma mansoni chromobox protein 0.0152 0.1013 0.1013
Trypanosoma cruzi oligopeptidase b 0.0027 0.003 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0166 0.0546
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0044 0.0164 0.0164
Echinococcus granulosus chromobox protein 2 0.0025 0.0013 0.0013
Plasmodium vivax heat shock protein, putative 0.059 0.4458 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.003 0.003
Trypanosoma brucei prolyl endopeptidase 0.0027 0.003 0.0092
Brugia malayi steroid hormone receptor 0.0044 0.0163 0.0231
Trichomonas vaginalis hypothetical protein 0.0025 0.0013 0.0036
Echinococcus multilocularis Tolloid protein 1 0.0104 0.0637 0.0637
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.016 0.0524
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.007 0.0365 0.0813
Brugia malayi Protein cec-1. 0.0025 0.0013 0.0019
Echinococcus multilocularis Smad4 0.0063 0.031 0.031
Schistosoma mansoni gabp alpha 0.0245 0.1747 0.1747
Brugia malayi glucose-6-phosphate dehydrogenase 0.0305 0.2216 0.3147
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.003 0.0092
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.007 0.0365 0.1211
Brugia malayi DNA-binding protein D-ETS-3 0.0036 0.0098 0.0138
Plasmodium vivax importin-beta 2, putative 0.0095 0.0562 0.1254
Brugia malayi Heterochromatin protein 1 0.0152 0.1013 0.1439
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0202 0.1406 0.1406
Echinococcus granulosus GPCR family 2 0.0172 0.1172 0.1172
Schistosoma mansoni heat shock protein 0.0156 0.1042 0.1042
Brugia malayi PHD-finger family protein 0.0062 0.0303 0.043
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.0166 0.0546
Schistosoma mansoni smad1 5 8 and 0.0063 0.031 0.031
Trichomonas vaginalis flap endonuclease-1, putative 0.0116 0.0728 0.2422
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0126
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0039 0.012
Leishmania major heat shock protein 83-1 0.0156 0.1042 0.3473
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0049
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0163 0.0163
Giardia lamblia Kinase, PLK 0.0404 0.2996 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0104 0.0631 0.0631
Toxoplasma gondii heat shock protein 75, putative 0.0103 0.0631 0.1411
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0116 0.0728 0.2422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0205
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0245 0.1747 0.2252
Trypanosoma brucei heat shock protein, putative 0.0156 0.1042 0.3473
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0363 0.1203
Leishmania major 6-phosphogluconolactonase 0.0027 0.0031 0.0096
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0024 0.0003 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0077 0.0421 0.1397
Trichomonas vaginalis chromobox protein, putative 0.0092 0.0539 0.1791
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0057 0.0266 0.088
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.007 0.0365 0.0813
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0103 0.0631 0.21
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0163 0.021
Loa Loa (eye worm) isocitrate dehydrogenase 0.0104 0.0631 0.0814
Echinococcus granulosus neuropeptide s receptor 0.0558 0.4207 0.4207
Onchocerca volvulus Arrow homolog 0.003 0.0055 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0163 0.021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0075 0.0242
Onchocerca volvulus Serine\/threonine kinase homolog 0.0404 0.2996 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0564 0.0801
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0305 0.2216 0.2856
Toxoplasma gondii calcium binding egf domain-containing protein 0.0034 0.0082 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0075 0.0242
Schistosoma mansoni DNA helicase recq5 0.0044 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0292 0.0967
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0163 0.0502
Echinococcus granulosus jumonji domain containing protein 0.0086 0.0493 0.0493
Echinococcus multilocularis ETS transcription factor Elf 1 0.0036 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0552 0.1835
Trypanosoma cruzi DNA damage repair protein, putative 0.0039 0.0121 0.0396
Schistosoma mansoni smad 0.0028 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0163 0.0231
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0039 0.012
Echinococcus multilocularis ETS transcription factor Elf 2 0.0036 0.0098 0.0098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0545 0.4099 0.5821
Mycobacterium tuberculosis Conserved protein 0.0043 0.016 0.0656
Onchocerca volvulus 0.0026 0.0025 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0564 0.0564
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0305 0.2216 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0103 0.0631 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.003 0.0092
Loa Loa (eye worm) matrixin family protein 0.0041 0.0142 0.0183
Brugia malayi SET domain containing protein 0.0028 0.0038 0.0053
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.003 0.0092
Mycobacterium ulcerans beta-lactamase 0.0043 0.016 0.0592
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0394 0.0879
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0394 0.1665
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.016 0.0656
Brugia malayi jmjC domain containing protein 0.0202 0.1406 0.1997
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.016 0.0524
Giardia lamblia NADPH oxidoreductase, putative 0.0177 0.1211 0.4038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0163 0.021
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0332 0.243 0.5447
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0013 0.0024
Echinococcus multilocularis chromobox protein 2 0.0025 0.0013 0.0013
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0036 0.0098 0.0126
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.003 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0303 0.0673

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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