Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.5654 | 0.5654 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0743 | 0.0743 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0135 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.803 | 0.803 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0743 | 0.0743 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1382 | 0.1382 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0743 | 0.0743 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.803 | 0.803 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0743 | 0.0743 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0743 | 0.0743 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 1 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0743 | 0.0743 |
Loa Loa (eye worm) | carboxylesterase | 0.0135 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2522 | 0.2522 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0135 | 1 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.3758 | 0.3758 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.803 | 0.803 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2936 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.