TDR Targets

Basic information

Technical information

TDR Targets ID: 1275610
Name: 2-piperazin-1-yl-4,6-di(piperidin-1-yl)-1,3,5 -triazine
MW: 331.459 | Formula: C17H29N7
H donors: 1 H acceptors: 3 LogP: 2.38 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C1CCN(CC1)c1nc(nc(n1)N1CCNCC1)N1CCCCC1
InChi: 1S/C17H29N7/c1-3-9-22(10-4-1)15-19-16(23-11-5-2-6-12-23)21-17(20-15)24-13-7-18-8-14-24/h18H,1-14H2
InChiKey: OURNSQBCMZOFSW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-piperazin-1-yl-4,6-bis(1-piperidyl)-1,3,5-triazine
2-(1-piperazinyl)-4,6-bis(1-piperidyl)-1,3,5-triazine
2-piperazin-1-yl-4,6-dipiperidino-s-triazine
SMR000012202
ChemDiv1_009522
2-Piperazin-1-yl-4,6-di-piperidin-1-yl-[1,3,5]triazine
MLS000026815
BAS 03320261
2-(1-piperazinyl)-4,6-di(1-piperidinyl)-1,3,5-triazine
TOS-BB-0556
Oprea1_814125
Oprea1_474128
A2964/0124833

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0174	0.0157
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0497	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0174	0.0321
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0174	0.0157
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0497	0.0497
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Leishmania major	hypothetical protein, conserved	0.003	0.0214	0.0405
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0174	0.0157
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0174	0.0174
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0174	0.0321
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0708	0.0692
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0174	0.0157
Brugia malayi	GnHR receptor homolog	0.0028	0.0174	0.0174
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0174	0.0321
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0107	0.1729	0.1729
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	amine GPCR	0.0028	0.0174	0.0321
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0266	0.489	0.4881
Schistosoma mansoni	hypothetical protein	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.003	0.0214	0.0198
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0497	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0708	0.1417
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1877	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0017	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0053	0.0659	0.0659
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0174	0.0157
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	hypothetical protein	0.0053	0.0659	0.1317
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	amine GPCR	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	hypothetical protein	0.0053	0.0659	0.1317
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0174	0.0157
Echinococcus multilocularis	muscleblind protein	0.0163	0.2849	0.2837
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0174	0.0321
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0497	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0266	0.489	0.4881
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0497	1
Echinococcus multilocularis	serotonin receptor	0.0028	0.0174	0.0157
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0174	0.0174
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0214	0.4111
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0174	0.0157
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0174	0.0321
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	hypothetical protein	0.0053	0.0659	0.1317
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0053	0.0659	0.0643
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Schistosoma mansoni	aldehyde dehydrogenase	0.0266	0.489	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0167	0.2926	0.2926
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0174	0.0321
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Brugia malayi	G-protein coupled receptor	0.0028	0.0174	0.0174
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0174	0.0157
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0264	0.4863	0.4854
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0174	0.0321
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0174	0.0174
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0174	0.0157
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0174	0.0157
Schistosoma mansoni	hypothetical protein	0.0114	0.1877	0.3816
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0167	0.2926	0.2914
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0174	0.0321
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Echinococcus multilocularis	survival motor neuron protein 1	0.0523	1	1
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0174	0.0174
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0017	0.0017
Brugia malayi	AKH receptor	0.0028	0.0174	0.0174
Echinococcus granulosus	sex peptide receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	geminin	0.0185	0.3284	0.3273
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0174	0.0157
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0174	0.0157
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0174	0.0321
Brugia malayi	G protein-coupled receptor	0.0028	0.0174	0.0174
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	hypothetical protein	0.0107	0.1729	0.3512
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0174	0.0157
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0174	0.0321
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0174	0.0157
Echinococcus granulosus	muscleblind protein	0.0163	0.2849	0.2837
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0174	0.0174
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0497	0.0481
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0497	1
Schistosoma mansoni	opsin-like receptor	0.0028	0.0174	0.0321
Brugia malayi	neuropeptide F receptor	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0214	0.4111
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0497	1
Echinococcus granulosus	serotonin receptor	0.0028	0.0174	0.0157
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	somatostatin receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	amine GPCR	0.0028	0.0174	0.0321
Echinococcus multilocularis	muscleblind protein 1	0.0163	0.2849	0.2837
Brugia malayi	G-protein coupled receptor	0.0028	0.0174	0.0174
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0174	0.0157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	survival motor neuron protein	0.0107	0.1729	0.3512
Onchocerca volvulus		0.0107	0.1729	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0214	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	survival motor neuron protein 1	0.0523	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0497	0.0481
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0174	0.0157
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0174	0.0157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0174	0.0157
Brugia malayi	photoreceptor-specific nuclear receptor	0.0264	0.4863	0.4863
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0174	0.0157
Schistosoma mansoni	opsin-like receptor	0.0028	0.0174	0.0321
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0053	0.0659	0.0643
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0174	0.0321
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0174	0.0157
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0174	0.0174
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0497	0.0985
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0266	0.489	1
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0174	0.0174
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0174	0.0157
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0167	0.2926	0.2926
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0266	0.489	1
Brugia malayi	Muscleblind-like protein	0.0163	0.2849	0.2849
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0497	0.0985
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0174	0.0157
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0174	0.0157
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	hypothetical protein	0.0028	0.0174	0.0157
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0214	0.4111
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus multilocularis	GPCR, family 2	0.0053	0.0659	0.0643
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0053	0.0659	0.0643
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0497	1
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0174	0.0157
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0174	0.0157
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0708	0.1417
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0266	0.489	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0708	0.0692
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0497	0.0481
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0497	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Brugia malayi	RE15519p	0.0028	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	amine GPCR	0.0028	0.0174	0.0321
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0174	0.0157
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0174	0.0157
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	serotonin receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Toxoplasma gondii	aldehyde dehydrogenase	0.0266	0.489	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0174	0.0157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0163	0.2849	0.2837
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0028	0.0174	0.0321
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0497	0.0481
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0708	0.0708
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	adenoreceptor	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0167	0.2926	0.2914
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0174	0.0157
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0174	0.0321
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0266	0.489	1
Schistosoma mansoni	myosin xvIII	0.0028	0.0174	0.0321
Brugia malayi	Latrophilin receptor protein 2	0.0053	0.0659	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0523	1	1
Brugia malayi	Serotonin receptor	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	geminin	0.0185	0.3284	0.3273
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0174	0.0174
Brugia malayi	hypothetical protein	0.003	0.0214	0.0214
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	amine GPCR	0.0028	0.0174	0.0321
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0174	0.0157
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0174	0.0157
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0497	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0643
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0174	0.0157
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0708	0.0692
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0174	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0174	0.0157
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0174	0.0174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0708	0.0692
Brugia malayi	neuropeptide F receptor	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Brugia malayi	putative neuropeptide receptor	0.0028	0.0174	0.0174
Echinococcus granulosus	GPCR family 2	0.0053	0.0659	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0174	0.0321
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0214	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0174	0.0157
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0497	1
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0174	0.0157
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0174	0.0174
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0174	0.0157
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0174	0.0174
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0497	0.0481
Schistosoma mansoni	hypothetical protein	0.0028	0.0174	0.0321
Brugia malayi	hypothetical protein	0.0028	0.0174	0.0174
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0174	0.0157
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0174	0.0321
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0174	0.0157
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0053	0.0659	0.0643
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0174	0.0157
Brugia malayi	Serotonin receptor	0.0028	0.0174	0.0174
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0708	0.1417
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0174	0.0157
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0266	0.489	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0266	0.489	1
Schistosoma mansoni	hypothetical protein	0.0185	0.3284	0.6704
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	opsin-like receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	hypothetical protein	0.0053	0.0659	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0497	0.0481
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0174	0.0321
Brugia malayi	sulfakinin receptor protein	0.0028	0.0174	0.0174
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0174	0.0157
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0708	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0174	0.0157
Schistosoma mansoni	hypothetical protein	0.0185	0.3284	0.6704
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0174	0.0157
Schistosoma mansoni	hypothetical protein	0.0028	0.0174	0.0321
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0174	0.0157
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0053	0.0659	0.0643
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0174	0.0321
Brugia malayi	Dopamine receptor	0.0028	0.0174	0.0174
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0163	0.2849	0.2837
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0174	0.0321
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0174	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0174	0.0321
Brugia malayi	latrophilin 2 splice variant baaae	0.0114	0.1877	0.1877
Brugia malayi	larval opioid receptor	0.0028	0.0174	0.0174
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0174	0.0157
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0174	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0174	0.0157

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3769 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702]	ChEMBL.	No reference
Potency (binding)	= 100 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1374589

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1275610