Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0279 | 0.0279 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2822 | 0.2616 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0279 | 0.0279 |
Schistosoma mansoni | jumonji domain containing protein | 0.0071 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0279 | 0.0279 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2822 | 0.2616 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2822 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2711 | 0.2711 |
Echinococcus granulosus | lamin | 0.0033 | 0.2822 | 0.2616 |
Leishmania major | hypothetical protein, conserved | 0.0019 | 0.0279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2822 | 0.2822 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0279 | 0.0279 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0279 | 0.0279 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0019 | 0.0279 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.2822 | 0.2616 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2822 | 0.2616 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2822 | 0.2822 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0279 | 0.0279 |
Onchocerca volvulus | 0.0033 | 0.2822 | 0.5 | |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0019 | 0.0279 | 0.5 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0019 | 0.0279 | 0.5 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0019 | 0.0279 | 0.5 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0019 | 0.0279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0279 | 0.0279 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2822 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0279 | 0.0279 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2822 | 0.2616 |
Schistosoma mansoni | lamin | 0.0033 | 0.2822 | 0.2616 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2822 | 0.2822 |
Onchocerca volvulus | 0.0033 | 0.2822 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2822 | 0.2822 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2822 | 0.2822 |
Plasmodium vivax | JmjC domain containing protein | 0.0019 | 0.0279 | 0.5 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0019 | 0.0279 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.