Detailed information for compound 1276188

Basic information

Technical information
  • TDR Targets ID: 1276188
  • Name: N-(4-methoxyphenyl)-2-[(5-oxo-[1,3]thiazolo[3 ,2-a]pyrimidin-7-yl)methylsulfanyl]acetamide
  • MW: 361.439 | Formula: C16H15N3O3S2
  • H donors: 1 H acceptors: 2 LogP: 1.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CSCc1cc(=O)n2c(n1)scc2
  • InChi: 1S/C16H15N3O3S2/c1-22-13-4-2-11(3-5-13)17-14(20)10-23-9-12-8-15(21)19-6-7-24-16(19)18-12/h2-8H,9-10H2,1H3,(H,17,20)
  • InChiKey: GJWYZTXZVVFPGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methoxyphenyl)-2-[(5-oxothiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]acetamide
  • N-(4-methoxyphenyl)-2-[(5-oxo-7-thiazolo[3,2-a]pyrimidinyl)methylthio]acetamide
  • 2-[(5-ketothiazolo[3,2-a]pyrimidin-7-yl)methylthio]-N-(4-methoxyphenyl)acetamide
  • N-(4-methoxyphenyl)-2-[(5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldo keto reductase 0.044 0.7502 0.8842
Echinococcus multilocularis 0.001 0.0006 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0485 0.0608
Echinococcus multilocularis voltage gated potassium channel 0.0129 0.2084 0.2082
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.004 0.0519 0.0684
Mycobacterium ulcerans hypothetical protein 0.0037 0.0474 0.0625
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0027 0.0034
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0474 0.0556
Schistosoma mansoni carbonic anhydrase 0.0139 0.2252 0.2649
Echinococcus granulosus intermediate filament protein 0.0028 0.0312 0.0365
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0225 0.0291
Trypanosoma brucei aldo/keto reductase, putative 0.0127 0.2051 0.2728
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0495 0.0621
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0129 0.2084 0.2624
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0225 0.028
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0129 0.2084 0.2454
Trichomonas vaginalis aldo/keto reductase, putative 0.044 0.7502 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.044 0.7502 0.9445
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.1013 0.1342
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0115 0.1832 0.2304
Schistosoma mansoni cpg binding protein 0.0034 0.0422 0.0491
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0225 0.0292
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0129 0.2084 0.2624
Echinococcus multilocularis voltage gated potassium channel 0.0129 0.2084 0.2082
Schistosoma mansoni aldo-keto reductase 0.044 0.7502 0.8841
Echinococcus multilocularis cpg binding protein 0.0034 0.0422 0.042
Brugia malayi Cyclic-nucleotide gated cation channel 0.0129 0.2084 0.2624
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0139 0.2252 0.2835
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.2084 0.2454
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0075 0.1142 0.1515
Trypanosoma cruzi aldo/keto reductase, putative 0.0127 0.2051 0.2728
Trypanosoma brucei aldo-keto reductase, putative 0.044 0.7502 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0163 0.2682 0.357
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0339 0.0444
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0055 0.0792 0.0994
Echinococcus granulosus two pore calcium channel protein 1 0.0129 0.2084 0.2454
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1673 0.197
Brugia malayi follicle stimulating hormone receptor 0.0465 0.7943 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0129 0.2084 0.2622
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.1013 0.1342
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.7829 0.7828
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0415 0.0544
Schistosoma mansoni transient receptor potential channel 0.0267 0.4482 0.5279
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0029 0.0336 0.0438
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0115 0.1832 0.5
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0225 0.0291
Onchocerca volvulus 0.044 0.7502 1
Toxoplasma gondii transporter, cation channel family protein 0.0129 0.2084 0.2772
Trypanosoma brucei carbonic anhydrase-like protein 0.0273 0.4586 0.611
Echinococcus multilocularis ryanodine receptor 44f 0.0129 0.2084 0.2082
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.2051 0.2727
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0027 0.0029
Schistosoma mansoni aldo-keto reductase 0.044 0.7502 0.8841
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0115 0.1832 0.2436
Brugia malayi isocitrate dehydrogenase 0.0011 0.0027 0.0034
Toxoplasma gondii hypothetical protein 0.004 0.0519 0.0684
Echinococcus granulosus ubiquitin specific protease 41 0.0029 0.0336 0.0393
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0007 0.0002
Entamoeba histolytica aldose reductase, putative 0.044 0.7502 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2226 0.2801
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1673 0.197
Giardia lamblia Aldose reductase 0.044 0.7502 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0129 0.2084 0.2772
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.2084 0.2451
Echinococcus multilocularis neuropeptide receptor A26 0.034 0.5769 0.5768
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0129 0.2084 0.2082
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.004 0.0519 0.2431
Onchocerca volvulus 0.044 0.7502 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0129 0.2084 0.2464
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0029 0.0336 0.0393
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0115 0.1832 0.2436
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0474 0.0623
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Schistosoma mansoni ryanodine receptor related 0.0129 0.2084 0.2451
Schistosoma mansoni lamin 0.0028 0.0312 0.0361
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0465 0.7943 1
Loa Loa (eye worm) oxidoreductase 0.044 0.7502 0.9444
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0115 0.1832 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0129 0.2084 0.2082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0474 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.1013 0.1342
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0006 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0027 0.0024
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0127 0.2051 0.2728
Leishmania major hypothetical protein, unknown function 0.0129 0.2084 0.2772
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0029 0.0336 0.0389
Schistosoma mansoni voltage-dependent calcium channel 0.0129 0.2084 0.2451
Echinococcus multilocularis integrin alpha ps 0.0106 0.1679 0.1677
Brugia malayi Cytochrome P450 family protein 0.0038 0.0485 0.061
Schistosoma mansoni hypothetical protein 0.019 0.3143 0.37
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0064
Echinococcus granulosus aldo keto reductase 0.044 0.7502 0.8842
Schistosoma mansoni ferritin light chain 0.001 0.0007 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0474 0.0625
Brugia malayi beta-lactamase 0.0037 0.0474 0.0597
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Schistosoma mansoni hypothetical protein 0.019 0.3143 0.37
Mycobacterium tuberculosis Conserved protein 0.0037 0.0474 0.0625
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0139 0.2252 0.2835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1673 0.1967
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0415 0.0544
Brugia malayi cation channel family protein 0.0129 0.2084 0.2624
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0011 0.0027 0.0028
Echinococcus multilocularis voltage gated potassium channel subunit 0.0127 0.2051 0.2049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0474 0.0625
Toxoplasma gondii hypothetical protein 0.0139 0.2252 0.2996
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0495 0.0581
Schistosoma mansoni carbonic anhydrase-related 0.0139 0.2252 0.2649
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0129 0.2084 0.2082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0495 0.0581
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0129 0.2084 0.2082
Giardia lamblia Aldose reductase 0.044 0.7502 1
Onchocerca volvulus 0.044 0.7502 1
Loa Loa (eye worm) ion channel NompC 0.0129 0.2084 0.2622
Onchocerca volvulus 0.044 0.7502 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0129 0.2084 0.2451
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Loa Loa (eye worm) oxidoreductase 0.044 0.7502 0.9444
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Echinococcus granulosus carbonic anhydrase II 0.0273 0.4586 0.5404
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0139 0.2252 0.2833
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.044 0.7502 1
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0006 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0115 0.1832 0.2436
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.2146 0.2528
Trypanosoma brucei prostaglandin f synthase 0.044 0.7502 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.044 0.7502 0.9445
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0273 0.4586 0.5774
Echinococcus granulosus sodium leak channel non selective protein 0.0129 0.2084 0.2454
Brugia malayi hypothetical protein 0.0129 0.2084 0.2624
Echinococcus granulosus two pore calcium channel protein 2 0.0129 0.2084 0.2454
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0129 0.2084 0.2622
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0088 0.011
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Echinococcus granulosus carbonic anhydrase 0.0139 0.2252 0.2652
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0474 0.0594
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.2146 0.2855
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Mycobacterium ulcerans oxidoreductase 0.044 0.7502 1
Plasmodium falciparum carbonic anhydrase 0.0139 0.2252 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0129 0.2084 0.2082
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0225 0.0292
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0339 0.1402
Giardia lamblia Fructose-bisphosphate aldolase 0.0335 0.5669 0.7482
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0474 0.0552
Schistosoma mansoni ferritin 0.001 0.0007 0.0001
Echinococcus granulosus aldehyde reductase 0.0312 0.5279 0.6221
Toxoplasma gondii hypothetical protein 0.0129 0.2084 0.2772
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0225 0.0223
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.2084 0.2082
Echinococcus granulosus short transient receptor potential channel 6 0.0267 0.4482 0.5281
Echinococcus multilocularis aldehyde reductase 0.0312 0.5279 0.5278
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.2146 0.2144
Toxoplasma gondii ABC1 family protein 0.0037 0.0474 0.0625
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0129 0.2084 0.2624
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.102 0.1196
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0139 0.2252 0.2835
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0129 0.2084 0.2082
Schistosoma mansoni apoferritin-2 0.001 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0139 0.2252 0.2835
Schistosoma mansoni voltage-gated cation channel 0.0129 0.2084 0.2451
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Schistosoma mansoni hypothetical protein 0.0139 0.2252 0.2649
Loa Loa (eye worm) hypothetical protein 0.044 0.7502 0.9444
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0339 0.0444
Echinococcus granulosus transient receptor potential gamma protein 0.0341 0.5774 0.6805
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0062 0.006
Trypanosoma cruzi aldo-keto reductase 0.044 0.7502 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.044 0.7502 1
Schistosoma mansoni integrin alpha-4 0.0453 0.7742 0.9124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.1673 0.2107
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0129 0.2084 0.2082
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.5669 0.7482
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0129 0.2084 0.2624
Echinococcus granulosus transient receptor potential ion channel A 0.0211 0.3519 0.4146
Echinococcus granulosus potassium large conductance calcium activated 0.0129 0.2084 0.2454
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Loa Loa (eye worm) voltage-gated calcium channel 0.0129 0.2084 0.2622
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0051 0.0715 0.0898
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.2146 0.2855
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0273 0.4586 0.5774
Schistosoma mansoni ferritin light chain 0.001 0.0007 0.0001
Schistosoma mansoni kinase 0.0034 0.0431 0.0501
Onchocerca volvulus 0.0037 0.0474 0.0225
Echinococcus multilocularis lamin dm0 0.0028 0.0312 0.031
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0129 0.2084 0.2451
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Loa Loa (eye worm) oxidoreductase 0.044 0.7502 0.9444
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.1013 0.1342
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0027 0.0028
Echinococcus granulosus voltage gated potassium channel subunit 0.0127 0.2051 0.2415
Echinococcus multilocularis potassium large conductance calcium activated 0.0129 0.2084 0.2082
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0127 0.2051 0.2727
Schistosoma mansoni microtubule-associated protein tau 0.0496 0.8484 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0474 0.0472
Echinococcus multilocularis two pore calcium channel protein 2 0.0129 0.2084 0.2082
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0163 0.2682 0.357
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0129 0.2084 0.2624
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.2084 0.2451
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0029 0.0336 0.0389
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0792 0.0994
Leishmania major hypothetical protein, conserved 0.0129 0.2084 0.2772
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0129 0.2084 0.2772
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Echinococcus granulosus integrin alpha ps 0.0051 0.0715 0.0841
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0129 0.2084 0.2082
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0129 0.2084 0.2082
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0129 0.2084 0.2622
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0129 0.2084 0.2454
Onchocerca volvulus 0.0037 0.0474 0.0225
Schistosoma mansoni hypothetical protein 0.0083 0.1269 0.1489
Echinococcus granulosus short transient receptor potential channel 6 0.0267 0.4482 0.5281
Schistosoma mansoni ferritin 0.001 0.0007 0.0001
Schistosoma mansoni hypothetical protein 0.0038 0.0495 0.0577
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0225 0.0292
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.044 0.7502 0.9445
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0225 0.0283
Toxoplasma gondii transporter, cation channel family protein 0.0129 0.2084 0.2772
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0129 0.2084 0.2454
Loa Loa (eye worm) hypothetical protein 0.0037 0.0474 0.0594
Schistosoma mansoni hypothetical protein 0.0458 0.7829 0.9226
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0129 0.2084 0.2454
Brugia malayi hypothetical protein 0.0029 0.0339 0.0426
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0129 0.2084 0.2454
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0474 0.0625
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0474 0.2211
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0474 0.0625
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0474 0.0594
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0027 0.0028
Mycobacterium tuberculosis Conserved protein 0.0037 0.0474 0.0625
Mycobacterium tuberculosis Conserved protein 0.0037 0.0474 0.0625
Leishmania major hypothetical protein, conserved 0.0037 0.0474 0.0625
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0027 0.0024
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0129 0.2084 0.2454
Echinococcus granulosus hyperpolarization activated cyclic 0.0129 0.2084 0.2454
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0129 0.2084 0.2454
Echinococcus multilocularis hyperpolarization activated cyclic 0.0129 0.2084 0.2082
Echinococcus multilocularis transfer RNA-Gly 0.0129 0.2084 0.2082
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0129 0.2084 0.2451
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0029 0.0336 0.0393
Brugia malayi olfactory channel protein osm-9 0.0129 0.2084 0.2624
Loa Loa (eye worm) hypothetical protein 0.0051 0.0715 0.0898
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0129 0.2084 0.2454
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0225 0.0292
Echinococcus multilocularis integrin alpha ps 0.0051 0.0715 0.0713
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0121 0.1935 0.2435
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.044 0.7502 1
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0474 0.0625
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0129 0.2084 0.2451
Leishmania major prostaglandin f synthase, putative 0.044 0.7502 1
Trypanosoma cruzi aldo/keto reductase, putative 0.044 0.7502 1
Treponema pallidum fructose-bisphosphate aldolase 0.0335 0.5669 1
Leishmania major carbonic anhydrase-like protein 0.0273 0.4586 0.611
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0029 0.0336 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0474 0.0625
Leishmania major hypothetical protein, conserved 0.0029 0.0339 0.0444
Echinococcus multilocularis aldo keto reductase 0.044 0.7502 0.7501
Plasmodium falciparum aldo-keto reductase, putative 0.0127 0.2051 0.9097
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Toxoplasma gondii exonuclease III APE 0.0023 0.0225 0.0292
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0129 0.2084 0.2451
Loa Loa (eye worm) CYP4Cod1 0.001 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0312 0.039
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.044 0.7502 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0115 0.1832 0.3223
Brugia malayi serine/threonine-protein kinase plk-2 0.0068 0.1013 0.1276
Echinococcus multilocularis aldo keto reductase 0.044 0.7502 0.7501
Brugia malayi voltage-dependent calcium channel 0.0129 0.2084 0.2624
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0064
Echinococcus granulosus microtubule associated protein 2 0.0496 0.8484 1
Echinococcus granulosus voltage gated potassium channel 0.0129 0.2084 0.2454
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0121 0.1935 0.2435
Echinococcus granulosus ferritin 0.001 0.0007 0.0006
Schistosoma mansoni calcium-activated potassium channel 0.0129 0.2084 0.2451
Mycobacterium ulcerans beta-lactamase 0.0037 0.0474 0.0625
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.2146 0.2524
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0129 0.2084 0.2624
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.044 0.7502 1
Mycobacterium ulcerans hypothetical protein 0.0127 0.2051 0.2728
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0027 0.0028
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0027 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1673 0.1967
Echinococcus granulosus aldo keto reductase 0.044 0.7502 0.8842
Schistosoma mansoni hypothetical protein 0.0038 0.0495 0.0577
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0129 0.2084 0.2082
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.5669 0.7482
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.2084 0.2082
Giardia lamblia Kinase, PLK 0.0068 0.1013 0.1083
Schistosoma mansoni lamin 0.0028 0.0312 0.0361
Brugia malayi ion channel NompC 0.0129 0.2084 0.2624
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.2084 0.2082
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0129 0.2084 0.2082
Loa Loa (eye worm) carbonic anhydrase 3 0.0273 0.4586 0.5772
Onchocerca volvulus 0.0037 0.0474 0.0225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Echinococcus multilocularis carbonic anhydrase 0.0139 0.2252 0.225
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.004 0.0519 0.0903
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Loa Loa (eye worm) oxidoreductase 0.044 0.7502 0.9444
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0225 0.0385
Loa Loa (eye worm) hypothetical protein 0.0203 0.3377 0.4249
Echinococcus granulosus cpg binding protein 0.0034 0.0422 0.0495
Brugia malayi Integrin alpha pat-2 precursor 0.0106 0.1679 0.2113
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1673 0.1672
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0129 0.2084 0.2772
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Brugia malayi latrophilin 2 splice variant baaae 0.0083 0.1269 0.1597
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0011 0.0027 0.0028
Brugia malayi NADH-dependent xylose reductase 0.0127 0.2051 0.2582
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0129 0.2084 0.2772
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.2258 0.2841
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Loa Loa (eye worm) hypothetical protein 0.0083 0.1269 0.1595
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.2084 0.2451
Echinococcus granulosus geminin 0.019 0.3143 0.3702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0474 0.0552
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.1673 0.2105
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0163 0.2682 0.357
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0336 0.044
Echinococcus multilocularis voltage dependent calcium channel 0.0129 0.2084 0.2082
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0013 0.0062 0.0075
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0129 0.2084 0.2454
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.2084 0.2454
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0225 0.1193
Schistosoma mansoni hypothetical protein 0.0038 0.0495 0.0577
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0115 0.1832 0.2436
Brugia malayi CXXC zinc finger family protein 0.0032 0.039 0.0491
Loa Loa (eye worm) calcium channel 0.0129 0.2084 0.2622
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0008
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0129 0.2084 0.2624
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0129 0.2084 0.2451
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1673 0.1672
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0129 0.2084 0.2464
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.3954 0.5267
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0339 0.1402
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0474 0.0623
Schistosoma mansoni potassium channel beta 0.0127 0.2051 0.2412
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0225 0.0292
Echinococcus granulosus voltage gated potassium channel 0.0129 0.2084 0.2454
Echinococcus granulosus carbonic anhydrase 0.0139 0.2252 0.2652
Echinococcus multilocularis integrin alpha ps 0.0106 0.1679 0.1677
Brugia malayi beta-lactamase family protein 0.0037 0.0474 0.0597
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.2084 0.2454
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0075 0.1142 0.1515
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0339 0.0444
Echinococcus granulosus TRP transient receptor potential channel 0.0203 0.3377 0.3978
Schistosoma mansoni cpg binding protein 0.0034 0.0422 0.0491
Mycobacterium ulcerans lipase LipD 0.0037 0.0474 0.0625
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.2084 0.2454
Echinococcus granulosus lamin 0.0028 0.0312 0.0365
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Entamoeba histolytica aldose reductase, putative 0.044 0.7502 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0339 0.0424
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0027 0.0024
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0129 0.2084 0.2624
Loa Loa (eye worm) hypothetical protein 0.0037 0.0474 0.0594
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0339 0.0444
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0129 0.2084 0.2624
Brugia malayi hypothetical protein 0.0019 0.0158 0.0199
Toxoplasma gondii transporter, cation channel family protein 0.0129 0.2084 0.2772
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0129 0.2084 0.2624
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.2146 0.2855
Schistosoma mansoni carbonic anhydrase-related 0.0139 0.2252 0.2649
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus multilocularis sodium channel protein 0.0129 0.2084 0.2082
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0029 0.0336 0.0422
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0339 0.1542
Schistosoma mansoni hypothetical protein 0.0129 0.2084 0.2451
Trichomonas vaginalis esterase, putative 0.0037 0.0474 0.0623
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.2146 0.2855
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.2084 0.2082
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0127 0.2051 0.2415
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0129 0.2084 0.2454
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0273 0.4586 0.5402
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0129 0.2084 0.2082
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.1013 0.1188
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.2258 0.2841
Loa Loa (eye worm) hypothetical protein 0.0139 0.2252 0.2833
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0115 0.1832 0.2157
Schistosoma mansoni pol-related 0.044 0.7502 0.8841
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0062 0.007
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0129 0.2084 0.2624
Echinococcus multilocularis ubiquitin specific protease 41 0.0029 0.0336 0.0333
Loa Loa (eye worm) ryanodine receptor 0.0129 0.2084 0.2622
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0121 0.1935 0.2437
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.2084 0.2454
Echinococcus multilocularis neuropeptide s receptor 0.034 0.5769 0.5768
Schistosoma mansoni ap endonuclease 0.0023 0.0225 0.0258
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0115 0.1832 0.8918
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.2051 0.2727
Echinococcus multilocularis conserved hypothetical protein 0.0129 0.2084 0.2082
Onchocerca volvulus 0.0127 0.2051 0.2419
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0225 0.0263
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0129 0.2084 0.2454
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0027 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.2051 0.2727
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0225 0.0979
Toxoplasma gondii aldose reductase, putative 0.044 0.7502 1
Echinococcus multilocularis expressed protein 0.001 0.0007 0.0005
Brugia malayi intermediate filament protein 0.0028 0.0312 0.0393
Echinococcus granulosus carbonic anhydrase 0.0139 0.2252 0.2652
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0336 0.0438
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0139 0.2252 0.2833
Brugia malayi cation channel family protein 0.0129 0.2084 0.2624
Loa Loa (eye worm) hypothetical protein 0.0037 0.0474 0.0594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1673 0.1967
Mycobacterium tuberculosis Conserved protein 0.0127 0.2051 0.2728
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0273 0.4586 0.611
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0011 0.0027 0.0028
Schistosoma mansoni ferritin 0.001 0.0007 0.0001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0115 0.1832 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus granulosus neuropeptide receptor A26 0.034 0.5769 0.6799
Echinococcus granulosus hyperpolarization activated cyclic 0.0129 0.2084 0.2454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Schistosoma mansoni cpg binding protein 0.0032 0.039 0.0453
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0273 0.4586 0.5772
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Echinococcus multilocularis carbonic anhydrase II 0.0273 0.4586 0.4585
Trypanosoma brucei polo-like protein kinase 0.0068 0.1013 0.1344
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0129 0.2084 0.2771
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0088 0.0107
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0273 0.4586 0.5402
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0127 0.2051 0.2728
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Loa Loa (eye worm) oxidoreductase 0.044 0.7502 0.9444
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0027 0.0024
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0007 0.0002
Echinococcus multilocularis two pore calcium channel protein 1 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0074 0.1121 0.1409
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0129 0.2084 0.2622
Brugia malayi beta-lactamase family protein 0.0037 0.0474 0.0597
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.044 0.7502 0.9445
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.1013 0.1342
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.2084 0.2451
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.2084 0.2082
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0129 0.2084 0.2624
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.2051 0.2727
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0127 0.2051 0.2582
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.2084 0.2451
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.039 0.0489
Loa Loa (eye worm) hypothetical protein 0.0038 0.0495 0.0621
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0115 0.1832 0.2436
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0029 0.0336 0.0333
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Schistosoma mansoni integrin alpha-ps 0.0106 0.1679 0.1973
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0127 0.2051 0.258
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0068 0.1013 0.1344
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0129 0.2084 0.2772
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0129 0.2084 0.2454
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Schistosoma mansoni carbonic anhydrase-related 0.0139 0.2252 0.2649
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0115 0.1832 0.183
Echinococcus granulosus peptidase Clp S14 family 0.0075 0.1142 0.1343
Echinococcus granulosus calcium activated potassium channel 0.0129 0.2088 0.2459
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.2084 0.2454
Brugia malayi Calcitonin receptor-like protein seb-1 0.0121 0.1935 0.2437
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0029 0.0336 0.0333
Entamoeba histolytica alcohol dehydrogenase, putative 0.0127 0.2051 0.251
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0068 0.1013 0.1011
Schistosoma mansoni integrin alpha-ps 0.0055 0.0792 0.0927
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0068 0.1013 0.1273
Schistosoma mansoni two-pore calcium channel 0.0129 0.2084 0.2451
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0474 0.0625
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.2146 0.2855
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0474 0.0625
Trichomonas vaginalis aldo/keto reductase, putative 0.044 0.7502 1
Echinococcus granulosus sodium channel protein 0.0129 0.2084 0.2454
Echinococcus multilocularis carbonic anhydrase 0.0139 0.2252 0.225
Entamoeba histolytica serine/threonine protein kinase, putative 0.0068 0.1013 0.1083
Echinococcus granulosus voltage dependent calcium channel 0.0129 0.2084 0.2454
Loa Loa (eye worm) integrin alpha pat-2 0.0106 0.1679 0.2111
Loa Loa (eye worm) voltage-dependent calcium channel 0.0129 0.2084 0.2622
Schistosoma mansoni voltage-gated ion channel 0.0129 0.2084 0.2451
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0129 0.2084 0.2454
Brugia malayi cytochrome P450 0.001 0.0006 0.0008
Echinococcus multilocularis musashi 0.0028 0.0312 0.031
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Schistosoma mansoni transient receptor potential channel 0.0341 0.5774 0.6804
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.1013 0.1342
Echinococcus multilocularis geminin 0.019 0.3143 0.3141
Toxoplasma gondii aldo-keto reductase 0.0127 0.2051 0.2728
Schistosoma mansoni hypothetical protein 0.0013 0.0057 0.006
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0007 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0027 0.0028
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.2146 0.2855
Echinococcus granulosus neuropeptide s receptor 0.034 0.5769 0.6799
Schistosoma mansoni integrin alpha 0.0106 0.1679 0.1973
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.004 0.0519 0.2211
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.2084 0.2454
Loa Loa (eye worm) beta-lactamase 0.0037 0.0474 0.0594
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0127 0.2051 0.2728
Echinococcus multilocularis peptidase Clp (S14 family) 0.0075 0.1142 0.114
Entamoeba histolytica aldose reductase, putative 0.044 0.7502 1
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0495 0.0623
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0129 0.2084 0.2624
Schistosoma mansoni 60S ribosomal protein L21 0.0129 0.2084 0.2451
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0029 0.0336 0.0152
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0027 0.0024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0129 0.2084 0.2772
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.2146 0.2524
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.2084 0.2454
Echinococcus multilocularis hyperpolarization activated cyclic 0.0129 0.2084 0.2082
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0029 0.0336 0.044
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0474 0.0623
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0225 0.0891
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0127 0.2051 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0267 0.4482 0.4481
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0474 0.0623
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0129 0.2084 0.2772
Mycobacterium leprae Possible oxidoreductase 0.0127 0.2051 0.2728
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0273 0.4586 0.611
Echinococcus multilocularis aldo keto reductase 0.044 0.7502 0.7501
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0336 0.044
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.2084 0.2454
Echinococcus multilocularis carbonic anhydrase 0.0139 0.2252 0.225
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0336 0.044
Echinococcus granulosus voltage dependent calcium channel 0.0129 0.2084 0.2454
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0129 0.2084 0.2771
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0057 0.0065
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0203 0.3377 0.3375
Schistosoma mansoni hypothetical protein 0.0051 0.0715 0.0837
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0129 0.2084 0.2454
Schistosoma mansoni transient receptor potential channel 0.0267 0.4482 0.5279
Echinococcus granulosus GPCR family 2 0.0038 0.0495 0.0581
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.2084 0.2454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0225 0.0292
Schistosoma mansoni ap endonuclease 0.0023 0.0225 0.0258
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.2084 0.2454
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0129 0.2084 0.2451
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0893 0.1183
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0029 0.0336 0.0152
Schistosoma mansoni hypothetical protein 0.0038 0.0495 0.0577
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0495 0.0493
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0129 0.2084 0.2624
Echinococcus multilocularis transient receptor potential ion channel A 0.0211 0.3519 0.3517
Echinococcus granulosus integrin alpha ps 0.0106 0.1679 0.1977
Echinococcus granulosus voltage gated hydrogen channel 1 0.0129 0.2084 0.2454
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0027 0.0024
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0057 0.0055
Leishmania major aldo-keto reductase-like protein 0.044 0.7502 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0474 0.0597
Toxoplasma gondii hypothetical protein 0.0129 0.2084 0.2772
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0129 0.2084 0.2454
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.2084 0.2082
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0312 0.039
Entamoeba histolytica alcohol dehydrogenase, putative 0.0127 0.2051 0.251
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.044 0.7502 1
Brugia malayi Probable ClpP-like protease 0.0115 0.1832 0.2306
Schistosoma mansoni transient receptor potential channel 4 0.0341 0.5774 0.6804
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0474 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.1013 0.1342
Trypanosoma cruzi polo-like protein kinase, putative 0.0068 0.1013 0.1344
Loa Loa (eye worm) hypothetical protein 0.0037 0.0474 0.0594
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0495 0.0493
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0474 0.0625
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0312 0.0393
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0129 0.2084 0.2082
Echinococcus multilocularis microtubule associated protein 2 0.0496 0.8484 0.8484
Echinococcus multilocularis shaker cognate 0.0129 0.2084 0.2082
Trichomonas vaginalis aldo/keto reductase, putative 0.044 0.7502 1
Onchocerca volvulus 0.044 0.7502 1
Echinococcus granulosus hypothetical protein 0.0129 0.2084 0.2454
Echinococcus granulosus hypothetical protein 0.044 0.7502 0.8842
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0129 0.2084 0.2454
Echinococcus multilocularis aldo keto reductase 0.044 0.7502 0.7501
Loa Loa (eye worm) hypothetical protein 0.0129 0.2084 0.2622
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0129 0.2084 0.2082
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.044 0.7502 0.8842
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0115 0.1832 0.8112
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0129 0.2084 0.2451
Echinococcus granulosus integrin alpha 3 0.0051 0.0715 0.0841
Brugia malayi MH2 domain containing protein 0.0139 0.2258 0.2843
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0495 0.0623
Loa Loa (eye worm) hypothetical protein 0.0029 0.0336 0.042
Trypanosoma cruzi polo-like protein kinase, putative 0.0068 0.1013 0.1344
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0075 0.1142 0.1515
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0068 0.1013 0.1192
Plasmodium falciparum aldehyde reductase, putative 0.0127 0.2051 0.9097
Echinococcus multilocularis voltage dependent calcium channel 0.0129 0.2084 0.2082
Onchocerca volvulus Serine\/threonine kinase homolog 0.0068 0.1013 0.0975
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0129 0.2084 0.2451
Echinococcus multilocularis transient receptor potential gamma protein 0.0341 0.5774 0.5774
Echinococcus granulosus ryanodine receptor 44f 0.0129 0.2084 0.2454
Loa Loa (eye worm) cytochrome P450 0.001 0.0006 0.0005
Echinococcus multilocularis calcium activated potassium channel 0.0129 0.2088 0.2086
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0129 0.2084 0.2454
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0312 0.039
Echinococcus multilocularis ferritin 0.001 0.0007 0.0005
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0007 0.0002
Schistosoma mansoni vesicular amine transporter 0.0129 0.2084 0.2451
Echinococcus multilocularis GPCR, family 2 0.0038 0.0495 0.0493
Trichomonas vaginalis aldo-keto reductase, putative 0.044 0.7502 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0474 0.0625
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0139 0.2252 0.2835
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.2084 0.2451
Schistosoma mansoni intermediate filament proteins 0.0028 0.0312 0.0361
Echinococcus granulosus lamin dm0 0.0028 0.0312 0.0365
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0129 0.2084 0.2451
Echinococcus granulosus dnaJ subfamily B 0.0458 0.7829 0.9227
Echinococcus granulosus expressed protein 0.001 0.0007 0.0006
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0474 0.0625
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.2084 0.2082
Loa Loa (eye worm) hypothetical protein 0.0341 0.5774 0.7269
Loa Loa (eye worm) hypothetical protein 0.0037 0.0474 0.0594
Loa Loa (eye worm) voltage-gated potassium channel 0.0129 0.2084 0.2622
Mycobacterium leprae Probable lipase LipE 0.0037 0.0474 0.0625
Plasmodium vivax aldehyde reductase, putative 0.0127 0.2051 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0129 0.2084 0.2624
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0051 0.0715 0.0901
Loa Loa (eye worm) hypothetical protein 0.0027 0.0303 0.0379
Brugia malayi Transient-receptor-potential like protein 0.0203 0.3377 0.4251
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.5669 0.7555
Mycobacterium leprae Conserved hypothetical protein 0.0312 0.5279 0.7035
Echinococcus multilocularis lamin 0.0028 0.0312 0.031
Onchocerca volvulus 0.0129 0.2084 0.2464
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.044 0.7502 0.7501
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0006 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.044 0.7502 1
Echinococcus granulosus shaker cognate 0.0129 0.2084 0.2454
Loa Loa (eye worm) hypothetical protein 0.0139 0.2252 0.2833
Onchocerca volvulus 0.044 0.7502 1
Schistosoma mansoni apoferritin-2 0.001 0.0007 0.0001
Schistosoma mansoni ferritin 0.001 0.0007 0.0001
Onchocerca volvulus 0.0032 0.039 0.0108
Echinococcus multilocularis integrin alpha 3 0.0051 0.0715 0.0713
Echinococcus multilocularis short transient receptor potential channel 6 0.0267 0.4482 0.4481
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0007 0.0002
Schistosoma mansoni peptidase Clp (S14 family) 0.0115 0.1832 0.2154
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0474 0.0623

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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