Detailed information for compound 1276196

Basic information

Technical information
  • TDR Targets ID: 1276196
  • Name: [[amino-(4-methylphenyl)methylidene]amino] 2- (4-nitrophenyl)propanoate
  • MW: 327.335 | Formula: C17H17N3O4
  • H donors: 1 H acceptors: 3 LogP: 3.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccc(cc1)[N+](=O)[O-])C)ON=C(c1ccc(cc1)C)N
  • InChi: 1S/C17H17N3O4/c1-11-3-5-14(6-4-11)16(18)19-24-17(21)12(2)13-7-9-15(10-8-13)20(22)23/h3-10,12H,1-2H3,(H2,18,19)
  • InChiKey: LVVVWJLQYOQHGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [[amino-(4-methylphenyl)methylene]amino] 2-(4-nitrophenyl)propanoate
  • 2-(4-nitrophenyl)propanoic acid [[amino-(4-methylphenyl)methylene]amino] ester
  • 2-(4-nitrophenyl)propionic acid [[amino-(4-methylphenyl)methylene]amino] ester
  • STK143984
  • MLS001181255
  • SMR000502388

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Saccharomyces cerevisiae protein transporter TIM10 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 Get druggable targets OG5_128839 All targets in OG5_128839
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Neospora caninum mitochondrial import inner membrane translocase subunit tim10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Schistosoma japonicum Mitochondrial import inner membrane translocase subunit Tim10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Babesia bovis mitochondrial transport complex Tim10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 Get druggable targets OG5_128839 All targets in OG5_128839
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii TIM10 family protein, putative Get druggable targets OG5_128839 All targets in OG5_128839
Neospora caninum Tim10/DDP family zinc finger containing protein, putative Get druggable targets OG5_128839 All targets in OG5_128839
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Theileria parva mitochondrial import inner membrane translocase subunit tim10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus expressed protein Get druggable targets OG5_128839 All targets in OG5_128839
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii small zinc finger-like protein-related Get druggable targets OG5_128839 All targets in OG5_128839
Plasmodium knowlesi mitochondrial import inner membrane translocase subunit TIM10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Echinococcus multilocularis expressed protein Get druggable targets OG5_128839 All targets in OG5_128839
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans protein trans. across mito. Intermembrane space Get druggable targets OG5_128839 All targets in OG5_128839
Plasmodium berghei mitochondrial import inner membrane translocase subunit TIM10, putative Get druggable targets OG5_128839 All targets in OG5_128839
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans protein trans. across mito. Intermembrane space Get druggable targets OG5_128839 All targets in OG5_128839
Loa Loa (eye worm) transport to inner mitochondrial membrane family member Get druggable targets OG5_128839 All targets in OG5_128839
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0037 0.1144 0.4625
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.1147 0.1251
Brugia malayi CXXC zinc finger family protein 0.0028 0.0847 0.0924
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.1147 0.3404
Mycobacterium tuberculosis Conserved protein 0.0037 0.1144 0.1254
Echinococcus multilocularis ferritin 0.0008 0.0143 0.0156
Echinococcus granulosus expressed protein 0.0008 0.0143 0.0156
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.1144 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0502 0.0548
Loa Loa (eye worm) hypothetical protein 0.0037 0.1144 0.1248
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1144 0.1144
Mycobacterium leprae Probable lipase LipE 0.0037 0.1144 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.1147 0.3404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0075 0.0075
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0058 0.189 0.2062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.1144 0.1254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.1147 0.3404
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0058 0.189 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0502 0.5
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0144 0.0157
Plasmodium vivax hypothetical protein, conserved 0.0037 0.1144 0.4625
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.337 0.3675
Schistosoma mansoni hypothetical protein 0.0054 0.175 0.5192
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.9169 1
Schistosoma mansoni survival motor neuron protein 0.0054 0.175 0.5192
Mycobacterium ulcerans beta-lactamase 0.0037 0.1144 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.1144 0.1254
Loa Loa (eye worm) hypothetical protein 0.0037 0.1144 0.1248
Onchocerca volvulus 0.0054 0.175 0.175
Mycobacterium tuberculosis Conserved protein 0.0037 0.1144 0.1254
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.1144 1
Brugia malayi beta-lactamase family protein 0.0037 0.1144 0.1248
Schistosoma mansoni ferritin 0.0008 0.0143 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1144 0.1144
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0502 0.0502
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Brugia malayi TAR-binding protein 0.0076 0.2558 0.2789
Mycobacterium leprae conserved hypothetical protein 0.0037 0.1144 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.8127 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0502 0.0548
Trichomonas vaginalis esterase, putative 0.0037 0.1144 0.1144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0075 0.0075
Onchocerca volvulus 0.0037 0.1147 0.1147
Loa Loa (eye worm) RNA binding protein 0.0076 0.2558 0.2789
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2558 0.7589
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0075 0.0075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.1144 0.1248
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.337 0.3675
Mycobacterium ulcerans lipase LipD 0.0037 0.1144 1
Echinococcus granulosus expressed protein 0.0058 0.189 0.2062
Mycobacterium ulcerans hypothetical protein 0.0037 0.1144 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0075 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.337 1
Schistosoma mansoni apoferritin-2 0.0008 0.0143 0.0426
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.1078 0.1176
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2558 0.7589
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.1144 0.1248
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0502 0.0548
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0075 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.1147 0.3404
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1144 0.1144
Schistosoma mansoni ferritin 0.0008 0.0143 0.0426
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.1144 0.1254
Loa Loa (eye worm) hypothetical protein 0.0263 0.9169 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2558 0.2789
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.877 0.9565
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.1144 0.1254
Brugia malayi beta-lactamase 0.0037 0.1144 0.1248
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1144 0.3396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.337 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0075 0.0075
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0144 0.0157
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.1147 0.1251
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.337 0.3675
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0144 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1144 0.1144
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.1144 0.1254
Trichomonas vaginalis ferritin, putative 0.0008 0.0143 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2558 0.7589
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.2013 0.5974
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0205 0.0223
Toxoplasma gondii TIM10 family protein, putative 0.0058 0.189 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0502 0.3587
Echinococcus multilocularis cpg binding protein 0.003 0.0904 0.0986
Echinococcus multilocularis expressed protein 0.0058 0.189 0.2062
Echinococcus granulosus tar DNA binding protein 0.0076 0.2558 0.2789
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0502 0.045
Trichomonas vaginalis set domain proteins, putative 0.0287 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0502 1
Schistosoma mansoni cpg binding protein 0.0028 0.0847 0.2513
Schistosoma mansoni ferritin light chain 0.0008 0.0143 0.0426
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0502 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0201 0.0219
Echinococcus granulosus cpg binding protein 0.003 0.0904 0.0986
Mycobacterium tuberculosis Conserved protein 0.0037 0.1144 0.1254
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0058 0.189 0.561
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0847 0.0924
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2558 0.2789
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.1144 0.1254
Loa Loa (eye worm) hypothetical protein 0.0037 0.1144 0.1248
Plasmodium vivax SET domain protein, putative 0.0037 0.1147 0.4645
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.1144 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.1144 0.1248
Loa Loa (eye worm) hypothetical protein 0.0037 0.1147 0.1251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0144 0.0157
Echinococcus multilocularis expressed protein 0.0008 0.0143 0.0156
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0144 0.0426
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0502 0.0502
Schistosoma mansoni ferritin 0.0008 0.0143 0.0426
Schistosoma mansoni cpg binding protein 0.003 0.0904 0.2682
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0205 0.0223
Schistosoma mansoni ferritin light chain 0.0008 0.0143 0.0426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0502 0.0548
Schistosoma mansoni ap endonuclease 0.0018 0.0502 0.1491
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2558 0.2789
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1144 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.1144 0.1248
Brugia malayi Pre-SET motif family protein 0.0037 0.1147 0.1251
Loa Loa (eye worm) beta-lactamase 0.0037 0.1144 0.1248
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0502 1
Brugia malayi beta-lactamase family protein 0.0037 0.1144 0.1248
Schistosoma mansoni cpg binding protein 0.003 0.0904 0.2682
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2558 0.2789
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0058 0.189 1
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.9169 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.337 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0058 0.189 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.175 0.1908
Schistosoma mansoni ap endonuclease 0.0018 0.0502 0.1491
Onchocerca volvulus 0.0037 0.1144 0.1144
Brugia malayi hypothetical protein 0.0263 0.9169 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0205 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.1144 0.1248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0039 0.0115
Leishmania major hypothetical protein, conserved 0.0037 0.1144 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.1144 0.1254
Onchocerca volvulus 0.0037 0.1144 0.1144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.337 0.3675
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1787 0.9254
Onchocerca volvulus 0.0037 0.1144 0.1144
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1144 0.1144
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.1147 0.4645
Brugia malayi Pre-SET motif family protein 0.0252 0.877 0.9565
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.1147 0.1251
Echinococcus granulosus ferritin 0.0008 0.0143 0.0156
Schistosoma mansoni ferritin 0.0008 0.0143 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.337 0.3675
Brugia malayi RNA binding protein 0.0076 0.2558 0.2789
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.337 0.3675
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1144 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.1144 0.1248
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2558 0.7589
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2558 0.7589
Trichomonas vaginalis helicase, putative 0.0006 0.0075 0.0075
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0058 0.189 0.2062
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Schistosoma mansoni apoferritin-2 0.0008 0.0143 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0075 0.0075
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.1144 0.1248
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1144 0.3396
Onchocerca volvulus 0.0028 0.0847 0.0847

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.99 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463190, AID463194, AID504542, AID504544] ChEMBL. No reference
IC50 (functional) = 22 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent TIM10 yeast counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463190, AID463194, AID493003] ChEMBL. No reference
IC50 (functional) = 41.9 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463190, AID463194, AID493003] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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