Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8208 | 1 |
Brugia malayi | angiogenesis inhibito | 0.0028 | 0.1981 | 0.1981 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0004 | 0.0004 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.8208 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.8208 | 0.8208 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.8208 | 0.8208 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8208 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.0004 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.8208 | 0.8208 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8208 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0004 | 0.0004 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0038 | 0.3264 | 0.3977 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8208 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.8208 | 0.8208 |
Echinococcus granulosus | adam | 0.0026 | 0.1749 | 0.213 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.8208 | 1 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.0014 | 0.0232 | 0.0232 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8208 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.8208 | 0.8208 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0004 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.0004 | 0.5 |
Onchocerca volvulus | Papilin homolog | 0.0029 | 0.2085 | 0.5 |
Echinococcus multilocularis | adam | 0.0026 | 0.1749 | 0.213 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2085 | 0.2085 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0004 | 0.0004 |
Brugia malayi | hypothetical protein | 0.0026 | 0.1749 | 0.1749 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0038 | 0.3264 | 0.3977 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0038 | 0.3264 | 0.3977 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 1 | 1 |
Brugia malayi | ADAMTS-like protease | 0.0028 | 0.1981 | 0.1981 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.0004 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0004 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.8208 | 0.8208 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1749 | 0.1749 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0026 | 0.1749 | 0.213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.5849 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.