Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0237 | 0.2773 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.904 | 0.904 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0335 | 0.4389 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.0733 | 0.6865 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0127 | 0.096 | 0.096 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.096 | 0.096 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | ACC-1 protein | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0127 | 0.096 | 0.9002 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0127 | 0.096 | 0.096 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0127 | 0.096 | 0.9002 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0113 | 0.0733 | 0.6865 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0237 | 0.2773 | 0.2773 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0127 | 0.096 | 0.9002 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0127 | 0.096 | 0.9002 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0127 | 0.096 | 0.9002 |
Onchocerca volvulus | Putative nachr subunit | 0.0127 | 0.096 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0407 | 0.556 | 0.556 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0918 | 0.0918 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0127 | 0.096 | 0.096 |
Echinococcus multilocularis | 0.0113 | 0.0733 | 0.6865 | |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Schistosoma mansoni | lipoxygenase | 0.0133 | 0.1067 | 1 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0127 | 0.096 | 0.096 |
Leishmania major | cytochrome p450-like protein | 0.0237 | 0.2773 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0113 | 0.0733 | 0.0733 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Echinococcus multilocularis | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0127 | 0.096 | 0.9002 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0312 | 0.4001 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0127 | 0.096 | 0.096 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0127 | 0.096 | 0.9002 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0133 | 0.1067 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0237 | 0.2773 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0113 | 0.0733 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Brugia malayi | Cytochrome P450 family protein | 0.0407 | 0.556 | 0.556 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Schistosoma mansoni | lipoxygenase | 0.0093 | 0.0408 | 0.3827 |
Onchocerca volvulus | 0.0127 | 0.096 | 1 | |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0127 | 0.096 | 0.9002 |
Onchocerca volvulus | 0.0127 | 0.096 | 1 | |
Brugia malayi | Cytochrome P450 family protein | 0.0237 | 0.2773 | 0.2773 |
Brugia malayi | Cation transporter family protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0127 | 0.096 | 0.096 |
Onchocerca volvulus | 0.0127 | 0.096 | 1 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0237 | 0.2773 | 0.558 |
Loa Loa (eye worm) | cytochrome P450 | 0.0113 | 0.0733 | 0.0733 |
Brugia malayi | cytochrome P450 | 0.0113 | 0.0733 | 0.0733 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0127 | 0.096 | 0.9002 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0127 | 0.096 | 0.9002 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.096 | 0.096 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0133 | 0.1067 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0127 | 0.096 | 0.096 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0127 | 0.096 | 0.9002 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0127 | 0.096 | 0.9002 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | Cation transporter family protein | 0.0127 | 0.096 | 0.096 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0237 | 0.2773 | 0.2773 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Mycobacterium leprae | putative cytochrome p450 | 0.0113 | 0.0733 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0237 | 0.2773 | 0.2773 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0127 | 0.096 | 0.9002 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0127 | 0.096 | 0.9002 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0113 | 0.0733 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0335 | 0.4389 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0127 | 0.096 | 0.9002 |
Schistosoma mansoni | cytochrome P450 | 0.0113 | 0.0733 | 0.6865 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 1 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0127 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | Cation transporter family protein | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0127 | 0.096 | 0.096 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0127 | 0.096 | 0.096 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0237 | 0.2773 | 1 |
Onchocerca volvulus | 0.0127 | 0.096 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0127 | 0.096 | 0.9002 |
Onchocerca volvulus | 0.0127 | 0.096 | 1 | |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.096 | 0.096 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | LGC-31 protein | 0.0127 | 0.096 | 0.096 |
Brugia malayi | Cytochrome P450 family protein | 0.0237 | 0.2773 | 0.2773 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0127 | 0.096 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.096 | 0.096 |
Onchocerca volvulus | 0.0127 | 0.096 | 1 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0127 | 0.096 | 0.9002 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0127 | 0.096 | 0.096 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0127 | 0.096 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.096 | 0.096 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.