Detailed information for compound 1277334

Basic information

Technical information
  • TDR Targets ID: 1277334
  • Name: N-(4-fluorophenyl)-4-(pyridin-3-ylmethylsulfa moyl)benzamide
  • MW: 385.412 | Formula: C19H16FN3O3S
  • H donors: 2 H acceptors: 4 LogP: 2.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)c1ccc(cc1)S(=O)(=O)NCc1cccnc1
  • InChi: 1S/C19H16FN3O3S/c20-16-5-7-17(8-6-16)23-19(24)15-3-9-18(10-4-15)27(25,26)22-13-14-2-1-11-21-12-14/h1-12,22H,13H2,(H,23,24)
  • InChiKey: NLZIPORZWWPJFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-fluorophenyl)-4-(3-pyridylmethylsulfamoyl)benzamide
  • ASN 05062000
  • N-(4-Fluoro-phenyl)-4-[(pyridin-3-ylmethyl)-sulfamoyl]-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.0037 0.0061 0.0055
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0142 0.0339 0.0333
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0017 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0131 0.0311 0.0412
Brugia malayi nuclear receptor NHR-88 0.0034 0.0054 0.0048
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.0454 0.0595
Schistosoma mansoni lozenge 0.0076 0.0166 0.0212
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.0454 0.0602
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0081 0.0177 0.0171
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Echinococcus granulosus mitogen activated protein kinase 0.0074 0.0159 0.021
Giardia lamblia PHD finger protein 15 0.004 0.0069 0.3711
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0185 0.0454 0.0602
Echinococcus granulosus dihydrofolate reductase 0.0505 0.1301 0.1726
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0055 0.0084
Brugia malayi hypothetical protein 0.0018 0.0011 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0182 0.0514
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0008 0.001
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0454 0.0602
Trypanosoma cruzi ISWI complex protein 0.0021 0.0019 0.0006
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0104 0.0239 0.0408
Echinococcus granulosus poly (ADP ribose) polymerase 0.0016 0.0005 0.0005
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0185 0.0454 0.0595
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0055 0.0072
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0185 0.0454 0.0448
Brugia malayi G protein-coupled receptor 0.0185 0.0454 0.0448
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0234 0.1443
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.0088 0.0197 0.0261
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0034 0.0054 0.2206
Trichomonas vaginalis glucosylceramidase, putative 0.0108 0.0249 0.154
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.0055 0.2249
Brugia malayi MH2 domain containing protein 0.0062 0.0127 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0034 0.0054 0.0082
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Mycobacterium leprae conserved hypothetical protein 0.0167 0.0406 0.11
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1742 0.4582 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0011 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0069 0.0034
Echinococcus multilocularis jumonji domain containing protein 0.0056 0.0111 0.0146
Echinococcus multilocularis abhydrolase domain containing protein 0.0038 0.0064 0.0084
Echinococcus multilocularis mitogen activated protein kinase 0.0074 0.0159 0.021
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0107
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0085 0.0188 0.0248
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0006 0.0007
Brugia malayi MH1 domain containing protein 0.0062 0.0127 0.0121
Brugia malayi Dopamine receptor protein 1 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0097 0.0221 0.0215
Mycobacterium ulcerans esterase/lipase LipP 0.0167 0.0406 0.1205
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.013 0.0309 0.0302
Schistosoma mansoni transient receptor potential channel 0.006 0.0122 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0156 0.0376 0.2384
Loa Loa (eye worm) hypothetical protein 0.0056 0.0112 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Echinococcus granulosus dna polymerase kappa 0.002 0.0017 0.0021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.0454 0.0602
Brugia malayi thymidylate synthase 0.1238 0.3244 0.324
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.005 0.0043
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0054 0.0048
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi Latrophilin receptor protein 2 0.0199 0.0491 0.0485
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0055 0.0072
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0014
Schistosoma mansoni jumonji domain containing protein 0.0104 0.024 0.031
Entamoeba histolytica hypothetical protein 0.0058 0.0118 0.5082
Brugia malayi TAR-binding protein 0.0144 0.0344 0.0338
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0185 0.0454 0.0448
Brugia malayi glutathione reductase 0.0036 0.0059 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0054 0.0048
Echinococcus multilocularis mothers against decapentaplegic 2 0.0028 0.0037 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.003
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0023 0.0024 0.0031
Schistosoma mansoni methyl-cpg binding protein mbd 0.0023 0.0025 0.0026
Echinococcus granulosus g protein coupled receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0145 0.0346 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0055 0.0255
Mycobacterium ulcerans hypothetical protein 0.0167 0.0406 0.1205
Brugia malayi Trypsin family protein 0.0038 0.0064 0.0058
Echinococcus granulosus sex peptide receptor 0.0185 0.0454 0.0602
Onchocerca volvulus 0.1238 0.3244 1
Schistosoma mansoni transient receptor potential channel 0.006 0.0122 0.0153
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0115 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0125 0.0335
Echinococcus multilocularis G-protein coupled receptor, putative 0.0185 0.0454 0.0602
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0034 0.0054 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Mycobacterium ulcerans lipase LipD 0.0167 0.0406 0.1205
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.0454 0.0602
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0054 0.0064
Schistosoma mansoni amine GPCR 0.0185 0.0454 0.0595
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0017 0.0036
Loa Loa (eye worm) thioredoxin reductase 0.0036 0.0059 0.0053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.0454 0.0602
Schistosoma mansoni amine GPCR 0.0185 0.0454 0.0595
Echinococcus granulosus methyl CpG binding domain protein 2 0.0023 0.0025 0.0033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0185 0.0454 0.0595
Schistosoma mansoni neuropeptide receptor 0.0185 0.0454 0.0595
Schistosoma mansoni hypothetical protein 0.004 0.0069 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0103 0.0236 0.0306
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0017 0.0036
Loa Loa (eye worm) RNA binding protein 0.0144 0.0344 0.0338
Echinococcus multilocularis dihydrofolate reductase 0.0505 0.1301 0.1726
Plasmodium falciparum epoxide hydrolase 1 0.0038 0.0064 0.0127
Schistosoma mansoni hypothetical protein 0.0185 0.0454 0.0595
Brugia malayi beta-lactamase family protein 0.0167 0.0406 0.04
Brugia malayi GnHR receptor homolog 0.0185 0.0454 0.0448
Loa Loa (eye worm) MH2 domain-containing protein 0.0907 0.2369 0.2364
Brugia malayi neuropeptide F receptor 0.0185 0.0454 0.0448
Echinococcus multilocularis survival motor neuron protein 1 0.1062 0.2778 0.3686
Brugia malayi G-protein coupled receptor 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi Immunoglobulin I-set domain containing protein 0.024 0.0601 0.0595
Onchocerca volvulus 0.0185 0.0454 0.1383
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Onchocerca volvulus 0.0185 0.0454 0.1383
Loa Loa (eye worm) TYRA-2 protein 0.0185 0.0454 0.0448
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0011 0.0007
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0185 0.0454 0.1383
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1066 0.2788 0.8588
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0021 0.0032
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.0055 0.0084
Echinococcus multilocularis somatostatin receptor 0.0185 0.0454 0.0602
Brugia malayi Dopamine receptor 0.0185 0.0454 0.0448
Loa Loa (eye worm) Smad1 0.0062 0.0127 0.0121
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0045 0.0084 0.0182
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0185 0.0454 0.0448
Leishmania major trypanothione reductase 0.0036 0.0059 0.0094
Loa Loa (eye worm) hypothetical protein 0.0167 0.0406 0.04
Brugia malayi hypothetical protein 0.1062 0.2778 0.2773
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0065 0.0325
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0069 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0234 0.1443
Echinococcus multilocularis RUN 0.0022 0.0021 0.0026
Loa Loa (eye worm) hypothetical protein 0.0608 0.1576 0.1571
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0017 0.0535
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Brugia malayi WGR domain containing protein 0.0055 0.0109 0.0103
Echinococcus multilocularis zinc finger protein 0.003 0.0042 0.0054
Trypanosoma brucei protein kinase, putative 0.0074 0.0159 0.0348
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0081 0.0177 0.0234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0006 0.0007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0124 0.0163
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0017 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0115 0.0217
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0065 0.0025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.2884 0.7609 0.7607
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0074 0.0159 0.0313
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0167 0.0406 0.053
Echinococcus granulosus geminin 0.0727 0.1891 0.2509
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Brugia malayi beta-lactamase family protein 0.0167 0.0406 0.04
Brugia malayi MH2 domain containing protein 0.0907 0.2369 0.2364
Brugia malayi Doublecortin family protein 0.0022 0.0021 0.0014
Schistosoma mansoni intermediate filament proteins 0.0145 0.0346 0.0452
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.0454 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Loa Loa (eye worm) hypothetical protein 0.0199 0.0491 0.0485
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0182 0.04
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Onchocerca volvulus 0.0145 0.0346 0.1051
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.0055 0.0065
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni transient receptor potential channel 4 0.0088 0.0198 0.0254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.0454 0.0595
Mycobacterium tuberculosis Probable reductase 0.0083 0.0182 0.0514
Echinococcus granulosus abhydrolase domain containing protein 0.0038 0.0064 0.0084
Echinococcus granulosus mothers against decapentaplegic 2 0.0028 0.0037 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0049 0.0094 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0167 0.0406 0.258
Schistosoma mansoni hypothetical protein 0.0185 0.0454 0.0595
Loa Loa (eye worm) hypothetical protein 0.0094 0.0211 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi Bromodomain containing protein 0.0106 0.0244 0.0238
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.01 0.0229 0.0302
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0065 0.0152
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0185 0.0454 0.0595
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0054 0.0071
Schistosoma mansoni smad 0.0028 0.0037 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Toxoplasma gondii ABC1 family protein 0.0167 0.0406 0.0776
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0185 0.0454 0.0448
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0054 0.0064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0036 0.0059 0.0078
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0454 0.0595
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0058 0.0118 0.0156
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0054 0.0048
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0045 0.0084 0.0147
Leishmania major cathepsin L-like protease 0.0044 0.0079 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0115 0.0217
Echinococcus granulosus mothers against decapentaplegic 5 0.0062 0.0127 0.0168
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0021 0.0026
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0032 0.0041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0167 0.0406 0.04
Schistosoma mansoni neuropeptide receptor 0.0185 0.0454 0.0595
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0159 0.0947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0081 0.0177 0.0234
Brugia malayi MH2 domain containing protein 0.0062 0.0127 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0589 0.1524 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0197 0.0254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0177 0.0227
Brugia malayi hypothetical protein 0.0094 0.0211 0.0205
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1238 0.3244 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0092 0.0207 0.0589
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0034 0.0053 0.0069
Giardia lamblia Kinase, CMGC MAPK 0.0074 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0406 0.04
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.002 0.0013
Echinococcus multilocularis neuropeptide receptor 0.0185 0.0454 0.0602
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0021 0.0026
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0011 0.0014
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0143
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0036 0.0059 0.0133
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Mycobacterium tuberculosis Probable hydrolase 0.0167 0.0406 0.1205
Echinococcus multilocularis transient receptor potential gamma protein 0.0088 0.0198 0.0261
Brugia malayi dihydrofolate reductase family protein 0.0505 0.1301 0.1296
Schistosoma mansoni lamin 0.0145 0.0346 0.0452
Brugia malayi MH2 domain containing protein 0.0028 0.0037 0.003
Plasmodium vivax hypothetical protein, conserved 0.004 0.0069 0.0139
Echinococcus multilocularis tumor protein p63 0.238 0.6273 0.8325
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0074 0.0159 0.0313
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0074 0.0159 0.0348
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0185 0.0454 0.0595
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Onchocerca volvulus 0.0185 0.0454 0.1383
Leishmania major cathepsin L-like protease 0.0044 0.0079 0.0138
Schistosoma mansoni zinc finger protein 0.0021 0.0019 0.0017
Onchocerca volvulus 0.0608 0.1576 0.4848
Schistosoma mansoni lipoxygenase 0.006 0.0124 0.0156
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0167 0.0406 0.1205
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0006 0.0007
Onchocerca volvulus 0.0185 0.0454 0.1383
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0062 0.0127 0.0168
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0054 0.0071
Echinococcus granulosus poly (ADP ribose) polymerase 0.0031 0.0046 0.006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0107
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0054 0.0048
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0125 0.0335
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0034 0.0054 0.0082
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0454 0.0602
Mycobacterium tuberculosis Probable lipase LipE 0.0167 0.0406 0.1205
Echinococcus granulosus G protein coupled receptor 139 0.0185 0.0454 0.0602
Trichomonas vaginalis D-aminoacylase, putative 0.0167 0.0406 0.258
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0045 0.0084 0.0147
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0055 0.0118
Echinococcus multilocularis dna polymerase eta 0.002 0.0017 0.0021
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0344 0.0448
Leishmania major hypothetical protein, conserved 0.0057 0.0115 0.0217
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0019
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0006 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Echinococcus granulosus GPCR family 2 0.0199 0.0491 0.065
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0054 0.0048
Echinococcus multilocularis fmrfamide receptor 0.0185 0.0454 0.0602
Schistosoma mansoni inositol monophosphatase 0.0039 0.0065 0.0079
Schistosoma mansoni cpg binding protein 0.0053 0.0103 0.0129
Onchocerca volvulus 0.0185 0.0454 0.1383
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0054 0.0071
Trypanosoma brucei unspecified product 0.002 0.0017 0.0036
Loa Loa (eye worm) nuclear factor I 0.0034 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0629 0.163 0.1625
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.0454 0.0602
Brugia malayi hypothetical protein 0.0058 0.0118 0.0112
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0156 0.0376 0.037
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0185 0.0454 0.0448
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0032 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0054 0.0064
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0054 0.0071
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0056 0.0074
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0055 0.0072
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.0454 0.0602
Schistosoma mansoni transcription factor LCR-F1 0.0058 0.0118 0.0149
Schistosoma mansoni myosin xvIII 0.0185 0.0454 0.0595
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0065 0.2719
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0065 0.0107
Onchocerca volvulus 0.0038 0.0064 0.0178
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0125 0.0156
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0125 0.0157
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.0454 0.0448
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0054 0.0071
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0074 0.0159 0.0153
Onchocerca volvulus 0.0185 0.0454 0.1383
Schistosoma mansoni neuropeptide receptor 0.0185 0.0454 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0234 0.1443
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0055 0.0109 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0054 0.0048
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0054 0.0064
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0454 0.0595
Schistosoma mansoni rab6-interacting 0.0022 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0058 0.0118 0.0149
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0054 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0054 0.0064
Loa Loa (eye worm) hypothetical protein 0.1062 0.2778 0.2773
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0006 0.0007
Echinococcus granulosus g protein coupled receptor 0.0185 0.0454 0.0602
Mycobacterium ulcerans thymidylate synthase 0.1238 0.3244 1
Brugia malayi RNA recognition motif domain containing protein 0.0144 0.0344 0.0338
Echinococcus multilocularis GPCR, family 2 0.0199 0.0491 0.065
Brugia malayi N-terminal motif family protein 0.0181 0.0443 0.0437
Brugia malayi Pre-SET motif family protein 0.0065 0.0135 0.0129
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0185 0.0454 0.0595
Brugia malayi CXXC zinc finger family protein 0.0047 0.0089 0.0083
Loa Loa (eye worm) hypothetical protein 0.0181 0.0443 0.0437
Brugia malayi MH1 domain containing protein 0.0062 0.0127 0.0121
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0038 0.0032
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.0454 0.0602
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0159 0.0947
Brugia malayi hypothetical protein 0.0589 0.1524 0.1519
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0079 0.0138
Echinococcus granulosus Smad4 0.0062 0.0127 0.0168
Echinococcus granulosus peregrin 0.0043 0.0078 0.0103
Echinococcus multilocularis mothers against decapentaplegic 5 0.0062 0.0127 0.0168
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0159 0.0947
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0135 0.0172
Entamoeba histolytica hypothetical protein 0.0058 0.0118 0.5082
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Echinococcus multilocularis PHD finger protein rhinoceros 0.004 0.0069 0.0091
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0039 0.0068 0.0062
Mycobacterium tuberculosis Hypothetical protein 0.0589 0.1524 0.4671
Mycobacterium tuberculosis Conserved protein 0.0167 0.0406 0.1205
Echinococcus multilocularis fmrfamide receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0099
Plasmodium vivax glutathione reductase, putative 0.0036 0.0059 0.0117
Schistosoma mansoni microtubule-associated protein tau 0.2856 0.7535 1
Schistosoma mansoni hypothetical protein 0.0676 0.1755 0.2323
Echinococcus granulosus jumonji domain containing protein 0.0056 0.0111 0.0146
Schistosoma mansoni biogenic amine receptor 0.0185 0.0454 0.0595
Echinococcus granulosus 7TM GPCR rhodopsin 0.0185 0.0454 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0177 0.0227
Echinococcus multilocularis dro:myosuppressin receptor 0.0185 0.0454 0.0602
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0135 0.0172
Loa Loa (eye worm) hypothetical protein 0.0167 0.0406 0.04
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0054 0.0048
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.0454 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0505 0.1301 0.398
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0031 0.0046 0.01
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0065 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0125 0.0335
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0088 0.0197 0.0261
Schistosoma mansoni zinc finger protein 0.003 0.0042 0.0047
Brugia malayi Tachykinin-like peptides receptor 99D 0.0185 0.0454 0.0448
Brugia malayi MH1 domain containing protein 0.0034 0.0054 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0199 0.0491 0.0485
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0048 0.0089 0.011
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0159 0.0947
Echinococcus granulosus tumor protein p63 0.238 0.6273 0.8325
Onchocerca volvulus 0.0185 0.0454 0.1383
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0185 0.0454 0.0595
Schistosoma mansoni hypothetical protein 0.0185 0.0454 0.0595
Echinococcus multilocularis orexin receptor type 2 0.0185 0.0454 0.0602
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0081 0.0177 0.0171
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0034 0.0054 0.0118
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0185 0.0454 0.0602
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.01 0.0229 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0185 0.0454 0.0602
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.0454 0.0595
Echinococcus granulosus lamin 0.0145 0.0346 0.0459
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.0055 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0054 0.0048
Schistosoma mansoni opsin-like receptor 0.0185 0.0454 0.0595
Loa Loa (eye worm) CYP4Cod1 0.0021 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0199 0.0491 0.065
Echinococcus multilocularis X box binding protein 1 0.0364 0.0928 0.123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0005
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0185 0.0454 0.0602
Echinococcus multilocularis dnaJ subfamily B 0.0676 0.1755 0.2329
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0054 0.0064
Mycobacterium tuberculosis Conserved protein 0.0167 0.0406 0.1205
Loa Loa (eye worm) melatonin receptor type 1A 0.0185 0.0454 0.0448
Loa Loa (eye worm) MH1 domain-containing protein 0.0028 0.0037 0.003
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0185 0.0454 0.0602
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0054 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0034 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Trypanosoma cruzi ISWI complex protein 0.0021 0.0019 0.0006
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0045 0.0084 0.0147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0629 0.163 0.1625
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0034 0.0054 0.2622
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0008 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0145 0.0346 0.034
Echinococcus multilocularis transcription factor Dp 1 0.0026 0.0033 0.0043
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0012 0.0014
Onchocerca volvulus 0.0034 0.0054 0.0148
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0079 0.0138
Echinococcus granulosus mitogen activated protein kinase 3 0.0074 0.0159 0.021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0054 0.0064
Onchocerca volvulus Huntingtin homolog 0.0094 0.0211 0.0634
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0081 0.0177 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Trichomonas vaginalis set domain proteins, putative 0.0508 0.1309 0.8575
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Echinococcus multilocularis lamin dm0 0.0145 0.0346 0.0459
Schistosoma mansoni rab6-interacting 0.0022 0.0021 0.0019
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0021 0.0026
Schistosoma mansoni smad 0.0062 0.0127 0.0161
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0034 0.0054 0.0082
Trichomonas vaginalis penicillin-binding protein, putative 0.0167 0.0406 0.258
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0106 0.0132
Brugia malayi Serotonin receptor 0.0185 0.0454 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0054 0.0048
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0185 0.0454 0.0602
Loa Loa (eye worm) latrophilin receptor protein 2 0.0199 0.0491 0.0485
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Echinococcus granulosus poly (ADP ribose) polymerase 0.0016 0.0005 0.0005
Echinococcus multilocularis lamin 0.0145 0.0346 0.0459
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0054 0.0148
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0054 0.0071
Echinococcus granulosus short transient receptor potential channel 6 0.006 0.0122 0.016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0167 0.0406 0.1205
Leishmania major cytochrome p450-like protein 0.0021 0.002 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0156 0.0376 0.2384
Schistosoma mansoni opsin-like receptor 0.0185 0.0454 0.0595
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0135 0.0179
Brugia malayi Bromodomain containing protein 0.0043 0.0078 0.0072
Echinococcus granulosus fmrfamide receptor 0.0185 0.0454 0.0602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Loa Loa (eye worm) hypothetical protein 0.0088 0.0197 0.0191
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0054 0.0071
Brugia malayi PHD-finger family protein 0.0018 0.0012 0.0006
Brugia malayi Cytochrome P450 family protein 0.0021 0.002 0.0013
Echinococcus granulosus fetal alzheimer antigen falz 0.0034 0.0053 0.0069
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0006 0.0007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0055 0.0084
Echinococcus multilocularis neuropeptide receptor 0.0185 0.0454 0.0602
Schistosoma mansoni poly [ADP-ribose] polymerase 0.01 0.0229 0.0295
Brugia malayi beta-lactamase 0.0167 0.0406 0.04
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.002 0.0007
Echinococcus granulosus neuropeptide FF receptor 2 0.0185 0.0454 0.0602
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0011 0.0007
Onchocerca volvulus 0.0508 0.1309 0.4024
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0054 0.0248
Schistosoma mansoni Smad4 0.0028 0.0037 0.004
Echinococcus multilocularis Smad4 0.0062 0.0127 0.0168
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0054 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0292 0.1826
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.0207 0.0589
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0126 0.0167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.0454 0.0602
Entamoeba histolytica hypothetical protein 0.0058 0.0118 0.5082
Brugia malayi G-protein coupled receptor 0.0185 0.0454 0.0448
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0008 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.1974 0.5195 0.6895
Schistosoma mansoni lamin 0.0145 0.0346 0.0452
Brugia malayi Melatonin receptor type 1A 0.0185 0.0454 0.0448
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0045 0.0084 0.3526
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0011 0.0014
Schistosoma mansoni hypothetical protein 0.0727 0.1891 0.2504
Onchocerca volvulus Glucosylceramidase homolog 0.0102 0.0234 0.0704
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0079 0.0138
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0045 0.0084 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0054 0.0071
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0055 0.012
Loa Loa (eye worm) hypothetical protein 0.0061 0.0126 0.012
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0185 0.0454 0.0602
Onchocerca volvulus 0.0185 0.0454 0.1383
Trichomonas vaginalis penicillin-binding protein, putative 0.0167 0.0406 0.258
Echinococcus granulosus alpha 1A adrenergic receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) thymidylate synthase 0.1238 0.3244 0.324
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0182 0.0514
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni amine GPCR 0.0185 0.0454 0.0595
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.0454 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0054 0.0048
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0054 0.0048
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0185 0.0454 0.0448
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0125 0.0335
Echinococcus multilocularis tar DNA binding protein 0.0144 0.0344 0.0455
Echinococcus multilocularis dna polymerase kappa 0.002 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0005
Brugia malayi AKH receptor 0.0185 0.0454 0.0448
Onchocerca volvulus 0.0047 0.0089 0.0256
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0167 0.0406 0.04
Loa Loa (eye worm) hypothetical protein 0.0167 0.0406 0.04
Schistosoma mansoni hypothetical protein 0.043 0.1103 0.1457
Loa Loa (eye worm) MH2 domain-containing protein 0.0028 0.0037 0.003
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.0454 0.0595
Schistosoma mansoni bromodomain containing protein 0.009 0.0201 0.0259
Onchocerca volvulus Huntingtin homolog 0.0094 0.0211 0.0634
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0167 0.0406 0.04
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1238 0.3244 1
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0045 0.0084 0.0077
Loa Loa (eye worm) hypothetical protein 0.007 0.0148 0.0142
Toxoplasma gondii thioredoxin reductase 0.0036 0.0059 0.0012
Echinococcus granulosus poly ADP ribose polymerase 1 0.01 0.0229 0.0302
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2559 0.3396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Echinococcus multilocularis G protein coupled receptor 139 0.0185 0.0454 0.0602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Plasmodium vivax thioredoxin reductase, putative 0.0036 0.0059 0.0117
Loa Loa (eye worm) inositol-1 0.0039 0.0065 0.0059
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.0454 0.0448
Brugia malayi Serotonin receptor 0.0185 0.0454 0.0448
Echinococcus multilocularis allatostatin A receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0065 0.0325
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Plasmodium vivax SET domain protein, putative 0.0065 0.0135 0.0283
Brugia malayi sulfakinin receptor protein 0.3786 1 1
Brugia malayi putative neuropeptide receptor 0.0185 0.0454 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Onchocerca volvulus 0.0167 0.0406 0.1233
Echinococcus multilocularis smad 0.0062 0.0127 0.0168
Echinococcus multilocularis serotonin receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.0055 0.0065
Echinococcus granulosus poly (ADP ribose) polymerase 0.0016 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.002 0.001
Brugia malayi G protein-coupled receptor F59B2.13 0.0185 0.0454 0.0448
Brugia malayi ORL1-like opioid receptor 0.0185 0.0454 0.0448
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0055 0.0072
Echinococcus granulosus poly adp ribose polymerase 2 0.0055 0.0109 0.0144
Echinococcus granulosus survival motor neuron protein 1 0.1062 0.2778 0.3686
Toxoplasma gondii histone lysine methyltransferase SET1 0.0096 0.0217 0.0359
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0054 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0344 0.0448
Echinococcus multilocularis serotonin receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0106 0.01
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0054 0.0105
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0055 0.0109 0.0144
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Echinococcus granulosus WGR domain containing protein 0.0031 0.0046 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0054 0.0248
Onchocerca volvulus 0.0185 0.0454 0.1383
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0055 0.0255
Schistosoma mansoni hypothetical protein 0.0199 0.0491 0.0644
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.0055 0.0072
Echinococcus granulosus lysine specific demethylase 5A 0.0054 0.0106 0.014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0006 0.0007
Brugia malayi hypothetical protein 0.0022 0.0021 0.0014
Brugia malayi RNA binding protein 0.0144 0.0344 0.0338
Schistosoma mansoni inositol monophosphatase 0.0039 0.0065 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.0454 0.0595
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0131 0.0311 0.0412
Echinococcus granulosus cpg binding protein 0.0053 0.0103 0.0136
Brugia malayi hypothetical protein 0.0037 0.0062 0.0055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0085 0.0188 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Echinococcus granulosus thymidylate synthase 0.1238 0.3244 0.4305
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0092 0.0207 0.0589
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.0454 0.0595
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0064 0.0077
Echinococcus granulosus X box binding protein 1 0.0364 0.0928 0.123
Schistosoma mansoni coup transcription factor 0.0034 0.0054 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0079 0.0138
Loa Loa (eye worm) hypothetical protein 0.013 0.0309 0.0302
Echinococcus granulosus neuropeptide receptor A26 0.1974 0.5195 0.6895
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0054 0.0048
Schistosoma mansoni lipoxygenase 0.0022 0.0021 0.0019
Brugia malayi hydrolase, alpha/beta fold family protein 0.0038 0.0064 0.0058
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1742 0.4582 1
Schistosoma mansoni histamine h1 receptor 0.0185 0.0454 0.0595
Echinococcus granulosus microtubule associated protein 2 0.2856 0.7535 1
Loa Loa (eye worm) hypothetical protein 0.043 0.1103 0.1097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0054 0.0048
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.0055 0.269
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0055 0.0083
Echinococcus granulosus g-protein coupled receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0608 0.1576 0.1571
Brugia malayi Cytochrome P450 family protein 0.0021 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni opsin-like receptor 0.0185 0.0454 0.0595
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0074 0.0159 0.0233
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.001
Mycobacterium ulcerans beta-lactamase 0.0167 0.0406 0.1205
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0058 0.0118 0.0156
Mycobacterium tuberculosis Probable lipase LipD 0.0167 0.0406 0.1205
Schistosoma mansoni hypothetical protein 0.0199 0.0491 0.0644
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0197 0.0254
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0054 0.0105
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0185 0.0454 0.0595
Echinococcus granulosus transient receptor potential gamma protein 0.0088 0.0198 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0088 0.0198 0.0192
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0185 0.0454 0.0602
Brugia malayi follicle stimulating hormone receptor 0.2884 0.7609 0.7607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.0454 0.0595
Loa Loa (eye worm) hypothetical protein 0.0067 0.0141 0.0135
Echinococcus granulosus somatostatin receptor 0.0185 0.0454 0.0602
Brugia malayi Intermediate filament tail domain containing protein 0.0145 0.0346 0.034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0054 0.0071
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0124 0.0163
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0021 0.0026
Echinococcus granulosus PHD finger protein rhinoceros 0.004 0.0069 0.0091
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0505 0.1301 0.3908
Brugia malayi EGF-like domain containing protein 0.024 0.0601 0.0595
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0021 0.0026
Echinococcus granulosus slit 2 protein 0.024 0.0601 0.0796
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0034 0.0054 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0054 0.0048
Echinococcus multilocularis sex peptide receptor 0.0185 0.0454 0.0602
Trypanosoma brucei hypothetical protein, conserved 0.0167 0.0406 0.0885
Entamoeba histolytica hypothetical protein 0.0058 0.0118 0.5082
Loa Loa (eye worm) hypothetical protein 0.0057 0.0115 0.0109
Brugia malayi larval opioid receptor 0.0185 0.0454 0.0448
Onchocerca volvulus 0.0167 0.0406 0.1233
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0017 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0077 0.0169 0.0162
Echinococcus granulosus tar DNA binding protein 0.0144 0.0344 0.0455
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0125 0.0237
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi steroid hormone receptor 0.0034 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0054 0.0048
Loa Loa (eye worm) glutathione reductase 0.0036 0.0059 0.0053
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.024 0.0601 0.0595
Schistosoma mansoni methyl-cpg binding protein mbd 0.0023 0.0025 0.0026
Echinococcus multilocularis peregrin 0.0043 0.0078 0.0103
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0054 0.0148
Schistosoma mansoni hypothetical protein 0.0199 0.0491 0.0644
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Plasmodium vivax hypothetical protein, conserved 0.0167 0.0406 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0054 0.0048
Echinococcus granulosus dnaJ subfamily B 0.0676 0.1755 0.2329
Chlamydia trachomatis dihydrofolate reductase 0.0505 0.1301 0.5
Echinococcus granulosus lamin dm0 0.0145 0.0346 0.0459
Brugia malayi intermediate filament protein 0.0145 0.0346 0.034
Onchocerca volvulus 0.0035 0.0055 0.0151
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0021 0.0014
Echinococcus granulosus dro:myosuppressin receptor 0.0185 0.0454 0.0602
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Schistosoma mansoni hypothetical protein 0.0217 0.0537 0.0706
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Schistosoma mansoni DNA polymerase eta 0.002 0.0017 0.0014
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.005 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0115 0.024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0182 0.0514
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.0454 0.0602
Schistosoma mansoni hypothetical protein 0.0199 0.0491 0.0644
Echinococcus multilocularis transient receptor potential ion channel A 0.0082 0.0181 0.0239
Echinococcus granulosus neuropeptide receptor 0.0185 0.0454 0.0602
Echinococcus granulosus thioredoxin glutathione reductase 0.0036 0.0059 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0156 0.0376 0.2384
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0185 0.0454 0.0595
Echinococcus multilocularis slit 2 protein 0.024 0.0601 0.0796
Echinococcus granulosus neuropeptide receptor 0.0185 0.0454 0.0602
Trichomonas vaginalis D-aminoacylase, putative 0.0167 0.0406 0.258
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.007 0.0148 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Schistosoma mansoni cellular tumor antigen P53 0.0348 0.0887 0.117
Brugia malayi mothers against decapentaplegic homolog 3 0.0028 0.0037 0.003
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0011 0.0005
Trypanosoma brucei cytochrome P450, putative 0.0021 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Echinococcus multilocularis g-protein coupled receptor 0.0185 0.0454 0.0602
Schistosoma mansoni dihydrofolate reductase 0.0505 0.1301 0.172
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0183 0.0176
Echinococcus granulosus zinc finger protein 0.003 0.0042 0.0054
Schistosoma mansoni transient receptor potential channel 0.0088 0.0198 0.0254
Mycobacterium leprae Probable lipase LipE 0.0167 0.0406 0.11
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0234 0.1443
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1742 0.4582 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0199 0.0491 0.065
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0055 0.0109 0.0203
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0106 0.0132
Brugia malayi putative neuropeptide receptor NPR1 0.0185 0.0454 0.0448
Treponema pallidum exodeoxyribonuclease (exoA) 0.0034 0.0054 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0185 0.0454 0.0602
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0017 0.0021
Onchocerca volvulus 0.0217 0.0537 0.164
Schistosoma mansoni loxhd1 0.0022 0.0021 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0156 0.0376 0.2384
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0144 0.0344 0.0338
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Trypanosoma brucei poly(adp-ribose) polymerase 0.0055 0.0109 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0054 0.0048
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0055 0.0109 0.0203
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0344 0.0448
Echinococcus multilocularis microtubule associated protein 2 0.2856 0.7535 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0006 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.0454 0.0602
Echinococcus multilocularis cpg binding protein 0.0053 0.0103 0.0136
Brugia malayi hypothetical protein 0.0608 0.1576 0.1571
Schistosoma mansoni neuropeptide receptor 0.0185 0.0454 0.0595
Schistosoma mansoni biogenic amine receptor 0.0185 0.0454 0.0595
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0054 0.0048
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0055 0.0109 0.0137
Loa Loa (eye worm) hypothetical protein 0.024 0.0601 0.0595
Onchocerca volvulus 0.0185 0.0454 0.1383
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0017 0.0014
Schistosoma mansoni Smad4 0.0062 0.0127 0.0161
Schistosoma mansoni alpha-1 adrenergic receptor 0.0185 0.0454 0.0595
Brugia malayi Cytochrome P450 family protein 0.0033 0.005 0.0043
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0034 0.0053 0.0062
Echinococcus granulosus short transient receptor potential channel 6 0.006 0.0122 0.016
Loa Loa (eye worm) hypothetical protein 0.0167 0.0406 0.04
Echinococcus granulosus peptide allatostatin:somatostatin 0.0185 0.0454 0.0602
Schistosoma mansoni adenoreceptor 0.0185 0.0454 0.0595
Loa Loa (eye worm) hypothetical protein 0.0069 0.0145 0.0139
Schistosoma mansoni hypothetical protein 0.0364 0.0928 0.1224
Brugia malayi MAP kinase sur-1 0.0074 0.0159 0.0153
Onchocerca volvulus 0.0185 0.0454 0.1383
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.004 0.0069 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Echinococcus multilocularis thymidylate synthase 0.1238 0.3244 0.4305
Brugia malayi exodeoxyribonuclease III family protein 0.0034 0.0054 0.0048
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0045 0.0084 0.0103
Echinococcus multilocularis mothers against decapentaplegic 6 0.0028 0.0037 0.0047
Brugia malayi PHD-finger family protein 0.004 0.0069 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0021 0.0026
Echinococcus granulosus allatostatin A receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) MH2 domain-containing protein 0.0062 0.0127 0.0121
Leishmania major hypothetical protein, conserved 0.0021 0.0019 0.0006
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Brugia malayi Calcitonin receptor-like protein seb-1 0.0629 0.163 0.1625
Brugia malayi RE15519p 0.0185 0.0454 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0054 0.0048
Echinococcus granulosus serotonin receptor 0.0185 0.0454 0.0602
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0234 0.1443
Brugia malayi cytoplasmic intermediate filament protein 0.0077 0.0169 0.0162
Echinococcus granulosus 7tm_1 domain containing protein 0.0185 0.0454 0.0602
Brugia malayi neuropeptide F receptor 0.0185 0.0454 0.0448
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.0454 0.0595
Brugia malayi Thioredoxin reductase 0.0036 0.0059 0.0053
Echinococcus granulosus beta LACTamase domain containing family member 0.0167 0.0406 0.0537
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0035 0.0055 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0234 0.1443
Echinococcus granulosus smad 0.0062 0.0127 0.0168
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0036 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0045 0.0084 0.011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0054 0.0071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.007 0.0148 0.0196
Brugia malayi Dihydrofolate reductase 0.0505 0.1301 0.1296
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.002 0.0007
Onchocerca volvulus 0.0185 0.0454 0.1383
Loa Loa (eye worm) hypothetical protein 0.0076 0.0165 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.043 0.1103 0.1097
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0217 0.0537 0.0532
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0081 0.0177 0.0227
Brugia malayi hypothetical protein 0.0018 0.0011 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.0454 0.0602
Onchocerca volvulus Neuropeptide F receptor homolog 0.0185 0.0454 0.1383
Loa Loa (eye worm) hypothetical protein 0.004 0.0069 0.0063
Brugia malayi WGR domain containing protein 0.01 0.0229 0.0222
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0006 0.0007
Onchocerca volvulus 0.0022 0.0021 0.0044
Brugia malayi Inositol-1 0.0039 0.0065 0.0059
Brugia malayi Smad1 0.0062 0.0127 0.0121
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0054 0.0071
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0017 0.0036
Echinococcus multilocularis neuropeptide FF receptor 2 0.0185 0.0454 0.0602
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0055 0.0255
Loa Loa (eye worm) beta-lactamase 0.0167 0.0406 0.04
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0185 0.0454 0.0602
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0167 0.0406 0.1205
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0182 0.0514
Onchocerca volvulus 0.0185 0.0454 0.1383
Loa Loa (eye worm) transcription factor SMAD2 0.0907 0.2369 0.2364
Schistosoma mansoni hypothetical protein 0.0028 0.0038 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0125 0.0164
Onchocerca volvulus 0.0031 0.0046 0.0123
Schistosoma mansoni hypothetical protein 0.0727 0.1891 0.2504
Schistosoma mansoni amine GPCR 0.0185 0.0454 0.0595
Brugia malayi ecdysteroid receptor 0.0034 0.0054 0.0048
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0185 0.0454 0.0602
Loa Loa (eye worm) hypothetical protein 0.0094 0.0211 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0115 0.024
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0182 0.0514
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0034 0.0054 0.0116
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Onchocerca volvulus Alhambra homolog 0.004 0.0069 0.0195
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.0454 0.0448
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0021 0.0032
Onchocerca volvulus 0.0065 0.0135 0.0399
Schistosoma mansoni smad1 5 8 and 0.0062 0.0127 0.0161
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.0443 0.1348
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0159 0.0313
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0006 0.0007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0034 0.0054 0.0116
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0185 0.0454 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0054 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0006 0.0007
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.004 0.0069 0.0084
Onchocerca volvulus 0.0185 0.0454 0.1383
Plasmodium falciparum glutathione reductase 0.0036 0.0059 0.0117
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.0454 0.0602
Trypanosoma brucei trypanothione reductase 0.0036 0.0059 0.0129
Onchocerca volvulus 0.0167 0.0406 0.1233
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0049 0.0094 0.0124
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Onchocerca volvulus Slit protein homolog 0.024 0.0601 0.1836
Brugia malayi jmjC domain containing protein 0.0054 0.0106 0.01
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Echinococcus granulosus transcription factor Dp 1 0.0026 0.0033 0.0043
Mycobacterium tuberculosis Conserved protein 0.0167 0.0406 0.1205
Echinococcus granulosus TGF beta signal transducer SmadC 0.0062 0.0127 0.0168
Echinococcus multilocularis geminin 0.0727 0.1891 0.2509
Onchocerca volvulus 0.0022 0.0021 0.0044
Brugia malayi Bromodomain containing protein 0.0053 0.0103 0.0097
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1742 0.4582 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0005
Loa Loa (eye worm) hydrolase 0.0038 0.0064 0.0058
Schistosoma mansoni biogenic amine receptor 0.0185 0.0454 0.0595
Echinococcus granulosus transient receptor potential ion channel A 0.0082 0.0181 0.0239
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0054 0.0064
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0045 0.0084 0.011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0199 0.0491 0.065
Schistosoma mansoni Smad4 0.0028 0.0037 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0006
Echinococcus multilocularis short transient receptor potential channel 6 0.006 0.0122 0.016
Echinococcus granulosus intermediate filament protein 0.0145 0.0346 0.0459
Schistosoma mansoni neuropeptide f receptor 76f 0.0185 0.0454 0.0595
Schistosoma mansoni polycystin 1-related 0.0022 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0028 0.0021
Brugia malayi hypothetical protein 0.0057 0.0115 0.0109
Brugia malayi Pre-SET motif family protein 0.0446 0.1146 0.1141
Echinococcus multilocularis mitogen activated protein kinase 3 0.0074 0.0159 0.021
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1742 0.4582 1
Echinococcus multilocularis neuropeptide s receptor 0.1974 0.5195 0.6895
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0185 0.0454 0.0602
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0012 0.0014
Onchocerca volvulus 0.0185 0.0454 0.1383
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0344 0.0448
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0011 0.0005
Echinococcus granulosus RUN 0.0022 0.0021 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0064 0.0077
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0017 0.0014
Brugia malayi jmjC domain containing protein 0.0131 0.0311 0.0305
Schistosoma mansoni cpg binding protein 0.0053 0.0103 0.0129
Schistosoma mansoni growth hormone secretagogue receptor 0.0185 0.0454 0.0595
Loa Loa (eye worm) hypothetical protein 0.0053 0.0103 0.0097
Echinococcus granulosus g protein coupled receptor 0.0185 0.0454 0.0602
Trichomonas vaginalis glucosylceramidase, putative 0.0108 0.0249 0.154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0065 0.0325
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0344 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0054 0.0048
Schistosoma mansoni hydrolase 0.0038 0.0064 0.0077
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.0454 0.0448
Schistosoma mansoni hypothetical protein 0.0185 0.0454 0.0595
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0054 0.0071
Schistosoma mansoni smad1 5 8 and 0.0062 0.0127 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0505 0.1301 0.398
Leishmania major hypothetical protein, conserved 0.0167 0.0406 0.0852
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0028 0.0037 0.0094
Brugia malayi nuclear hormone receptor 0.0034 0.0054 0.0048
Trichomonas vaginalis esterase, putative 0.0167 0.0406 0.258
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0056 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0156 0.0376 0.2384
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.005
Echinococcus granulosus neuropeptide s receptor 0.1974 0.5195 0.6895
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0067 0.0141 0.0135
Brugia malayi Dopamine receptor protein 2 0.0185 0.0454 0.0448
Loa Loa (eye worm) runx1 0.0076 0.0166 0.016
Loa Loa (eye worm) hypothetical protein 0.0348 0.0887 0.0881
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0081 0.0177 0.0234
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0185 0.0454 0.0448
Loa Loa (eye worm) TAR-binding protein 0.0144 0.0344 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0054 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0036
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0017 0.001
Echinococcus multilocularis lysine specific demethylase 5A 0.0048 0.0092 0.0121
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0589 0.1524 0.3302
Schistosoma mansoni amine GPCR 0.0185 0.0454 0.0595
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0115 0.0252
Echinococcus granulosus orexin receptor type 2 0.0185 0.0454 0.0602
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0199 0.0491 0.065
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0062 0.0127 0.0161
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0125 0.0157
Brugia malayi hypothetical protein 0.0022 0.0021 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Echinococcus granulosus mothers against decapentaplegic 6 0.0028 0.0037 0.0047
Brugia malayi hypothetical protein 0.0185 0.0454 0.0448
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0185 0.0454 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Echinococcus multilocularis musashi 0.0145 0.0346 0.0459
Onchocerca volvulus 0.024 0.0601 0.1835
Plasmodium falciparum thioredoxin reductase 0.0036 0.0059 0.0117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0629 0.163 0.1625
Loa Loa (eye worm) dihydrofolate reductase 0.0505 0.1301 0.1296
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0167 0.0406 0.053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0054 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0054 0.0064
Loa Loa (eye worm) MH1 domain-containing protein 0.0062 0.0127 0.0121
Loa Loa (eye worm) CXXC zinc finger family protein 0.0047 0.0089 0.0083
Trypanosoma brucei ISWI complex protein 0.0021 0.0019 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0054 0.0071
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1742 0.4582 1
Trypanosoma cruzi hypothetical protein, conserved 0.0167 0.0406 0.0852
Schistosoma mansoni cpg binding protein 0.0047 0.0089 0.011
Onchocerca volvulus 0.0185 0.0454 0.1383
Onchocerca volvulus 0.0348 0.0887 0.272
Trypanosoma cruzi hypothetical protein, conserved 0.0167 0.0406 0.0852
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0234 0.1443
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0074 0.0159 0.0313
Echinococcus multilocularis beta LACTamase domain containing family member 0.0167 0.0406 0.0537
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0159 0.0203
Echinococcus multilocularis short transient receptor potential channel 6 0.006 0.0122 0.016
Loa Loa (eye worm) hypothetical protein 0.0145 0.0346 0.034
Onchocerca volvulus 0.0145 0.0346 0.1051
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0065 0.0086
Loa Loa (eye worm) hypothetical protein 0.3786 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0185 0.0454 0.0602
Schistosoma mansoni survival motor neuron protein 0.0217 0.0537 0.0706
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0023 0.0025 0.0033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0092 0.0207 0.0476
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1238 0.3244 0.4301
Leishmania major cathepsin L-like protease 0.0044 0.0079 0.0138
Plasmodium falciparum phd finger protein, putative 0.004 0.0069 0.0139
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0185 0.0454 0.0448
Echinococcus granulosus dna polymerase eta 0.002 0.0017 0.0021
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0074 0.0159 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0054 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.0454 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0054 0.0048
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0446 0.1146 0.1141
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0017 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0156 0.0376 0.2384
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.0454 0.0602
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0056 0.005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0135 0.018
Onchocerca volvulus 0.0185 0.0454 0.1383
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0048
Leishmania major hypothetical protein, conserved 0.0038 0.0064 0.0104
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0167 0.0406 0.1205
Brugia malayi nuclear receptor RXR 0.0018 0.0011 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0059 0.0094
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0054 0.0071
Schistosoma mansoni smad1 5 8 and 0.0062 0.0127 0.0161
Echinococcus multilocularis Protein lozenge 0.0076 0.0166 0.0219
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0156 0.0376 0.037
Brugia malayi MH1 domain containing protein 0.0034 0.0054 0.0048
Echinococcus granulosus hypothetical protein 0.0185 0.0454 0.0602
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0054 0.0064
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0159 0.0313
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0065 1
Mycobacterium tuberculosis Probable esterase LipL 0.0167 0.0406 0.1205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0079 0.0173
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0125 0.0164
Echinococcus multilocularis g protein coupled receptor 0.0185 0.0454 0.0602
Schistosoma mansoni ap endonuclease 0.0034 0.0054 0.0063
Schistosoma mansoni ap endonuclease 0.0034 0.0054 0.0063

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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