Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.078 | 0.3419 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.5744 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2798 | 0.0669 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2798 | 0.4252 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2798 | 0.4724 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.2282 | 0.16 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1882 | 0.3083 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0067 | 0.2282 | 0.3244 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0619 | 0.2714 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2798 | 0.0669 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2798 | 0.4252 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0812 | 0.0375 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.2282 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 0.2282 | 0.3799 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.2282 | 0.16 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2798 | 0.2162 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.5744 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0619 | 0.2714 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2798 | 0.2162 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1882 | 0.2465 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2798 | 0.4724 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.2282 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0619 | 0.7399 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0812 | 0.1165 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.5744 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2798 | 0.2162 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.078 | 0.3419 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2798 | 0.2162 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2798 | 0.4252 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2798 | 0.4724 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1882 | 0.2465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2798 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1882 | 0.3083 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0619 | 0.0821 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.078 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.92 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.