Detailed information for compound 1277682

Basic information

Technical information
  • TDR Targets ID: 1277682
  • Name: N-[2-(5-phenylthieno[3,2-e]pyrimidin-4-yl)sul fanylphenyl]propanamide
  • MW: 391.509 | Formula: C21H17N3OS2
  • H donors: 1 H acceptors: 3 LogP: 5.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)Nc1ccccc1Sc1ncnc2c1c(cs2)c1ccccc1
  • InChi: 1S/C21H17N3OS2/c1-2-18(25)24-16-10-6-7-11-17(16)27-21-19-15(14-8-4-3-5-9-14)12-26-20(19)22-13-23-21/h3-13H,2H2,1H3,(H,24,25)
  • InChiKey: RGXVYXJYRRZNBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[(5-phenyl-4-thieno[3,2-e]pyrimidinyl)thio]phenyl]propanamide
  • N-[2-[(5-phenylthieno[3,2-e]pyrimidin-4-yl)thio]phenyl]propionamide
  • STOCK3S-77202
  • MLS000590140
  • N-[2-(5-Phenyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-phenyl]-propionamide
  • SMR000219380
  • ZINC00728962

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0288 0.0288
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0571 0.0377
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0571 0.2958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0288 0.0288
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4621 0.4621
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.1017 0.1744
Loa Loa (eye worm) hypothetical protein 0.0029 0.1017 0.1017
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0727 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0022 0.0554 0.7455
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0288 0.3526
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0127 0.8409 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0571 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.4209 0.4209
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0048
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0288 0.3526
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0065 0.3769 0.4452
Echinococcus multilocularis nervana 2 0.0127 0.8409 1
Onchocerca volvulus 0.0033 0.1313 0.033
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.1017 0.1744
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0288 0.3526
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0025 0.0727 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0288 0.0288
Schistosoma mansoni transmemberane protein 0.0127 0.8409 1
Schistosoma mansoni ap endonuclease 0.0023 0.0571 0.035
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0127 0.8409 1
Echinococcus multilocularis nervana 2 0.0127 0.8409 1
Echinococcus granulosus nervana 2 0.0127 0.8409 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0571 0.7712
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.1017 1
Schistosoma mansoni lamin 0.0033 0.1313 0.1263
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0288 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1017 0.1744
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1017 0.0973
Loa Loa (eye worm) hypothetical protein 0.0065 0.3769 0.3769
Echinococcus multilocularis lamin dm0 0.0033 0.1313 0.1517
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0022 0.0554 0.7455
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0727 0.0541
Loa Loa (eye worm) hypothetical protein 0.004 0.1904 0.1904
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0571 0.063
Leishmania major calcium-translocating P-type ATPase 0.0022 0.0554 0.3652
Schistosoma mansoni ATPase 0.0022 0.0554 0.0328
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4621 0.5471
Loa Loa (eye worm) hypothetical protein 0.0021 0.0472 0.0472
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0127 0.8409 1
Schistosoma mansoni ATPase 0.0022 0.0554 0.0328
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0022 0.0554 0.0609
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0022 0.0554 0.3652
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0022 0.0554 0.3652
Echinococcus granulosus intermediate filament protein 0.0033 0.1313 0.1517
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0063 0.3596 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.1313 0.1313
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0727 0.0541
Brugia malayi Na,K-ATPase alpha subunit 0.0065 0.3769 0.3738
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0025 0.0727 0.0815
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0025 0.0727 0.0541
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0571 0.063
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0727 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0127 0.8409 1
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0727 0.0815
Brugia malayi jmjC domain containing protein 0.0019 0.0288 0.024
Onchocerca volvulus 0.0127 0.8409 0.8229
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4621 0.4621
Echinococcus multilocularis nervana 2 0.0127 0.8409 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.4621 0.4621
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0127 0.8409 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4621 0.4595
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0025 0.0727 0.0815
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0571 0.1011
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0288 0.0288
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1313 0.1313
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0025 0.0727 0.0815
Brugia malayi Membrane calcium atpase protein 3 0.0025 0.0727 0.0682
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0025 0.0727 0.0814
Onchocerca volvulus 0.0063 0.3596 0.2871
Onchocerca volvulus 0.0033 0.1313 0.033
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0288 0.029
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0056 0.309 0.3057
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0025 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0554 0.0554
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0025 0.0727 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0571 0.1011
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0288 0.029
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0025 0.0727 1
Brugia malayi TAR-binding protein 0.0076 0.4621 0.4595
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0022 0.0554 0.7455
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1313 0.1313
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.1017 0.1744
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0127 0.8409 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0472 0.0472
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1017 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0472 0.4206
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0025 0.0727 1
Echinococcus granulosus calcium transporting atpase 0.0025 0.0727 0.0815
Brugia malayi jmjC domain containing protein 0.0019 0.0288 0.024
Onchocerca volvulus Huntingtin homolog 0.0148 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4621 0.5336
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0127 0.8409 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0025 0.0727 0.0541
Leishmania major P-type ATPase, putative 0.0025 0.0727 0.6019
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.1017 1
Schistosoma mansoni jumonji domain containing protein 0.0071 0.4209 0.4828
Loa Loa (eye worm) hypothetical protein 0.0021 0.0472 0.0472
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0025 0.0727 0.0815
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0025 0.0727 1
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0016 0.0048 0.0048
Schistosoma mansoni ap endonuclease 0.0023 0.0571 0.035
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0727 0.0541
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4621 0.5336
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0472 0.139
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4621 0.5336
Leishmania major calcium-transporting ATPase, putative 0.0025 0.0727 0.6019
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0025 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0288 0.0288
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0127 0.8409 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0127 0.8409 1
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0288 0.029
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0022 0.0554 0.7455
Schistosoma mansoni lamin 0.0033 0.1313 0.1263
Loa Loa (eye worm) hypothetical protein 0.0029 0.1017 0.1017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0472 0.0472
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0288 0.029
Plasmodium vivax P-type ATPase4, putative 0.0025 0.0727 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.4209 0.4978
Loa Loa (eye worm) hypothetical protein 0.0051 0.2673 0.2673
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0571 0.6466
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0025 0.0727 0.0815
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0127 0.8409 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0472 0.4206
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1017 1
Brugia malayi jmjC domain containing protein 0.0019 0.0288 0.024
Onchocerca volvulus Huntingtin homolog 0.0148 1 1
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0065 0.3769 0.3769
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0571 0.3892
Loa Loa (eye worm) hypothetical protein 0.0029 0.1017 0.1017
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0288 0.029
Brugia malayi jmjC domain containing protein 0.0071 0.4209 0.4181
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0571 0.0054
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0065 0.3769 1
Onchocerca volvulus 0.0127 0.8409 0.8229
Loa Loa (eye worm) hypothetical protein 0.0127 0.8409 0.8409
Schistosoma mansoni intermediate filament proteins 0.0033 0.1313 0.1263
Echinococcus granulosus phd:f box containing protein 0.0019 0.0288 0.029
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4621 0.5336
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0065 0.3769 0.4286
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1313 0.1271
Echinococcus multilocularis nervana 2 0.0127 0.8409 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0472 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1017 0.1744
Echinococcus granulosus nervana 2 0.0127 0.8409 1
Echinococcus multilocularis lamin 0.0033 0.1313 0.1517
Leishmania major calcium motive p-type ATPase, putative 0.0025 0.0727 0.6019
Toxoplasma gondii exonuclease III APE 0.0023 0.0571 0.6466
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0288 0.029
Echinococcus granulosus nervana 2 0.0127 0.8409 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0025 0.0727 0.0815
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0571 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.4209 0.4978
Brugia malayi jmjC domain containing protein 0.0019 0.0288 0.024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0175 0.0175
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.4209 0.4828
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0025 0.0727 1
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0022 0.0554 0.6069
Echinococcus granulosus nervana 2 0.0127 0.8409 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.8409 0.8409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0472 0.0472
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0571 0.0318
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0288 0.029
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0571 0.0526
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0571 0.6466
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0025 0.0727 0.3727
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4621 0.5336
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.1017 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0127 0.8409 1
Brugia malayi jmjC domain containing protein 0.0071 0.4209 0.4181
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0288 0.029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.1017 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0127 0.8409 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.4209 0.4828
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.4209 0.4978
Loa Loa (eye worm) hypothetical protein 0.0044 0.2149 0.2149
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1017 0.1744
Echinococcus multilocularis musashi 0.0033 0.1313 0.1517
Brugia malayi intermediate filament protein 0.0033 0.1313 0.1271
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.4209 0.4978
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0054 0.2918 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1017 0.0973
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1017 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1269 0.1269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0571 0.7712
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0065 0.3769 0.4286
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0022 0.0554 0.0609
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0288 0.029
Echinococcus granulosus Na:K ATPase alpha subunit 0.0065 0.3769 0.4452
Echinococcus granulosus lamin dm0 0.0033 0.1313 0.1517
Plasmodium vivax calcium-transporting ATPase, putative 0.0025 0.0727 1
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0025 0.0727 0.0815
Echinococcus granulosus tar DNA binding protein 0.0076 0.4621 0.5471
Brugia malayi RNA binding protein 0.0076 0.4621 0.4595
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1017 0.0973
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0727 0.0682
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0571 0.7712
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.1017 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0022 0.0554 0.7455
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0056 0.309 0.309
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0175 0.0127
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.1017 0.1744
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0025 0.0727 0.0815
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0022 0.0554 0.7455
Echinococcus granulosus lamin 0.0033 0.1313 0.1517
Mycobacterium ulcerans hypothetical protein 0.0029 0.1017 0.1744
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0571 0.0571
Toxoplasma gondii P-type ATPase4, putative 0.0025 0.0727 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0239 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 0.0794 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.