Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1662 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0264 | 0.0264 |
Brugia malayi | Carboxylesterase family protein | 0.0281 | 0.1314 | 0.1314 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0281 | 0.1314 | 0.1314 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0281 | 0.1314 | 0.1314 |
Onchocerca volvulus | 0.0281 | 0.1314 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0281 | 0.1314 | 0.1314 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0114 | 0.0264 | 0.0264 |
Onchocerca volvulus | 0.0281 | 0.1314 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0281 | 0.1314 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0264 | 0.0264 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | carboxylesterase | 0.0281 | 0.1314 | 0.1314 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0281 | 0.1314 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0281 | 0.1314 | 0.1314 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0281 | 0.1314 | 0.5 |
Onchocerca volvulus | 0.0281 | 0.1314 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0281 | 0.1314 | 0.1314 |
Brugia malayi | Carboxylesterase family protein | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Onchocerca volvulus | 0.0281 | 0.1314 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0281 | 0.1314 | 0.1314 |
Onchocerca volvulus | 0.0281 | 0.1314 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0281 | 0.1314 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0167 | 0.0595 | 0.0595 |
Brugia malayi | Carboxylesterase family protein | 0.1662 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1662 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1662 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1662 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1662 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0167 | 0.0595 | 0.0595 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0281 | 0.1314 | 0.1314 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0167 | 0.0595 | 0.0595 |
Echinococcus granulosus | acetylcholinesterase | 0.1662 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1662 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0281 | 0.1314 | 0.1314 |
Brugia malayi | Carboxylesterase family protein | 0.0281 | 0.1314 | 0.1314 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | carboxylesterase | 0.1662 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1662 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0595 | 0.0595 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0281 | 0.1314 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0281 | 0.1314 | 0.1314 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0281 | 0.1314 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1662 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1314 | 0.1314 |
Echinococcus multilocularis | neuroligin | 0.0281 | 0.1314 | 0.1314 |
Echinococcus granulosus | neuroligin | 0.0281 | 0.1314 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.1662 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.