Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0079 | 0.1693 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6708 | 0.6708 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.1693 | 1 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0072 | 0.1418 | 0.1418 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Schistosoma mansoni | gabp alpha | 0.0072 | 0.1418 | 0.1418 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0072 | 0.1418 | 0.1418 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0199 | 0.6464 | 0.6464 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0199 | 0.6464 | 0.6464 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.0599 | 0.0599 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1418 | 0.1418 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0079 | 0.1693 | 0.1693 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0199 | 0.6464 | 0.6464 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.6708 | 0.6708 |
Schistosoma mansoni | ets-related | 0.022 | 0.7327 | 0.7327 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6708 | 0.6708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6708 | 0.6708 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.1693 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0079 | 0.1693 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Loa Loa (eye worm) | fli-1 protein | 0.022 | 0.7327 | 0.7327 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0287 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0998 | 0.0998 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.1693 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0287 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0287 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0052 | 0.0599 | 0.0749 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.1693 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0052 | 0.0599 | 0.3536 |
Brugia malayi | Probable ClpP-like protease | 0.0079 | 0.1693 | 0.1693 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Loa Loa (eye worm) | TAR-binding protein | 0.0199 | 0.6464 | 0.6464 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1418 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0287 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Brugia malayi | Fli-1 protein | 0.022 | 0.7327 | 0.7327 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0072 | 0.1418 | 0.1418 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0052 | 0.0599 | 0.0749 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.0599 | 0.0599 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0287 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0287 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0287 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0287 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.7995 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.