Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0187 | 0.5988 | 0.5988 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0187 | 0.5988 | 1 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0141 | 0.369 | 0.3638 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0267 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0125 | 0.2909 | 0.4858 |
Trypanosoma brucei | polo-like protein kinase | 0.0187 | 0.5988 | 0.5988 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0187 | 0.5988 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0187 | 0.5988 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0267 | 1 | 1 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0141 | 0.369 | 0.3638 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0187 | 0.5988 | 0.5955 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.011 | 0.2141 | 0.2077 |
Brugia malayi | CHE-14 protein | 0.011 | 0.2141 | 0.2077 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0267 | 1 | 1 |
Echinococcus granulosus | nibrin | 0.0141 | 0.369 | 0.3638 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0141 | 0.369 | 0.5 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.0141 | 0.369 | 0.5 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0141 | 0.369 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.1269 | 0.2119 |
Schistosoma mansoni | DNA ligase IV | 0.0141 | 0.369 | 0.3638 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0187 | 0.5988 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0187 | 0.5988 | 1 |
Schistosoma mansoni | kinase | 0.0095 | 0.1392 | 0.1322 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.011 | 0.2141 | 0.2077 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0141 | 0.369 | 0.2535 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0141 | 0.369 | 0.6162 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0187 | 0.5988 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0267 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0187 | 0.5988 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0141 | 0.369 | 0.6162 |
Echinococcus multilocularis | protein dispatched 1 | 0.011 | 0.2141 | 0.2077 |
Giardia lamblia | Kinase, PLK | 0.0187 | 0.5988 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0187 | 0.5988 | 0.5988 |
Brugia malayi | topoisomerase | 0.0141 | 0.369 | 0.3638 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0141 | 0.369 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.011 | 0.2141 | 0.2077 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.011 | 0.2141 | 0.2077 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0141 | 0.369 | 0.369 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.369 | 0.6162 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.369 | 0.6162 |
Echinococcus multilocularis | protein patched | 0.011 | 0.2141 | 0.2077 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0187 | 0.5988 | 0.5988 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0187 | 0.5988 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0187 | 0.5988 | 0.5955 |
Brugia malayi | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Echinococcus multilocularis | nibrin | 0.0141 | 0.369 | 0.3638 |
Brugia malayi | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0141 | 0.369 | 0.6162 |
Trichomonas vaginalis | rotamase, putative | 0.0069 | 0.0081 | 0.0135 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0141 | 0.369 | 0.369 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0267 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0141 | 0.369 | 0.6162 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0141 | 0.369 | 0.3638 |
Schistosoma mansoni | patched 1 | 0.011 | 0.2141 | 0.2077 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0125 | 0.2909 | 0.4858 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.011 | 0.2141 | 0.2077 |
Treponema pallidum | DNA ligase (lig) | 0.0141 | 0.369 | 0.5 |
Chlamydia trachomatis | DNA ligase | 0.0141 | 0.369 | 0.5 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0141 | 0.369 | 0.3638 |
Schistosoma mansoni | topbp1 | 0.0141 | 0.369 | 0.3638 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0187 | 0.5988 | 0.5955 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.369 | 0.6162 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0187 | 0.5988 | 0.5955 |
Echinococcus granulosus | Protein patched homolog 1 | 0.011 | 0.2141 | 0.2077 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.369 | 0.6162 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0267 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.1269 | 0.2119 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0141 | 0.369 | 0.6162 |
Schistosoma mansoni | topbp1 | 0.0141 | 0.369 | 0.3638 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0141 | 0.369 | 0.369 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0141 | 0.369 | 0.369 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0141 | 0.369 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0141 | 0.369 | 0.6162 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0187 | 0.5988 | 0.5955 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0125 | 0.2909 | 0.4858 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0141 | 0.369 | 0.369 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.011 | 0.2141 | 0.2077 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0141 | 0.369 | 0.3638 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.369 | 0.3638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.2141 | 0.3576 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.0081 | 0.0135 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.369 | 0.6162 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2141 | 0.2077 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0141 | 0.369 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0187 | 0.5988 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0141 | 0.369 | 0.6162 |
Brugia malayi | DKFZp564C0469 protein | 0.0141 | 0.369 | 0.3638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.