Detailed information for compound 1278775

Basic information

Technical information
  • TDR Targets ID: 1278775
  • Name: N-methyl-1-benzofuran-2-carboxamide
  • MW: 175.184 | Formula: C10H9NO2
  • H donors: 1 H acceptors: 1 LogP: 1.94 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1cc2c(o1)cccc2
  • InChi: 1S/C10H9NO2/c1-11-10(12)9-6-7-4-2-3-5-8(7)13-9/h2-6H,1H3,(H,11,12)
  • InChiKey: WTBNLIYCUGYIRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-methylbenzofuran-2-carboxamide
  • N-methyl-2-benzofurancarboxamide
  • MLS000071515
  • SMR000041286
  • A4079/0173838
  • ZINC00535370

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus expressed protein 0.0017 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0065 0.0367
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0058 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.002 0.0024
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0549 1
Leishmania major mitochondrial DNA polymerase beta 0.0618 0.323 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0013 0.0041
Brugia malayi ecdysteroid receptor 0.0032 0.0083 0.0083
Schistosoma mansoni apoferritin-2 0.0017 0.0004 0.0005
Leishmania major hypothetical protein, conserved 0.0031 0.0075 0.0233
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.1187 0.1187
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0056
Trypanosoma brucei unspecified product 0.0019 0.0013 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0138 0.1178
Schistosoma mansoni microtubule-associated protein tau 0.1549 0.823 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0108 0.0928
Trichomonas vaginalis esterase, putative 0.019 0.0931 0.7972
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0058 0.0358
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0083 0.0101
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0931 0.7972
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0931 0.1131
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0083 0.0168
Schistosoma mansoni thyroid hormone receptor 0.028 0.1413 0.1717
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0058 0.0181
Loa Loa (eye worm) latrophilin receptor protein 2 0.0225 0.1117 0.1117
Schistosoma mansoni DNA polymerase eta 0.0019 0.0013 0.0016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0297 0.036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0065 0.0367
Plasmodium vivax hypothetical protein, conserved 0.019 0.0931 1
Mycobacterium tuberculosis Probable esterase LipL 0.019 0.0931 0.1443
Echinococcus multilocularis dna polymerase eta 0.0019 0.0013 0.0016
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0151 0.0183
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0083 0.0101
Loa Loa (eye worm) hypothetical protein 0.0077 0.0323 0.0323
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0083 0.0101
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0293 0.1482 0.4588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0083 0.0083
Mycobacterium leprae Probable lipase LipE 0.019 0.0931 1
Echinococcus multilocularis tumor protein p63 0.0338 0.1724 0.2094
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0122 0.0379
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0083 0.0101
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0185 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.007 0.0596
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0225 0.1117 0.1357
Brugia malayi hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0176 0.0214
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0176 0.0214
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0026 0.0133
Entamoeba histolytica hypothetical protein 0.0076 0.0321 0.5733
Loa Loa (eye worm) beta-lactamase 0.019 0.0931 0.0931
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.002 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0185 0.1584
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0151 0.0183
Brugia malayi beta-lactamase family protein 0.019 0.0931 0.0931
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Echinococcus granulosus ferritin 0.0017 0.0004 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0083 0.0083
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0058 0.0181
Entamoeba histolytica hypothetical protein 0.0076 0.0321 0.5733
Brugia malayi Flap endonuclease-1 0.0027 0.0058 0.0058
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0094 0.0114
Brugia malayi beta-lactamase 0.019 0.0931 0.0931
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0213
Brugia malayi hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi TAR-binding protein 0.0774 0.4068 0.4068
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0378 0.1169
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0065 0.0367
Loa Loa (eye worm) inositol-1 0.0045 0.0151 0.0151
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.1187 0.1187
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0321 0.039
Brugia malayi CHE-14 protein 0.0051 0.0185 0.0185
Schistosoma mansoni coup transcription factor 0.0032 0.0083 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0083 0.0083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0225 0.1117 0.1357
Brugia malayi Calcitonin receptor-like protein seb-1 0.071 0.3721 0.3721
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0774 0.4068 0.4068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0021 0.0066
Schistosoma mansoni hypothetical protein 0.0225 0.1117 0.1357
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0026
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0151 0.1289
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0041
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.019 0.0931 0.0931
Schistosoma mansoni tar DNA-binding protein 0.0774 0.4068 0.4942
Loa Loa (eye worm) hypothetical protein 0.019 0.0931 0.0931
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0083 0.0083
Echinococcus granulosus dna polymerase eta 0.0019 0.0013 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0252 0.0307
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0125 0.131
Onchocerca volvulus 0.0234 0.1168 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0064 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0069 0.0084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0083 0.0101
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0823 0.1
Schistosoma mansoni hypothetical protein 0.0248 0.1241 0.1508
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0153 0.0186
Schistosoma mansoni ferritin 0.0017 0.0004 0.0005
Plasmodium vivax SET domain protein, putative 0.0029 0.0069 0.0481
Loa Loa (eye worm) hypothetical protein 0.0051 0.0185 0.0185
Onchocerca volvulus 0.0032 0.0083 0.0168
Echinococcus multilocularis neuropeptide receptor 0.0621 0.3246 0.3944
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0065 0.0201
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0378 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0083 0.0083
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0058 0.0181
Schistosoma mansoni hypothetical protein 0.0225 0.1117 0.1357
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.002 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0931 0.7972
Onchocerca volvulus 0.019 0.0931 0.7853
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0083 0.0083
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0002 0.0002
Echinococcus multilocularis ferritin 0.0017 0.0004 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0176 0.0176
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0083 0.0083
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.019 0.0931 0.1443
Schistosoma mansoni hypothetical protein 0.0485 0.2516 0.3056
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0176 0.0546
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0083 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0122 0.1045
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0176 0.151
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0176 0.0546
Echinococcus granulosus neuropeptide receptor 0.0621 0.3246 0.3944
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0065 0.0961
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0094 0.0114
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.019 0.0931 0.1443
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0151 0.1289
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1879 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0465
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0013 0.0041
Echinococcus granulosus tar DNA binding protein 0.0774 0.4068 0.4942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0089 0.0762
Trypanosoma cruzi ISWI complex protein 0.0031 0.0075 0.0233
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0083 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0931 0.2882
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0176 0.0546
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.048 0.1485
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0002 0.0002
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0083 0.0101
Loa Loa (eye worm) hypothetical protein 0.0081 0.0348 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0083 0.0101
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0101 0.0101
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0151 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0083 0.0101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0065
Brugia malayi Bromodomain containing protein 0.015 0.0716 0.0716
Leishmania major hypothetical protein, conserved 0.019 0.0931 0.2882
Echinococcus granulosus expressed conserved protein 0.0112 0.0511 0.0621
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0618 0.323 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Schistosoma mansoni ferritin 0.0017 0.0004 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.002 0.0024
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0013 0.0041
Brugia malayi steroid hormone receptor 0.0032 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.071 0.3721 0.3721
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0213
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0321 0.039
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0083 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0931 0.2882
Mycobacterium tuberculosis Probable conserved lipoprotein 0.019 0.0931 0.1443
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0931 0.7972
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.007 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0083 0.0101
Trypanosoma cruzi ISWI complex protein 0.0031 0.0075 0.0233
Brugia malayi RNA binding protein 0.0774 0.4068 0.4068
Loa Loa (eye worm) hypothetical protein 0.0049 0.0176 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0083 0.0101
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.4213 0.5119
Schistosoma mansoni zinc finger protein 0.0039 0.0121 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0931 0.7972
Brugia malayi Bromodomain containing protein 0.0077 0.0322 0.0322
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0176 0.0546
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1168 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0153 0.0186
Loa Loa (eye worm) hypothetical protein 0.0062 0.0247 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0122 0.1045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.071 0.3721 0.3721
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Schistosoma mansoni patched 1 0.0051 0.0185 0.0225
Echinococcus granulosus beta LACTamase domain containing family member 0.019 0.0931 0.1131
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0151 0.0466
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0618 0.323 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) RNA binding protein 0.0774 0.4068 0.4068
Echinococcus multilocularis expressed protein 0.0017 0.0004 0.0005
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0013 0.0041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.019 0.0931 0.0931
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0176 0.151
Brugia malayi Pre-SET motif family protein 0.0206 0.1015 0.1015
Brugia malayi PHD-finger family protein 0.005 0.0178 0.0178
Echinococcus granulosus flap endonuclease 1 0.0027 0.0058 0.0071
Mycobacterium ulcerans hypothetical protein 0.0029 0.0065 0.0367
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0176 0.3042
Echinococcus multilocularis expressed conserved protein 0.0112 0.0511 0.0621
Echinococcus multilocularis microtubule associated protein 2 0.1549 0.823 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0176 0.0546
Giardia lamblia GTOR 0.0049 0.0176 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0185 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0083 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0176 0.151
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0083 0.0083
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.019 0.0931 0.0931
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0083 0.0083
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0225 0.1117 0.1357
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0931 0.7972
Brugia malayi Pre-SET motif family protein 0.0029 0.0069 0.0069
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0618 0.323 1
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0083 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.0552 0.067
Schistosoma mansoni bromodomain containing protein 0.0126 0.059 0.0717
Echinococcus granulosus tumor protein p63 0.0338 0.1724 0.2094
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0549 0.0668
Brugia malayi latrophilin 2 splice variant baaae 0.0485 0.2516 0.2516
Brugia malayi beta-lactamase family protein 0.019 0.0931 0.0931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0122 0.1045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0108 0.0928
Mycobacterium ulcerans esterase/lipase LipP 0.019 0.0931 0.5601
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0065 0.0065
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0083 0.0083
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0065 0.0961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0083 0.0713
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0176 0.3042
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0056
Schistosoma mansoni apoferritin-2 0.0017 0.0004 0.0005
Brugia malayi nuclear receptor NHR-88 0.0032 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0076 0.0321 0.5733
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0083 0.0101
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0176 0.0214
Loa Loa (eye worm) hypothetical protein 0.019 0.0931 0.0931
Schistosoma mansoni tar DNA-binding protein 0.0774 0.4068 0.4942
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0065 0.0961
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0297 0.036
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0252 0.0307
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0069 0.0084
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0151 0.0886
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0083 0.0101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0002 0.0002
Leishmania major DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0083 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0774 0.4068 0.4942
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0248 0.1241 0.1508
Trypanosoma brucei hypothetical protein, conserved 0.019 0.0931 0.2882
Mycobacterium ulcerans beta-lactamase 0.019 0.0931 0.5601
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1015 0.1015
Schistosoma mansoni thyroid hormone receptor 0.028 0.1413 0.1717
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0122 0.0379
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0058 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0465
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0122 0.1045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0026
Echinococcus multilocularis GPCR, family 2 0.0225 0.1117 0.1357
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0225 0.1117 0.1357
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0176 0.0546
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0013 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.0552 0.067
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0013 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0083 0.0101
Loa Loa (eye worm) hypothetical protein 0.019 0.0931 0.0931
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0004 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.019 0.0931 0.1443
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0083 0.0101
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0083 0.0083
Toxoplasma gondii ABC1 family protein 0.019 0.0931 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0463
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0559 0.068
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0151 0.1289
Mycobacterium tuberculosis Conserved protein 0.019 0.0931 0.1443
Schistosoma mansoni flap endonuclease-1 0.0025 0.0044 0.0054
Loa Loa (eye worm) hypothetical protein 0.0085 0.0369 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.007 0.0596
Onchocerca volvulus 0.019 0.0931 0.7853
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0125 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0108 0.0928
Schistosoma mansoni tar DNA-binding protein 0.0774 0.4068 0.4942
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0058 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0083 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0065 0.0201
Loa Loa (eye worm) hypothetical protein 0.019 0.0931 0.0931
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0248 0.1241 0.1508
Echinococcus granulosus dna polymerase kappa 0.0019 0.0013 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0463
Echinococcus granulosus GPCR family 2 0.0225 0.1117 0.1357
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0213
Brugia malayi Inositol-1 0.0045 0.0151 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0321 0.039
Schistosoma mansoni hypothetical protein 0.0225 0.1117 0.1357
Echinococcus multilocularis zinc finger protein 0.0039 0.0121 0.0147
Echinococcus granulosus microtubule associated protein 2 0.1549 0.823 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0151 0.0183
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0931 0.1131
Plasmodium falciparum flap endonuclease 1 0.0027 0.0058 1
Schistosoma mansoni ferritin light chain 0.0017 0.0004 0.0005
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0058 0.2764
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0013 0.0113
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0016
Schistosoma mansoni ferritin 0.0017 0.0004 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0326 0.1659 0.2577
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.019 0.0931 0.5601
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0065 0.0367
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0083 0.0101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0083 0.0101
Loa Loa (eye worm) pigment dispersing factor receptor c 0.071 0.3721 0.3721
Schistosoma mansoni ferritin 0.0017 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0141 0.067 0.067
Echinococcus multilocularis beta LACTamase domain containing family member 0.019 0.0931 0.1131
Schistosoma mansoni tar DNA-binding protein 0.0774 0.4068 0.4942
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0151 0.0466
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0378 0.1169
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0083 0.0168
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0083 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0252 0.0307
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0122 0.0379
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0065 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0151 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0083 0.0083
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0069 0.0127
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0108 0.0928
Schistosoma mansoni neuropeptide receptor 0.0621 0.3246 0.3944
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0041
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0378 0.1169
Toxoplasma gondii hypothetical protein 0.01 0.0446 0.4446
Trichomonas vaginalis ferritin, putative 0.0017 0.0004 0.0034
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0094 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0465
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni inositol monophosphatase 0.0045 0.0151 0.0183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0225 0.1117 0.1117
Schistosoma mansoni zinc finger protein 0.0031 0.0075 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0065 0.0095
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0108 0.0573
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0036 0.0113
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0153 0.0186
Mycobacterium tuberculosis Conserved protein 0.019 0.0931 0.1443
Brugia malayi hypothetical protein 0.0076 0.0321 0.0321
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0083 0.0101
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0065 0.0656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0068 0.0582
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0002 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0065 0.0656
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0083 0.0101
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.019 0.0931 0.0931
Mycobacterium leprae conserved hypothetical protein 0.019 0.0931 1
Onchocerca volvulus 0.019 0.0931 0.7853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0108 0.0928
Brugia malayi nuclear hormone receptor 0.0032 0.0083 0.0083
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0549 0.0668
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0083 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0108 0.0928
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0058 0.0071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0069 0.0084
Mycobacterium ulcerans hypothetical protein 0.0326 0.1659 1
Brugia malayi MH2 domain containing protein 0.0238 0.1187 0.1187
Echinococcus granulosus zinc finger protein 0.0039 0.0121 0.0147
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0823 0.1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0013 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0065 0.0367
Mycobacterium tuberculosis Conserved protein 0.019 0.0931 0.1443
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0026 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0083 0.0168
Schistosoma mansoni hypothetical protein 0.0031 0.0075 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0122 0.1045
Trypanosoma brucei ISWI complex protein 0.0031 0.0075 0.0233
Loa Loa (eye worm) hypothetical protein 0.0064 0.0252 0.0252
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0176 0.0214
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.1482 0.4588
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0065
Onchocerca volvulus 0.0049 0.0176 0.1012
Schistosoma mansoni hypothetical protein 0.0049 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0485 0.2516 0.2516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0083 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0065 0.0367
Echinococcus multilocularis protein patched 0.0051 0.0185 0.0225
Schistosoma mansoni ferritin light chain 0.0017 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0083 0.0101
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0065 0.0201
Schistosoma mansoni hypothetical protein 0.0076 0.0321 0.039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0083 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0068 0.0582
Mycobacterium ulcerans hypothetical protein 0.019 0.0931 0.5601
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0041 0.0132 0.0161
Brugia malayi Latrophilin receptor protein 2 0.0225 0.1117 0.1117
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0151 0.256
Echinococcus multilocularis G protein coupled receptor 139 0.0621 0.3246 0.3944
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0013 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.019 0.0931 0.1443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0108 0.0928
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0065 0.0065
Onchocerca volvulus 0.0029 0.0069 0.0042
Mycobacterium tuberculosis Probable lipase LipD 0.019 0.0931 0.1443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0054 0.0463
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0225 0.1117 0.1117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0252 0.0307
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0083 0.0101
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0094 0.0114
Mycobacterium ulcerans lipase LipD 0.019 0.0931 0.5601
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0013 0.0113
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.1482 0.4588
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0083 0.0083
Brugia malayi RNA recognition motif domain containing protein 0.0774 0.4068 0.4068
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0185 0.0225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0225 0.1117 0.1357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0083 0.0083
Brugia malayi nuclear receptor RXR 0.0017 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0076 0.0321 0.5733
Loa Loa (eye worm) hypothetical protein 0.0119 0.0549 0.0549
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1214 0.6427 1
Loa Loa (eye worm) TAR-binding protein 0.0774 0.4068 0.4068
Echinococcus multilocularis thyroid hormone receptor alpha 0.028 0.1413 0.1717
Echinococcus multilocularis protein dispatched 1 0.0058 0.0224 0.0272
Echinococcus multilocularis tar DNA binding protein 0.0774 0.4068 0.4942
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0151 0.0466
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0151 0.0466
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0083 0.0101
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0065 0.0095
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0026
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0016
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0132 0.0132

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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