Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0407 | 0.1064 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0407 | 0.0407 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0407 | 0.1064 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2854 | 0.2854 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3823 | 0.3823 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1721 | 0.4503 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3823 | 0.3823 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2854 | 0.2854 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0407 | 0.0407 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3823 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2854 | 0.2854 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1721 | 0.1721 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1721 | 0.1721 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0407 | 0.0407 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3823 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0407 | 0.0407 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0407 | 0.0407 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3823 | 0.3823 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0407 | 0.1064 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3823 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3823 | 0.3823 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3823 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2854 | 0.2854 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0407 | 0.1064 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3823 | 0.3823 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0407 | 0.0407 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3823 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0407 | 0.0407 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3823 | 0.3823 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3823 | 0.3823 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0407 | 0.0407 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3823 | 0.3823 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.