Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0094 | 0.1879 | 0.5844 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0086 | 0.1629 | 0.5059 |
Schistosoma mansoni | glutamate receptor kainate | 0.0044 | 0.0357 | 0.1065 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0044 | 0.0357 | 0.1115 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0052 | 0.0607 | 0.1851 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0104 | 0.217 | 0.6758 |
Echinococcus granulosus | glutamate receptor 2 | 0.0052 | 0.0607 | 0.1851 |
Onchocerca volvulus | 0.0033 | 0.0018 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.4227 | 0.3871 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0138 | 0.3197 | 0.9982 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0062 | 0.0918 | 0.0358 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0102 | 0.2117 | 0.659 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0139 | 0.3202 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4813 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0018 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0139 | 0.3202 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0052 | 0.0607 | 0.1851 |
Schistosoma mansoni | glutamate receptor kainate | 0.0044 | 0.0357 | 0.1065 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0094 | 0.1879 | 0.5844 |
Echinococcus granulosus | glutamate receptor 2 | 0.0036 | 0.0119 | 0.0319 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0052 | 0.0607 | 0.1851 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3202 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0104 | 0.217 | 0.6758 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0044 | 0.0357 | 0.1065 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0139 | 0.3202 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0052 | 0.0607 | 0.1851 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0086 | 0.1629 | 0.5059 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0102 | 0.2117 | 0.659 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0139 | 0.3202 | 1 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0044 | 0.0357 | 0.1065 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0044 | 0.0357 | 0.1065 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0052 | 0.0607 | 0.1851 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0052 | 0.0607 | 0.1851 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0044 | 0.0357 | 0.1065 |
Loa Loa (eye worm) | carboxylesterase | 0.0139 | 0.3202 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0139 | 0.3202 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0052 | 0.0607 | 0.1851 |
Echinococcus granulosus | acetylcholinesterase | 0.0139 | 0.3202 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0018 | 0.0056 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0044 | 0.0357 | 0.1065 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0052 | 0.0607 | 0.1851 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0044 | 0.0357 | 0.1065 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0044 | 0.0357 | 0.1115 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0018 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3202 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0044 | 0.0357 | 0.1065 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.3202 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0139 | 0.3202 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.4227 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0018 | 0.0056 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4813 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.3202 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0139 | 0.3202 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0052 | 0.0607 | 0.1851 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0104 | 0.217 | 0.6758 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0036 | 0.0119 | 0.0319 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0807 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.