Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | insulin-degrading enzyme | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0102 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0064 | 0.0034 |
Trypanosoma cruzi | peptidase, putative | 0.0029 | 0.0166 | 0.0073 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0102 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0064 | 0.0034 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0064 | 0.0016 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0102 | 0.0043 |
Brugia malayi | insulin-degrading enzyme | 0.0029 | 0.0166 | 0.0115 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0102 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0877 | 0.8939 | 0.8934 |
Plasmodium falciparum | hexokinase | 0.0877 | 0.8939 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0317 | 0.0318 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0102 | 0.0077 |
Echinococcus granulosus | neuropeptide s receptor | 0.0558 | 0.5646 | 0.6316 |
Loa Loa (eye worm) | hexokinase | 0.0271 | 0.2674 | 0.2941 |
Trypanosoma cruzi | hexokinase, putative | 0.0877 | 0.8939 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.055 | 0.5559 | 0.5294 |
Entamoeba histolytica | hexokinase 2 | 0.0877 | 0.8939 | 1 |
Echinococcus granulosus | nardilysin | 0.0029 | 0.0166 | 0.0186 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0029 | 0.0166 | 0.0149 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0317 | 0.0284 |
Echinococcus granulosus | hexokinase | 0.0877 | 0.8939 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0064 | 0.0034 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0317 | 0.0354 |
Brugia malayi | Hexokinase family protein | 0.0877 | 0.8939 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0877 | 0.8939 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0317 | 0.027 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0317 | 0.0243 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1359 | 0.1459 |
Brugia malayi | Hexokinase family protein | 0.0271 | 0.2674 | 0.2941 |
Loa Loa (eye worm) | hexokinase | 0.0877 | 0.8939 | 1 |
Echinococcus granulosus | 3'partial|nardilysin | 0.0029 | 0.0166 | 0.0186 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0102 | 0.0077 |
Toxoplasma gondii | rhoptry metalloprotease toxolysin TLN1 | 0.0029 | 0.0166 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0293 | 0.0258 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0102 | 0.5 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0029 | 0.0166 | 0.0149 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.849 | 0.9496 |
Echinococcus multilocularis | insulin degrading enzyme | 0.0029 | 0.0166 | 0.0119 |
Chlamydia trachomatis | insulinase family protease III | 0.0029 | 0.0166 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0064 | 0.0016 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0064 | 0.0072 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1359 | 0.1459 |
Schistosoma mansoni | hexokinase | 0.0877 | 0.8939 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0877 | 0.8939 | 0.8934 |
Loa Loa (eye worm) | hexokinase type II | 0.0877 | 0.8939 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0877 | 0.8939 | 1 |
Toxoplasma gondii | peptidase M16 inactive domain-containing protein | 0.0018 | 0.0048 | 0.0054 |
Onchocerca volvulus | 0.0877 | 0.8939 | 1 | |
Echinococcus multilocularis | neuropeptide s receptor | 0.0558 | 0.5646 | 0.5624 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0064 | 0.0072 |
Brugia malayi | hexokinase | 0.0877 | 0.8939 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0064 | 0.0034 |
Echinococcus multilocularis | nardilysin | 0.0029 | 0.0166 | 0.0119 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0102 | 0.5 |
Leishmania major | hexokinase, putative | 0.0877 | 0.8939 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1985 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0598 | 0.6055 | 0.675 |
Trypanosoma brucei | hexokinase, putative | 0.0877 | 0.8939 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.849 | 0.9498 |
Brugia malayi | Hexokinase family protein | 0.055 | 0.5559 | 0.6191 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1985 | 0.2191 |
Toxoplasma gondii | insulysin, putative | 0.0028 | 0.0152 | 0.017 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0029 | 0.0166 | 0.0149 |
Loa Loa (eye worm) | hexokinase | 0.055 | 0.5559 | 0.6191 |
Trypanosoma brucei | hexokinase | 0.0877 | 0.8939 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.049 | 0.048 |
Trypanosoma cruzi | peptidase, putative | 0.0029 | 0.0166 | 0.0073 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0317 | 0.0243 |
Echinococcus granulosus | hexokinase type 2 | 0.0877 | 0.8939 | 1 |
Echinococcus granulosus | insulin degrading enzyme | 0.0029 | 0.0166 | 0.0186 |
Leishmania major | hexokinase, putative | 0.0877 | 0.8939 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0293 | 0.0291 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0102 | 0.0054 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0293 | 0.0258 |
Echinococcus granulosus | geminin | 0.0205 | 0.1985 | 0.222 |
Loa Loa (eye worm) | insulin-degrading enzyme | 0.0029 | 0.0166 | 0.0115 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0558 | 0.5646 | 0.5624 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0064 | 0.0016 |
Echinococcus multilocularis | hexokinase | 0.0877 | 0.8939 | 0.8934 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.049 | 0.048 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1985 | 0.2191 |
Onchocerca volvulus | 0.0877 | 0.8939 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.049 | 0.048 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.849 | 0.8483 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0102 | 0.0114 |
Brugia malayi | hexokinase type II | 0.0279 | 0.2751 | 0.3028 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.049 | 0.048 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.2751 | 0.3028 |
Trypanosoma brucei | peptidase, putative | 0.0029 | 0.0166 | 0.0073 |
Toxoplasma gondii | hexokinase | 0.0877 | 0.8939 | 1 |
Leishmania major | phosphoglycan beta 1,3 galactosyltransferase 5 | 0.0029 | 0.0166 | 0.0073 |
Onchocerca volvulus | 0.0877 | 0.8939 | 1 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0102 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0877 | 0.8939 | 1 |
Echinococcus granulosus | hexokinase | 0.0877 | 0.8939 | 1 |
Trypanosoma brucei | hexokinase | 0.0877 | 0.8939 | 1 |
Echinococcus multilocularis | nardilysin | 0.0029 | 0.0166 | 0.0119 |
Treponema pallidum | hexokinase (hxk) | 0.0877 | 0.8939 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0877 | 0.8939 | 1 |
Toxoplasma gondii | sporozoite developmental protein | 0.0029 | 0.0166 | 0.0186 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0317 | 0.0318 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0317 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.2751 | 0.3028 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0102 | 0.5 |
Brugia malayi | hypothetical protein | 0.0182 | 0.1755 | 0.1905 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0102 | 0.0114 |
Echinococcus multilocularis | hexokinase | 0.0877 | 0.8939 | 0.8934 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1359 | 0.1459 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0558 | 0.5646 | 0.6316 |
Onchocerca volvulus | 0.055 | 0.5559 | 0.5294 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0064 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1755 | 0.1905 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0029 | 0.0166 | 0.0149 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0317 | 0.0243 |
Plasmodium vivax | hexokinase, putative | 0.0877 | 0.8939 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 15.884 uM | PUBCHEM_BIOASSAY: Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
EC50 (binding) | > 54.705 uM | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay for activators of recombinant IDE. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588439, AID588440, AID588442] | ChEMBL. | No reference |
EC50 (functional) | > 54.705 uM | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay to identify fluorescent artifacts and/or optically active compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] | ChEMBL. | No reference |
IC50 (functional) | = 28.324 uM | PUBCHEM_BIOASSAY: Counterscreen for activators of insulin-degrading enzyme (IDE): fluorescence-based cell-based high throughput dose response LDH release assay to identify compounds that are cytotoxic to HEK cells or compromise cell membrane permeability. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] | ChEMBL. | No reference |
IC50 (functional) | 38.789 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 64.449 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0035 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1853 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.5774 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.