TDR Targets

Basic information

Technical information

TDR Targets ID: 1280222
Name: 3-methoxy-N'-(4-methylphenyl)sulfonylbenzohyd razide
MW: 320.364 | Formula: C15H16N2O4S
H donors: 2 H acceptors: 3 LogP: 2.39 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C(=O)NNS(=O)(=O)c1ccc(cc1)C
InChi: 1S/C15H16N2O4S/c1-11-6-8-14(9-7-11)22(19,20)17-16-15(18)12-4-3-5-13(10-12)21-2/h3-10,17H,1-2H3,(H,16,18)
InChiKey: CAEXBMMLMUKZAS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-methoxy-N'-(4-methylphenyl)sulfonyl-benzohydrazide
BAS 01190021
ZINC00325265

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0354	0.0574
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0171	0.0171
Echinococcus granulosus	serotonin transporter	0.0088	0.5124	1
Brugia malayi	hypothetical protein	0.0015	0.0064	0.0064
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0623	0.5
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0842	0.1538
Onchocerca volvulus		0.0019	0.0354	0.0574
Schistosoma mansoni	peroxidasin	0.0051	0.2563	0.494
Onchocerca volvulus		0.0088	0.5124	1
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0842	0.0842
Schistosoma mansoni	notch	0.0016	0.0171	0.0212
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0171	0.0171
Echinococcus granulosus	intermediate filament protein	0.0026	0.0842	0.1538
Schistosoma mansoni	hypothetical protein	0.005	0.2506	0.4825
Brugia malayi	Blistered cuticle protein 3	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Echinococcus granulosus	delta-like protein 1	0.0016	0.0171	0.0212
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.2563	0.2563
Echinococcus multilocularis	notch	0.0016	0.0171	0.0212
Brugia malayi	Cadherin domain containing protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.2563	0.2563
Brugia malayi	hypothetical protein	0.0019	0.0354	0.0354
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Onchocerca volvulus		0.0051	0.2563	0.494
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0015	0.0064	0.0064
Echinococcus multilocularis	neurogenic locus protein delta	0.0016	0.0171	0.0212
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.022	0.5371
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0088	0.5124	0.5124
Schistosoma mansoni	septate junction protein	0.0016	0.0171	0.0212
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0623	0.3277
Brugia malayi	EGF-like domain containing protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0017	0.022	0.022
Giardia lamblia	High cysteine protein	0.0016	0.0171	0.5
Schistosoma mansoni	cell polarity protein	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Mycobacterium ulcerans	putative regulatory protein	0.0035	0.1449	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Onchocerca volvulus		0.0026	0.0842	0.1538
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0623	0.3277
Brugia malayi	EGF-like domain containing protein	0.0016	0.0171	0.0171
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.274	0.5289
Echinococcus multilocularis	protein jagged 1	0.0016	0.0171	0.0212
Echinococcus granulosus	protein jagged 2	0.0016	0.0171	0.0212
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0088	0.5124	0.5124
Onchocerca volvulus	Peroxidasin homolog	0.0051	0.2563	0.494
Loa Loa (eye worm)	blistered cuticle protein 3	0.0051	0.2563	0.2563
Onchocerca volvulus		0.0016	0.0171	0.0212
Echinococcus multilocularis	slit 2 protein	0.0016	0.0171	0.0212
Brugia malayi	EGF-like domain containing protein	0.0016	0.0171	0.0171
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.2563	0.2563
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0623	0.0623
Brugia malayi	EGF-like domain containing protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.2563	0.2563
Brugia malayi	hypoxia-induced factor 1	0.0146	0.915	0.915
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0623	0.3277
Onchocerca volvulus		0.0026	0.0842	0.1538
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0015	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0017	0.022	0.022
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.2563	0.2563
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0354	0.0574
Onchocerca volvulus		0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0015	0.0064	0.0064
Brugia malayi	GCC2 and GCC3 family protein	0.0016	0.0171	0.0171
Schistosoma mansoni	lamin	0.0026	0.0842	0.1538
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0623	0.5
Echinococcus multilocularis	neural cadherin	0.0016	0.0171	0.0212
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0623	0.3277
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Echinococcus multilocularis	lamin	0.0026	0.0842	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0017	0.022	0.022
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.022	1
Onchocerca volvulus		0.0023	0.0623	0.1105
Toxoplasma gondii	EGF family domain-containing protein	0.0016	0.0171	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0354	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Echinococcus multilocularis	protein jagged 2	0.0016	0.0171	0.0212
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0787	0.0787
Schistosoma mansoni	single-minded	0.0047	0.2299	0.4417
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0015	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0064
Onchocerca volvulus	Neurogenic locus notch homolog	0.0016	0.0171	0.0212
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0354	0.0574
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.2563	0.2563
Brugia malayi	Cadherin domain containing protein	0.0016	0.0171	0.0171
Echinococcus multilocularis	peroxidasin	0.0051	0.2563	0.494
Echinococcus multilocularis	fibropellin Ia	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0354	0.0574
Loa Loa (eye worm)	norepinephrine transporter	0.0088	0.5124	0.5124
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0623	0.3277
Schistosoma mansoni	slit	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0017	0.022	0.022
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0016	0.0171	0.0212
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.1449	0.2738
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Onchocerca volvulus	Peroxidasin homolog	0.0051	0.2563	0.494
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0064
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0623	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.1449	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0842	0.0842
Echinococcus multilocularis	lamin dm0	0.0026	0.0842	0.1538
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0623	0.5
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0623	0.3277
Echinococcus granulosus	notch	0.0016	0.0171	0.0212
Treponema pallidum	sodium- and chloride- dependent transporter	0.0088	0.5124	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0088	0.5124	0.5124
Echinococcus granulosus	protein jagged 2	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Onchocerca volvulus		0.0016	0.0171	0.0212
Echinococcus multilocularis	serotonin transporter	0.0088	0.5124	1
Brugia malayi	Muscle positioning protein 4	0.0016	0.0171	0.0171
Echinococcus multilocularis	neurogenic locus protein delta	0.0016	0.0171	0.0212
Brugia malayi	hypothetical protein	0.0051	0.2563	0.2563
Schistosoma mansoni	laminin gamma-3 chain	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0146	0.915	0.915
Echinococcus multilocularis	RUN	0.0019	0.0354	0.0574
Onchocerca volvulus		0.0016	0.0171	0.0212
Echinococcus granulosus	lamin dm0	0.0026	0.0842	0.1538
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0015	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Echinococcus multilocularis	neurogenic locus notch protein	0.0016	0.0171	0.0212
Echinococcus granulosus	single minded 2	0.0035	0.1449	0.2738
Echinococcus multilocularis	protein jagged 1	0.0016	0.0171	0.0212
Brugia malayi	Peroxidasin	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0623	0.0623
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0623	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Brugia malayi	intermediate filament protein	0.0026	0.0842	0.0842
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0171	0.0171
Echinococcus granulosus	fibropellin Ia	0.0016	0.0171	0.0212
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0623	1
Loa Loa (eye worm)	Notch2	0.0016	0.0171	0.0171
Schistosoma mansoni	sodium/chloride dependent transporter	0.0088	0.5124	1
Echinococcus granulosus	RUN	0.0019	0.0354	0.0574
Onchocerca volvulus	Dual oxidase homolog	0.0051	0.2563	0.494
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Brugia malayi	EGF-like domain containing protein	0.0016	0.0171	0.0171
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0088	0.5124	1
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.2563	0.2563
Schistosoma mansoni	lipoxygenase	0.0054	0.274	0.5289
Schistosoma mansoni	lipoxygenase	0.0019	0.0354	0.0574
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.022	0.5371
Brugia malayi	hypothetical protein	0.0019	0.0354	0.0354
Schistosoma mansoni	rab6-interacting	0.0019	0.0354	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Echinococcus multilocularis	musashi	0.0026	0.0842	0.1538
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.2299	0.4417
Schistosoma mansoni	lamin	0.0026	0.0842	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Schistosoma mansoni	hypothetical protein	0.0019	0.0354	0.0574
Onchocerca volvulus	Slit protein homolog	0.0016	0.0171	0.0212
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0623	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0623	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0064
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0623	0.5
Echinococcus granulosus	peroxidasin	0.0051	0.2563	0.494
Schistosoma mansoni	hypothetical protein	0.0016	0.0171	0.0212
Schistosoma mansoni	notch	0.0016	0.0171	0.0212
Onchocerca volvulus	Putative cubilin	0.0016	0.0171	0.0212
Echinococcus multilocularis	neurogenic locus notch protein	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0088	0.5124	0.5124
Onchocerca volvulus	Chorion peroxidase homolog	0.0051	0.2563	0.494
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0842	0.0842
Schistosoma mansoni	hypothetical protein	0.0016	0.0171	0.0212
Echinococcus granulosus	neurogenic locus notch protein 4	0.0016	0.0171	0.0212
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0623	0.5
Onchocerca volvulus		0.0016	0.0171	0.0212
Onchocerca volvulus	Peroxidase homolog	0.0051	0.2563	0.494
Schistosoma mansoni	hypothetical protein	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Onchocerca volvulus		0.0051	0.2563	0.494
Brugia malayi	Delta serrate ligand family protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0017	0.022	0.022
Schistosoma mansoni	hypothetical protein	0.0016	0.0171	0.0212
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0787	0.0787
Echinococcus granulosus	protein jagged 1	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0809	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0088	0.5124	0.5124
Schistosoma mansoni	notch	0.0016	0.0171	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	serotonin transporter b	0.0088	0.5124	0.5124
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0064
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0623	0.5
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.022	0.139
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0354	1
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0354	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Schistosoma mansoni	hypothetical protein	0.0016	0.0171	0.0212
Onchocerca volvulus	Peroxidase homolog	0.0051	0.2563	0.494
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0623	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0064
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.2563	0.2563
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.274	0.5289
Echinococcus granulosus	neurogenic locus notch protein	0.0016	0.0171	0.0212
Onchocerca volvulus		0.0019	0.0354	0.0574
Brugia malayi	EGF-like domain containing protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0159	1	1
Schistosoma mansoni	polycystin 1-related	0.0019	0.0354	0.0574
Echinococcus granulosus	slit 2 protein	0.0016	0.0171	0.0212
Schistosoma mansoni	hypothetical protein	0.0016	0.0171	0.0212
Schistosoma mansoni	peroxidasin	0.0051	0.2563	0.494
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Schistosoma mansoni	notch	0.0016	0.0171	0.0212
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0016	0.0171	0.0212
Onchocerca volvulus		0.0051	0.2563	0.494
Schistosoma mansoni	loxhd1	0.0019	0.0354	0.0574
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0623	0.0623
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0354	1
Loa Loa (eye worm)	notch protein	0.0016	0.0171	0.0171
Schistosoma mansoni	hypothetical protein	0.0016	0.0171	0.0212
Echinococcus granulosus	neural cadherin	0.0016	0.0171	0.0212
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0016	0.0171	0.0212
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0016	0.0171	0.0212
Brugia malayi	Doublecortin family protein	0.0019	0.0354	0.0354
Schistosoma mansoni	notch	0.0016	0.0171	0.0212
Echinococcus granulosus	neurogenic locus protein delta	0.0016	0.0171	0.0212
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0015	0.0064	0.0064
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0623	1
Echinococcus granulosus	lamin	0.0026	0.0842	0.1538
Brugia malayi	PAS domain containing protein	0.0047	0.2299	0.2299
Onchocerca volvulus		0.0035	0.1449	0.2738
Brugia malayi	EGF-like domain containing protein	0.0016	0.0171	0.0171
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0354	0.0574
Echinococcus granulosus	neurogenic locus notch protein	0.0016	0.0171	0.0212
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0354	0.0574
Schistosoma mansoni	rab6-interacting	0.0019	0.0354	0.0574
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.2563	0.2563
Schistosoma mansoni	notch	0.0016	0.0171	0.0212
Brugia malayi	notch-like transmembrane receptor	0.0016	0.0171	0.0171
Echinococcus granulosus	protein jagged 1	0.0016	0.0171	0.0212
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0623	0.3277
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0623	0.3277
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0842	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0354	0.0354

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 70.7946 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1386520

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1280222