Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.052 | 0.5286 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.052 | 0.5286 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.052 | 0.5286 | 1 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0045 | 0.0085 |
Loa Loa (eye worm) | thymidylate synthase | 0.052 | 0.5286 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.052 | 0.5286 | 1 |
Onchocerca volvulus | 0.052 | 0.5286 | 0.5 | |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0045 | 0.0085 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0045 | 0.0085 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1425 | 0.2695 |
Echinococcus multilocularis | thymidylate synthase | 0.052 | 0.5286 | 0.5264 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0511 | 0.089 |
Brugia malayi | thymidylate synthase | 0.052 | 0.5286 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.052 | 0.5286 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0511 | 0.0468 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.052 | 0.5286 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0511 | 0.0968 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.052 | 0.5286 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.052 | 0.5286 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0511 | 0.089 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0247 | 0.2485 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0511 | 0.0468 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0045 | 0.0085 |
Brugia malayi | Smad1 | 0.001 | 0.0045 | 0.0085 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1425 | 0.2695 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0045 | 0.0085 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.052 | 0.5286 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.052 | 0.5286 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0697 | 0.1244 |
Brugia malayi | hypothetical protein | 0.0247 | 0.2485 | 0.4702 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0045 | 0.0085 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1425 | 0.2695 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0697 | 0.1244 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0247 | 0.2485 | 0.3897 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0511 | 0.0968 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0697 | 0.0655 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0697 | 0.1244 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0511 | 0.089 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.052 | 0.5286 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0511 | 0.089 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0511 | 0.089 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0045 | 0.0085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.