Detailed information for compound 1280544

Basic information

Technical information
  • TDR Targets ID: 1280544
  • Name: ethyl 4-cyclopropyl-2-[[2-[2-(1,3-dioxo-3a,4, 5,6,7,7a-hexahydroisoindol-2-yl)acetyl]oxyace tyl]amino]thiophene-3-carboxylate
  • MW: 462.516 | Formula: C22H26N2O7S
  • H donors: 1 H acceptors: 5 LogP: 3.31 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(scc1C1CC1)NC(=O)COC(=O)CN1C(=O)C2C(C1=O)CCCC2
  • InChi: 1S/C22H26N2O7S/c1-2-30-22(29)18-15(12-7-8-12)11-32-19(18)23-16(25)10-31-17(26)9-24-20(27)13-5-3-4-6-14(13)21(24)28/h11-14H,2-10H2,1H3,(H,23,25)
  • InChiKey: JNZPBHZFNZWDPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-cyclopropyl-2-[[2-[2-(1,3-dioxo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl)-1-oxoethoxy]-1-oxoethyl]amino]-3-thiophenecarboxylic acid ethyl ester
  • 4-cyclopropyl-2-[[2-[2-(1,3-diketo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl)acetyl]oxyacetyl]amino]thiophene-3-carboxylic acid ethyl ester
  • ethyl 4-cyclopropyl-2-[2-[2-(1,3-dioxo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl)ethanoyloxy]ethanoylamino]thiophene-3-carboxylate
  • T5277117
  • MLS000335262
  • SMR000250020

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0042 0.038 0.1478
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0042 0.038 0.1478
Plasmodium vivax vivapain-2 0.005 0.0495 1
Echinococcus multilocularis cysteine protease 0.005 0.0495 0.0478
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0056 0.0154
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.3446 0.4189
Schistosoma mansoni smad1 5 8 and 0.0027 0.0168 0.015
Entamoeba histolytica prolyl oligopeptidase family protein 0.0042 0.038 0.7391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Schistosoma mansoni polyadenylate binding protein 0.0018 0.0046 0.0028
Schistosoma mansoni polyadenylate binding protein 0.0018 0.0046 0.0028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.093 0.0913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Schistosoma mansoni ap endonuclease 0.0019 0.0056 0.0038
Loa Loa (eye worm) hypothetical protein 0.0255 0.3387 0.4118
Brugia malayi Latrophilin receptor protein 2 0.0081 0.093 0.113
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0391 0.1204
Echinococcus granulosus cysteine protease 0.0026 0.0154 0.0136
Plasmodium vivax unspecified product 0.0026 0.0154 0.2854
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0154 0.2239
Toxoplasma gondii hypothetical protein 0.0042 0.038 0.1596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Onchocerca volvulus 0.0054 0.0557 0.0412
Brugia malayi prolyl oligopeptidase family protein 0.0177 0.2288 0.2781
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0211 0.0193
Brugia malayi prolyl oligopeptidase family protein 0.0042 0.038 0.0462
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0177 0.2288 0.9256
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0168 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.003
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.128 0.8837
Schistosoma mansoni hypothetical protein 0.0081 0.093 0.0913
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Toxoplasma gondii exonuclease III APE 0.0019 0.0056 0.0166
Echinococcus granulosus chromobox protein 1 0.0071 0.0785 0.0768
Echinococcus multilocularis tar DNA binding protein 0.0259 0.3446 0.3434
Plasmodium vivax hypothetical protein, conserved 0.0042 0.038 0.7598
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0154 0.0136
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0154 0.0555
Schistosoma mansoni smad1 5 8 and 0.0027 0.0168 0.015
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0056 0.0068
Echinococcus granulosus geminin 0.034 0.4581 0.4571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0495 0.1945
Plasmodium vivax glutathione reductase, putative 0.0046 0.0444 0.8936
Treponema pallidum bacterioferrin (TpF1) 0.0035 0.0284 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0042 0.038 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0042 0.038 1
Mycobacterium tuberculosis Probable reductase 0.0106 0.128 0.8837
Toxoplasma gondii prolyl endopeptidase 0.0042 0.038 0.1596
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0785 0.2477
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0056 0.0122
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0557 0.0678
Echinococcus multilocularis polyadenylate binding protein 0.0018 0.0046 0.0028
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0056 0.0265
Brugia malayi Thioredoxin reductase 0.0046 0.0444 0.054
Brugia malayi prolyl oligopeptidase family protein 0.0042 0.038 0.0462
Brugia malayi glutathione reductase 0.0046 0.0444 0.054
Echinococcus multilocularis microtubule associated protein 2 0.0725 1 1
Leishmania major cathepsin L-like protease 0.005 0.0495 0.1945
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.093 0.0913
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0297 0.0279
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0444 0.1738
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0211 0.0849
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0168 0.015
Schistosoma mansoni hypothetical protein 0.034 0.4581 0.4571
Brugia malayi chromobox protein homolog 3 0.004 0.0349 0.0424
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0438 0.0533
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Loa Loa (eye worm) RNA binding protein 0.0259 0.3446 0.4189
Plasmodium falciparum cysteine proteinase falcipain 3 0.005 0.0495 1
Onchocerca volvulus 0.005 0.0495 0.0333
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.003
Brugia malayi MH1 domain containing protein 0.0027 0.0168 0.0204
Leishmania major poly(A)-binding protein 2 0.0018 0.0046 0.0115
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.225 0.2735
Onchocerca volvulus Cathepsin L homolog 0.005 0.0495 0.0333
Entamoeba histolytica cysteine protease, putative 0.005 0.0495 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0154 0.044
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0527 0.7215 0.721
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.3446 0.4189
Onchocerca volvulus 0.0041 0.0373 0.0181
Loa Loa (eye worm) transcription factor SMAD2 0.0392 0.5312 0.6459
Echinococcus multilocularis smad 0.0027 0.0168 0.015
Loa Loa (eye worm) prolyl oligopeptidase 0.0042 0.038 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Echinococcus granulosus lamin dm0 0.0054 0.0557 0.054
Onchocerca volvulus 0.005 0.0495 0.0333
Loa Loa (eye worm) prolyl oligopeptidase 0.0527 0.7215 0.8772
Loa Loa (eye worm) hypothetical protein 0.0175 0.225 0.2735
Brugia malayi Cathepsin L-like precursor 0.005 0.0495 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0132 0.1649 0.1634
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.093 0.0913
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.154 0.1525
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.033 0.6248
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0056 0.0038
Echinococcus multilocularis prolyl endopeptidase 0.0042 0.038 0.0363
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0154 0.2239
Entamoeba histolytica prolyl oligopeptidase family protein 0.0042 0.038 0.7391
Loa Loa (eye worm) hypothetical protein 0.0053 0.0543 0.0661
Echinococcus granulosus cathepsin L cysteine proteinase 0.005 0.0495 0.0478
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0161 0.0144
Brugia malayi Heterochromatin protein 1 0.0071 0.0785 0.0954
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3446 0.3434
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.3387 0.4118
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0444 0.8936
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0154 0.0555
Schistosoma mansoni hypothetical protein 0.0081 0.093 0.0913
Toxoplasma gondii cathepsin CPL 0.005 0.0495 0.2101
Loa Loa (eye worm) acetyltransferase 0.0142 0.1788 0.2174
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.0284 0.7329
Schistosoma mansoni ferritin 0.0035 0.0284 0.0266
Echinococcus multilocularis acylamino acid releasing enzyme 0.0042 0.038 0.0363
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0042 0.038 0.0363
Schistosoma mansoni chromobox protein 0.0071 0.0785 0.0768
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1732 0.1717
Loa Loa (eye worm) hypothetical protein 0.0181 0.2343 0.2849
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1788 0.1773
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0042 0.038 0.117
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0042 0.038 0.0363
Brugia malayi RNA binding protein 0.0259 0.3446 0.4189
Trichomonas vaginalis ferritin, putative 0.0035 0.0284 0.0858
Loa Loa (eye worm) hypothetical protein 0.0081 0.093 0.113
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0785 0.2477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0495 0.0478
Brugia malayi Cathepsin L-like precursor 0.005 0.0495 0.0602
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0379 0.1591
Brugia malayi Smad1 0.0027 0.0168 0.0204
Loa Loa (eye worm) fibroinase 0.005 0.0495 0.0602
Schistosoma mansoni smad 0.0027 0.0168 0.015
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0056 0.0122
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Brugia malayi RNA binding protein 0.0132 0.1649 0.2004
Plasmodium vivax polyadenylate-binding protein, putative 0.0018 0.0046 0.0589
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0211 0.0193
Onchocerca volvulus Cathepsin F homolog 0.005 0.0495 0.0333
Trypanosoma brucei polyadenylate-binding protein 1 0.0018 0.0046 0.0115
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0177 0.2288 1
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0599 0.8225 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0495 0.0602
Echinococcus multilocularis chromobox protein 1 0.0071 0.0785 0.0768
Plasmodium vivax unspecified product 0.0017 0.0024 0.0134
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.5484
Loa Loa (eye worm) hypothetical protein 0.0135 0.1699 0.2066
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.038 0.117
Loa Loa (eye worm) hypothetical protein 0.0042 0.038 0.0462
Schistosoma mansoni hypothetical protein 0.0124 0.154 0.1525
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0177 0.2288 0.2274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0211 0.0193
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0154 0.0136
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0154 0.0136
Onchocerca volvulus 0.0599 0.8225 1
Onchocerca volvulus 0.005 0.0495 0.0333
Loa Loa (eye worm) hypothetical protein 0.003 0.0211 0.0256
Leishmania major oligopeptidase b 0.0042 0.038 0.1478
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0132 0.1649 0.1634
Loa Loa (eye worm) glutathione reductase 0.0046 0.0444 0.054
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0297 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0262 0.079
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3446 0.3434
Echinococcus granulosus Smad4 0.0027 0.0168 0.015
Schistosoma mansoni chromobox protein 0.0071 0.0785 0.0768
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0154 0.0187
Trypanosoma cruzi prolyl endopeptidase 0.0042 0.038 0.1478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0349 0.015
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0056 0.1422
Entamoeba histolytica prolyl oligopeptidase family protein 0.0042 0.038 0.7391
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0495 0.0478
Echinococcus multilocularis musashi 0.0054 0.0557 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0186 0.0543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.003
Trypanosoma cruzi major cysteine proteinase, putative 0.0149 0.1897 0.7662
Loa Loa (eye worm) Smad1 0.0027 0.0168 0.0204
Trypanosoma cruzi oligopeptidase b 0.0042 0.038 0.1478
Plasmodium falciparum cysteine proteinase falcipain 2b 0.005 0.0495 1
Trypanosoma cruzi polyadenylate-binding protein 1, putative 0.0018 0.0046 0.0115
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0391 0.1204
Echinococcus granulosus Dipeptidyl peptidase 9 0.0177 0.2288 0.2274
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.033 0.8615
Onchocerca volvulus 0.005 0.0495 0.0333
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0056 0.0792
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0056 0.0068
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0018 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0444 0.054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2711 0.3296
Schistosoma mansoni lamin 0.0054 0.0557 0.054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0211 0.0193
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.154 0.1525
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0024 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.038 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0154 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.3387 0.4118
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0161 0.0144
Onchocerca volvulus 0.0052 0.0525 0.0371
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.128 0.8837
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.168 0.1665
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0018 0.5
Schistosoma mansoni hypothetical protein 0.0036 0.0297 0.0279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0438 0.0421
Leishmania major cathepsin L-like protease 0.005 0.0495 0.1945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0154 0.0555
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0056
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.038 0.7391
Leishmania major poly(A)-binding protein 3 0.0018 0.0046 0.0115
Trypanosoma brucei polyadenylate-binding protein 2 0.0018 0.0046 0.0115
Leishmania major cathepsin L-like protease 0.019 0.247 1
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0527 0.7215 0.721
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Plasmodium falciparum polyadenylate-binding protein, putative 0.0018 0.0046 0.0589
Brugia malayi TAR-binding protein 0.0259 0.3446 0.4189
Schistosoma mansoni smad1 5 8 and 0.0027 0.0168 0.015
Schistosoma mansoni apoferritin-2 0.0035 0.0284 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Echinococcus multilocularis lamin 0.0054 0.0557 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0379 0.7571
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0495 0.0478
Brugia malayi Pre-SET motif family protein 0.003 0.0211 0.0256
Echinococcus multilocularis lamin dm0 0.0054 0.0557 0.054
Toxoplasma gondii polyadenylate binding protein, putative 0.0018 0.0046 0.0124
Plasmodium vivax SET domain protein, putative 0.003 0.0211 0.404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0438 0.0421
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0495 0.154
Echinococcus granulosus tumor protein p63 0.0355 0.4798 0.4788
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0056 0.0154
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1446 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0557 0.0678
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.0495 0.0602
Onchocerca volvulus 0.005 0.0495 0.0333
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0168 0.015
Brugia malayi prolyl oligopeptidase family protein 0.0042 0.038 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0154 0.044
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0154 0.0555
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0132 0.1649 0.1634
Schistosoma mansoni ferritin 0.0035 0.0284 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Schistosoma mansoni ferritin 0.0035 0.0284 0.0266
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0379 0.1166
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3446 0.3434
Brugia malayi Cathepsin L-like precursor 0.005 0.0495 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0262 0.0245
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.093 0.113
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.247 1
Echinococcus multilocularis expressed protein 0.0035 0.0284 0.0266
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0379 0.1166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0056 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Brugia malayi hypothetical protein 0.0135 0.1699 0.2066
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0444 0.0427
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.0284 0.7329
Brugia malayi MH2 domain containing protein 0.0027 0.0168 0.0204
Plasmodium falciparum cysteine proteinase falcipain 2a 0.005 0.0495 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0024 0.003
Echinococcus granulosus smad 0.0027 0.0168 0.015
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.2343 0.2645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Plasmodium vivax vivapain-1 0.0026 0.0154 0.2854
Brugia malayi Cathepsin L-like precursor 0.005 0.0495 0.0602
Brugia malayi prolyl oligopeptidase family protein 0.0527 0.7215 0.8772
Schistosoma mansoni hypothetical protein 0.0175 0.225 0.2236
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.0284 0.186
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0132 0.1649 0.1634
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0042 0.038 0.1478
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0177 0.2288 0.9256
Plasmodium falciparum glutathione reductase 0.0046 0.0444 0.8936
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1446 1
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0042 0.038 0.1596
Trypanosoma brucei prolyl oligopeptidase, putative 0.0042 0.038 0.1478
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0056 0.1422
Loa Loa (eye worm) hypothetical protein 0.0033 0.0262 0.0319
Echinococcus granulosus ferritin 0.0035 0.0284 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0349 0.1068
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0438 0.0533
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0202 0.0246
Brugia malayi cathepsin L-like precursor 0.0033 0.0262 0.0319
Onchocerca volvulus 0.005 0.0495 0.0333
Echinococcus granulosus lamin 0.0054 0.0557 0.054
Echinococcus multilocularis GPCR, family 2 0.0081 0.093 0.0913
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0195 0.0178
Leishmania major trypanothione reductase 0.0046 0.0444 0.1738
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0557 0.0678
Loa Loa (eye worm) hypothetical protein 0.0054 0.0557 0.0678
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0056 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Brugia malayi N-terminal motif family protein 0.0181 0.2343 0.2849
Loa Loa (eye worm) hypothetical protein 0.004 0.0349 0.0424
Brugia malayi Cathepsin L-like precursor 0.005 0.0495 0.0602
Leishmania major cathepsin L-like protease 0.005 0.0495 0.1945
Trichomonas vaginalis set domain proteins, putative 0.0236 0.3114 1
Loa Loa (eye worm) cysteine protease 0.005 0.0495 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0349 0.1068
Loa Loa (eye worm) hypothetical protein 0.0042 0.038 0.0462
Brugia malayi polyadenylate-binding protein 1 0.0018 0.0046 0.0056
Brugia malayi Cathepsin L-like precursor 0.0017 0.0024 0.003
Plasmodium falciparum thioredoxin reductase 0.0046 0.0444 0.8936
Leishmania major cathepsin L-like protease 0.019 0.247 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.093 0.0913
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0154 0.0187
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.5484
Schistosoma mansoni hypothetical protein 0.0081 0.093 0.0913
Echinococcus multilocularis Smad4 0.0027 0.0168 0.015
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0785 0.0954
Trypanosoma brucei oligopeptidase b 0.0042 0.038 0.1478
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0024 0.003
Echinococcus granulosus cathepsin l1 0.0033 0.0262 0.0245
Schistosoma mansoni apoferritin-2 0.0035 0.0284 0.0266
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0444 0.2985
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.3387 0.4118
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Leishmania major cathepsin L-like protease 0.005 0.0495 0.1945
Echinococcus granulosus tar DNA binding protein 0.0259 0.3446 0.3434
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0297 0.0279
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0438 0.0421
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.128 0.8837
Loa Loa (eye worm) hypothetical protein 0.0033 0.0262 0.0319
Echinococcus multilocularis ferritin 0.0035 0.0284 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0525 0.0638
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0379 0.0362
Brugia malayi MH2 domain containing protein 0.0027 0.0168 0.0204
Schistosoma mansoni thyroid hormone receptor 0.0134 0.168 0.1665
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0438 0.0421
Loa Loa (eye worm) hypothetical protein 0.0033 0.0262 0.0319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Onchocerca volvulus 0.005 0.0495 0.0333
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0391 0.0203
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.0284 0.186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0056 0.1042
Loa Loa (eye worm) hypothetical protein 0.0042 0.038 0.0462
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0042 0.038 0.7391
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0495 0.0602
Onchocerca volvulus 0.0033 0.0262 0.0043
Leishmania major cysteine peptidase A (CPA) 0.005 0.0495 0.1945
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3446 0.3434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0495 0.0478
Loa Loa (eye worm) MH2 domain-containing protein 0.0392 0.5312 0.6459
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0495 0.0478
Brugia malayi hypothetical protein 0.0599 0.8225 1
Schistosoma mansoni hypothetical protein 0.034 0.4581 0.4571
Leishmania major cathepsin L-like protease 0.005 0.0495 0.1945
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0035 0.0284 1
Mycobacterium tuberculosis Probable peptidase 0.0042 0.038 0.2538
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0154 0.2239
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0495 1
Schistosoma mansoni Smad4 0.0027 0.0168 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0042 0.038 1
Echinococcus granulosus cathepsin L 0.0026 0.0154 0.0136
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0024 0.0026
Echinococcus multilocularis chromobox protein 1 0.0071 0.0785 0.0768
Schistosoma mansoni intermediate filament proteins 0.0054 0.0557 0.054
Brugia malayi MH1 domain containing protein 0.0027 0.0168 0.0204
Brugia malayi Pre-SET motif family protein 0.0207 0.2711 0.3296
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0042 0.038 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.038 0.1478
Echinococcus granulosus cathepsin l cysteine peptidase 0.005 0.0495 0.0478
Echinococcus multilocularis tumor protein p63 0.0355 0.4798 0.4788
Brugia malayi Cathepsin L-like precursor 0.0033 0.0262 0.0319
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.128 0.8571
Trypanosoma cruzi oligopeptidase b 0.0042 0.038 0.1478
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0444 0.0427
Echinococcus granulosus cathepsin l1 0.005 0.0495 0.0478
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0177 0.2288 0.2274
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0174 0.2238 0.9052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1446 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0262 0.4708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0262 0.079
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0177 0.2288 0.9256
Leishmania major cathepsin L-like protease 0.019 0.247 1
Brugia malayi Cathepsin L-like precursor 0.005 0.0495 0.0602
Toxoplasma gondii thioredoxin reductase 0.0046 0.0444 0.1878
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0168 0.0204
Trypanosoma brucei trypanothione reductase 0.0046 0.0444 0.1738
Giardia lamblia Alanyl dipeptidyl peptidase 0.0042 0.038 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0042 0.038 0.7391
Trypanosoma cruzi cruzipain precursor, putative 0.019 0.247 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0527 0.7215 0.8737
Echinococcus granulosus expressed protein 0.0035 0.0284 0.0266
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0527 0.7215 0.721
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0132 0.1649 0.1634
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.5484
Loa Loa (eye worm) ctsf protein 0.005 0.0495 0.0602
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0525 0.0508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0179
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0056 0.0792
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0373 0.0356
Echinococcus multilocularis cathepsin L 0.0026 0.0154 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0161 0.0196
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0042 0.038 0.1478
Onchocerca volvulus Cathepsin L homolog 0.005 0.0495 0.0333
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0042 0.038 0.2538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0042 0.038 0.0363
Onchocerca volvulus 0.0054 0.0557 0.0412
Echinococcus granulosus GPCR family 2 0.0081 0.093 0.0913
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0202 0.0246
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.128 0.8837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Brugia malayi intermediate filament protein 0.0054 0.0557 0.0678
Plasmodium vivax vivapain-2 0.005 0.0495 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1446 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.033 0.6545
Schistosoma mansoni hypothetical protein 0.0081 0.093 0.0913
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0154 0.2239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0438 0.0421
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0042 0.038 0.1478
Brugia malayi Cathepsin L-like precursor 0.0033 0.0262 0.0319
Schistosoma mansoni thyroid hormone receptor 0.0134 0.168 0.1665
Echinococcus granulosus chromobox protein 1 0.0071 0.0785 0.0768
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0154 0.2239
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0042 0.038 0.0833
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1788 0.2174
Echinococcus granulosus polyadenylate binding protein 0.0018 0.0046 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.247 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0154 0.2239
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0495 0.154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Schistosoma mansoni ap endonuclease 0.0019 0.0056 0.0038
Brugia malayi Cathepsin L-like cysteine proteinase 0.0033 0.0262 0.0319
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0056 0.1042
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0168 0.015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0211 0.0193
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0154 0.2239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0154 0.0555
Schistosoma mansoni microtubule-associated protein tau 0.0725 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.247 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Schistosoma mansoni polyadenylate binding protein 0.0018 0.0046 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Loa Loa (eye worm) hypothetical protein 0.0132 0.1649 0.2004
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0177 0.2288 0.9256
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0211 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.247 1
Plasmodium vivax vivapain-3 0.0026 0.0154 0.2854
Echinococcus multilocularis cysteine protease 0.005 0.0495 0.0478
Schistosoma mansoni cathepsin s 0.0017 0.0024 0.0006
Echinococcus granulosus intermediate filament protein 0.0054 0.0557 0.054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0495 0.0478
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0438 0.0421
Loa Loa (eye worm) hypothetical protein 0.0031 0.0228 0.0278
Echinococcus multilocularis geminin 0.034 0.4581 0.4571
Plasmodium falciparum peptidase, putative 0.0042 0.038 0.7598
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1788 0.1773
Schistosoma mansoni ferritin 0.0035 0.0284 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0186 0.0543
Schistosoma mansoni ferritin light chain 0.0035 0.0284 0.0266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0438 0.0421
Schistosoma mansoni ferritin light chain 0.0035 0.0284 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0024 0.0026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0168 0.015
Schistosoma mansoni tar DNA-binding protein 0.0259 0.3446 0.3434
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.5484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0154 0.0555
Loa Loa (eye worm) hypothetical protein 0.005 0.0495 0.0602
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0042 0.038 0.117
Echinococcus granulosus prolyl endopeptidase 0.0042 0.038 0.0363
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0168 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0495 0.154
Echinococcus granulosus acylamino acid releasing enzyme 0.0042 0.038 0.0363
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0379 0.1591
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.093 0.113
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0179
Trypanosoma cruzi polyadenylate-binding protein, putative 0.0018 0.0046 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0259 0.3446 0.4189
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.128 0.8837
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0154 0.2854
Schistosoma mansoni lamin 0.0054 0.0557 0.054
Brugia malayi MH2 domain containing protein 0.0392 0.5312 0.6459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0495 0.154
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0056 0.0038
Onchocerca volvulus 0.0236 0.3114 0.3609
Brugia malayi hypothetical protein 0.0036 0.0297 0.0361
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0177 0.2288 0.9256
Trypanosoma brucei prolyl endopeptidase 0.0042 0.038 0.1478
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0154 0.0555
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0042 0.038 0.1478

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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