TDR Targets

Basic information

Technical information

TDR Targets ID: 1280654
Name: 1-[2-(4-ethylpiperazin-1-yl)ethyl]-3-(4-nitro phenyl)urea
MW: 321.375 | Formula: C15H23N5O3
H donors: 2 H acceptors: 3 LogP: 0.97 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)CCNC(=O)Nc1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C15H23N5O3/c1-2-18-9-11-19(12-10-18)8-7-16-15(21)17-13-3-5-14(6-4-13)20(22)23/h3-6H,2,7-12H2,1H3,(H2,16,17,21)
InChiKey: GUHDXDYYMJJFSK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[2-(4-ethyl-1-piperazinyl)ethyl]-3-(4-nitrophenyl)urea
SMR000308827
MLS000730551
N-[2-(4-ethylpiperazin-1-yl)ethyl]-N'-(4-nitrophenyl)urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear receptor NHR-88	0.0114	0.2665	0.2975
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Brugia malayi	ecdysone receptor	0.0114	0.2665	0.2975
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0606	0.0606
Brugia malayi	TAR-binding protein	0.0045	0.0427	0.0477
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0045	0.0427	0.0427
Echinococcus granulosus	epidermal growth factor receptor	0.0308	0.896	0.896
Echinococcus granulosus	thioredoxin glutathione reductase	0.0052	0.0661	0.0661
Loa Loa (eye worm)	hypothetical protein	0.018	0.4815	0.4815
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0606	0.0606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0242	0.6808	0.6808
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0114	0.2665	0.2665
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0128	0.3109	0.3109
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0242	0.6808	0.6808
Loa Loa (eye worm)	nuclear hormone receptor	0.0114	0.2665	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0128	0.3109	0.3109
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0114	0.2665	0.2665
Brugia malayi	Muscleblind-like protein	0.018	0.4815	0.5374
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0242	0.6808	0.7598
Brugia malayi	hypothetical protein	0.0128	0.3109	0.347
Brugia malayi	Nuclear hormone receptor-like 1	0.0242	0.6808	0.7598
Brugia malayi	Nuclear hormone receptor-like 1	0.0128	0.3109	0.347
Brugia malayi	nuclear hormone receptor family member odr-7	0.0114	0.2665	0.2975
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0114	0.2665	0.2665
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0242	0.6808	0.6808
Loa Loa (eye worm)	TK/INSR protein kinase	0.0098	0.216	0.216
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Schistosoma mansoni	nuclear receptor	0.0114	0.2665	0.2665
Brugia malayi	orphan nuclear receptor NR2E1	0.0114	0.2665	0.2975
Brugia malayi	nuclear receptor NHR-88	0.0242	0.6808	0.7598
Brugia malayi	ecdysteroid receptor	0.0242	0.6808	0.7598
Brugia malayi	nuclear hormone receptor	0.0114	0.2665	0.2975
Schistosoma mansoni	tyrosine kinase	0.0166	0.4336	0.4336
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0242	0.6808	0.6808
Schistosoma mansoni	hypothetical protein	0.0043	0.0375	0.0375
Schistosoma mansoni	tyrosine kinase	0.0164	0.4279	0.4279
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0242	0.6808	0.6808
Schistosoma mansoni	thyroid hormone receptor	0.0242	0.6808	0.6808
Mycobacterium tuberculosis	Probable dehydrogenase	0.0119	0.2833	0.8342
Brugia malayi	Furin-like cysteine rich region family protein	0.0308	0.896	1
Schistosoma mansoni	nuclear hormone receptor	0.0242	0.6808	0.6808
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0242	0.6808	1
Schistosoma mansoni	thyroid hormone receptor	0.0242	0.6808	0.6808
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0242	0.6808	0.6808
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0128	0.3109	0.3109
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0606	0.0606
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0114	0.2665	0.2665
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0242	0.6808	0.6808
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0242	0.6808	0.6808
Schistosoma mansoni	nuclear hormone receptor	0.0114	0.2665	0.2665
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0242	0.6808	0.7598
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0119	0.2833	0.8342
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0242	0.6808	0.6808
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0242	0.6808	0.6808
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0102	0.2259	0.6137
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0242	0.6808	0.6808
Echinococcus multilocularis	epidermal growth factor receptor	0.0308	0.896	0.896
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Schistosoma mansoni	tyrosine kinase	0.0098	0.216	0.216
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0427	0.0427
Echinococcus granulosus	insulin receptor	0.0098	0.216	0.216
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Schistosoma mansoni	tyrosine kinase	0.0308	0.896	0.896
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Loa Loa (eye worm)	steroid hormone receptor	0.0242	0.6808	0.6808
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0242	0.6808	0.7598
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0242	0.6808	0.6808
Schistosoma mansoni	nuclear hormone receptor	0.0114	0.2665	0.2665
Brugia malayi	Thioredoxin reductase	0.0052	0.0661	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0242	0.6808	0.7598
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0114	0.2665	0.2665
Brugia malayi	photoreceptor-specific nuclear receptor	0.0242	0.6808	0.7598
Echinococcus multilocularis	tar DNA binding protein	0.0045	0.0427	0.0427
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0242	0.6808	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0114	0.2665	0.2665
Echinococcus multilocularis	epidermal growth factor receptor	0.0166	0.4336	0.4336
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0119	0.2833	0.8342
Schistosoma mansoni	tyrosine kinase	0.0098	0.216	0.216
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Brugia malayi	Steroid receptor seven-up type 2	0.0242	0.6808	0.7598
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0242	0.6808	0.6808
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0166	0.4336	0.4336
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0242	0.6808	0.7598
Brugia malayi	nuclear receptor RXR	0.0114	0.2665	0.2975
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0242	0.6808	0.6808
Schistosoma mansoni	tyrosine kinase	0.0166	0.4336	0.4336
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0102	0.2259	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0242	0.6808	0.6808
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Brugia malayi	nuclear hormone receptor	0.0242	0.6808	0.7598
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0208	0.5706	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0242	0.6808	0.6808
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0128	0.3109	0.3109
Schistosoma mansoni	tyrosine kinase	0.0164	0.4279	0.4279
Loa Loa (eye worm)	RNA binding protein	0.0045	0.0427	0.0427
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0128	0.3109	0.3109
Schistosoma mansoni	RAR-like nuclear receptor	0.0242	0.6808	0.6808
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0242	0.6808	0.6808
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0242	0.6808	0.7598
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0052	0.0661	0.0661
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0242	0.6808	0.7598
Brugia malayi	nuclear receptor RXR	0.0128	0.3109	0.347
Brugia malayi	Nuclear hormone receptor E75	0.0114	0.2665	0.2975
Echinococcus multilocularis	muscleblind protein 1	0.018	0.4815	0.4815
Trypanosoma brucei	trypanothione reductase	0.0052	0.0661	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0242	0.6808	0.6808
Loa Loa (eye worm)	hypothetical protein	0.0128	0.3109	0.3109
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.034	1	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0427	0.0427
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0119	0.2833	0.8342
Schistosoma mansoni	nuclear receptor nhr-48	0.0114	0.2665	0.2665
Schistosoma mansoni	hypothetical protein	0.034	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0375	0.0375
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0128	0.3109	0.3109
Echinococcus granulosus	muscleblind protein	0.018	0.4815	0.4815
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0133	0.3264	1
Loa Loa (eye worm)	DR-78	0.0114	0.2665	0.2665
Onchocerca volvulus		0.0242	0.6808	1
Plasmodium vivax	glutathione reductase, putative	0.0052	0.0661	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0119	0.2833	0.8342
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.0661	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0114	0.2665	0.2665
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0242	0.6808	0.6808
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0427	0.0427
Echinococcus multilocularis	insulin receptor	0.0098	0.216	0.216
Mycobacterium tuberculosis	Probable reductase	0.0119	0.2833	0.8342
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0242	0.6808	0.7598
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0242	0.6808	0.6808
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0242	0.6808	0.6808
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0242	0.6808	0.6808
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0242	0.6808	0.6808
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0133	0.3264	1
Brugia malayi	glutathione reductase	0.0052	0.0661	0.0738
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0242	0.6808	0.6808
Toxoplasma gondii	thioredoxin reductase	0.0052	0.0661	1
Brugia malayi	Protein kinase domain containing protein	0.0098	0.216	0.2411
Echinococcus multilocularis	nuclear receptor nhr 48	0.0114	0.2665	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Plasmodium vivax	thioredoxin reductase, putative	0.0052	0.0661	1
Loa Loa (eye worm)	thioredoxin reductase	0.0052	0.0661	0.0661
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0606	0.0606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0606	0.0606
Schistosoma mansoni	zinc finger protein	0.0114	0.2665	0.2665
Onchocerca volvulus	Protein ultraspiracle homolog	0.0242	0.6808	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0114	0.2665	0.2665
Echinococcus granulosus	tar DNA binding protein	0.0045	0.0427	0.0427
Brugia malayi	hypothetical protein	0.0043	0.0375	0.0418
Brugia malayi	hypothetical protein	0.0114	0.2665	0.2975
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0114	0.2665	0.2665
Echinococcus granulosus	epidermal growth factor receptor	0.0166	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0606	0.0606
Schistosoma mansoni	tyrosine kinase	0.0164	0.4279	0.4279
Brugia malayi	RNA recognition motif domain containing protein	0.0045	0.0427	0.0477
Leishmania major	trypanothione reductase	0.0052	0.0661	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0242	0.6808	0.6808
Brugia malayi	nuclear receptor NHR-67	0.0114	0.2665	0.2975
Schistosoma mansoni	nuclear receptor	0.0114	0.2665	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Giardia lamblia	Fructose-bisphosphate aldolase	0.0208	0.5706	0.5
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Echinococcus multilocularis		0.0095	0.206	0.206
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0133	0.3264	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0208	0.5706	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0242	0.6808	0.6808
Echinococcus multilocularis	snurportin 1	0.034	1	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0208	0.5706	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.3109	0.3109
Echinococcus multilocularis	ecdysone induced protein 78C	0.0242	0.6808	0.6808
Mycobacterium tuberculosis	Probable oxidoreductase	0.0133	0.3264	1
Brugia malayi	RNA, U transporter 1	0.0091	0.1906	0.2127
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0242	0.6808	0.7598
Echinococcus granulosus	nuclear receptor nhr 48	0.0114	0.2665	0.2665
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0114	0.2665	0.2975
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0242	0.6808	0.7598
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0242	0.6808	0.6808
Brugia malayi	conserved hypotetical protein	0.0114	0.2665	0.2975
Brugia malayi	tailless protein	0.0114	0.2665	0.2975
Plasmodium falciparum	thioredoxin reductase	0.0052	0.0661	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0098	0.216	0.216
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0242	0.6808	0.7598
Brugia malayi	steroid hormone receptor	0.0242	0.6808	0.7598
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0242	0.6808	0.7598
Brugia malayi	RNA binding protein	0.0045	0.0427	0.0477
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0606	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Loa Loa (eye worm)	hypothetical protein	0.0114	0.2665	0.2665
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0098	0.216	0.216
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0119	0.2833	0.5709
Schistosoma mansoni	coup transcription factor	0.0242	0.6808	0.6808
Loa Loa (eye worm)	hypothetical protein	0.0128	0.3109	0.3109
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0242	0.6808	0.6808
Loa Loa (eye worm)	hypothetical protein	0.018	0.4815	0.4815
Loa Loa (eye worm)	hypothetical protein	0.0128	0.3109	0.3109
Brugia malayi	Nuclear hormone receptor-like 1	0.0128	0.3109	0.347
Loa Loa (eye worm)	TAR-binding protein	0.0045	0.0427	0.0427
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0242	0.6808	0.7598
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0427	0.0427
Schistosoma mansoni	tar DNA-binding protein	0.0045	0.0427	0.0427
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0208	0.5706	0.5
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0242	0.6808	0.6808
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0375	0.0375
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0114	0.2665	0.2665
Brugia malayi	hypothetical protein	0.0128	0.3109	0.347
Loa Loa (eye worm)	glutathione reductase	0.0052	0.0661	0.0661
Brugia malayi	hypothetical protein	0.0114	0.2665	0.2975
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0308	0.896	0.896
Plasmodium falciparum	glutathione reductase	0.0052	0.0661	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0375	0.0375
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0242	0.6808	0.6808
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0114	0.2665	0.2665
Echinococcus multilocularis	muscleblind protein	0.018	0.4815	0.4815
Brugia malayi	Nuclear hormone receptor E75	0.0114	0.2665	0.2975
Echinococcus multilocularis	FTZ F1 alpha	0.0242	0.6808	0.6808
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0242	0.6808	0.6808
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0114	0.2665	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6808	0.6808
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0114	0.2665	0.2665
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0114	0.2665	0.2665
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0114	0.2665	0.2975

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.8048 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	15.8489 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1384356

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1280654