Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.2165 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.2165 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1358 | 0.6158 | 0.6158 |
Trypanosoma brucei | hexokinase, putative | 0.2165 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.2165 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.2165 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.2165 | 1 | 1 |
Onchocerca volvulus | 0.1358 | 0.6158 | 0.6158 | |
Trypanosoma cruzi | hexokinase, putative | 0.2165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0688 | 0.2968 | 0.2968 |
Entamoeba histolytica | hexokinase 1 | 0.2165 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.2165 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.067 | 0.288 | 0.288 |
Brugia malayi | nuclear hormone receptor | 0.1401 | 0.6361 | 0.6361 |
Echinococcus multilocularis | hexokinase type 2 | 0.2165 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.2165 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.2165 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.2165 | 1 | 1 |
Onchocerca volvulus | 0.2165 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.2165 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1401 | 0.6361 | 0.6361 |
Echinococcus granulosus | hexokinase | 0.2165 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.2165 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0688 | 0.2968 | 0.2968 |
Toxoplasma gondii | hexokinase | 0.2165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0688 | 0.2968 | 0.2968 |
Onchocerca volvulus | Hexokinase homolog | 0.1358 | 0.6158 | 0.6158 |
Onchocerca volvulus | 0.2165 | 1 | 1 | |
Onchocerca volvulus | 0.2165 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.2165 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.2165 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.2165 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.2165 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.2165 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.1358 | 0.6158 | 0.6158 |
Trypanosoma cruzi | hexokinase, putative | 0.2165 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.2165 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1436 | 0.6525 | 0.6525 |
Loa Loa (eye worm) | hypothetical protein | 0.1477 | 0.6722 | 0.6722 |
Trypanosoma brucei | hexokinase | 0.2165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.137 | 0.6215 | 0.6215 |
Echinococcus multilocularis | hexokinase | 0.2165 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.067 | 0.288 | 0.288 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.