Detailed information for compound 1281168

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.527 | Formula: C26H29N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.69 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN1CCC(CC1)Oc1ccc(cc1)C(=O)NCc1ccccn1
  • InChi: 1S/C26H29N3O3/c1-31-25-7-4-5-20(17-25)19-29-15-12-24(13-16-29)32-23-10-8-21(9-11-23)26(30)28-18-22-6-2-3-14-27-22/h2-11,14,17,24H,12-13,15-16,18-19H2,1H3,(H,28,30)
  • InChiKey: WHNNTTMERJKMAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0058 0.0638
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.001
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0019 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0062 0.008 0.1168
Mycobacterium tuberculosis Possible penicillin-binding protein 0.071 0.1149 0.1145
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0026 0.002
Onchocerca volvulus 0.0029 0.0026 0.0213
Mycobacterium ulcerans lipase LipD 0.0111 0.0161 0.0155
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.001 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0161 0.0157
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0003
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0055 0.0069 0.101
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.001
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Brugia malayi intermediate filament protein 0.0026 0.0021 0.0021
Trypanosoma brucei glucose transporter 1E 0.0064 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.005 0.006 0.0869
Brugia malayi beta-lactamase 0.0111 0.0161 0.0161
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0129 0.0128
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.6079 1 1
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.008 0.5033
Leishmania major protein kinase, putative 0.0064 0.0084 0.0077
Leishmania major hypothetical protein, conserved 0.0019 0.001 0.0003
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0161 0.0157
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0129
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.006 0.0077 0.113
Echinococcus granulosus neutral sphingomyelinase 0.0019 0.001 0.0015
Brugia malayi exodeoxyribonuclease III family protein 0.0095 0.0134 0.0134
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0026 0.0365
Trichomonas vaginalis set domain proteins, putative 0.0482 0.0773 0.1966
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.015 0.0143
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.0003
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0021 0.0298
Brugia malayi beta-lactamase family protein 0.0111 0.0161 0.0161
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0019 0.001 0.001
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0026 0.0019
Loa Loa (eye worm) sugar transporter 0.0029 0.0026 0.0365
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.2374 0.3891 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0084 0.0084
Brugia malayi PHD-finger family protein 0.0035 0.0036 0.0035
Trypanosoma brucei protein kinase, putative 0.0104 0.015 0.015
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0084 0.0077
Entamoeba histolytica protein kinase, putative 0.0064 0.0084 0.0191
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0036 0.0029
Brugia malayi hypoxia-induced factor 1 0.0146 0.0219 0.0219
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0048 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0161 0.0155
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0026 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0161 0.0391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0215 0.0542
Schistosoma mansoni glucose transport protein 0.0206 0.0318 0.0318
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0084 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0215 0.0214
Onchocerca volvulus 0.0111 0.0161 0.1988
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0009
Schistosoma mansoni rab6-interacting 0.0022 0.0015 0.0014
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0097 0.0091
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0026 0.0365
Onchocerca volvulus 0.0026 0.0021 0.0154
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.006 0.0059
Brugia malayi MAP kinase sur-1 0.0104 0.015 0.0149
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.6079 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.015 0.0143
Brugia malayi RNA binding protein 0.0131 0.0195 0.0194
Brugia malayi hypothetical protein 0.0022 0.0015 0.0014
Onchocerca volvulus 0.0035 0.0036 0.0342
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0062 0.008 0.1168
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.015 0.0143
Schistosoma mansoni sugar transporter 0.0029 0.0026 0.0025
Loa Loa (eye worm) sugar transporter 0.0206 0.0318 0.4697
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0219 0.3229
Plasmodium falciparum dihydroorotate dehydrogenase 0.6079 1 1
Schistosoma mansoni ap endonuclease 0.0095 0.0134 0.0134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0095 0.0134 0.0128
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.001
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.6079 1 1
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.6079 1 1
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.0003
Onchocerca volvulus 0.0029 0.0026 0.0213
Leishmania major RNA-editing complex protein MP100, putative 0.0019 0.001 0.0003
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.015 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0215 0.0542
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0157 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.2374 0.3891 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.001 0.0124
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.001 0.0009
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.015 0.014
Onchocerca volvulus 0.0029 0.0026 0.0213
Echinococcus granulosus traf and tnf receptor associated protein 0.0019 0.001 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trypanosoma brucei RNA editing exonuclease 2 0.0019 0.001 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0169 0.2489
Schistosoma mansoni sugar transporter 0.0029 0.0026 0.0025
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0318 0.0795
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0084 0.0191
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0215 0.3163
Echinococcus granulosus single minded 2 0.0035 0.0036 0.0082
Echinococcus granulosus lamin 0.0026 0.0021 0.0045
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0095 0.0134 0.0134
Brugia malayi TAR-binding protein 0.0131 0.0195 0.0194
Entamoeba histolytica hypothetical protein 0.0109 0.0157 0.038
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0026 0.0025
Leishmania major glucose transporter, lmgt3 0.0064 0.0084 0.0077
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.008 0.0196
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0195 0.0194
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Leishmania major pantothenate kinase subunit, putative 0.002 0.0011 0.0005
Echinococcus granulosus RUN 0.0022 0.0015 0.0029
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0078 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0195 0.0194
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0097 0.0088
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0042 0.0027
Plasmodium falciparum mitogen-activated protein kinase 2 0.0334 0.0529 0.0523
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0206 0.0318 0.0809
Brugia malayi MH2 domain containing protein 0.0116 0.0169 0.0169
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0084 0.0205
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.001 0.0003
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0084 0.0074
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0077
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0195 0.2865
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0026 0.0019
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 0.001
Entamoeba histolytica protein kinase, putative 0.0064 0.0084 0.0191
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0026 0.0025
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0069 0.0168
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0161 0.0161
Trypanosoma cruzi pantothenate kinase subunit, putative 0.002 0.0011 0.0005
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0015 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.006 0.0059
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0054 0.0114
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0115 0.0286
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.0084 0.1222
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.0372 0.5488
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0161 0.0391
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0097 0.0091
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0016 0.0016
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0019 0.001 0.0015
Trypanosoma cruzi mitochondrial protein 99, putative 0.0019 0.001 0.0003
Brugia malayi Zinc finger, C2H2 type family protein 0.2374 0.3891 0.3891
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0019 0.001 0.0003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0058 0.0058
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0026 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0215 0.0542
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0298
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0134 0.0322
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0115 0.0114
Onchocerca volvulus 0.0022 0.0015 0.0072
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0036 0.0516
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0157 0.0394
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0058 0.014
Echinococcus granulosus synaptojanin 1 0.0019 0.001 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0195 0.0194
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.015 0.0149
Schistosoma mansoni lipoxygenase 0.0063 0.0082 0.0081
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.0326 0.0829
Mycobacterium tuberculosis Conserved protein 0.0111 0.0161 0.0157
Loa Loa (eye worm) hypothetical protein 0.0083 0.0115 0.1687
Schistosoma mansoni synaptojanin 0.0019 0.001 0.0009
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.6079 1 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0019 0.001 0.0015
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0019 0.001 0.0015
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0084 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0026 0.0042
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0195 0.0491
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0084 0.0077
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0026 0.0021
Onchocerca volvulus 0.0083 0.0115 0.1382
Plasmodium falciparum DNase I-like protein, putative 0.0019 0.001 0.0003
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0019 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0111 0.0161 0.0155
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2374 0.3891 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0168 0.0422
Echinococcus multilocularis solute carrier family 22 0.0029 0.0026 0.0056
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0048 0.0114
Leishmania major hypothetical protein, conserved 0.0029 0.0026 0.002
Onchocerca volvulus 0.0022 0.0015 0.0072
Toxoplasma gondii sugar transporter ST3 0.0029 0.0026 0.0016
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0026 0.0056
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0069 0.0168
Schistosoma mansoni hypothetical protein 0.0359 0.0569 0.0569
Schistosoma mansoni ap endonuclease 0.0095 0.0134 0.0134
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0084 0.0077
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0016 0.0011
Brugia malayi Pre-SET motif family protein 0.0424 0.0676 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0026 0.0042
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0054 0.0054
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0054 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0078 0.0191
Giardia lamblia PHD finger protein 15 0.0035 0.0036 0.1889
Brugia malayi mbt repeat family protein 0.0049 0.0058 0.0058
Trichomonas vaginalis esterase, putative 0.0111 0.0161 0.0391
Entamoeba histolytica hypothetical protein 0.0023 0.0017 0.0018
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0046 0.0054 0.0114
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0026 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.008 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Brugia malayi hypothetical protein 0.0159 0.0239 0.0239
Echinococcus granulosus solute carrier family 22 0.0029 0.0026 0.0056
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0195 0.2865
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0058 0.014
Schistosoma mansoni intermediate filament proteins 0.0026 0.0021 0.0021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.0318 0.0809
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0219
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0115 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Echinococcus multilocularis solute carrier family 22 0.0029 0.0026 0.0056
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0084 0.0084
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0036 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0161 0.0161
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.001 0.0124
Loa Loa (eye worm) hypothetical protein 0.0111 0.0161 0.2371
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0095 0.0134 0.0128
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0026 0.0056
Echinococcus multilocularis deoxyribonuclease 1 2 0.0019 0.001 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0161 0.0155
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0026 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0019 0.001 0.0003
Onchocerca volvulus 0.0029 0.0026 0.0213
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0086 0.0119 0.1747
Echinococcus granulosus lamin dm0 0.0026 0.0021 0.0045
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2374 0.3891 0.3888
Schistosoma mansoni dihydroorotate dehydrogenase 0.6079 1 1
Echinococcus granulosus General substrate transporter 0.0177 0.027 0.0686
Brugia malayi hypothetical protein 0.0109 0.0157 0.0156
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0084 0.0077
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0015 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0161 0.0146
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0015 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Giardia lamblia Sugar-proton symporter 0.0029 0.0026 0.1161
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2374 0.3891 1
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.015 0.0361
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0004
Mycobacterium tuberculosis Probable exported protein 0.0019 0.001 0.0005
Echinococcus granulosus geminin 0.0359 0.0569 0.1454
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0034 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0015
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0026 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0195 0.0194
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.001 0.0005
Schistosoma mansoni neutral sphingomyelinase 0.0019 0.001 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0078 0.0078
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0019 0.001 0.0003
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0054 0.0053
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.001 0.0129
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.006 0.0869
Brugia malayi Sugar transporter family protein 0.0029 0.0026 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0015
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0054 0.0048
Brugia malayi Cam kinase protein 1 0.0064 0.0084 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.001
Trypanosoma brucei unspecified product 0.0019 0.001 0.001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0084 0.0205
Loa Loa (eye worm) RNA binding protein 0.0131 0.0195 0.2865
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0019 0.001 0.0015
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0084 0.0074
Trypanosoma brucei sugar transporter, putative 0.0029 0.0026 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0161 0.0391
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0097 0.0097
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.0558
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0098 0.1431
Loa Loa (eye worm) hypothetical protein 0.0111 0.0161 0.2371
Mycobacterium ulcerans hypothetical protein 0.0023 0.0016 0.001
Loa Loa (eye worm) beta-lactamase 0.0111 0.0161 0.2371
Schistosoma mansoni polycystin 1-related 0.0022 0.0015 0.0014
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.015 0.0375
Schistosoma mansoni nocturnin 0.0019 0.001 0.0009
Schistosoma mansoni glucose transport protein 0.0206 0.0318 0.0318
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0082 0.02
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0215 0.0542
Schistosoma mansoni sugar transporter 0.0029 0.0026 0.0025
Onchocerca volvulus 0.0029 0.0026 0.0213
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0026 0.0042
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0161 0.0405
Echinococcus multilocularis lamin 0.0026 0.0021 0.0045
Leishmania major dihydroorotate dehydrogenase 0.6079 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Schistosoma mansoni hypothetical protein 0.0035 0.0036 0.0035
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.0318 0.0809
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0054 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.001
Echinococcus multilocularis synaptojanin 1 0.0019 0.001 0.0015
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0095 0.0134 0.013
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0084 0.0205
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.008 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0019 0.001 0.0003
Onchocerca volvulus 0.0029 0.0026 0.0213
Onchocerca volvulus 0.0029 0.0026 0.0213
Schistosoma mansoni eyes absent homolog 0.0086 0.0119 0.0119
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0019 0.001 0.0003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0078 0.0069
Schistosoma mansoni loxhd1 0.0022 0.0015 0.0014
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Brugia malayi CCR4 0.0019 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0034 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Schistosoma mansoni protein kinase 0.0064 0.0084 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0219
Brugia malayi Bromodomain containing protein 0.0035 0.0036 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Echinococcus multilocularis dna polymerase kappa 0.0019 0.001 0.0015
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0054 0.3168
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0004 0.0003
Schistosoma mansoni lamin 0.0026 0.0021 0.0021
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.008 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Loa Loa (eye worm) hypothetical protein 0.0159 0.0239 0.3529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0095 0.0134 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0019 0.001 0.0003
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2374 0.3891 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0124
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0161 0.0157
Echinococcus granulosus tar DNA binding protein 0.0131 0.0195 0.0491
Brugia malayi hypothetical protein 0.0086 0.0119 0.0119
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0026 0.002
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.6079 1 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0004
Echinococcus granulosus peregrin 0.0035 0.0036 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0015 0.0029
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0026 0.0026
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0054 0.0053
Schistosoma mansoni glucose transporter 0.0029 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0054 0.0781
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0019 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0215 0.0214
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0054 0.0053
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.2374 0.3891 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0219
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0019 0.001 0.001
Brugia malayi follicle stimulating hormone receptor 0.0239 0.0372 0.0371
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.0318 0.0809
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0042 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0084 0.019
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.0003
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0097 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0134 0.0128
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2374 0.3891 1
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0014 0.1615
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Onchocerca volvulus 0.0029 0.0026 0.0213
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0036 0.0035
Onchocerca volvulus 0.0111 0.0161 0.1988
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0016 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.001 0.0004
Echinococcus multilocularis lamin dm0 0.0026 0.0021 0.0045
Giardia lamblia DINP protein human, muc B family 0.0019 0.001 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0026 0.0042
Echinococcus multilocularis dna polymerase eta 0.0019 0.001 0.0015
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.001 0.0001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.2374 0.3891 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0048 0.0697
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0084 0.1222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0016 0.0011
Onchocerca volvulus 0.0029 0.0026 0.0213
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Leishmania major hypothetical protein, conserved 0.0111 0.0161 0.0155
Onchocerca volvulus 0.0029 0.0026 0.0213
Loa Loa (eye worm) hypothetical protein 0.0111 0.0161 0.2371
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0095 0.0134 0.0118
Onchocerca volvulus 0.0029 0.0026 0.0213
Giardia lamblia Hexose transporter 0.0029 0.0026 0.1161
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.001 0.0001
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.008 0.0196
Plasmodium falciparum hexose transporter 0.0206 0.0318 0.0312
Brugia malayi hypothetical protein 0.0029 0.0026 0.0025
Toxoplasma gondii sugar transporter ST2 0.0029 0.0026 0.0016
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.001 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.015 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0078 0.0078
Onchocerca volvulus Putative transporter 0.0029 0.0026 0.0213
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0084 0.1222
Echinococcus multilocularis solute carrier family 22 0.0029 0.0026 0.0056
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0019 0.001 0.0124
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0161 0.2371
Mycobacterium tuberculosis Conserved protein 0.0111 0.0161 0.0157
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0016 0.001
Echinococcus granulosus dna polymerase kappa 0.0019 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0846
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0077
Plasmodium falciparum protein kinase 6 0.0877 0.1424 0.1418
Plasmodium vivax SET domain protein, putative 0.0061 0.0078 0.0072
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0084 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0084 0.019
Schistosoma mansoni single-minded 0.0047 0.0056 0.0055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0215 0.0214
Onchocerca volvulus 0.0049 0.0058 0.0638
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0161 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0084 0.0083
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.0676 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0161 0.0157
Plasmodium falciparum protein kinase 7 0.0584 0.0941 0.0935
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0161 0.0161
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.015 0.0361
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0019 0.001 0.0003
Echinococcus multilocularis General substrate transporter 0.0177 0.027 0.0686
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0048 0.0114
Echinococcus multilocularis solute carrier family 22 0.0029 0.0026 0.0056
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Onchocerca volvulus 0.0029 0.0026 0.0213
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.015 0.0143
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.015 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0095 0.0134 0.0128
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0077
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0095 0.0134 0.0336
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0084 0.0077
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0161 0.0405
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0076 0.0185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0516
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0017 0.2138
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0074 0.0181
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1592 0.2602 0.6684
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0206
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0095 0.0134 0.0322
Echinococcus multilocularis traf and tnf receptor associated protein 0.0019 0.001 0.0015
Echinococcus multilocularis peregrin 0.0035 0.0036 0.0083
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Brugia malayi hypothetical protein 0.0029 0.0026 0.0025
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0019 0.001 0.0003
Toxoplasma gondii ABC1 family protein 0.0111 0.0161 0.0152
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0084 0.0205
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0082 0.02
Onchocerca volvulus 0.0029 0.0026 0.0213
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0015 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0004 0.0003
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0069 0.0168
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0161 0.0391
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0195 0.0194
Onchocerca volvulus 0.0029 0.0026 0.0213
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.015 0.2199
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0084 0.0074
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0019 0.001 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Onchocerca volvulus Alhambra homolog 0.0035 0.0036 0.0347
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.015 0.0361
Plasmodium vivax exodeoxyribonuclease III, putative 0.0019 0.001 0.0003
Schistosoma mansoni sugar transporter 0.0029 0.0026 0.0025
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0019 0.001 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0161 0.0155
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.015 0.0143
Brugia malayi Sugar transporter family protein 0.0029 0.0026 0.0025
Brugia malayi major facilitator superfamily protein 0.0029 0.0026 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0084 0.019
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0003
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0058 0.014
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0026 0.0025
Brugia malayi beta-lactamase family protein 0.0111 0.0161 0.0161
Schistosoma mansoni carbon catabolite repressor protein 0.0019 0.001 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Onchocerca volvulus 0.0482 0.0773 1
Brugia malayi jmjC domain containing protein 0.0043 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0111 0.0161 0.2371
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0359 0.0569 0.0569
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0042 0.0038
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.6079 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0015 0.0029
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.001 0.0124
Brugia malayi Doublecortin family protein 0.0022 0.0015 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0026 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Echinococcus multilocularis neutral sphingomyelinase 0.0019 0.001 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.0318 0.0809
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0084 0.019
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.001 0.0124
Plasmodium falciparum phd finger protein, putative 0.0035 0.0036 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.001 0.0003
Plasmodium vivax CDK-related protein kinase 6, putative 0.0877 0.1424 0.1418
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0124
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0058 0.0058
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0016 0.001
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0015 0.0029
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0054 0.0048
Leishmania major endonuclease/exonuclease protein-like protein 0.0019 0.001 0.0003
Brugia malayi Sugar transporter family protein 0.0206 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0124
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0084 0.019
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0054 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Mycobacterium ulcerans sugar transporter 0.0029 0.0026 0.0019
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.015 0.0375
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.6079 1 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0026 0.0042
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.0318 0.0809
Echinococcus granulosus solute carrier family 22 0.0029 0.0026 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0485
Leishmania major DNA polymerase kappa, putative 0.0019 0.001 0.0004
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0084 0.0205
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0009
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0059 0.0141
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0036 0.0083
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0021 0.0298
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2374 0.3891 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.001
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0026 0.0025
Toxoplasma gondii facilitative glucose transporter GT1 0.0206 0.0318 0.0309
Echinococcus granulosus solute carrier family 22 0.0029 0.0026 0.0056
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Schistosoma mansoni lamin 0.0026 0.0021 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0036 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.015 0.0361
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0016 0.001
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0019 0.001 0.0003
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0019 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0206
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0077
Schistosoma mansoni rab6-interacting 0.0022 0.0015 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0134 0.0128
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0045 0.009
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0161 0.0157
Echinococcus multilocularis musashi 0.0026 0.0021 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0084 0.019
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0124
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0017 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0109 0.0157 0.038
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0015 0.0206
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.001 0.0009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.001 0.0004
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0069 0.0069
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0084 0.0077
Mycobacterium tuberculosis Conserved protein 0.0111 0.0161 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0161 0.0391
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0026 0.0009
Schistosoma mansoni hypothetical protein 0.0022 0.0015 0.0014
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.0326 0.0829
Leishmania major glucose transporter, lmgt1 0.0064 0.0084 0.0077
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0058 0.0058
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.008 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Schistosoma mansoni cript-related 0.0019 0.001 0.0009
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0168 0.0422
Leishmania major glucose transporter, lmgt2 0.0064 0.0084 0.0077
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0078 0.0191
Brugia malayi hypothetical protein 0.0022 0.0015 0.0014
Mycobacterium ulcerans beta-lactamase 0.0111 0.0161 0.0155
Onchocerca volvulus 0.0029 0.0026 0.0213
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0161 0.0155
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.001 0.001
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0054 0.0048
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0036 0.0035
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0084 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0015
Loa Loa (eye worm) MBCTL1 0.0055 0.0069 0.101
Loa Loa (eye worm) hypothetical protein 0.0111 0.0161 0.2371
Onchocerca volvulus 0.0023 0.0016 0.0084
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0026 0.0056
Leishmania major hypothetical protein, conserved 0.0019 0.001 0.0003
Schistosoma mansoni glucose transport protein 0.0206 0.0318 0.0318
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0084 0.0205
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0036 0.0083
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0097 0.0091
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0078 0.0191
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0017 0.0007
Echinococcus granulosus solute carrier family 22 0.0029 0.0026 0.0056
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.6079 1 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0334 0.0529 0.0523
Toxoplasma gondii exonuclease III APE 0.0095 0.0134 0.0125
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.015 0.0375
Echinococcus granulosus dna polymerase eta 0.0019 0.001 0.0015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.001 0.0005
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.001 0.0015
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.008 0.0064
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.0318 0.0809
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0054 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.001
Leishmania major DNA polymerase eta, putative 0.0019 0.001 0.0004
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.002 0.0277
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0014 0.0358
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0084 0.0077
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0017 0.001
Echinococcus granulosus intermediate filament protein 0.0026 0.0021 0.0045
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0084 0.0084
Trypanosoma cruzi mitochondrial protein 99, putative 0.0019 0.001 0.0003
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0017 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0021 0.0021
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0016 0.001
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0097 0.0091
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.0318 0.0809
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0054 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0109 0.0157 0.0156
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0054 0.0048
Onchocerca volvulus 0.0026 0.0021 0.0154
Mycobacterium leprae Probable lipase LipE 0.0111 0.0161 0.0146
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.2374 0.3891 1
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0134 0.0322
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Toxoplasma gondii protein kinase, putative 0.0584 0.0941 0.0932
Echinococcus multilocularis RUN 0.0022 0.0015 0.0029
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0095 0.0134 0.8915
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0095 0.0134 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0084 0.0083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.015 0.0375
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0058 0.014
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0015 0.0009
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0054 0.0048
Trypanosoma brucei glucose transporter, putative 0.0064 0.0084 0.0084
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0026 0.0042
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0069 0.0168
Brugia malayi jmjC domain containing protein 0.0115 0.0168 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0161 0.0155
Schistosoma mansoni synaptojanin 0.0019 0.001 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0017 0.0001
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0036 0.0026
Schistosoma mansoni hypothetical protein 0.0206 0.0318 0.0318
Brugia malayi major facilitator superfamily protein 0.0029 0.0026 0.0025
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0026 0.0019
Toxoplasma gondii sugar transporter ST1 0.0029 0.0026 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0315 0.0498 0.0497
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0084 0.0205
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0084 0.0077
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0084 0.0077
Schistosoma mansoni protein kinase 0.0064 0.0084 0.0083
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0334 0.0529 0.052
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0084 0.0077
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0054 0.0129
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0169 0.2489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0215 0.0214
Loa Loa (eye worm) hypothetical protein 0.0111 0.0161 0.2371
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0095 0.0134 0.0336
Brugia malayi Pre-SET motif family protein 0.0061 0.0078 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0076 0.0185
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Brugia malayi hypothetical protein 0.0029 0.0026 0.0025
Entamoeba histolytica hypothetical protein 0.0109 0.0157 0.038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0157 0.0394
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0058 0.0846
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0195 0.0194
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0019 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0286
Brugia malayi PAS domain containing protein 0.0047 0.0056 0.0055
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.6079 1 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0115 0.0114
Entamoeba histolytica hypothetical protein 0.0109 0.0157 0.038
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0084 0.019
Trypanosoma cruzi hexose transporter 0.0064 0.0084 0.0077
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0059 0.0141
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.2374 0.3891 1
Plasmodium vivax sugar transporter, putative 0.0029 0.0026 0.0019
Trypanosoma brucei glucose transporter 2A 0.0064 0.0084 0.0084
Brugia malayi mbt repeat family protein 0.0049 0.0058 0.0058
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0036 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0077
Onchocerca volvulus 0.0061 0.0078 0.0898
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.005 0.0061 0.0885
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0019 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Echinococcus multilocularis geminin 0.0359 0.0569 0.1454
Schistosoma mansoni DNA polymerase eta 0.0019 0.001 0.0009
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.6079 1 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Onchocerca volvulus 0.0111 0.0161 0.1988
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0161 0.0157
Onchocerca volvulus 0.0029 0.0026 0.0213
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0026 0.0019
Schistosoma mansoni lipoxygenase 0.0022 0.0015 0.0014
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.008 0.0182
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.001
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0097 0.0091
Plasmodium vivax hexose transporter 0.0206 0.0318 0.0312
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0365
Loa Loa (eye worm) hypothetical protein 0.0061 0.0078 0.114
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0004 0.004
Schistosoma mansoni protein kinase 0.0064 0.0084 0.0083
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0017 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0095 0.0134 0.1974
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.001 0.0124
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0161 0.0157
Loa Loa (eye worm) hypothetical protein 0.0086 0.0119 0.1747
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0026 0.0042

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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