TDR Targets

Basic information

Technical information

TDR Targets ID: 1281391
Name: 1-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3 -[N-(4-methylphenyl)sulfonyl-C-phenylcarbonim idoyl]thiourea
MW: 519.638 | Formula: C26H25N5O3S2
H donors: 1 H acceptors: 3 LogP: 5.45 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccc(cc1)S(=O)(=O)NC(=NC(=Nc1c(C)n(n(c1=O)c1ccccc1)C)S)c1ccccc1
InChi: 1S/C26H25N5O3S2/c1-18-14-16-22(17-15-18)36(33,34)29-24(20-10-6-4-7-11-20)28-26(35)27-23-19(2)30(3)31(25(23)32)21-12-8-5-9-13-21/h4-17H,1-3H3,(H2,27,28,29,35)
InChiKey: QAPFXWDHCQBYKQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-3-[N-(4-methylphenyl)sulfonyl-C-phenyl-carbonimidoyl]thiourea
1-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-3-[(Z)-(4-methylphenyl)sulfonylimino-phenylmethyl]thiourea
1-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-3-[(E)-(4-methylphenyl)sulfonylimino-phenylmethyl]thiourea
1-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-3-[(4-methylphenyl)sulfonylimino-phenylmethyl]thiourea
1-(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)-3-[N-(4-methylphenyl)sulfonyl-C-phenyl-carbonimidoyl]thiourea
MLS000776572
SMR000371817
T0400-0447

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	v-ets avian erythroblastosis virus E26 oncogene homolog	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ets-related	Get druggable targets OG5_131947	All targets in OG5_131947
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K09435 transcriptional regulator ERG, putative	Get druggable targets OG5_131947	All targets in OG5_131947
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0576	0.1017
Schistosoma mansoni	serine/threonine-protein kinase	0.0025	0.0137	0.0137
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0036	0.0391	0.0539
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.098
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.0832
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0023	0.0087	0.0153
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0083	0.1438	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0025	0.0135	0.0238
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0058	0.0102
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0043	0.0555	0.098
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0043	0.0555	0.3861
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0576	0.1017
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0043	0.0555	0.0555
Schistosoma mansoni	gliotactin	0.0025	0.0135	0.0135
Brugia malayi	Carboxylesterase family protein	0.0025	0.0135	0.0243
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0043	0.0555	0.084
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0025	0.0135	0.0238
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0083	0.1438	1
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0043	0.0555	0.0832
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0188	0.381	0.6724
Brugia malayi	p70 ribosomal S6 kinase beta	0.0034	0.0341	0.0616
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0044	0.0566	0.0998
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0043	0.0555	0.098
Entamoeba histolytica	P-glycoprotein-2, putative	0.0044	0.0576	1
Trichomonas vaginalis	abcb9, putative	0.0044	0.0576	0.1017
Schistosoma mansoni	acetylcholinesterase	0.0025	0.0135	0.0135
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Schistosoma mansoni	lipoxygenase	0.0021	0.0058	0.0058
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0043	0.0555	0.098
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0043	0.0555	0.0555
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0043	0.0555	0.0555
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0043	0.0555	0.098
Loa Loa (eye worm)	hypothetical protein	0.0126	0.2412	0.4354
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0091	0.0161
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Echinococcus granulosus	acetylcholinesterase	0.0146	0.2856	0.504
Schistosoma mansoni	smdr2	0.0044	0.0576	0.0576
Echinococcus multilocularis	multidrug resistance protein 1	0.0044	0.0576	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0135	0.0243
Mycobacterium ulcerans	carboxylesterase, LipT	0.0025	0.0135	0.0324
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0091	0.0093
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.0832
Entamoeba histolytica	P-glycoprotein-2	0.0044	0.0576	1
Echinococcus multilocularis	Glutaredoxin protein 5	0.0022	0.0081	0.0143
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0576	0.1017
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0022	0.0081	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0271	0.5666	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0083	0.1438	0.2538
Entamoeba histolytica	P-glyco protein 6, putative	0.0044	0.0576	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Entamoeba histolytica	protein kinase, putative	0.0036	0.0391	0.6223
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0044	0.0576	0.1017
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0044	0.0576	0.1228
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0043	0.0555	0.1002
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0043	0.0555	0.0555
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0043	0.0555	0.1002
Loa Loa (eye worm)	multidrug resistance protein 3	0.0044	0.0576	0.1041
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0083	0.1438	0.2597
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0058	0.0102
Echinococcus multilocularis	ATP binding cassette sub family B	0.0044	0.0566	0.0998
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0043	0.0555	0.0555
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0043	0.0555	0.0555
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0271	0.5666	1
Onchocerca volvulus		0.0021	0.0058	0.1002
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0391	0.0707
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0091	0.0161
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0083	0.1438	0.2538
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0126	0.2412	0.514
Schistosoma mansoni	ap endonuclease	0.0023	0.0091	0.0091
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0146	0.2856	0.2856
Onchocerca volvulus		0.0025	0.0135	0.2339
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0576	0.1017
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0023	0.0087	0.0603
Toxoplasma gondii	GAF domain-containing protein	0.0083	0.1438	0.3065
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0058	0.0102
Plasmodium vivax	multidrug resistance protein 1, putative	0.0044	0.0576	0.4008
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0576	0.1017
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0083	0.1438	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0576	0.1017
Loa Loa (eye worm)	carboxylesterase	0.0025	0.0135	0.0243
Schistosoma mansoni	loxhd1	0.0021	0.0058	0.0058
Echinococcus multilocularis	multidrug resistance protein 1	0.0031	0.0276	0.0487
Echinococcus granulosus	nervana 2	0.0022	0.0081	0.0143
Giardia lamblia	Hypothetical protein	0.0043	0.0555	0.2015
Trichomonas vaginalis	abcb9, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0391	0.0691
Echinococcus granulosus	RUN	0.0021	0.0058	0.0102
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0091	0.0161
Entamoeba histolytica	protein kinase, putative	0.0034	0.0341	0.5202
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.3861
Trichomonas vaginalis	conserved hypothetical protein	0.0228	0.4693	0.8282
Brugia malayi	Carboxylesterase family protein	0.0146	0.2856	0.5156
Schistosoma mansoni	gabp alpha	0.0087	0.1544	0.1544
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Brugia malayi	Carboxylesterase family protein	0.0025	0.0135	0.0243
Entamoeba histolytica	P-glycoprotein-2	0.0044	0.0576	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Brugia malayi	Carboxylesterase family protein	0.0146	0.2856	0.5156
Echinococcus granulosus	serine/threonine protein kinase	0.0025	0.0137	0.0241
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0576	0.1017
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0043	0.0555	0.098
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0271	0.5666	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0576	0.1017
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0023	0.0087	0.0153
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0044	0.0576	0.3602
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0135	0.0243
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0091	0.0008
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0126	0.2412	0.4256
Brugia malayi	Doublecortin family protein	0.0021	0.0058	0.0104
Echinococcus multilocularis	acetylcholinesterase	0.0146	0.2856	0.504
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.3861
Loa Loa (eye worm)	hypothetical protein	0.0126	0.2412	0.4354
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0576	0.1017
Echinococcus granulosus	multidrug resistance protein 1	0.0031	0.0276	0.0487
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Brugia malayi	hypothetical protein	0.0021	0.0058	0.0104
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0126	0.2412	0.4256
Schistosoma mansoni	multidrug resistance protein	0.0044	0.0576	0.0576
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0043	0.0555	0.098
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0576	0.1017
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0043	0.0555	0.098
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0555	0.084
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0025	0.0137	0.1021
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Onchocerca volvulus		0.0025	0.0135	0.2339
Entamoeba histolytica	P-glycoprotein 5, putative	0.0044	0.0576	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0576	0.1017
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0126	0.2412	0.4257
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Echinococcus granulosus	carboxylesterase 5A	0.0146	0.2856	0.504
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0576	0.1017
Brugia malayi	Fli-1 protein	0.0265	0.5539	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0555	0.084
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0043	0.0555	0.084
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	abcb9, putative	0.0044	0.0576	0.1017
Brugia malayi	ABC transporter family protein	0.0044	0.0576	0.1041
Echinococcus multilocularis	GA binding protein alpha chain	0.0087	0.1544	0.2725
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0555	0.1002
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0576	0.1017
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0058	0.0104
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0576	0.1017
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0555	0.084
Entamoeba histolytica	P-glycoprotein-5	0.0044	0.0576	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0044	0.0576	0.1017
Brugia malayi	Carboxylesterase family protein	0.0025	0.0135	0.0243
Schistosoma mansoni	multidrug resistance protein	0.0044	0.0576	0.0576
Schistosoma mansoni	rab6-interacting	0.0021	0.0058	0.0058
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0043	0.0555	0.098
Schistosoma mansoni	multidrug resistance protein	0.0044	0.0576	0.0576
Plasmodium falciparum	phosphodiesterase delta, putative	0.0043	0.0555	0.3861
Trichomonas vaginalis	conserved hypothetical protein	0.0228	0.4693	0.8282
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1438	0.2596
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.3861
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.3861
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0091	0.0634
Plasmodium vivax	phosphodiesterase gamma, putative	0.0043	0.0555	0.3861
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0043	0.0555	0.0555
Toxoplasma gondii	hypothetical protein	0.0083	0.1438	0.3065
Echinococcus multilocularis	rac serine:threonine kinase	0.0025	0.0137	0.0241
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0271	0.5666	1
Trypanosoma cruzi	Protein kinase B	0.0025	0.0137	0.009
Echinococcus granulosus	acetylcholinesterase	0.0146	0.2856	0.504
Brugia malayi	multidrug resistance protein 3	0.0044	0.0576	0.1041
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0058	0.0402
Brugia malayi	Ets-domain containing protein	0.0087	0.1544	0.2787
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0058	0.0104
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.3861
Onchocerca volvulus		0.0025	0.0135	0.2339
Trichomonas vaginalis	spcc417.12 protein, putative	0.0025	0.0135	0.0238
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0043	0.0555	0.0832
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0043	0.0555	0.0832
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0091	0.0634
Echinococcus multilocularis	neuroligin	0.0025	0.0135	0.0238
Leishmania major	hypothetical protein, conserved	0.0043	0.0555	0.0832
Brugia malayi	hypothetical protein	0.0021	0.0058	0.0104
Giardia lamblia	hypothetical protein	0.0043	0.0555	0.2015
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0091	0.0008
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0271	0.5666	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2856	0.5156
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0576	0.1017
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0576	0.1017
Schistosoma mansoni	polycystin 1-related	0.0021	0.0058	0.0058
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0022	0.0081	0.0143
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0271	0.5666	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0058	0.0402
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0083	0.1438	0.2597
Echinococcus granulosus	nervana 2	0.0022	0.0081	0.0143
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0126	0.2412	0.4354
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0126	0.2412	0.4256
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0188	0.381	0.6673
Brugia malayi	hypothetical protein	0.0025	0.0135	0.0243
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0555	0.084
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0391	0.0691
Onchocerca volvulus		0.0025	0.0135	0.2339
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0126	0.2412	0.4354
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0043	0.0555	0.098
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0271	0.5666	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0058	0.0102
Toxoplasma gondii	exonuclease III APE	0.0023	0.0091	0.0194
Entamoeba histolytica	P-glycoprotein-1	0.0044	0.0576	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0135	0.0243
Loa Loa (eye worm)	PDE1B protein	0.0043	0.0555	0.1002
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0391	0.0691
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0126	0.2412	0.4257
Echinococcus multilocularis	nervana 2	0.0022	0.0081	0.0143
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0087	0.1544	0.2787
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0555	0.084
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0126	0.2412	0.4257
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.098
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0576	0.1041
Mycobacterium ulcerans	putative regulatory protein	0.0083	0.1438	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0034	0.0341	0.0616
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0025	0.0135	0.0135
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0576	0.1017
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0043	0.0555	0.0832
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0043	0.0555	0.098
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0576	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2856	0.5156
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0043	0.0555	0.1002
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0043	0.0555	0.1002
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0091	0.5
Loa Loa (eye worm)	carboxylesterase	0.0025	0.0135	0.0243
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Trichomonas vaginalis	taga, putative	0.0044	0.0576	0.1017
Schistosoma mansoni	serine/threonine-protein kinase	0.0025	0.0137	0.0137
Leishmania major	p-glycoprotein	0.0044	0.0576	0.087
Trichomonas vaginalis	conserved hypothetical protein	0.0228	0.4693	0.8282
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0555	0.098
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0135	0.0243
Schistosoma mansoni	ap endonuclease	0.0023	0.0091	0.0091
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0025	0.0137	0.009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0135	0.0243
Loa Loa (eye worm)	fli-1 protein	0.0265	0.5539	1
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.1438	0.2538
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0058	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0555	0.1002
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0044	0.0576	0.1041
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Echinococcus multilocularis	para nitrobenzyl esterase	0.0025	0.0135	0.0238
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0043	0.0555	0.098
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0576	0.1017
Schistosoma mansoni	BC026374 protein (S09 family)	0.0025	0.0135	0.0135
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0271	0.5666	0.5666
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0091	0.5
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0091	0.0165
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0576	0.1017
Leishmania major	hypothetical protein, conserved	0.0043	0.0555	0.0832
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0025	0.0135	0.0324
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0043	0.0555	0.098
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0391	0.0691
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0044	0.0576	0.5
Echinococcus granulosus	serine threonine protein kinase nrc	0.0023	0.0087	0.0153
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0025	0.0135	0.0324
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0025	0.0137	0.1021
Loa Loa (eye worm)	acetylcholinesterase 1	0.0146	0.2856	0.5156
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0091	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0391	0.0691
Onchocerca volvulus		0.0044	0.0576	1
Echinococcus multilocularis	acetylcholinesterase	0.0146	0.2856	0.504
Plasmodium falciparum	multidrug resistance protein 1	0.0044	0.0576	0.4008
Echinococcus granulosus	para nitrobenzyl esterase	0.0025	0.0135	0.0238
Entamoeba histolytica	protein kinase, putative	0.0036	0.0391	0.6223
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0043	0.0555	0.0555
Echinococcus multilocularis	RUN	0.0021	0.0058	0.0102
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Schistosoma mansoni	hypothetical protein	0.0021	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0058	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0566	0.1021
Echinococcus granulosus	neuroligin	0.0025	0.0135	0.0238
Mycobacterium ulcerans	putative regulatory protein	0.0083	0.1438	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0044	0.0576	0.087
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0391	0.0691
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0126	0.2412	0.2412
Echinococcus granulosus	GA binding protein alpha chain	0.0087	0.1544	0.2725
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0391	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1259	0.2273
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.098
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0031	0.0276	0.0487
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0555	0.098
Plasmodium falciparum	GAF domain-related protein, putative	0.0083	0.1438	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0126	0.2412	0.4256
Toxoplasma gondii	hypothetical protein	0.0083	0.1438	0.3065
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0576	0.1017
Brugia malayi	Carboxylesterase family protein	0.0025	0.0135	0.0243
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Echinococcus multilocularis	carboxylesterase 5A	0.0146	0.2856	0.504
Schistosoma mansoni	rab6-interacting	0.0021	0.0058	0.0058
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0025	0.0135	0.0238
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0188	0.381	0.6724
Echinococcus granulosus	multidrug resistance protein 1	0.0031	0.0276	0.0487
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0043	0.0555	0.3861
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0126	0.2412	0.4256
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0555	0.098
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0025	0.0135	0.0135
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0271	0.5666	1
Onchocerca volvulus		0.0021	0.0058	0.1002
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0576	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0135	0.0243
Echinococcus multilocularis	nervana 2	0.0022	0.0081	0.0143
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0126	0.2412	0.4257
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0043	0.0555	0.1002
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0126	0.2412	0.2412
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0044	0.0576	0.1017
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0091	0.0161
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0025	0.0135	0.0135
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Plasmodium vivax	hypothetical protein, conserved	0.0083	0.1438	1
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0043	0.0555	0.098
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0126	0.2412	1
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0576	0.1017
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0555	0.0832
Echinococcus granulosus	BC026374 protein S09 family	0.0025	0.0135	0.0238
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0025	0.0135	0.0135
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0058	0.0102
Brugia malayi	Ets-domain containing protein	0.0087	0.1544	0.2787
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0576	0.1017
Toxoplasma gondii	AGC kinase	0.0034	0.0341	0.0728
Loa Loa (eye worm)	carboxylesterase	0.0146	0.2856	0.5156
Echinococcus granulosus	Glutaredoxin protein 5	0.0022	0.0081	0.0143
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0043	0.0555	0.098
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0025	0.0135	0.0324
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0043	0.0555	0.084
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0271	0.5666	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0271	0.5666	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0576	0.1041
Mycobacterium leprae	conserved hypothetical protein	0.0083	0.1438	0.5
Toxoplasma gondii	hypothetical protein	0.0228	0.4693	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0135	0.0243
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0576	0.1017
Onchocerca volvulus		0.0025	0.0135	0.2339
Schistosoma mansoni	ets-related	0.0265	0.5539	0.5539
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0271	0.5666	1
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0023	0.0087	0.0603
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0044	0.0576	0.1228
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0555	0.084
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0043	0.0555	0.1183
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0043	0.0555	0.084
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0025	0.0135	0.0238
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0036	0.0391	0.0707
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0043	0.0555	0.3861
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0576	0.1017
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0091	0.0165

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.6169 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 79.4328 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1390413

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1281391